Structure-Based Optimization of Protein Tyrosine Phosphatase 1B Inhibitors: From the Active Site to the Second Phosphotyrosine Binding Site
Wilson, Douglas P, Wan, Zhao-Kui, Xu, Wei-Xin, Kirincich, Steven J, Follows, Bruce C, Joseph-McCarthy, Diane, Foreman, Kenneth, Moretto, Alessandro, Wu, Junjun, Zhu, Min, Binnun, Eva, Zhang, Yan-Ling, Tam, May, Erbe, David V, Tobin, James, Xu, Xin, Leung, Louis, Shilling, Adam, Tam, Steve Y, Mansour, Tarek S, Lee, Jinbo
Published in Journal of medicinal chemistry (20.09.2007)
Published in Journal of medicinal chemistry (20.09.2007)
Get full text
Journal Article
An Aldol Approach to the Synthesis of the EF Fragment of Spongistatin 1
Crimmins, Michael T, Katz, Jason D, McAtee, Laura C, Tabet, Elie A, Kirincich, Steven J
Published in Organic letters (22.03.2001)
Published in Organic letters (22.03.2001)
Get full text
Journal Article
Discovery of Ecopladib, an Indole Inhibitor of Cytosolic Phospholipase Α2α
Lee, Katherine L, Foley, Megan A, Chen, Lihren, Behnke, Mark L, Lovering, Frank E, Kirincich, Steven J, Wang, Weiheng, Shim, Jaechul, Tam, Steve, Shen, Marina W. H, Khor, SooPeang, Xu, Xin, Goodwin, Debra G, Ramarao, Manjunath K, Nickerson-Nutter, Cheryl, Donahue, Frances, Ku, M. Sherry, Clark, James D, McKew, John C
Published in Journal of medicinal chemistry (22.03.2007)
Published in Journal of medicinal chemistry (22.03.2007)
Get full text
Journal Article
Indole Cytosolic Phospholipase A2 α Inhibitors: Discovery and in Vitro and in Vivo Characterization of 4-{3-[5-Chloro-2-(2-{[(3,4-dichlorobenzyl)sulfonyl]amino}ethyl)-1-(diphenylmethyl)-1H-indol-3-yl]propyl}benzoic Acid, Efipladib
McKew, John C, Lee, Katherine L, Shen, Marina W. H, Thakker, Paresh, Foley, Megan A, Behnke, Mark L, Hu, Baihua, Sum, Fuk-Wah, Tam, Steve, Hu, Yonghan, Chen, Lihren, Kirincich, Steven J, Michalak, Ronald, Thomason, Jennifer, Ipek, Manus, Wu, Kun, Wooder, Lane, Ramarao, Manjunath K, Murphy, Elizabeth A, Goodwin, Debra G, Albert, Leo, Xu, Xin, Donahue, Frances, Ku, M. Sherry, Keith, James, Nickerson-Nutter, Cheryl L, Abraham, William M, Williams, Cara, Hegen, Martin, Clark, James D
Published in Journal of medicinal chemistry (26.06.2008)
Published in Journal of medicinal chemistry (26.06.2008)
Get full text
Journal Article
Discovery of ecopladib, an indole inhibitor of cytosolic phospholipase A2α
LEE, Katherine L, FOLEY, Megan A, KHOR, Soopeang, XIN XU, GOODWIN, Debra G, RAMARAO, Manjunath K, NICKERSON-NUTTER, Cheryl, DONAHUE, Frances, SHERRY KU, M, DARK, James D, MCKEW, John C, CHEN, Lihren, BEHNKE, Mark L, LOVERING, Frank E, KIRINCICH, Steven J, WEIHENG WANG, SHIM, Jaechul, TAM, Steve, SHEN, Marina W. H
Published in Journal of medicinal chemistry (22.03.2007)
Published in Journal of medicinal chemistry (22.03.2007)
Get full text
Journal Article
Benzhydrylquinazolinediones: Novel cytosolic phospholipase A2α inhibitors with improved physicochemical properties
KIRINCICH, Steven J, JASON XIANG, GREEN, Neal, TAM, Steve, YANG, Hui Y, SHIM, Jaechul, SHEN, Marina W. H, CLARK, James D, MCKEW, John C
Published in Bioorganic & medicinal chemistry (01.07.2009)
Published in Bioorganic & medicinal chemistry (01.07.2009)
Get full text
Journal Article
Molecular activation of PPARγ by angiotensin II type 1-receptor antagonists
Erbe, David V., Gartrell, Katherine, Zhang, Yan-Ling, Suri, Vipin, Kirincich, Steven J., Will, Sarah, Perreault, Mylene, Wang, Suyue, Tobin, James F.
