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A landmark in drug discovery based on complex natural product synthesis

A landmark in drug discovery based on complex natural product synthesis

by Kawano, Satoshi, Ito, Ken, Yahata, Kenzo, Kira, Kazunobu, Abe, Takanori, Akagi, Tsuyoshi, Asano, Makoto, Iso, Kentaro, Sato, Yuki, Matsuura, Fumiyoshi, Ohashi, Isao, Matsumoto, Yasunobu, Isomura, Minetaka, Sasaki, Takeo, Fukuyama, Takashi, Miyashita, Yusuke, Kaburagi, Yosuke, Yokoi, Akira, Asano, Osamu, Owa, Takashi, Kishi, Yoshito
Published in Scientific reports (17.06.2019)

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Journal Article

Enhanced secretion of glucagon-like peptide 1 by biguanide compounds

Enhanced secretion of glucagon-like peptide 1 by biguanide compounds

by Yasuda, Nobuyuki, Inoue, Takashi, Nagakura, Tadashi, Yamazaki, Kazuto, Kira, Kazunobu, Saeki, Takao, Tanaka, Isao
Published in Biochemical and biophysical research communications (15.11.2002)

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Journal Article

Metformin Causes Reduction of Food Intake and Body Weight Gain and Improvement of Glucose Intolerance in Combination with Dipeptidyl Peptidase IV Inhibitor in Zucker fa/fa Rats

Metformin Causes Reduction of Food Intake and Body Weight Gain and Improvement of Glucose Intolerance in Combination with Dipeptidyl Peptidase IV Inhibitor in Zucker fa/fa Rats

by Yasuda, Nobuyuki, Inoue, Takashi, Nagakura, Tadashi, Yamazaki, Kazuto, Kira, Kazunobu, Saeki, Takao, Tanaka, Isao
Published in The Journal of pharmacology and experimental therapeutics (01.08.2004)

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Journal Article

Synthesis of the BCD-ring of ciguatoxin 1B using an acetylene cobalt complex and vinylsilane strategy

Synthesis of the BCD-ring of ciguatoxin 1B using an acetylene cobalt complex and vinylsilane strategy

by Kira, Kazunobu, Hamajima, Akinari, Isobe, Minoru
Published in Tetrahedron (04.03.2002)

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Journal Article

Synthesis of the BCDE rings of ciguatoxin 1B via an acetylene biscobalthexacarbonyl-vinylsilane strategy

Synthesis of the BCDE rings of ciguatoxin 1B via an acetylene biscobalthexacarbonyl-vinylsilane strategy

by Kira, K, Isobe, M
Published in Tetrahedron letters (09.04.2001)

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Journal Article

7-But-2-ynyl-9-(6-methoxy-pyridin-3-yl)-6-piperazin-1-yl-7,9-dihydro-purin-8-one Is a Novel Competitive and Selective Inhibitor of Dipeptidyl Peptidase IV with an Antihyperglycemic Activity

7-But-2-ynyl-9-(6-methoxy-pyridin-3-yl)-6-piperazin-1-yl-7,9-dihydro-purin-8-one Is a Novel Competitive and Selective Inhibitor of Dipeptidyl Peptidase IV with an Antihyperglycemic Activity

by Yamazaki, Kazuto, Yasuda, Nobuyuki, Inoue, Takashi, Nagakura, Tadashi, Kira, Kazunobu, Shinoda, Masanobu, Saeki, Takao, Tanaka, Isao
Published in The Journal of pharmacology and experimental therapeutics (01.12.2006)

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Journal Article

Mechanistic studies on the hydrosilylation of an acetylene cobalt complex; trapping an active catalyst Co2(CO)6 causing olefin-isomerization and O-silylation

Mechanistic studies on the hydrosilylation of an acetylene cobalt complex; trapping an active catalyst Co2(CO)6 causing olefin-isomerization and O-silylation

by Kira, Kazunobu, Tanda, Hiromichi, Hamajima, Akinari, Baba, Takayuki, Takai, Shigeyuki, Isobe, Minoru
Published in Tetrahedron (01.08.2002)

