Hypoxia stimulates the EMT of gastric cancer cells through autocrine TGFβ signaling
Matsuoka, Junko, Yashiro, Masakazu, Doi, Yosuke, Fuyuhiro, Yuhiko, Kato, Yukihiro, Shinto, Osamu, Noda, Satoru, Kashiwagi, Shinichiro, Aomatsu, Naoki, Hirakawa, Toshiki, Hasegawa, Tsuyoshi, Shimizu, Kiyoshi, Shimizu, Toshiyuki, Miwa, Atsushi, Yamada, Nobuya, Sawada, Tetsuji, Hirakawa, Kosei
Published in PloS one (17.05.2013)
Published in PloS one (17.05.2013)
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Notch2 Is Preferentially Expressed in Mature B Cells and Indispensable for Marginal Zone B Lineage Development
Saito, Toshiki, Chiba, Shigeru, Ichikawa, Motoshi, Kunisato, Atsushi, Asai, Takashi, Shimizu, Kiyoshi, Yamaguchi, Tomoyuki, Yamamoto, Go, Seo, Sachiko, Kumano, Keiki, Nakagami-Yamaguchi, Etsuko, Hamada, Yoshio, Aizawa, Shinichi, Hirai, Hisamaru
Published in Immunity (Cambridge, Mass.) (01.05.2003)
Published in Immunity (Cambridge, Mass.) (01.05.2003)
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Ki26894, a novel transforming growth factor‐β type I receptor kinase inhibitor, inhibits in vitro invasion and in vivo bone metastasis of a human breast cancer cell line
Ehata, Shogo, Hanyu, Aki, Fujime, Makoto, Katsuno, Yoko, Fukunaga, Erina, Goto, Kouichiro, Ishikawa, Yuichi, Nomura, Kimie, Yokoo, Hiroshi, Shimizu, Toshiyuki, Ogata, Etsuro, Miyazono, Kohei, Shimizu, Kiyoshi, Imamura, Takeshi
Published in Cancer science (01.01.2007)
Published in Cancer science (01.01.2007)
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An inhibitor of transforming growth factor beta type I receptor ameliorates muscle atrophy in a mouse model of caveolin 3-deficient muscular dystrophy
Ohsawa, Yutaka, Okada, Tadashi, Nishimatsu, Shin-ichiro, Ishizaki, Masatoshi, Suga, Tomohiro, Fujino, Masahiro, Murakami, Tatsufumi, Uchino, Makoto, Tsuchida, Kunihiro, Noji, Sumihare, Hinohara, Atsushi, Shimizu, Toshiyuki, Shimizu, Kiyoshi, Sunada, Yoshihide
Published in Laboratory investigation (01.08.2012)
Published in Laboratory investigation (01.08.2012)
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Combination effect of a TGF‐β receptor kinase inhibitor with 5‐FU analog S1 on lymph node metastasis of scirrhous gastric cancer in mice
Shinto, Osamu, Yashiro, Masakazu, Kawajiri, Hidemi, Shimizu, Kiyoshi, Shimizu, Toshiyuki, Miwa, Atsushi, Hirakawa, Kosei
Published in Cancer science (01.08.2010)
Published in Cancer science (01.08.2010)
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Functional Diversity among Notch1, Notch2, and Notch3 Receptors
Shimizu, Kiyoshi, Chiba, Shigeru, Saito, Toshiki, Kumano, Keiki, Hamada, Yoshio, Hirai, Hisamaru
Published in Biochemical and biophysical research communications (08.03.2002)
Published in Biochemical and biophysical research communications (08.03.2002)
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Notch1 inhibits differentiation of hematopoietic cells by sustaining GATA-2 expression
Kumano, Keiki, Chiba, Shigeru, Shimizu, Kiyoshi, Yamagata, Tetsuya, Hosoya, Noriko, Saito, Toshiki, Takahashi, Tokiharu, Hamada, Yoshio, Hirai, Hisamaru
Published in Blood (01.12.2001)
Published in Blood (01.12.2001)
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Manic Fringe and Lunatic Fringe Modify Different Sites of the Notch2 Extracellular Region, Resulting in Different Signaling Modulation
Shimizu, Kiyoshi, Chiba, Shigeru, Saito, Toshiki, Kumano, Keiki, Takahashi, Tokiharu, Hirai, Hisamaru
Published in The Journal of biological chemistry (13.07.2001)
Published in The Journal of biological chemistry (13.07.2001)
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Binding of Delta1, Jagged1, and Jagged2 to Notch2 Rapidly Induces Cleavage, Nuclear Translocation, and Hyperphosphorylation of Notch2
Shimizu, Kiyoshi, Chiba, Shigeru, Hosoya, Noriko, Kumano, Keiki, Saito, Toshiki, Kurokawa, Mineo, Kanda, Yoshinobu, Hamada, Yoshio, Hirai, Hisamaru
Published in Molecular and Cellular Biology (01.09.2000)
Published in Molecular and Cellular Biology (01.09.2000)
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Amelioration of diabetic peripheral neuropathy by implantation of hematopoietic mononuclear cells in streptozotocin-induced diabetic rats
Hasegawa, Takamasa, Kosaki, Atsushi, Shimizu, Kiyoshi, Matsubara, Hiroaki, Mori, Yasukiyo, Masaki, Hiroya, Toyoda, Nagaoki, Inoue-Shibata, Megumi, Nishikawa, Mitsushige, Iwasaka, Toshiji
Published in Experimental neurology (01.06.2006)
Published in Experimental neurology (01.06.2006)
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Notch1 oncoprotein antagonizes TGF‐β/Smad‐mediated cell growth suppression via sequestration of coactivator p300