Published in Vascular pharmacology (01.09.2006)
Published in Vascular pharmacology (01.09.2006)
Get full text
Journal Article
Indole cytosolic phospholipase A(2) alpha inhibitors: Discovery and in vitro and in vivo characterization of 4-{3-[5-chloro-2-(2-{[(3,4-dichlorobenzyl)sulfonyl]amino}ethyl)-1-(diphenylmethyl)-1H-indol-3-yl]propyl}benzoic acid, efipladib
McKew, John C., Lee, Katherine L., Shen, Marina W. H., Thakker, Paresh, Foley, Megan A., Behnke, Mark L., Hu, Baihua, Sum, Fuk-Wah, Tam, Steve, Hu, Yonghan, Chen, Lihren, Kirincich, Steven J., Michalak, Ronald, Thomason, Jennifer, Ipek, Manus, Wu, Kun, Wooder, Lane, Ramarao, Manjunath K., Murphy, Elizabeth A., Goodwin, Debra G., Albert, Leo, Xu, Xin, Donahue, Frances, Ku, M. Sherry, Keith, James, Nickerson-Nutter, Cheryl L., Abraham, William M., Williams, Cara, Hegen, Martin, Clark, James D.
Published in Journal of medicinal chemistry (26.06.2008)
Published in Journal of medicinal chemistry (26.06.2008)
Get full text
Journal Article
Discovery of ecopladib, an indole inhibitor of cytosolic phospholipase A(2)alpha
Lee, Katherine L., Foley, Megan A., Chen, Lihren, Behnke, Mark L., Lovering, Frank E., Kirincich, Steven J., Wang, Weiheng, Shim, Jaechul, Tam, Steve, Shen, Marina W. H., Khor, SooPeang, Xu, Xin, Goodwin, Debra G., Ramarao, Manjunath K., Nickerson-Nutter, Cheryl, Donahue, Frances, Ku, M. Sherry, Clark, James D., McKew, John C.
Published in Journal of medicinal chemistry (22.03.2007)
Published in Journal of medicinal chemistry (22.03.2007)
Get full text
Journal Article
Characterization of PTP1b Inhibitors: Development of a Novel ELISA for Insulin Receptor De-Phosphorylation
Yan-Ling, Zhang, Tam, May, Xu, Weixin, Kirincich, Steven J
Published in Diabetes (New York, N.Y.) (01.06.2005)
Get full text
Published in Diabetes (New York, N.Y.) (01.06.2005)
Journal Article
Benzhydrylquinazolinediones: Novel cytosolic phospholipase A sub(2) alpha inhibitors with improved physicochemical properties
Kirincich, Steven J, Xiang, Jason, Green, Neal, Tam, Steve, Yang, Hui Y, Shim, Jaechul, Shen, Marina WH, Clark, James D, McKew, John C
Published in Bioorganic & medicinal chemistry (01.07.2009)
Published in Bioorganic & medicinal chemistry (01.07.2009)
Get full text
Journal Article
Identification of Novel, Active-Site Inhibitors of PTP1b
Yan-Ling, Zhang, Xu, Weixin, Zhao-Kui, Wan, Kirincich, Steven J
Published in Diabetes (New York, N.Y.) (01.06.2005)
Get full text
Published in Diabetes (New York, N.Y.) (01.06.2005)
Journal Article
Indole Cytosolic Phospholipase A 2 α Inhibitors: Discovery and in Vitro and in Vivo Characterization of 4-{3-[5-Chloro-2-(2-{[(3,4-dichlorobenzyl)sulfonyl]amino}ethyl)-1-(diphenylmethyl)-1 H -indol-3-yl]propyl}benzoic Acid, Efipladib
McKew, John C., Lee, Katherine L., Shen, Marina W. H., Thakker, Paresh, Foley, Megan A., Behnke, Mark L., Hu, Baihua, Sum, Fuk-Wah, Tam, Steve, Hu, Yonghan, Chen, Lihren, Kirincich, Steven J., Michalak, Ronald, Thomason, Jennifer, Ipek, Manus, Wu, Kun, Wooder, Lane, Ramarao, Manjunath K., Murphy, Elizabeth A., Goodwin, Debra G., Albert, Leo, Xu, Xin, Donahue, Frances, Ku, M. Sherry, Keith, James, Nickerson-Nutter, Cheryl L., Abraham, William M., Williams, Cara, Hegen, Martin, Clark, James D.
