Search Results - "KIYAMA RYUICHI" :: K.UTB vyhledávací portál | TBU Library Retrieval Portal

Carbamoyl Pyridone HIV‑1 Integrase Inhibitors. 1. Molecular Design and Establishment of an Advanced Two-Metal Binding Pharmacophore

Carbamoyl Pyridone HIV‑1 Integrase Inhibitors. 1. Molecular Design and Establishment of an Advanced Two-Metal Binding Pharmacophore

by Kawasuji, Takashi, Johns, Brian A, Yoshida, Hiroshi, Taishi, Teruhiko, Taoda, Yoshiyuki, Murai, Hitoshi, Kiyama, Ryuichi, Fuji, Masahiro, Yoshinaga, Tomokazu, Seki, Takahiro, Kobayashi, Masanori, Sato, Akihiko, Fujiwara, Tamio
Published in Journal of medicinal chemistry (25.10.2012)

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Journal Article

Homology Modeling of Gelatinase Catalytic Domains and Docking Simulations of Novel Sulfonamide Inhibitors

Homology Modeling of Gelatinase Catalytic Domains and Docking Simulations of Novel Sulfonamide Inhibitors

by Kiyama, Ryuichi, Tamura, Yoshinori, Watanabe, Fumihiko, Tsuzuki, Hiroshige, Ohtani, Mitsuaki, Yodo, Mitsuaki
Published in Journal of medicinal chemistry (20.05.1999)

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Journal Article

GAME SYSTEM, GAME CONTROL DEVICE, AND PROGRAM

GAME SYSTEM, GAME CONTROL DEVICE, AND PROGRAM

by KOGAMI KENJI, KIYAMA RYUICHI
Year of Publication 01.04.2021

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Patent

GAME SYSTEM, GAME CONTROL DEVICE, AND PROGRAM

GAME SYSTEM, GAME CONTROL DEVICE, AND PROGRAM

by KOGAMI KENJI, KIYAMA RYUICHI
Year of Publication 06.06.2019

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Patent

Carbamoyl Pyridone HIV‑1 Integrase Inhibitors 3. A Diastereomeric Approach to Chiral Nonracemic Tricyclic Ring Systems and the Discovery of Dolutegravir (S/GSK1349572) and (S/GSK1265744)

Carbamoyl Pyridone HIV‑1 Integrase Inhibitors 3. A Diastereomeric Approach to Chiral Nonracemic Tricyclic Ring Systems and the Discovery of Dolutegravir (S/GSK1349572) and (S/GSK1265744)

by Johns, Brian A, Kawasuji, Takashi, Weatherhead, Jason G, Taishi, Teruhiko, Temelkoff, David P, Yoshida, Hiroshi, Akiyama, Toshiyuki, Taoda, Yoshiyuki, Murai, Hitoshi, Kiyama, Ryuichi, Fuji, Masahiro, Tanimoto, Norihiko, Jeffrey, Jerry, Foster, Scott A, Yoshinaga, Tomokazu, Seki, Takahiro, Kobayashi, Masanori, Sato, Akihiko, Johnson, Matthew N, Garvey, Edward P, Fujiwara, Tamio
Published in Journal of medicinal chemistry (25.07.2013)

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Journal Article

Carbamoyl Pyridone HIV‑1 Integrase Inhibitors. 2. Bi- and Tricyclic Derivatives Result in Superior Antiviral and Pharmacokinetic Profiles

Carbamoyl Pyridone HIV‑1 Integrase Inhibitors. 2. Bi- and Tricyclic Derivatives Result in Superior Antiviral and Pharmacokinetic Profiles

by Kawasuji, Takashi, Johns, Brian A, Yoshida, Hiroshi, Weatherhead, Jason G, Akiyama, Toshiyuki, Taishi, Teruhiko, Taoda, Yoshiyuki, Mikamiyama-Iwata, Minako, Murai, Hitoshi, Kiyama, Ryuichi, Fuji, Masahiro, Tanimoto, Norihiko, Yoshinaga, Tomokazu, Seki, Takahiro, Kobayashi, Masanori, Sato, Akihiko, Garvey, Edward P, Fujiwara, Tamio
Published in Journal of medicinal chemistry (14.02.2013)

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Journal Article

Development of vaccines and therapeutics for COVID-19

Development of vaccines and therapeutics for COVID-19

by Ryuichi, Kiyama
Published in Proceedings for Annual Meeting of The Japanese Pharmacological Society (2022)

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Journal Article

3-Hydroxy-1,5-dihydro-pyrrol-2-one derivatives as advanced inhibitors of HIV integrase

3-Hydroxy-1,5-dihydro-pyrrol-2-one derivatives as advanced inhibitors of HIV integrase

by Kawasuji, Takashi, Fuji, Masahiro, Yoshinaga, Tomokazu, Sato, Akihiko, Fujiwara, Tamio, Kiyama, Ryuichi
Published in Bioorganic & medicinal chemistry (15.08.2007)

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Journal Article

A platform for designing HIV integrase inhibitors. Part 2: A two-metal binding model as a potential mechanism of HIV integrase inhibitors

A platform for designing HIV integrase inhibitors. Part 2: A two-metal binding model as a potential mechanism of HIV integrase inhibitors

by Kawasuji, Takashi, Fuji, Masahiro, Yoshinaga, Tomokazu, Sato, Akihiko, Fujiwara, Tamio, Kiyama, Ryuichi
Published in Bioorganic & medicinal chemistry (15.12.2006)

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Journal Article

A platform for designing HIV integrase inhibitors. Part 1: 2-Hydroxy-3-heteroaryl acrylic acid derivatives as novel HIV integrase inhibitor and modeling of hydrophilic and hydrophobic pharmacophores