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Journal Article

The combination of metformin and a dipeptidyl peptidase IV inhibitor prevents 5-fluorouracil-induced reduction of small intestine weight

The combination of metformin and a dipeptidyl peptidase IV inhibitor prevents 5-fluorouracil-induced reduction of small intestine weight

by Yamazaki, Kazuto, Yasuda, Nobuyuki, Inoue, Takashi, Nagakura, Tadashi, Kira, Kazunobu, Saeki, Takao, Tanaka, Isao
Published in European journal of pharmacology (19.03.2004)

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Journal Article

syn-trans fused bicyclic ether formation via acetylene-biscobalthexacarbonyl complex

syn-trans fused bicyclic ether formation via acetylene-biscobalthexacarbonyl complex

by Isobe, M, Hosokawa, S, Kira, K
Published in Chemistry letters (01.06.1996)

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Journal Article

Sodium hypophosphite decomplexation of acetylenebiscobalthexacarbonyls to cis-olefins

Sodium hypophosphite decomplexation of acetylenebiscobalthexacarbonyls to cis-olefins

by Takai, S, Ploypradith, P, Hamajima, A, Kira, K, Isobe, M
Published in Synlett (2002)

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Journal Article

MACROCYCLIC COMPOUND AND USES THEREOF

MACROCYCLIC COMPOUND AND USES THEREOF

by KISHI YOSHITO, KIRA KAZUNOBU, ITO KEN
Year of Publication 05.03.2024

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Patent

MACROCYCLIC COMPOUND AND USES THEREOF

MACROCYCLIC COMPOUND AND USES THEREOF

by KISHI YOSHITO, KIRA KAZUNOBU, ITO KEN
Year of Publication 22.02.2024

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Patent

MACROCYCLIC COMPOUNDS AND USES THEREOF

MACROCYCLIC COMPOUNDS AND USES THEREOF

by KISHI YOSHITO, KIRA KAZUNOBU, ITO KEN
Year of Publication 24.10.2023

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Patent

Ten-Gram-Scale Total Synthesis of the Anticancer Drug Candidate E7130 to Supply Clinical Trials

Ten-Gram-Scale Total Synthesis of the Anticancer Drug Candidate E7130 to Supply Clinical Trials

by Kaburagi, Yosuke, Kira, Kazunobu, Yahata, Kenzo, Iso, Kentaro, Sato, Yuki, Matsuura, Fumiyoshi, Ohashi, Isao, Matsumoto, Yasunobu, Isomura, Minetaka, Sasaki, Takeo, Fukuyama, Takashi, Miyashita, Yusuke, Azuma, Hiroshi, Iida, Daisuke, Ishida, Tasuku, Itano, Wataru, Matsuda, Masaaki, Matsukura, Masayuki, Murai, Norio, Nagao, Satoshi, Seki, Masashi, Yamamoto, Akihiko, Yamamoto, Yuji, Yoneda, Naoki, Watanabe, Yuzo, Kamada, Atsushi, Kayano, Akio, Tagami, Katsuya, Asano, Osamu, Owa, Takashi, Kishi, Yoshito
Published in Organic letters (12.04.2024)

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Journal Article

What Does It Take to Develop Structurally Complex Molecules by Total Synthesis? Rapid Process Development and GMP Manufacturing of E7130 Drug Substance for First-in-Human Clinical Study

