Search Results - "KINZEL, OLAF" :: K.UTB vyhledávací portál | TBU Library Retrieval Portal

Discovery of Raltegravir, a Potent, Selective Orally Bioavailable HIV-Integrase Inhibitor for the Treatment of HIV-AIDS Infection

Discovery of Raltegravir, a Potent, Selective Orally Bioavailable HIV-Integrase Inhibitor for the Treatment of HIV-AIDS Infection

by Summa, Vincenzo, Petrocchi, Alessia, Bonelli, Fabio, Crescenzi, Benedetta, Donghi, Monica, Ferrara, Marco, Fiore, Fabrizio, Gardelli, Cristina, Gonzalez Paz, Odalys, Hazuda, Daria J, Jones, Philip, Kinzel, Olaf, Laufer, Ralph, Monteagudo, Edith, Muraglia, Ester, Nizi, Emanuela, Orvieto, Federica, Pace, Paola, Pescatore, Giovanna, Scarpelli, Rita, Stillmock, Kara, Witmer, Marc V, Rowley, Michael
Published in Journal of medicinal chemistry (25.09.2008)

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Author Correction: Preclinical and clinical characterization of the RORγt inhibitor JNJ-61803534

Author Correction: Preclinical and clinical characterization of the RORγt inhibitor JNJ-61803534

by Xue, Xiaohua, De Leon-Tabaldo, Aimee, Luna-Roman, Rosa, Castro, Glenda, Albers, Michael, Schoetens, Freddy, DePrimo, Samuel, Devineni, Damayanthi, Wilde, Thomas, Goldberg, Steve, Kinzel, Olaf, Hoffmann, Thomas, Fourie, Anne M, Thurmond, Robin L
Published in Scientific reports (06.04.2022)

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FXR controls the tumor suppressor NDRG2 and FXR agonists reduce liver tumor growth and metastasis in an orthotopic mouse xenograft model

FXR controls the tumor suppressor NDRG2 and FXR agonists reduce liver tumor growth and metastasis in an orthotopic mouse xenograft model

by Deuschle, Ulrich, Schüler, Julia, Schulz, Andreas, Schlüter, Thomas, Kinzel, Olaf, Abel, Ulrich, Kremoser, Claus
Published in PloS one (09.10.2012)

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Preclinical and clinical characterization of the RORγt inhibitor JNJ-61803534

Preclinical and clinical characterization of the RORγt inhibitor JNJ-61803534

by Xue, Xiaohua, De Leon-Tabaldo, Aimee, Luna-Roman, Rosa, Castro, Glenda, Albers, Michael, Schoetens, Freddy, DePrimo, Samuel, Devineni, Damayanthi, Wilde, Thomas, Goldberg, Steve, Kinzel, Olaf, Hoffmann, Thomas, Fourie, Anne M, Thurmond, Robin L
Published in Scientific reports (26.05.2021)

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Synthetic farnesoid X receptor agonists induce high-density lipoprotein-mediated transhepatic cholesterol efflux in mice and monkeys and prevent atherosclerosis in cholesteryl ester transfer protein transgenic low-density lipoprotein receptor (-/-) mice

Synthetic farnesoid X receptor agonists induce high-density lipoprotein-mediated transhepatic cholesterol efflux in mice and monkeys and prevent atherosclerosis in cholesteryl ester transfer protein transgenic low-density lipoprotein receptor (-/-) mice

by Hambruch, Eva, Miyazaki-Anzai, Shinobu, Hahn, Ulrike, Matysik, Silke, Boettcher, Alfred, Perović-Ottstadt, Sanja, Schlüter, Thomas, Kinzel, Olaf, Krol, Helen Desiree, Deuschle, Ulrich, Burnet, Michael, Levi, Moshe, Schmitz, Gerd, Miyazaki, Makoto, Kremoser, Claus
Published in The Journal of pharmacology and experimental therapeutics (01.12.2012)

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3-Hydroxy-4-oxo-4H-pyrido[1,2-a]pyrimidine-2-carboxylates--a new class of HIV-1 integrase inhibitors

3-Hydroxy-4-oxo-4H-pyrido[1,2-a]pyrimidine-2-carboxylates--a new class of HIV-1 integrase inhibitors

by Donghi, Monica, Kinzel, Olaf D, Summa, Vincenzo
Published in Bioorganic & medicinal chemistry letters (01.04.2009)

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The nuclear bile acid receptor FXR controls the liver derived tumor suppressor histidine‐rich glycoprotein