A platform for designing HIV integrase inhibitors. Part 1: 2-Hydroxy-3-heteroaryl acrylic acid derivatives as novel HIV integrase inhibitor and modeling of hydrophilic and hydrophobic pharmacophores

by Kawasuji, Takashi, Yoshinaga, Tomokazu, Sato, Akihiko, Yodo, Mitsuaki, Fujiwara, Tamio, Kiyama, Ryuichi
Published in Bioorganic & medicinal chemistry (15.12.2006)

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Journal Article

Novel Angiotensin II Receptor Antagonists. Design, Synthesis, and in Vitro Evaluation of Dibenzo[a,d]cycloheptene and Dibenzo[b,f]oxepin Derivatives. Searching for Bioisosteres of Biphenyltetrazole Using a Three-Dimensional Search Technique

Novel Angiotensin II Receptor Antagonists. Design, Synthesis, and in Vitro Evaluation of Dibenzo[a,d]cycloheptene and Dibenzo[b,f]oxepin Derivatives. Searching for Bioisosteres of Biphenyltetrazole Using a Three-Dimensional Search Technique

by Kiyama, Ryuichi, Honma, Tsunetoshi, Hayashi, Kunio, Ogawa, Masayoshi, Hara, Mariko, Fujimoto, Masafumi, Fujishita, Toshio
Published in Journal of medicinal chemistry (01.07.1995)

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Journal Article

Ligand−Protein DataBase: Linking Protein−Ligand Complex Structures to Binding Data

Ligand−Protein DataBase: Linking Protein−Ligand Complex Structures to Binding Data

by Roche, Olivier, Kiyama, Ryuichi, Brooks, Charles L
Published in Journal of medicinal chemistry (25.10.2001)

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Journal Article

Synthesis and Antiviral Activity of 7-Benzyl-4-hydroxy-1,5-naphthyridin-2(1H)-one HIV Integrase Inhibitors

Synthesis and Antiviral Activity of 7-Benzyl-4-hydroxy-1,5-naphthyridin-2(1H)-one HIV Integrase Inhibitors

by Boros, Eric E, Edwards, Cynthia E, Foster, Scott A, Fuji, Masahiro, Fujiwara, Tamio, Garvey, Edward P, Golden, Pamela L, Hazen, Richard J, Jeffrey, Jerry L, Johns, Brian A, Kawasuji, Takashi, Kiyama, Ryuichi, Koble, Cecilia S, Kurose, Noriyuki, Miller, Wayne H, Mote, Angela L, Murai, Hitoshi, Sato, Akihiko, Thompson, James B, Woodward, Mark C, Yoshinaga, Tomokazu
Published in Journal of medicinal chemistry (14.05.2009)

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Journal Article

Synthesis and Evaluation of Novel Pyrazolo[1, 5-a]pyrimidine Derivatives as Nonpeptide Angiotensin II Receptor Antagonists

Synthesis and Evaluation of Novel Pyrazolo[1, 5-a]pyrimidine Derivatives as Nonpeptide Angiotensin II Receptor Antagonists

by KIYAMA, Ryuichi, HAYASHI, Kunio, HARA, Mariko, FUJIMOTO, Masafumi, KAWABATA, Tomoji, KAWAKAMI, Masaru, NAKAJIMA, Shigeyuki, FUJISHITA, Toshio
Published in Chemical & pharmaceutical bulletin (1995)

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Journal Article

INHIBITOR FOR ENZYME HAVING TWO DIVALENT METAL IONS AS ACTIVE CENTERS

INHIBITOR FOR ENZYME HAVING TWO DIVALENT METAL IONS AS ACTIVE CENTERS

by KIYAMA, RYUICHI, KAWASUJI, TAKASHI
Year of Publication 20.12.2001

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Patent

ANTIVIRAL AGENT

ANTIVIRAL AGENT

by TADA YUKIO, FUJISHITA TOSHIO, KAWASUJI TAKASHI, TAKECHI SHOZO, FUJI MASAHIRO, KIYAMA RYUICHI, KANDA YASUHIKO
Year of Publication 03.08.2010

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Patent

Novel angiotensin II receptor antagonists. Design, synthesis, and in vitro evaluation of dibenzo[a,d]cycloheptene and dibenzo[b,f]oxepin derivatives. Searching for bioisosteres of biphenylyltetrazole using a three-dimensional search technique

Novel angiotensin II receptor antagonists. Design, synthesis, and in vitro evaluation of dibenzo[a,d]cycloheptene and dibenzo[b,f]oxepin derivatives. Searching for bioisosteres of biphenylyltetrazole using a three-dimensional search technique

by KIYAMA, R, HONMA, T, HAYASHI, K, OGAWA, M, HARA, M, FUJIMOTO, M, FUJISHITA, T
Published in Journal of medicinal chemistry (07.07.1995)

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Journal Article

ANTIVIRAL AGENT

ANTIVIRAL AGENT

by TAKECHI, SHOZO, KIYAMA, RYUICHI, KANDA, YASUHIKO, FUJI, MASAHIRO, TADA, YUKIO, FUJISHITA, TOSHIO, KAWASUJI, TAKASHI
Year of Publication 27.02.2003

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Patent

Inhibitor for enzyme having two divalent metal ions as active center

Inhibitor for enzyme having two divalent metal ions as active center

by KAWASUJI TAKASHI, KIYAMA RYUICHI
Year of Publication 18.03.2010

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Patent

ANTIVIRAL AGENT

ANTIVIRAL AGENT

by MASAHIRO FUJI, YASUHIKO KANDA, SHOZO TAKECHI, YUKIO TADA, TAKASHI KAWASUJI, RYUICHI KIYAMA, TOSHIO FUJISHITA
Year of Publication 10.05.2017

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Patent