Masuda, Shigeo, Kumano, Keiki, Shimizu, Kiyoshi, Imai, Yoichi, Kurokawa, Mineo, Ogawa, Seishi, Miyagishi, Makoto, Taira, Kazunari, Hirai, Hisamaru, Chiba, Shigeru
Published in Cancer science (01.05.2005)
Published in Cancer science (01.05.2005)
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Relationship between the cAMP levels in leukocytes and the cytokine balance in patients surviving gram negative bacterial pneumonia
Matsumoto, Tomio, Hayamizu, Keisuke, Marubayashi, Seiji, Shimizu, Kiyoshi, Hamamoto, Aki, Yamaguchi, Tsuyoshi, Hashizume, Junji, Onabe, Takashi, Asahara, Toshimasa, Ohdan, Hideki
Published in Journal of Clinical Biochemistry and Nutrition (01.03.2011)
Published in Journal of Clinical Biochemistry and Nutrition (01.03.2011)
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Integrity of intracellular domain of Notch ligand is indispensable for cleavage required for release of the Notch2 intracellular domain
Shimizu, Kiyoshi, Chiba, Shigeru, Saito, Toshiki, Takahashi, Tokiharu, Kumano, Keiki, Hamada, Yoshio, Hirai, Hisamaru
Published in The EMBO journal (01.02.2002)
Published in The EMBO journal (01.02.2002)
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Homeoprotein DLX-1 Interacts with Smad4 and Blocks a Signaling Pathway from Activin A in Hematopoietic Cells
Chiba, Shigeru, Takeshita, Kenichi, Imai, Yoichi, Kumano, Keiki, Kurokawa, Mineo, Masuda, Shigeo, Shimizu, Kiyoshi, Nakamura, Shuji, Ruddle, Frank H., Hirai, Hisamaru
Published in Proceedings of the National Academy of Sciences - PNAS (23.12.2003)
Published in Proceedings of the National Academy of Sciences - PNAS (23.12.2003)
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Cancer‐associated fibroblasts might sustain the stemness of scirrhous gastric cancer cells via transforming growth factor‐β signaling
Hasegawa, Tsuyoshi, Yashiro, Masakazu, Nishii, Takafumi, Matsuoka, Junko, Fuyuhiro, Yuhiko, Morisaki, Tamami, Fukuoka, Tatsunari, Shimizu, Kiyoshi, Shimizu, Toshiyuki, Miwa, Atsushi, Hirakawa, Kosei
Published in International journal of cancer (15.04.2014)
Published in International journal of cancer (15.04.2014)
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Intraoperative Myogenic Motor Evoked Potentials Induced by Direct Electrical Stimulation of the Exposed Motor Cortex Under Isoflurane and Sevoflurane
Kawaguchi, Masahiko, Sakamoto, Takanori, Ohnishi, Hideyuki, Shimizu, Kiyoshi, Karasawa, Jun, Furuya, Hitoshi
Published in Anesthesia and analgesia (01.03.1996)
Published in Anesthesia and analgesia (01.03.1996)
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Blockade of the interaction between BMP9 and endoglin on erythroid progenitors promotes erythropoiesis in mice
Yamaguchi, Ayami, Hirano, Ikuo, Narusawa, Shiho, Shimizu, Kiyoshi, Ariyama, Hiroyuki, Yamawaki, Kengo, Nagao, Kenji, Yamamoto, Masayuki, Shimizu, Ritsuko
Published in Genes to cells : devoted to molecular & cellular mechanisms (01.10.2021)
Published in Genes to cells : devoted to molecular & cellular mechanisms (01.10.2021)
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Long-term intraocular pressure-lowering efficacy and safety of ripasudil-brimonidine fixed-dose combination for glaucoma and ocular hypertension: a multicentre, open-label, phase 3 study
Tanihara, Hidenobu, Yamamoto, Tetsuya, Aihara, Makoto, Koizumi, Noriko, Fukushima, Atsuki, Kawakita, Koji, Kojima, Satoshi, Nakamura, Toka, Suganami, Hideki
Published in Graefe's archive for clinical and experimental ophthalmology (01.08.2024)
Published in Graefe's archive for clinical and experimental ophthalmology (01.08.2024)
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One‐year clinical evaluation of 0.4% ripasudil (K‐115) in patients with open‐angle glaucoma and ocular hypertension
Tanihara, Hidenobu, Inoue, Toshihiro, Yamamoto, Tetsuya, Kuwayama, Yasuaki, Abe, Haruki, Fukushima, Atsuki, Suganami, Hideki, Araie, Makoto, Uchino, Miki, Iwasaki, Miki, Ono, Koichi, Sekiyama, Eiichi, Takahashi, Yoshinori, Fujie, Keiko, Shin, Hideyo, Kaneko, Taku, Shiba, Hiroharu, Ijuin, Nobuo, Tani, Emiko, Manabe, Yoichi, Yamana, Yasuo, Arai, Mikki, Kurata, Yoshinori, Shirao, Makoto, Inoue, Kenji, Ono, Ryuichiro, Matsumoto, Jun, Hatano, Hiroshi, Ouchi, Keiko, Kitagawa, Atsuko, Mizote, Hideaki, Kato, Hitoshi, Wakiyama, Harumi, Migita, Masayoshi, Hashida, Setsuko, Kawabata, Hidehito, Shimizu, Kiyoshi, Yamabayashi, Shigeki, Sugiura, Torao, Kubota, Yasutaka, Taguchi, Koji, Miyata, Kazunori, Ohtani, Shinichiro
Published in Acta ophthalmologica (Oxford, England) (01.02.2016)
Published in Acta ophthalmologica (Oxford, England) (01.02.2016)
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