The nuclear bile acid receptor FXR controls the liver derived tumor suppressor histidine‐rich glycoprotein

by Deuschle, Ulrich, Birkel, Manfred, Hambruch, Eva, Hornberger, Martin, Kinzel, Olaf, Perović‐Ottstadt, Sanja, Schulz, Andreas, Hahn, Ulrike, Burnet, Michael, Kremoser, Claus
Published in International journal of cancer (01.06.2015)

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Identification of MK-5710 ((8aS)-8a-methyl-1,3-dioxo-2-[(1S,2R)-2-phenylcyclopropyl]-N-(1-phenyl-1H-pyrazol-5-yl)hexahydroimid azo[1,5-a]pyrazine-7(1H)-carboxamide), a potent smoothened antagonist for use in Hedgehog pathway dependent malignancies, Part 1

Identification of MK-5710 ((8aS)-8a-methyl-1,3-dioxo-2-[(1S,2R)-2-phenylcyclopropyl]-N-(1-phenyl-1H-pyrazol-5-yl)hexahydroimid azo[1,5-a]pyrazine-7(1H)-carboxamide), a potent smoothened antagonist for use in Hedgehog pathway dependent malignancies, Part 1

by Malancona, Savina, Altamura, Sergio, Filocamo, Gessica, Kinzel, Olaf, Hernando, Jose Ignacio Martin, Rowley, Michael, Scarpelli, Rita, Steinkühler, Christian, Jones, Philip
Published in Bioorganic & medicinal chemistry letters (01.08.2011)

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Tetrazole thioacetanilides: Potent non-nucleoside inhibitors of WT HIV reverse transcriptase and its K103N mutant

Tetrazole thioacetanilides: Potent non-nucleoside inhibitors of WT HIV reverse transcriptase and its K103N mutant

by Muraglia, Ester, Kinzel, Olaf D., Laufer, Ralph, Miller, Michael D., Moyer, Gregory, Munshi, Vandna, Orvieto, Federica, Palumbi, Maria Cecilia, Pescatore, Giovanna, Rowley, Michael, Williams, Peter D., Summa, Vincenzo
Published in Bioorganic & medicinal chemistry letters (15.05.2006)

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Identification of MK-5710 ((8aS)-8a-methyl-1,3-dioxo-2-[(1S,2R)-2-phenylcyclo- propyl]-N-(1-phenyl-1H-pyrazol-5-yl)hexahydro-imidazo[1,5-a]pyrazine-7(1H)-carboxamide), a potent smoothened antagonist for use in Hedgehog pathway dependent malignancies, Part 2

Identification of MK-5710 ((8aS)-8a-methyl-1,3-dioxo-2-[(1S,2R)-2-phenylcyclo- propyl]-N-(1-phenyl-1H-pyrazol-5-yl)hexahydro-imidazo[1,5-a]pyrazine-7(1H)-carboxamide), a potent smoothened antagonist for use in Hedgehog pathway dependent malignancies, Part 2

by Kinzel, Olaf, Alfieri, Anna, Altamura, Sergio, Brunetti, Mirko, Bufali, Simone, Colaceci, Fabrizio, Ferrigno, Federica, Filocamo, Gessica, Fonsi, Massimiliano, Gallinari, Paola, Malancona, Savina, Hernando, Jose Ignacio Martin, Monteagudo, Edith, Orsale, Maria Vittoria, Palumbi, Maria Cecilia, Pucci, Vincenzo, Rowley, Michael, Sasso, Romina, Scarpelli, Rita, Steinkühler, Christian, Jones, Philip
Published in Bioorganic & medicinal chemistry letters (01.08.2011)

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3-Hydroxy-4-oxo-4H-pyrido[1,2-a]pyrimidine-2-carboxylates-fast access to a heterocyclic scaffold for HIV-1 integrase inhibitors

3-Hydroxy-4-oxo-4H-pyrido[1,2-a]pyrimidine-2-carboxylates-fast access to a heterocyclic scaffold for HIV-1 integrase inhibitors

by Kinzel, Olaf D., Ball, Richard G., Donghi, Monica, Maguire, Courtney K., Muraglia, Ester, Pesci, Silvia, Rowley, Michael, Summa, Vincenzo
Published in Tetrahedron letters (10.11.2008)

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3-Hydroxy-4-oxo-4H-pyrido[1,2-a]pyrimidine-2-carboxylates-A new class of HIV-1 integrase inhibitors

3-Hydroxy-4-oxo-4H-pyrido[1,2-a]pyrimidine-2-carboxylates-A new class of HIV-1 integrase inhibitors

by DONGHI, Monica, KINZEL, Olaf D, SUMMA, Vincenzo
Published in Bioorganic & medicinal chemistry letters (01.04.2009)

