Design of phosphodiesterase 4D (PDE4D) allosteric modulators for enhancing cognition with improved safety
Burgin, Alex B, Gurney, Mark E, Magnusson, Olafur T, Singh, Jasbir, Witte, Pam, Staker, Bart L, Bjornsson, Jon M, Thorsteinsdottir, Margret, Hrafnsdottir, Sigrun, Hagen, Timothy, Kiselyov, Alex S, Stewart, Lance J
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Published in Nature biotechnology (01.01.2010)
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Synthesis and antiproliferative activity of conformationally restricted 1,2,3-triazole analogues of combretastatins in the sea urchin embryo model and against human cancer cell lines
Demchuk, Dmitry V., Samet, Alexander V., Chernysheva, Natalia B., Ushkarov, Vladimir I., Stashina, Galina A., Konyushkin, Leonid D., Raihstat, Mikhail M., Firgang, Sergei I., Philchenkov, Alex A., Zavelevich, Michael P., Kuiava, Ludmila M., Chekhun, Vasyl F., Blokhin, Dmitry Yu, Kiselyov, Alex S., Semenova, Marina N., Semenov, Victor V.
Published in Bioorganic & medicinal chemistry (15.01.2014)
Published in Bioorganic & medicinal chemistry (15.01.2014)
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iMyoblasts for ex vivo and in vivo investigations of human myogenesis and disease modeling
Guo, Dongsheng, Daman, Katelyn, Chen, Jennifer Jc, Shi, Meng-Jiao, Yan, Jing, Matijasevic, Zdenka, Rickard, Amanda M, Bennett, Monica H, Kiselyov, Alex, Zhou, Haowen, Bang, Anne G, Wagner, Kathryn R, Maehr, René, King, Oliver D, Hayward, Lawrence J, Emerson, Jr, Charles P
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Published in eLife (25.01.2022)
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Sea Urchin Embryo Model As a Reliable in Vivo Phenotypic Screen to Characterize Selective Antimitotic Molecules. Comparative evaluation of Combretapyrazoles, -isoxazoles, -1,2,3-triazoles, and -pyrroles as Tubulin-Binding Agents
Semenova, Marina N, Demchuk, Dmitry V, Tsyganov, Dmitry V, Chernysheva, Natalia B, Samet, Alexander V, Silyanova, Eugenia A, Kislyi, Victor P, Maksimenko, Anna S, Varakutin, Alexander E, Konyushkin, Leonid D, Raihstat, Mikhail M, Kiselyov, Alex S, Semenov, Victor V
Published in ACS combinatorial science (10.12.2018)
Published in ACS combinatorial science (10.12.2018)
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Novel Long-Acting Oxytocin Analog with Increased Efficacy in Reducing Food Intake and Body Weight
Elfers, Clinton T, Blevins, James E, Salameh, Therese S, Lawson, Elizabeth A, Silva, David, Kiselyov, Alex, Roth, Christian L
Published in International journal of molecular sciences (24.09.2022)
Published in International journal of molecular sciences (24.09.2022)
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Discovery of Leukotriene A4 Hydrolase Inhibitors Using Metabolomics Biased Fragment Crystallography
Davies, Douglas R, Mamat, Bjorn, Magnusson, Olafur T, Christensen, Jeff, Haraldsson, Magnus H, Mishra, Rama, Pease, Brian, Hansen, Erik, Singh, Jasbir, Zembower, David, Kim, Hidong, Kiselyov, Alex S, Burgin, Alex B, Gurney, Mark E, Stewart, Lance J