Published in Journal of medicinal chemistry (01.06.2008)
Published in Journal of medicinal chemistry (01.06.2008)
Get full text
Journal Article
Discovery of Ecopladib, an indole inhibitor of cytosolic phospholipase A2alpha
Lee, Katherine L, Foley, Megan A, Chen, Lihren, Behnke, Mark L, Lovering, Frank E, Kirincich, Steven J, Wang, Weiheng, Shim, Jaechul, Tam, Steve, Shen, Marina W H, Khor, Soopeang, Xu, Xin, Goodwin, Debra G, Ramarao, Manjunath K, Nickerson-Nutter, Cheryl, Donahue, Frances, Ku, M Sherry, Clark, James D, McKew, John C
Published in Journal of medicinal chemistry (22.03.2007)
Get full text
Published in Journal of medicinal chemistry (22.03.2007)
Journal Article
Discovery of Ecopladib, an Indole Inhibitor of Cytosolic Phospholipase Α 2 α
Lee, Katherine L., Foley, Megan A., Chen, Lihren, Behnke, Mark L., Lovering, Frank E., Kirincich, Steven J., Wang, Weiheng, Shim, Jaechul, Tam, Steve, Shen, Marina W. H., Khor, SooPeang, Xu, Xin, Goodwin, Debra G., Ramarao, Manjunath K., Nickerson-Nutter, Cheryl, Donahue, Frances, Ku, M. Sherry, Clark, James D., McKew, John C.
Published in Journal of medicinal chemistry (01.03.2007)
Published in Journal of medicinal chemistry (01.03.2007)
Get full text
Journal Article
Indole Cytosolic Phospholipase A2 α Inhibitors : Discovery and in Vitro and in Vivo Characterization of 4-{3-[5-Chloro-2-(2-{[(3,4-dichlorobenzyl)sulfonyl]amino}ethyl)-l-(diphenylmethyl)-1H-indol-3-yl]propyl}benzoic Acid, Efipladib
MCKEW, John C, LEE, Katherine L, CHEN, Lihren, KIRINCICH, Steven J, MICHALAK, Ronald, THOMASON, Jennifer, IPEK, Manus, KUN WU, WOODER, Lane, RAMARAO, Manjunath K, MURPHY, Elizabeth A, GOODWIN, Debra G, SHEN, Marina W. H, ALBERT, Leo, XIN XU, DONAHUE, Frances, SHERRY KU, M, KEITH, James, NICKERSON-NUTTER, Cheryl L, ABRAHAM, William M, WILLIAMS, Cara, HEGEN, Martin, CLARK, James D, THAKKER, Paresh, FOLEY, Megan A, BEHNKE, Mark L, BAIHUA HU, SUM, Fuk-Wah, TAM, Steve, YONGHAN HU
Published in Journal of medicinal chemistry (2008)
Get full text
Published in Journal of medicinal chemistry (2008)
Journal Article
Structure-based optimization of protein tyrosine phosphatase 1Β inhibitors : From the active site to the second phosphotyrosine binding site
WILSON, Douglas P, WAN, Zhao-Kui, BINNUN, Eva, ZHANG, Yan-Ling, TAM, May, ERBE, David V, TOBIN, James, XIN XU, LEUNG, Louis, SHILLING, Adam, TAM, Steve Y, MANSOUR, Tarek S, XU, Wei-Xin, LEE, Jinbo, KIRINCICH, Steven J, FOLLOWS, Bruce C, JOSEPH-MCCARTHY, Diane, FOREMAN, Kenneth, MORETTO, Alessandro, JUNJUN WU, MIN ZHU
Published in Journal of medicinal chemistry (2007)
Get full text
Published in Journal of medicinal chemistry (2007)
Journal Article