X-ray Crystal Structure of the Novel Enhanced-Affinity Glucocorticoid Agonist Fluticasone Furoate in the Glucocorticoid Receptor−Ligand Binding Domain
Biggadike, Keith, Bledsoe, Randy K, Hassell, Anne M, Kirk, Barrie E, McLay, Iain M, Shewchuk, Lisa M, Stewart, Eugene L
Published in Journal of medicinal chemistry (26.06.2008)
Published in Journal of medicinal chemistry (26.06.2008)
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Use of diethylaminosulphur trifluoride (DAST) in the preparation of synthons of carbocyclic nucleosides
BIGGADIKE, K, BORTHWICK, A. D, EVANS, D, EXALL, A. M, KIRK, B. E, ROBERTS, S. M, STEPHENSON, L, YOUDS, P
Published in Journal of the Chemical Society, Perkin Transactions 1 (1988)
Published in Journal of the Chemical Society, Perkin Transactions 1 (1988)
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Fluoro carbocyclic nucleosides: synthesis and antiviral activity of 2'- and 6'-fluoro carbocyclic pyrimidine nucleosides including carbocyclic 1-(2-deoxy-2-fluoro-.beta.-D-arabinofuranosyl)-5-methyluracil and carbocyclic 1-(2-deoxy-2-fluoro-.beta.-D-arabinofuranosyl)-5-iodouracil
Borthwick, Alan D, Evans, Derek N, Kirk, Barrie E, Biggadike, Keith, Exall, Anne M, Youds, Peter, Roberts, Stanley M, Knight, David J, Coates, Jonathan A. V
Published in Journal of medicinal chemistry (01.01.1990)
Published in Journal of medicinal chemistry (01.01.1990)
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The Squalestatins: Inhibitors of Squalene Synthase. Enzyme Inhibitory Activities and in Vivo Evaluation of C3-Modified Analogues
Procopiou, Panayiotis A, Cox, Brian, Kirk, Barrie E, Lester, Michael G, McCarthy, Alun D, Sareen, Meenu, Sharratt, Peter J, Snowden, Michael A, Spooner, Stephen J, Watson, Nigel S, Widdowson, Julia
Published in Journal of medicinal chemistry (29.03.1996)
Published in Journal of medicinal chemistry (29.03.1996)
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The Squalestatins: Novel Inhibitors of Squalene Synthase. Enzyme Inhibitory Activities and in vivo Evaluation of C1-Modified Analogs
Procopiou, Panayiotis A, Bailey, Esme J, Bamford, Mark J, Craven, Andy P, Dymock, Brian W, Houston, John G, Hutson, Julie L, Kirk, Barrie E, McCarthy, Alun D
Published in Journal of medicinal chemistry (01.09.1994)
Published in Journal of medicinal chemistry (01.09.1994)
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The Squalestatins: Synthesis and Biological Activity of Some C3-Modified Analogs; Replacement of a Carboxylic Acid or Methyl Ester with an Isoelectronic Heterocyclic Functionality
Bamford, Mark J, Chan, Chuen, Craven, Andrew P, Dymock, Brian W, Green, Darren, Henson, Richard A, Kirk, Barrie E, Lester, Michael G, Procopiou, Panayiotis A
Published in Journal of medicinal chemistry (01.09.1995)
Published in Journal of medicinal chemistry (01.09.1995)
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Inhibitors of cholesterol biosynthesis. 1. 3,5-Dihydroxy-7-(N-imidazolyl)-6-heptenoates and -heptanoates, a novel series of 3-hydroxy-3-methylglutarate-CoA reductase inhibitors
Chan, Chuen, Bailey, Esme J, Hartley, C. David, Hayman, David F, Hutson, Julie L, Inglis, Graham G. A, Jones, Paul S, Keeling, Suzanne E, Kirk, Barrie E
Published in Journal of medicinal chemistry (01.11.1993)
Published in Journal of medicinal chemistry (01.11.1993)
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Fluorocarbocyclic nucleosides: synthesis and antiviral activity of 2'- and 6'-fluorocarbocyclic 2'-deoxyguanosines
Borthwick, Alan D, Kirk, Barrie E, Biggadike, Keith, Exall, Anne M, Butt, Suzanne, Roberts, Stanley M, Knight, David J, Coates, Jonathan A. V, Ryan, D. Michael
