Discovery of Ledipasvir (GS-5885): A Potent, Once-Daily Oral NS5A Inhibitor for the Treatment of Hepatitis C Virus Infection
Link, John O., Taylor, James G., Xu, Lianhong, Mitchell, Michael, Guo, Hongyan, Liu, Hongtao, Kato, Darryl, Kirschberg, Thorsten, Sun, Jianyu, Squires, Neil, Parrish, Jay, Keller, Terry, Yang, Zheng-Yu, Yang, Chris, Matles, Mike, Wang, Yujin, Wang, Kelly, Cheng, Guofeng, Tian, Yang, Mogalian, Erik, Mondou, Elsa, Cornpropst, Melanie, Perry, Jason, Desai, Manoj C.
Published in Journal of medicinal chemistry (13.03.2014)
Published in Journal of medicinal chemistry (13.03.2014)
Get full text
Journal Article
Selective thyroid hormone receptor β agonists with oxadiazolone acid isosteres
Kirschberg, Thorsten A., Jones, Christopher T., Xu, Yingzi, Fenaux, Martijn, Halcomb, Randall L., Wang, Yujin, Klucher, Kevin
Published in Bioorganic & medicinal chemistry letters (01.11.2020)
Published in Bioorganic & medicinal chemistry letters (01.11.2020)
Get full text
Journal Article
Structural and Binding Analysis of Pyrimidinol Carboxylic Acid and N-Hydroxy Quinazolinedione HIV-1 RNase H Inhibitors
LANSDON, Eric B, QI LIU, KIRSCHBERG, Thorsten A, LEAVITT, Stephanie A, BALAKRISHNAN, Mini, PERRY, Jason K, LANCASTER-MOYER, Candra, KUTTY, Nilima, XIAOHONG LIU, SQUIRES, Neil H, WATKINS, William J
Published in Antimicrobial Agents and Chemotherapy (01.06.2011)
Published in Antimicrobial Agents and Chemotherapy (01.06.2011)
Get full text
Journal Article
RNase H Active Site Inhibitors of Human Immunodeficiency Virus Type 1 Reverse Transcriptase: Design, Biochemical Activity, and Structural Information
Kirschberg, Thorsten A, Balakrishnan, Mini, Squires, Neil H, Barnes, Tiffany, Brendza, Katherine M, Chen, Xiaowu, Eisenberg, Eugene J, Jin, Weili, Kutty, Nilima, Leavitt, Stephanie, Liclican, Albert, Liu, Qi, Liu, Xiaohong, Mak, John, Perry, Jason K, Wang, Michael, Watkins, William J, Lansdon, Eric B
Published in Journal of medicinal chemistry (08.10.2009)
Published in Journal of medicinal chemistry (08.10.2009)
Get full text
Journal Article
Direct binding of ledipasvir to HCV NS5A: mechanism of resistance to an HCV antiviral agent
Kwon, Hyock Joo, Xing, Weimei, Chan, Katie, Niedziela-Majka, Anita, Brendza, Katherine M, Kirschberg, Thorsten, Kato, Darryl, Link, John O, Cheng, Guofeng, Liu, Xiaohong, Sakowicz, Roman
Published in PloS one (09.04.2015)
Published in PloS one (09.04.2015)
Get full text
Journal Article
Nucleotide Prodrug Containing a Nonproteinogenic Amino Acid To Improve Oral Delivery of a Hepatitis C Virus Treatment
Feng, Joy Y, Wang, Ting, Park, Yeojin, Babusis, Darius, Birkus, Gabriel, Xu, Yili, Voitenleitner, Christian, Fenaux, Martijn, Yang, Huiling, Eng, Stacey, Tirunagari, Neeraj, Kirschberg, Thorsten, Cho, Aesop, Ray, Adrian S
Published in Antimicrobial agents and chemotherapy (01.08.2018)
Published in Antimicrobial agents and chemotherapy (01.08.2018)
Get full text
Journal Article
Biochemical characterization of recombinant influenza A polymerase heterotrimer complex: Endonuclease activity and evaluation of inhibitors
Xing, Weimei, Barauskas, Ona, Kirschberg, Thorsten, Niedziela-Majka, Anita, Clarke, Michael, Birkus, Gabriel, Weissburg, Perry, Liu, Xiaohong, Schultz, Brian E, Sakowicz, Roman, Kwon, HyockJoo, Feng, Joy Y
Published in PloS one (15.08.2017)
Published in PloS one (15.08.2017)
Get full text
Journal Article
Novel, sulfonamide linked inhibitors of the hepatitis C virus NS3 protease
Kirschberg, Thorsten A., Squires, Neil H., Yang, Huiling, Corsa, Amoreena C., Tian, Yang, Tirunagari, Neeraj, Sheng, X. Christopher, Kim, Choung U.