Published in Journal of medicinal chemistry (13.08.2009)
Published in Journal of medicinal chemistry (13.08.2009)
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Benzimidazolyl-pyrazolo[3,4‑b]pyridinones, Selective Inhibitors of MOLT‑4 Leukemia Cell Growth and Sea Urchin Embryo Spiculogenesis: Target Quest
Lichitsky, Boris V, Komogortsev, Andrey N, Dudinov, Arkady A, Krayushkin, Mikhail M, Khodot, Evgenii N, Samet, Alexander V, Silyanova, Eugenia A, Konyushkin, Leonid D, Karpov, Alexei S, Gorses, Delphine, Radimerski, Thomas, Semenova, Marina N, Kiselyov, Alex S, Semenov, Victor V
Published in ACS combinatorial science (09.12.2019)
Published in ACS combinatorial science (09.12.2019)
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Polyalkoxybenzenes from Plants. 5. Parsley Seed Extract in Synthesis of Azapodophyllotoxins Featuring Strong Tubulin Destabilizing Activity in the Sea Urchin Embryo and Cell Culture Assays
Semenova, Marina N, Kiselyov, Alex S, Tsyganov, Dmitry V, Konyushkin, Leonid D, Firgang, Sergei I, Semenov, Roman V, Malyshev, Oleg R, Raihstat, Mikhail M, Fuchs, Fabian, Stielow, Anne, Lantow, Margareta, Philchenkov, Alex A, Zavelevich, Michael P, Zefirov, Nikolay S, Kuznetsov, Sergei A, Semenov, Victor V
Published in Journal of medicinal chemistry (27.10.2011)
Published in Journal of medicinal chemistry (27.10.2011)
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Structure−Activity Relationship Studies Leading to the Identification of (2E)-3-[l-[(2,4-Dichlorophenyl)methyl]-5-fluoro-3-methyl-lH-indol-7-yl]-N-[(4,5-dichloro-2-thienyl)sulfonyl]-2-propenamide (DG-041), a Potent and Selective Prostanoid EP3 Receptor Antagonist, as a Novel Antiplatelet Agent That Does Not Prolong Bleeding
Singh, Jasbir, Zeller, Wayne, Zhou, Nian, Hategan, Georgeta, Mishra, Rama K, Polozov, Alex, Yu, Peng, Onua, Emmanuel, Zhang, Jun, Ramírez, José L, Sigthorsson, Gudmundur, Thorsteinnsdottir, Margret, Kiselyov, Alex. S, Zembower, David E, Andrésson, Thorkell, Gurney, Mark E
Published in Journal of medicinal chemistry (14.01.2010)
Published in Journal of medicinal chemistry (14.01.2010)
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Synthesis of Antimitotic Polyalkoxyphenyl Derivatives of Combretastatin Using Plant Allylpolyalkoxybenzenes
Semenov, Victor V, Kiselyov, Alex S, Titov, Ilia Y, Sagamanova, Irina K, Ikizalp, Natalie N, Chernysheva, Natalia B, Tsyganov, Dmitry V, Konyushkin, Leonid D, Firgang, Sergei I, Semenov, Roman V, Karmanova, Irina B, Raihstat, Mikhail M, Semenova, Marina N
Published in Journal of natural products (Washington, D.C.) (29.11.2010)
Published in Journal of natural products (Washington, D.C.) (29.11.2010)
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Synthesis and anti-mitotic activity of 6,7-dihydro-4H-isothiazolo[4,5-b]pyridin-5-ones: In vivo and cell-based studies
Semenov, Victor V., Lichitsky, Boris V., Komogortsev, Andrey N., Dudinov, Arkady A., Krayushkin, Mikhail M., Konyushkin, Leonid D., Atamanenko, Olga P., Karmanova, Irina B., Strelenko, Yuri A., Shor, Boris, Semenova, Marina N., Kiselyov, Alex S.
