Babesia microti: from Mice to Ticks to an Increasing Number of Highly Susceptible Humans
Westblade, Lars F, Simon, Matthew S, Mathison, Blaine A, Kirkman, Laura A
Published in Journal of clinical microbiology (01.10.2017)
Published in Journal of clinical microbiology (01.10.2017)
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Structures revealing mechanisms of resistance and collateral sensitivity of Plasmodium falciparum to proteasome inhibitors
Hsu, Hao-Chi, Li, Daqiang, Zhan, Wenhu, Ye, Jianxiang, Liu, Yi Jing, Leung, Annie, Qin, Junling, Crespo, Benigno, Gamo, Francisco-Javier, Zhang, Hao, Cui, Liwang, Roth, Alison, Kirkman, Laura A, Li, Huilin, Lin, Gang
Published in Nature communications (14.12.2023)
Published in Nature communications (14.12.2023)
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Evolution of Host Specificity by Malaria Parasites through Altered Mechanisms Controlling Genome Maintenance
Siao, Michelle C, Borner, Janus, Perkins, Susan L, Deitsch, Kirk W, Kirkman, Laura A
Published in mBio (17.03.2020)
Published in mBio (17.03.2020)
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Direct evidence for the adaptive role of copy number variation on antifolate susceptibility in Plasmodium falciparum
Heinberg, Adina, Siu, Edwin, Stern, Chaya, Lawrence, Elizabeth A., Ferdig, Michael T., Deitsch, Kirk W., Kirkman, Laura A.
Published in Molecular microbiology (01.05.2013)
Published in Molecular microbiology (01.05.2013)
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Journal Article
Telomere length dynamics in response to DNA damage in malaria parasites
Reed, Jake, Kirkman, Laura A., Kafsack, Björn F., Mason, Christopher E., Deitsch, Kirk W.
Published in iScience (19.02.2021)
Published in iScience (19.02.2021)
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Journal Article
A Histone Methyltransferase Inhibitor Can Reverse Epigenetically Acquired Drug Resistance in the Malaria Parasite Plasmodium falciparum
Chan, Amanda, Dziedziech, Alexis, Kirkman, Laura A, Deitsch, Kirk W, Ankarklev, Johan
Published in Antimicrobial agents and chemotherapy (21.05.2020)
Published in Antimicrobial agents and chemotherapy (21.05.2020)
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Journal Article
Clinical and Molecular Evidence of Atovaquone and Azithromycin Resistance in Relapsed Babesia microti Infection Associated With Rituximab and Chronic Lymphocytic Leukemia
Simon, Matthew S., Westblade, Lars F., Dziedziech, Alexis, Visone, Joseph E., Furman, Richard R., Jenkins, Stephen G., Schuetz, Audrey N., Kirkman, Laura A.
Published in Clinical infectious diseases (01.10.2017)
Published in Clinical infectious diseases (01.10.2017)
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Journal Article
Antimalarial proteasome inhibitor reveals collateral sensitivity from intersubunit interactions and fitness cost of resistance
Kirkman, Laura A., Zhan, Wenhu, Visone, Joseph, Dziedziech, Alexis, Singh, Pradeep K., Fan, Hao, Tong, Xinran, Bruzual, Igor, Hara, Ryoma, Kawasaki, Masanori, Imaeda, Toshihiro, Okamoto, Rei, Sato, Kenjiro, Michino, Mayako, Alvaro, Elena Fernandez, Guiang, Liselle F., Sanz, Laura, Mota, Daniel J., Govindasamy, Kavitha, Wang, Rong, Ling, Yan, Tumwebaze, Patrick K., Sukenick, George, Shi, Lei, Vendome, Jeremie, Bhanot, Purnima, Rosenthal, Philip J., Aso, Kazuyoshi, Foley, Michael A., Cooper, Roland A., Kafsack, Bjorn, Doggett, J. Stone, Nathan, Carl F., Lin, Gang
Published in Proceedings of the National Academy of Sciences - PNAS (17.07.2018)
Published in Proceedings of the National Academy of Sciences - PNAS (17.07.2018)