Published in Bioorganic & medicinal chemistry letters (01.02.2014)
Published in Bioorganic & medicinal chemistry letters (01.02.2014)
Get full text
Journal Article
Conjugation of arginine oligomers to cyclosporin A facilitates topical delivery and inhibition of inflammation
Rothbard, Jonathan B, Khavari, Paul A, Garlington, Sarah, Lin, Qun, Kirschberg, Thorsten, Kreider, Erik, McGrane, P. Leo, Wender, Paul A
Published in Nature medicine (01.11.2000)
Published in Nature medicine (01.11.2000)
Get full text
Journal Article
Correction to Discovery of Ledipasvir (GS-5885): A Potent, Once-Daily Oral NS5A Inhibitor for the Treatment of Hepatitis C Virus Infection
Link, John O, Taylor, James G, Xu, Lianhong, Mitchell, Michael, Guo, Hongyan, Liu, Hongtao, Kato, Darryl, Kirschberg, Thorsten, Sun, Jianyu, Squires, Neil, Parrish, Jay, Kellar, Terry, Yang, Zheng-Yu, Yang, Chris, Matles, Mike, Wang, Yujin, Wang, Kelly, Cheng, Guofeng, Tian, Yang, Mogalian, Erik, Mondou, Elsa, Cornpropst, Melanie, Perry, Jason, Desai, Manoj C
Published in Journal of medicinal chemistry (25.08.2016)
Published in Journal of medicinal chemistry (25.08.2016)
Get full text
Journal Article
Synthesis and characterization of 1′-C-cyano-2′-fluoro-2′-C-methyl pyrimidine nucleosides as HCV polymerase inhibitors
Kirschberg, Thorsten A., Mish, Michael R., Zhang, Lijun, Squires, Neil H., Wang, Ke-Yu, Cho, Aesop, Feng, Joy Y., Fenaux, Martijn, Babusis, Darius, Park, Yeojin, Ray, Adrian S., Kim, Choung U.
Published in Bioorganic & medicinal chemistry letters (01.03.2015)
Published in Bioorganic & medicinal chemistry letters (01.03.2015)
Get full text
Journal Article
Triazole derivatives as non-nucleoside inhibitors of HIV-1 reverse transcriptase—Structure–activity relationships and crystallographic analysis
Kirschberg, Thorsten A., Balakrishnan, Mini, Huang, Wei, Hluhanich, Rebecca, Kutty, Nilima, Liclican, Albert C., McColl, Damian J., Squires, Neil H., Lansdon, Eric B.
Published in Bioorganic & medicinal chemistry (01.02.2008)
Published in Bioorganic & medicinal chemistry (01.02.2008)
Get full text
Journal Article
Synthesis of 1′-C-Cyano Pyrimidine Nucleosides and Characterization as HCV Polymerase Inhibitors
Kirschberg, Thorsten A., Mish, Michael, Squires, Neil H., Zonte, Sebastian, Aktoudianakis, Evangelos, Metobo, Sammy, Butler, Thomas, Ju, Xie, Cho, Aesop, Ray, Adrian S., Kim, Choung U.
Published in Nucleosides, nucleotides & nucleic acids (02.11.2015)
Published in Nucleosides, nucleotides & nucleic acids (02.11.2015)
Get full text
Journal Article
SAT066 - TERN-501, a potent and selective agonist of thyroid hormone receptor beta, strongly reduces histological features and biomarkers of non-alcoholic steatohepatitis associated pathology in rodent models
Kirschberg, Thorsten, Jones, Christopher, Xu, Yingzi, Wang, Yujin, Fenaux, Martijn, Klucher, Kevin
Published in Journal of hepatology (01.08.2020)
Published in Journal of hepatology (01.08.2020)
Get full text
Journal Article
TERN-501, a potent and selective agonist of thyroid hormone receptor beta, strongly reduces histological features and biomarkers of non-alcoholic steatohepatitis associated pathology in rodent models
Kirschberg, Thorsten, Jones, Christopher, Xu, Yingzi, Wang, Yujin, Fenaux, Martijn, Klucher, Kevin
Published in Journal of hepatology (01.08.2020)
Published in Journal of hepatology (01.08.2020)
Get full text
Journal Article
Bmf-500: An Orally Bioavailable Covalent Inhibitor of FLT3 with High Selectivity and Potent Antileukemic Activity in FLT3-Mutated AML
Law, Brian, Rughwani, Tripta, Archer, Tenley C., Kumar, Lekha, Lu, Daniel, Somanath, Priyanka, Ma, Yan, Wang, Xiaodong, Sperandio, David, Morris, Steve, Kirschberg, Thorsten, Balakrishnan, Mini, Butler, Thomas
Published in Blood (15.11.2022)
Published in Blood (15.11.2022)
Get full text
Journal Article
간 장애의 조합 치료
KIRSCHBERG THORSTEN A, JONES CHRISTOPHER T, KLUCHER KEVIN, FENAUX MARTIJN
Year of Publication 20.02.2023
Get full text
Year of Publication 20.02.2023
Patent
갑상선 호르몬 수용체 베타 작용제 화합물
KIRSCHBERG THORSTEN A, XU YINGZI, ROMERO F. ANTHONY, KLUCHER KEVIN, FENAUX MARTIJN, REEVES COREY, HALCOMB RANDALL
Year of Publication 02.11.2023
Get full text
Year of Publication 02.11.2023
Patent