Immuno- and Constitutive Proteasome Crystal Structures Reveal Differences in Substrate and Inhibitor Specificity
Huber, Eva M., Basler, Michael, Schwab, Ricarda, Heinemeyer, Wolfgang, Kirk, Christopher J., Groettrup, Marcus, Groll, Michael
Published in Cell (17.02.2012)
Published in Cell (17.02.2012)
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Journal Article
Prevention of experimental colitis by a selective inhibitor of the immunoproteasome
Basler, Michael, Dajee, Maya, Moll, Carlo, Groettrup, Marcus, Kirk, Christopher J
Published in The Journal of immunology (1950) (01.07.2010)
Published in The Journal of immunology (1950) (01.07.2010)
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Journal Article
Proteasome Inhibitors and Their Pharmacokinetics, Pharmacodynamics, and Metabolism
Wang, Jinhai, Fang, Ying, Fan, R Andrea, Kirk, Christopher J
Published in International journal of molecular sciences (27.10.2021)
Published in International journal of molecular sciences (27.10.2021)
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Journal Article
Nonproteasomal Targets of the Proteasome Inhibitors Bortezomib and Carfilzomib: a Link to Clinical Adverse Events
ARASTU-KAPUR, Shirin, ANDERL, Janet L, KIRK, Christopher J, KRAUS, Marianne, PARLATI, Francesco, SHENK, Kevin D, LEE, Susan J, MUCHAMUEL, Tony, BENNETT, Mark K, DRIESSEN, Christoph, BALL, Andrew J
Published in Clinical cancer research (01.05.2011)
Published in Clinical cancer research (01.05.2011)
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Beneficial effect of novel proteasome inhibitors in murine lupus via dual inhibition of type I interferon and autoantibody-secreting cells
Ichikawa, H. Travis, Conley, Thomas, Muchamuel, Tony, Jiang, Jing, Lee, Susan, Owen, Teresa, Barnard, Jennifer, Nevarez, Sarah, Goldman, Bruce I., Kirk, Christopher J., Looney, R. John, Anolik, Jennifer H.
Published in Arthritis & rheumatology (Hoboken, N.J.) (01.02.2012)
Published in Arthritis & rheumatology (Hoboken, N.J.) (01.02.2012)
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Journal Article
Co‐inhibition of immunoproteasome subunits LMP2 and LMP7 is required to block autoimmunity
Basler, Michael, Lindstrom, Michelle M, LaStant, Jacob J, Bradshaw, J Michael, Owens, Timothy D, Schmidt, Christian, Maurits, Elmer, Tsu, Christopher, Overkleeft, Herman S, Kirk, Christopher J, Langrish, Claire L, Groettrup, Marcus
Published in EMBO reports (01.12.2018)
Published in EMBO reports (01.12.2018)
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Journal Article
A novel orally active proteasome inhibitor ONX 0912 triggers in vitro and in vivo cytotoxicity in multiple myeloma
Chauhan, Dharminder, Singh, Ajita V., Aujay, Monette, Kirk, Christopher J., Bandi, Madhavi, Ciccarelli, Bryan, Raje, Noopur, Richardson, Paul, Anderson, Kenneth C.
Published in Blood (02.12.2010)
Published in Blood (02.12.2010)
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Journal Article
Reactive glia show increased immunoproteasome activity in Alzheimer's disease
ORRE, Marie, KAMPHUIS, Willem, OVAA, Huib, HOL, Elly M, DOVES, Stephanie, KOOIJMAN, Lieneke, CHAN, Elena T, KIRK, Christopher J, SMITH, Vanessa Dimayuga, KOOT, Sanne, MAMBER, Carlyn, JANSEN, Anne H
Published in Brain (London, England : 1878) (01.05.2013)
Published in Brain (London, England : 1878) (01.05.2013)
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Journal Article
A selective inhibitor of the immunoproteasome subunit LMP7 blocks cytokine production and attenuates progression of experimental arthritis
Basler, Michael, Aujay, Monette A, Groettrup, Marcus, Kalim, Khalid W, Shields, Jamie, Jiang, Jing, Kirk, Christopher J, Muchamuel, Tony, Suzuki, Erika, Bennett, Mark K, Ring, Eileen R, Demo, Susan D, Shwonek, Peter, Lauer, Christoph, Sylvain, Catherine, Parlati, Francesco
Published in Nature medicine (01.07.2009)
Published in Nature medicine (01.07.2009)
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Journal Article
Signal peptide mimicry primes Sec61 for client-selective inhibition
Rehan, Shahid, Tranter, Dale, Sharp, Phillip P., Craven, Gregory B., Lowe, Eric, Anderl, Janet L., Muchamuel, Tony, Abrishami, Vahid, Kuivanen, Suvi, Wenzell, Nicole A., Jennings, Andy, Kalyanaraman, Chakrapani, Strandin, Tomas, Javanainen, Matti, Vapalahti, Olli, Jacobson, Matthew P., McMinn, Dustin, Kirk, Christopher J., Huiskonen, Juha T., Taunton, Jack, Paavilainen, Ville O.