Published in European journal of medicinal chemistry (05.01.2017)
Published in European journal of medicinal chemistry (05.01.2017)
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cis-Restricted 3‑Aminopyrazole Analogues of Combretastatins: Synthesis from Plant Polyalkoxybenzenes and Biological Evaluation in the Cytotoxicity and Phenotypic Sea Urchin Embryo Assays
Tsyganov, Dmitry V, Konyushkin, Leonid D, Karmanova, Irina B, Firgang, Sergei I, Strelenko, Yuri A, Semenova, Marina N, Kiselyov, Alex S, Semenov, Victor V
Published in Journal of natural products (Washington, D.C.) (23.08.2013)
Published in Journal of natural products (Washington, D.C.) (23.08.2013)
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Novel derivatives of 1,3,4-oxadiazoles are potent mitostatic agents featuring strong microtubule depolymerizing activity in the sea urchin embryo and cell culture assays
Kiselyov, Alex S., Semenova, Marina N., Chernyshova, Natalya B., Leitao, Andrei, Samet, Alexandr V., Kislyi, Konstantine A., Raihstat, Mikhail M., Oprea, Tudor, Lemcke, Heiko, Lantow, Margaréta, Weiss, Dieter G., Ikizalp, Nazli N., Kuznetsov, Sergei A., Semenov, Victor V.
Published in European journal of medicinal chemistry (01.05.2010)
Published in European journal of medicinal chemistry (01.05.2010)
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A facile synthesis and microtubule-destabilizing properties of 4-(1H-benzo[d]imidazol-2-yl)-furazan-3-amines
Stepanov, Andrei I., Astrat'ev, Alexander A., Sheremetev, Aleksei B., Lagutina, Nataliya K., Palysaeva, Nadezhda V., Tyurin, Aleksei Yu, Aleksandrova, Nataliya S., Sadchikova, Nataliya P., Suponitsky, Kyrill Yu, Atamanenko, Olga P., Konyushkin, Leonid D., Semenov, Roman V., Firgang, Sergei I., Kiselyov, Alex S., Semenova, Marina N., Semenov, Victor V.
Published in European journal of medicinal chemistry (13.04.2015)
Published in European journal of medicinal chemistry (13.04.2015)
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Efficient Synthesis of Glaziovianin A Isoflavone Series from Dill and Parsley Extracts and Their in Vitro/in Vivo Antimitotic Activity
Semenov, Victor V, Tsyganov, Dmitry V, Semenova, Marina N, Chuprov-Netochin, Roman N, Raihstat, Mikhail M, Konyushkin, Leonid D, Volynchuk, Polina B, Marusich, Elena I, Nazarenko, Vera V, Leonov, Sergey V, Kiselyov, Alex S
Published in Journal of natural products (Washington, D.C.) (27.05.2016)
Published in Journal of natural products (Washington, D.C.) (27.05.2016)
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Comparative in vivo evaluation of polyalkoxy substituted 4H-chromenes and oxa-podophyllotoxins as microtubule destabilizing agents in the phenotypic sea urchin embryo assay
Semenova, Marina N., Tsyganov, Dmitry V., Malyshev, Oleg R., Ershov, Oleg V., Bardasov, Ivan N., Semenov, Roman V., Kiselyov, Alex S., Semenov, Victor V.
Published in Bioorganic & medicinal chemistry letters (15.08.2014)
Published in Bioorganic & medicinal chemistry letters (15.08.2014)
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Discovery of 4-[(2S)-2-{[4-(4-Chlorophenoxy)phenoxy]methyl}-1-pyrrolidinyl]butanoic Acid (DG-051) as a Novel Leukotriene A4 Hydrolase Inhibitor of Leukotriene B4 Biosynthesis
Sandanayaka, Vincent, Mamat, Bjorn, Mishra, Rama K, Winger, Jennifer, Krohn, Michael, Zhou, Li-Ming, Keyvan, Monica, Enache, Livia, Sullins, David, Onua, Emmanuel, Zhang, Jun, Halldorsdottir, Gudrun, Sigthorsdottir, Heida, Thorlaksdottir, Audur, Sigthorsson, Gudmundur, Thorsteinnsdottir, Margret, Davies, Douglas R, Stewart, Lance J, Zembower, David E, Andresson, Thorkell, Kiselyov, Alex S, Singh, Jasbir, Gurney, Mark E
Published in Journal of medicinal chemistry (28.01.2010)
Published in Journal of medicinal chemistry (28.01.2010)
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