Published in Journal of medicinal chemistry (01.03.1991)
Published in Journal of medicinal chemistry (01.03.1991)
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2'-Deoxy-2'-fluoro-ara-aristeromycin, a new anti-herpes agent: the first direct introduction of a 2'-fluoro substituent into a carbocyclic nucleoside
BIGGADIKE, K, BORTHWICK, A. D, EXALL, A. M, KIRK, B. E, WARD, R. A
Published in Journal of the Chemical Society. Chemical communications (1988)
Published in Journal of the Chemical Society. Chemical communications (1988)
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SYNTHESIS AND ENZYMATIC RESOLUTION OF CARBOCYCLIC 2'-ARA-FLUORO-GUANOSINE - A POTENT NEW ANTI-HERPETIC AGENT
BORTHWICK, AD, BUTT, S, BIGGADIKE, K, EXALL, AM, ROBERTS, SM, YOUDS, PM, KIRK, BE, BOOTH, BR, CAMERON, JM, COX, SW, MARR, CLP, SHILL, MD
Published in Journal of the Chemical Society. Chemical communications (1988)
Published in Journal of the Chemical Society. Chemical communications (1988)
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Synthesis of fluorinated carbocyclic nucleosides: preparation of carbocyclic 1-(2'-deoxy-6'-fluororibofuranosyl)-5-iodouracils
BIGGADIKE, K, BORTHWICK, A. D, EXALL, A. M, KIRK, B. E, ROBERTS, S. M, YOUDS, P, SLAWIN, A. M. Z, WILLIAMS, D. J
Published in Journal of the Chemical Society. Chemical communications (1987)
Published in Journal of the Chemical Society. Chemical communications (1987)
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Synthesis of fluorinated carbocyclic nucleosides: preparation of (±)-carbocyclic-FMAU and some congeners
BIGGADIKE, K, BORTHWICK, A. D, EVANS, D, EXALL, A. M, KIRK, B. E, ROBERTS, S. M, STEPHENSON, L, YOUDS, P, SLAWIN, A. M. Z, WILLIAMS, D. J
Published in Journal of the Chemical Society. Chemical communications (1987)
Published in Journal of the Chemical Society. Chemical communications (1987)
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Fluorocarbocyclic nucleosides : synthesis and antiviral activity of 2'- and 6'-fluorocarbocyclic 2'-deoxy guanosines
BORTHWICK, A. D, KIRK, B. E, BIGGADIKE, K, EXALL, A. M, BUTT, S, ROBERTS, S. M, KNIGHT, D. J, COATES, J. A. V, RYAN, D. M
Published in Journal of medicinal chemistry (01.03.1991)
Published in Journal of medicinal chemistry (01.03.1991)
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Inhibitors of cholesterol biosynthesis. 1. 3,5-Dihydroxy-7-(N-imidazolyl)-6-heptenoates and -heptanoates, a novel series of HMG-CoA reductase inhibitors
Chan, C, Bailey, E J, Hartley, C D, Hayman, D F, Hutson, J L, Inglis, G G, Jones, P S, Keeling, S E, Kirk, B E, Lamont, R B
Published in Journal of medicinal chemistry (12.11.1993)
Published in Journal of medicinal chemistry (12.11.1993)
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The squalestatins: potent inhibitors of squalene synthase. The role of the tricarboxylic acid moiety
Watson, Nigel S., Bell, Richard, Chan, Chuen, Cox, Brian, Hutson, Julie L., Keeling, Suzanne E., Kirk, Barrie E., Procopiou, Panayiotis A., Steeples, Ian P., Widdowson, Julia
Published in Bioorganic & medicinal chemistry letters (01.12.1993)
Published in Bioorganic & medicinal chemistry letters (01.12.1993)
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The squalestatins: novel inhibitors of squalene synthase. The optimal C1 chain-length requirements
Procopiou, Panayiotis A., Bailey, Esme J., Hutson, Julie L., Kirk, Barrie E., Sharratt, Peter J., Spooner, Stephen J., Watson, Nigel S.
Published in Bioorganic & medicinal chemistry letters (1993)
Published in Bioorganic & medicinal chemistry letters (1993)
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