Published in Nature chemical biology (01.09.2023)
Published in Nature chemical biology (01.09.2023)
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Journal Article
Antitumor activity of PR-171, a novel irreversible inhibitor of the proteasome
DEMO, Susan D, KIRK, Christopher J, SHENK, Kevin D, SMYTH, Mark S, SUN, Congcong M, VALLONE, Marcy K, WOO, Tina M, MOLINEAUX, Christopher J, BENNETT, Mark K, AUJAY, Monette A, BUCHHOLZ, Tonia J, DAJEE, Maya, HO, Mark N, JING JIANG, LAIDIG, Guy J, LEWIS, Evan R, PARLATI, Francesco
Published in Cancer research (Chicago, Ill.) (01.07.2007)
Published in Cancer research (Chicago, Ill.) (01.07.2007)
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Journal Article
Discovery and Early Clinical Development of Selective Immunoproteasome Inhibitors
Kirk, Christopher J, Muchamuel, Tony, Wang, Jinhai, Fan, R Andrea
Published in Cells (Basel, Switzerland) (21.12.2021)
Published in Cells (Basel, Switzerland) (21.12.2021)
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Journal Article
Molecular mechanisms of bortezomib resistant adenocarcinoma cells
Suzuki, Erika, Demo, Susan, Deu, Edgar, Keats, Jonathan, Arastu-Kapur, Shirin, Bergsagel, P Leif, Bennett, Mark K, Kirk, Christopher J
Published in PloS one (22.12.2011)
Published in PloS one (22.12.2011)
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Journal Article
Design and Synthesis of an Orally Bioavailable and Selective Peptide Epoxyketone Proteasome Inhibitor (PR-047)
Zhou, Han-Jie, Aujay, Monette A, Bennett, Mark K, Dajee, Maya, Demo, Susan D, Fang, Ying, Ho, Mark N, Jiang, Jing, Kirk, Christopher J, Laidig, Guy J, Lewis, Evan R, Lu, Yan, Muchamuel, Tony, Parlati, Francesco, Ring, Eileen, Shenk, Kevin D, Shields, Jamie, Shwonek, Peter J, Stanton, Timothy, Sun, Congcong M, Sylvain, Catherine, Woo, Tina M, Yang, Jinfu
Published in Journal of medicinal chemistry (14.05.2009)
Published in Journal of medicinal chemistry (14.05.2009)
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Journal Article
Zetomipzomib (KZR-616) attenuates lupus in mice via modulation of innate and adaptive immune responses
Muchamuel, Tony, Fan, R Andrea, Anderl, Janet L, Bomba, Darrin J, Johnson, Henry W B, Lowe, Eric, Tuch, Brian B, McMinn, Dustin L, Millare, Beatriz, Kirk, Christopher J
Published in Frontiers in immunology (10.03.2023)
Published in Frontiers in immunology (10.03.2023)
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Journal Article
The antiviral immune response in mice devoid of immunoproteasome activity
Basler, Michael, Beck, Ulrike, Kirk, Christopher J, Groettrup, Marcus
Published in The Journal of immunology (1950) (01.12.2011)
Published in The Journal of immunology (1950) (01.12.2011)
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Journal Article
The immunoproteasome in antigen processing and other immunological functions
Basler, Michael, Kirk, Christopher J, Groettrup, Marcus
Published in Current opinion in immunology (01.02.2013)
Published in Current opinion in immunology (01.02.2013)
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Journal Article
Proteasome-based mechanisms of intrinsic and acquired bortezomib resistance in non-small cell lung cancer
de Wilt, Leonie H.A.M., Jansen, Gerrit, Assaraf, Yehuda G., van Meerloo, Johan, Cloos, Jacqueline, Schimmer, Aaron D., Chan, Elena T., Kirk, Christopher J., Peters, Godefridus J., Kruyt, Frank A.E.
Published in Biochemical pharmacology (15.01.2012)
Published in Biochemical pharmacology (15.01.2012)
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