Multivalent histone engagement by the linked tandem Tudor and PHD domains of UHRF1 is required for the epigenetic inheritance of DNA methylation
Rothbart, Scott B, Dickson, Bradley M, Ong, Michelle S, Krajewski, Krzysztof, Houliston, Scott, Kireev, Dmitri B, Arrowsmith, Cheryl H, Strahl, Brian D
Published in Genes & development (01.06.2013)
Published in Genes & development (01.06.2013)
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Discovery and Characterization of a Cellular Potent Positive Allosteric Modulator of the Polycomb Repressive Complex 1 Chromodomain, CBX7
Lamb, Kelsey N, Bsteh, Daniel, Dishman, Sarah N, Moussa, Hagar F, Fan, Huitao, Stuckey, Jacob I, Norris, Jacqueline L, Cholensky, Stephanie H, Li, Dongxu, Wang, Jingkui, Sagum, Cari, Stanton, Benjamin Z, Bedford, Mark T, Pearce, Kenneth H, Kenakin, Terry P, Kireev, Dmitri B, Wang, Gang Greg, James, Lindsey I, Bell, Oliver, Frye, Stephen V
Published in Cell chemical biology (17.10.2019)
Published in Cell chemical biology (17.10.2019)
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A chemical probe targeting the PWWP domain alters NSD2 nucleolar localization
Dilworth, David, Hanley, Ronan P, Ferreira de Freitas, Renato, Allali-Hassani, Abdellah, Zhou, Mengqi, Mehta, Naimee, Marunde, Matthew R, Ackloo, Suzanne, Carvalho Machado, Raquel Arminda, Khalili Yazdi, Aliakbar, Owens, Dominic D G, Vu, Victoria, Nie, David Y, Alqazzaz, Mona, Marcon, Edyta, Li, Fengling, Chau, Irene, Bolotokova, Albina, Qin, Su, Lei, Ming, Liu, Yanli, Szewczyk, Magdalena M, Dong, Aiping, Kazemzadeh, Sina, Abramyan, Tigran, Popova, Irina K, Hall, Nathan W, Meiners, Matthew J, Cheek, Marcus A, Gibson, Elisa, Kireev, Dmitri, Greenblatt, Jack F, Keogh, Michael-C, Min, Jinrong, Brown, Peter J, Vedadi, Masoud, Arrowsmith, Cheryl H, Barsyte-Lovejoy, Dalia, James, Lindsey I, Schapira, Matthieu
Published in Nature chemical biology (01.01.2022)
Published in Nature chemical biology (01.01.2022)
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In silico fragment-based discovery of CIB1-directed anti-tumor agents by FRASE-bot
An, Yi, Lim, Jiwoong, Glavatskikh, Marta, Wang, Xiaowen, Norris-Drouin, Jacqueline, Hardy, P Brian, Leisner, Tina M, Pearce, Kenneth H, Kireev, Dmitri
Published in Nature communications (02.07.2024)
Published in Nature communications (02.07.2024)
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Discovery of a 2,4-Diamino-7-aminoalkoxyquinazoline as a Potent and Selective Inhibitor of Histone Lysine Methyltransferase G9a
Liu, Feng, Chen, Xin, Allali-Hassani, Abdellah, Quinn, Amy M, Wasney, Gregory A, Dong, Aiping, Barsyte, Dalia, Kozieradzki, Ivona, Senisterra, Guillermo, Chau, Irene, Siarheyeva, Alena, Kireev, Dmitri B, Jadhav, Ajit, Herold, J. Martin, Frye, Stephen V, Arrowsmith, Cheryl H, Brown, Peter J, Simeonov, Anton, Vedadi, Masoud, Jin, Jian
Published in Journal of medicinal chemistry (24.12.2009)
Published in Journal of medicinal chemistry (24.12.2009)
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MERTK activation drives osimertinib resistance in EGFR-mutant non-small cell lung cancer
Yan, Dan, Huelse, Justus M, Kireev, Dmitri, Tan, Zikang, Chen, Luxiao, Goyal, Subir, Wang, Xiaodong, Frye, Stephen V, Behera, Madhusmita, Schneider, Frank, Ramalingam, Suresh S, Owonikoko, Taofeek, Earp, H Shelton, DeRyckere, Deborah, Graham, Douglas K
Published in The Journal of clinical investigation (01.08.2022)
Published in The Journal of clinical investigation (01.08.2022)
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Protein Lysine Methyltransferase G9a Inhibitors: Design, Synthesis, and Structure Activity Relationships of 2,4-Diamino-7-aminoalkoxy-quinazolines