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Nonsteroidal FXR Ligands: Current Status and Clinical Applications

Nonsteroidal FXR Ligands: Current Status and Clinical Applications

by Gege, Christian, Hambruch, Eva, Hambruch, Nina, Kinzel, Olaf, Kremoser, Claus
Published in Handbook of experimental pharmacology (01.01.2019)

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Knocking on FXR's door: the "hammerhead"-structure series of FXR agonists - amphiphilic isoxazoles with potent in vitro and in vivo activities

Knocking on FXR's door: the "hammerhead"-structure series of FXR agonists - amphiphilic isoxazoles with potent in vitro and in vivo activities

by Gege, Christian, Kinzel, Olaf, Steeneck, Christoph, Schulz, Andreas, Kremoser, Claus
Published in Current topics in medicinal chemistry (2014)

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Discovery and optimization of substituted oxalamides as novel heme-displacing IDO1 inhibitors

Discovery and optimization of substituted oxalamides as novel heme-displacing IDO1 inhibitors

by Steeneck, Christoph, Kinzel, Olaf, Anderhub, Simon, Hornberger, Martin, Pinto, Sheena, Morschhaeuser, Barbara, Albers, Michael, Sonnek, Christina, Czekańska, Marta, Hoffmann, Thomas
Published in Bioorganic & medicinal chemistry letters (01.02.2021)

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PS-133-LXR inverse agonists reduce steatosis and fibrosis in the STAM mouse model but also improve insulin sensitivity in a high fat diet mouse clamp study

PS-133-LXR inverse agonists reduce steatosis and fibrosis in the STAM mouse model but also improve insulin sensitivity in a high fat diet mouse clamp study

by Hambruch, Eva, Gege, Christian, Kinzel, Olaf, Hauser, Katharina, Birkel, Manfred, Deuschle, Ulrich, Kremoser, Claus
Published in Journal of hepatology (01.04.2019)

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Discovery of highly potent heme-displacing IDO1 inhibitors based on a spirofused bicyclic scaffold

Discovery of highly potent heme-displacing IDO1 inhibitors based on a spirofused bicyclic scaffold

by Kinzel, Olaf, Steeneck, Christoph, Anderhub, Simon, Hornberger, Martin, Pinto, Sheena, Morschhaeuser, Barbara, Albers, Michael, Sonnek, Christina, Wang, Yansong, Mallinger, Aurélie, Czekańska, Marta, Hoffmann, Thomas
Published in Bioorganic & medicinal chemistry letters (01.02.2021)

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The Synthesis and Antibacterial Activity of two Pyoverdin-ampicillin Conjugates, Entering Pseudomonas aeruginosa via the Pyoverdin-mediated Iron Uptake Pathway

The Synthesis and Antibacterial Activity of two Pyoverdin-ampicillin Conjugates, Entering Pseudomonas aeruginosa via the Pyoverdin-mediated Iron Uptake Pathway

by KINZEL, OLAF, TAPPE, ROBERT, GERUS, IGOR, BUDZIKIEWICZ, HERBERT
Published in Journal of antibiotics (1998)

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Development of Cilofexor, an intestinally-biased Farnesoid X Receptor agonist, for the treatment of fatty liver disease

Development of Cilofexor, an intestinally-biased Farnesoid X Receptor agonist, for the treatment of fatty liver disease

by Hollenback, David, Hambruch, Eva, Fink, Gero, Birkel, Manfred, Schulz, Andreas, Hornberger, Martin, Liu, Kathy, Staiger, Kelly MacLennan, Krol, Helen Desiree, Deuschle, Ulrich, Steeneck, Christoph, Kinzel, Olaf, Liles, John T, Budas, Grant, Watkins, William J, Kremoser, Claus
Published in The Journal of pharmacology and experimental therapeutics (26.02.2024)

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Discovery of Hydroxyamidine Based Inhibitors of IDO1 for Cancer Immunotherapy with Reduced Potential for Glucuronidation

Discovery of Hydroxyamidine Based Inhibitors of IDO1 for Cancer Immunotherapy with Reduced Potential for Glucuronidation

by Steeneck, Christoph, Kinzel, Olaf, Anderhub, Simon, Hornberger, Martin, Pinto, Sheena, Morschhaeuser, Barbara, Braun, Floriane, Kleymann, Gerald, Hoffmann, Thomas
Published in ACS medicinal chemistry letters (13.02.2020)

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