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Dual-pharmacophore artezomibs hijack the Plasmodium ubiquitin-proteasome system to kill malaria parasites while overcoming drug resistance
Zhan, Wenhu, Li, Daqiang, Subramanyaswamy, Shubha Bevkal, Liu, Yi Jing, Yang, Changmei, Zhang, Hao, Harris, Jacob C., Wang, Rong, Zhu, Songbiao, Rocha, Hedy, Sherman, Julian, Qin, Junling, Herring, Mikayla, Simwela, Nelson V., Waters, Andrew P., Sukenick, George, Cui, Liwang, Rodriguez, Ana, Deng, Haiteng, Nathan, Carl F., Kirkman, Laura A., Lin, Gang
Published in Cell chemical biology (18.05.2023)
Published in Cell chemical biology (18.05.2023)
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Journal Article
Design, Synthesis, and Optimization of Macrocyclic Peptides as Species-Selective Antimalaria Proteasome Inhibitors
Zhang, Hao, Ginn, John, Zhan, Wenhu, Liu, Yi J., Leung, Annie, Toita, Akinori, Okamoto, Rei, Wong, Tzu-Tshin, Imaeda, Toshihiro, Hara, Ryoma, Yukawa, Takafumi, Michino, Mayako, Vendome, Jeremie, Beuming, Thijs, Sato, Kenjiro, Aso, Kazuyoshi, Meinke, Peter T., Nathan, Carl F., Kirkman, Laura A., Lin, Gang
Published in Journal of medicinal chemistry (14.07.2022)
Published in Journal of medicinal chemistry (14.07.2022)
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Journal Article
Case Report: Mucosal Leishmaniasis in New York City
Murray, Henry W, Eiras, Daniel P, Kirkman, Laura A, Chai, Raymond L, Caplivski, Daniel
Published in The American journal of tropical medicine and hygiene (01.06.2020)
Published in The American journal of tropical medicine and hygiene (01.06.2020)
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Journal Article
Susceptibilities of Ugandan Plasmodium falciparum Isolates to Proteasome Inhibitors
Garg, Shreeya, Kreutzfeld, Oriana, Chelebieva, Sevil, Tumwebaze, Patrick K, Byaruhanga, Oswald, Okitwi, Martin, Orena, Stephen, Katairo, Thomas, Nsobya, Samuel L, Conrad, Melissa D, Aydemir, Ozkan, Legac, Jennifer, Gould, Alexandra E, Bayles, Brett R, Bailey, Jeffrey A, Duffey, Maelle, Lin, Gang, Kirkman, Laura A, Cooper, Roland A, Rosenthal, Philip J
Published in Antimicrobial agents and chemotherapy (18.10.2022)
Published in Antimicrobial agents and chemotherapy (18.10.2022)
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Journal Article
Development of a Highly Selective Plasmodium falciparum Proteasome Inhibitor with Anti‐malaria Activity in Humanized Mice
Zhan, Wenhu, Zhang, Hao, Ginn, John, Leung, Annie, Liu, Yi J., Michino, Mayako, Toita, Akinori, Okamoto, Rei, Wong, Tzu‐Tshin, Imaeda, Toshihiro, Hara, Ryoma, Yukawa, Takafumi, Chelebieva, Sevil, Tumwebaze, Patrick K., Lafuente‐Monasterio, Maria Jose, Martinez‐Martinez, Maria Santos, Vendome, Jeremie, Beuming, Thijs, Sato, Kenjiro, Aso, Kazuyoshi, Rosenthal, Philip J., Cooper, Roland A., Meinke, Peter T., Nathan, Carl F., Kirkman, Laura A., Lin, Gang
Published in Angewandte Chemie International Edition (19.04.2021)
Published in Angewandte Chemie International Edition (19.04.2021)
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Journal Article
Improvement of Asparagine Ethylenediamines as Anti-malarial Plasmodium-Selective Proteasome Inhibitors
Zhan, Wenhu, Visone, Joseph, Ouellette, Tierra, Harris, Jacob C, Wang, Rong, Zhang, Hao, Singh, Pradeep K, Ginn, John, Sukenick, George, Wong, Tzu-Tshin, Okoro, Judith I, Scales, Ryan M, Tumwebaze, Patrick K, Rosenthal, Philip J, Kafsack, Björn F. C, Cooper, Roland A, Meinke, Peter T, Kirkman, Laura A, Lin, Gang
Published in Journal of medicinal chemistry (11.07.2019)
Published in Journal of medicinal chemistry (11.07.2019)
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