What Does It Take to Develop Structurally Complex Molecules by Total Synthesis? Rapid Process Development and GMP Manufacturing of E7130 Drug Substance for First-in-Human Clinical Study

by Sasaki, Takeo, Yahata, Kenzo, Isomura, Minetaka, Ohashi, Isao, Fukuyama, Takashi, Miyashita, Yusuke, Watanabe, Yuzo, Murai, Norio, Matsuda, Masaaki, Kamada, Atsushi, Kaburagi, Yosuke, Kira, Kazunobu, Iso, Kentaro, Sato, Yuki, Matsuura, Fumiyoshi, Matsumoto, Yasunobu, Azuma, Hiroshi, Iida, Daisuke, Ishida, Tasuku, Itano, Wataru, Nagao, Satoshi, Seki, Masashi, Yamamoto, Akihiko, Yamamoto, Yuji, Yoneda, Naoki, Matsukura, Masayuki, Asano, Osamu, Kayano, Akio, Tagami, Katsuya, Owa, Takashi, Kishi, Yoshito
Published in Organic process research & development (21.06.2024)

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Journal Article

마크로시클릭 화합물 및 그의 용도

마크로시클릭 화합물 및 그의 용도

by KISHI YOSHITO, KIRA KAZUNOBU, ITO KEN
Year of Publication 10.12.2019

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Patent

Abstract 4183: Mechanism of action analysis of anti-CAF activity of E7130, a novel tumor-microenvironment ameliorator

Abstract 4183: Mechanism of action analysis of anti-CAF activity of E7130, a novel tumor-microenvironment ameliorator

by Abe, Takanori, Kawano, Satoshi, Ito, Ken, Yahata, Kenzo, Kira, Kazunobu, Akagi, Tsuyoshi, Asano, Makoto, Iso, Kentaro, Sato, Yuki, Matsuura, Fumiyoshi, Ohashi, Isao, Matsumoto, Yasunobu, Isomura, Minetaka, Sasaki, Takeo, Fukuyama, Takashi, Miyashita, Yusuke, Kaburagi, Yosuke, Yokoi, Akira, Asano, Osamu, Owa, Takashi, Kishi, Yoshito
Published in Cancer research (Chicago, Ill.) (15.08.2020)

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Journal Article

Abstract 4179: E7130 derived from total synthesis of halichondrin as a novel tumor-microenvironment ameliorator

Abstract 4179: E7130 derived from total synthesis of halichondrin as a novel tumor-microenvironment ameliorator

by Kawano, Satoshi, Abe, Takanori, Ito, Ken, Yahata, Kenzo, Kira, Kazunobu, Akagi, Tsuyoshi, Asano, Makoto, Iso, Kentaro, Sato, Yuki, Matsuura, Fumiyoshi, Ohashi, Isao, Matsumoto, Yasunobu, Isomura, Minetaka, Sasaki, Takeo, Fukuyama, Takashi, Miyashita, Yusuke, Kaburagi, Yosuke, Yokoi, Akira, Asano, Osamu, Owa, Takashi, Kishi, Yoshito
Published in Cancer research (Chicago, Ill.) (15.08.2020)

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Journal Article

E3024, 3-but-2-ynyl-5-methyl-2-piperazin-1-yl-3,5-dihydro-4H-imidazo [4,5-d]pyridazin-4-one tosylate, is a novel, selective and competitive dipeptidyl peptidase-IV inhibitor

E3024, 3-but-2-ynyl-5-methyl-2-piperazin-1-yl-3,5-dihydro-4H-imidazo [4,5-d]pyridazin-4-one tosylate, is a novel, selective and competitive dipeptidyl peptidase-IV inhibitor

by YASUDA, Nobuyuki, NAGAKURA, Tadashi, KIRA, Kazunobu, IKUTA, Hironori, OKADA, Toshimi, SAEKI, Takao, ASANO, Osamu, TANAKA, Isao, INOUE, Takashi, YAMAZAKI, Kazuto, KATSUTANI, Naruo, TAKENAKA, Osamu, CLARK, Richard, MATSUURA, Fumiyoshi, EMORI, Eita, YOSHIKAWA, Seiji
Published in European journal of pharmacology (01.10.2006)

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Journal Article

MACROCYCLIC COMPOUND AND USES THEREOF

MACROCYCLIC COMPOUND AND USES THEREOF

by KISHI YOSHITO, KIRA KAZUNOBU, ITO KEN
Year of Publication 15.11.2018

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Patent

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