Liu, Feng, Chen, Xin, Allali-Hassani, Abdellah, Quinn, Amy M, Wigle, Tim J, Wasney, Gregory A, Dong, Aiping, Senisterra, Guillermo, Chau, Irene, Siarheyeva, Alena, Norris, Jacqueline L, Kireev, Dmitri B, Jadhav, Ajit, Herold, J. Martin, Janzen, William P, Arrowsmith, Cheryl H, Frye, Stephen V, Brown, Peter J, Simeonov, Anton, Vedadi, Masoud, Jin, Jian
Published in Journal of medicinal chemistry (12.08.2010)
Published in Journal of medicinal chemistry (12.08.2010)
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Discovery of a chemical probe for the L3MBTL3 methyllysine reader domain
James, Lindsey I, Barsyte-Lovejoy, Dalia, Zhong, Nan, Krichevsky, Liubov, Korboukh, Victoria K, Herold, J Martin, MacNevin, Christopher J, Norris, Jacqueline L, Sagum, Cari A, Tempel, Wolfram, Marcon, Edyta, Guo, Hongbo, Gao, Cen, Huang, Xi-Ping, Duan, Shili, Emili, Andrew, Greenblatt, Jack F, Kireev, Dmitri B, Jin, Jian, Janzen, William P, Brown, Peter J, Bedford, Mark T, Arrowsmith, Cheryl H, Frye, Stephen V
Published in Nature chemical biology (01.03.2013)
Published in Nature chemical biology (01.03.2013)
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Reprogramming CBX8-PRC1 function with a positive allosteric modulator
Suh, Junghyun L., Bsteh, Daniel, Hart, Bryce, Si, Yibo, Weaver, Tyler M., Pribitzer, Carina, Lau, Roy, Soni, Shivani, Ogana, Heather, Rectenwald, Justin M., Norris, Jacqueline L., Cholensky, Stephanie H., Sagum, Cari, Umana, Jessica D., Li, Dongxu, Hardy, Brian, Bedford, Mark T., Mumenthaler, Shannon M., Lenz, Heinz-Josef, Kim, Yong-Mi, Wang, Gang Greg, Pearce, Ken H., James, Lindsey I., Kireev, Dmitri B., Musselman, Catherine A., Frye, Stephen V., Bell, Oliver
Published in Cell chemical biology (21.04.2022)
Published in Cell chemical biology (21.04.2022)
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Chromodomain Ligand Optimization via Target-Class Directed Combinatorial Repurposing
Barnash, Kimberly D, Lamb, Kelsey N, Stuckey, Jacob I, Norris, Jacqueline L, Cholensky, Stephanie H, Kireev, Dmitri B, Frye, Stephen V, James, Lindsey I
Published in ACS chemical biology (16.09.2016)
Published in ACS chemical biology (16.09.2016)
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Design and Construction of a Focused DNA-Encoded Library for Multivalent Chromatin Reader Proteins
Rectenwald, Justin M, Guduru, Shiva Krishna Reddy, Dang, Zhao, Collins, Leonard B, Liao, Yi-En, Norris-Drouin, Jacqueline L, Cholensky, Stephanie H, Kaufmann, Kyle W, Hammond, Scott M, Kireev, Dmitri B, Frye, Stephen V, Pearce, Kenneth H
Published in Molecules (Basel, Switzerland) (22.02.2020)
Published in Molecules (Basel, Switzerland) (22.02.2020)
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Small-Molecule Ligands of Methyl-Lysine Binding Proteins: Optimization of Selectivity for L3MBTL3
James, Lindsey I, Korboukh, Victoria K, Krichevsky, Liubov, Baughman, Brandi M, Herold, J. Martin, Norris, Jacqueline L, Jin, Jian, Kireev, Dmitri B, Janzen, William P, Arrowsmith, Cheryl H, Frye, Stephen V
Published in Journal of medicinal chemistry (26.09.2013)
Published in Journal of medicinal chemistry (26.09.2013)
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Small-Molecule Ligands of Methyl-Lysine Binding Proteins
Herold, J. Martin, Wigle, Tim J, Norris, Jacqueline L, Lam, Robert, Korboukh, Victoria K, Gao, Cen, Ingerman, Lindsey A, Kireev, Dmitri B, Senisterra, Guillermo, Vedadi, Masoud, Tripathy, Ashutosh, Brown, Peter J, Arrowsmith, Cheryl H, Jin, Jian, Janzen, William P, Frye, Stephen V
Published in Journal of medicinal chemistry (14.04.2011)
Published in Journal of medicinal chemistry (14.04.2011)
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Discovery of selective activators of PRC2 mutant EED-I363M
Suh, Junghyun L, Barnash, Kimberly D, Abramyan, Tigran M, Li, Fengling, The, Juliana, Engelberg, Isabelle A, Vedadi, Masoud, Brown, Peter J, Kireev, Dmitri B, Arrowsmith, Cheryl H, James, Lindsey I, Frye, Stephen V
Published in Scientific reports (25.04.2019)
Published in Scientific reports (25.04.2019)
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A simulation model of heterochromatin formation at submolecular detail
Williams, Michael R., Xiaokang, Yan, Hathaway, Nathaniel A., Kireev, Dmitri
Published in iScience (15.07.2022)
Published in iScience (15.07.2022)
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Quantitative Characterization of Bivalent Probes for a Dual Bromodomain Protein, Transcription Initiation Factor TFIID Subunit 1
Suh, Junghyun L, Watts, Brian, Stuckey, Jacob I, Norris-Drouin, Jacqueline L, Cholensky, Stephanie H, Dickson, Bradley M, An, Yi, Mathea, Sebastian, Salah, Eidarus, Knapp, Stefan, Khan, Abid, Adams, Alexander T, Strahl, Brian D, Sagum, Cari A, Bedford, Mark T, James, Lindsey I, Kireev, Dmitri B, Frye, Stephen V
Published in Biochemistry (Easton) (10.04.2018)
Published in Biochemistry (Easton) (10.04.2018)
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Pseudo-Cyclization through Intramolecular Hydrogen Bond Enables Discovery of Pyridine Substituted Pyrimidines as New Mer Kinase Inhibitors
Zhang, Weihe, Zhang, Dehui, Stashko, Michael A, DeRyckere, Deborah, Hunter, Debra, Kireev, Dmitri, Miley, Michael J, Cummings, Christopher, Lee, Minjung, Norris-Drouin, Jacqueline, Stewart, Wendy M, Sather, Susan, Zhou, Yingqiu, Kirkpatrick, Gregory, Machius, Mischa, Janzen, William P, Earp, H. Shelton, Graham, Douglas K, Frye, Stephen V, Wang, Xiaodong
Published in Journal of medicinal chemistry (12.12.2013)
Published in Journal of medicinal chemistry (12.12.2013)
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Journal Article
Discovery of Macrocyclic Pyrimidines as MerTK‐Specific Inhibitors
McIver, Andrew L., Zhang, Weihe, Liu, Qingyang, Jiang, Xinpeng, Stashko, Michael A., Nichols, James, Miley, Michael J., Norris‐Drouin, Jacqueline, Machius, Mischa, DeRyckere, Deborah, Wood, Edgar, Graham, Douglas K., Earp, H. Shelton, Kireev, Dmitri, Frye, Stephen V., Wang, Xiaodong
Published in ChemMedChem (03.02.2017)
Published in ChemMedChem (03.02.2017)
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Correction to “Quantitative Characterization of Bivalent Probes for a Dual Bromodomain Protein, Transcription Initiation Factor TFIID subunit 1”
Suh, Junghyun L, Watts, Brian, Stuckey, Jacob I, Norris-Drouin, Jacqueline L, Cholensky, Stephanie H, Dickson, Bradley M, An, Yi, Mathea, Sebastian, Salah, Eidarus, Knapp, Stefan, Khan, Abid, Adams, Alexander T, Strahl, Brian D, Sagum, Cari A, Bedford, Mark T, James, Lindsey I, Kireev, Dmitri B, Frye, Stephen V
Published in Biochemistry (Easton) (11.12.2018)
Published in Biochemistry (Easton) (11.12.2018)
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Identification of Non-Peptide Malignant Brain Tumor (MBT) Repeat Antagonists by Virtual Screening of Commercially Available Compounds
Kireev, Dmitri, Wigle, Tim J, Norris-Drouin, Jacqueline, Herold, J. Martin, Janzen, William P, Frye, Stephen V
Published in Journal of medicinal chemistry (11.11.2010)
Published in Journal of medicinal chemistry (11.11.2010)
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