Compounds Designs of CK2α Inhibitors Derived from Virtual Screening Hit Compounds by Computational Chemistry with Crystallography
Nakamura, Shinya, Nishiwaki, Keiji, Tsuyuguchi, Masato, Kinoshita, Takayoshi, Oishi, Shinya, Ohno, Hiroaki, Nakanishi, Isao
Published in Chemical & pharmaceutical bulletin (01.09.2024)
Published in Chemical & pharmaceutical bulletin (01.09.2024)
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Design, Synthesis and Structure–Activity Relationship Studies of Protein Kinase CK2 Inhibitors Containing a Purine Scaffold
Nishiwaki, Keiji, Nakamura, Shinya, Yoshioka, Kenji, Nakagawa, Eri, Nakatani, Shiori, Tsuyuguchi, Masato, Kinoshita, Takayoshi, Nakanishi, Isao
Published in Chemical & pharmaceutical bulletin (01.07.2023)
Published in Chemical & pharmaceutical bulletin (01.07.2023)
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Foretinib Overcomes Entrectinib Resistance Associated with the NTRK1 G667C Mutation in NTRK1 Fusion-Positive Tumor Cells in a Brain Metastasis Model
Nishiyama, Akihiro, Yamada, Tadaaki, Kita, Kenji, Wang, Rong, Arai, Sachiko, Fukuda, Koji, Tanimoto, Azusa, Takeuchi, Shinji, Tange, Shoichiro, Tajima, Atsushi, Furuya, Noritaka, Kinoshita, Takayoshi, Yano, Seiji
Published in Clinical cancer research (15.05.2018)
Published in Clinical cancer research (15.05.2018)
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High-resolution structure discloses the potential for allosteric regulation of mitogen-activated protein kinase kinase 7
Kinoshita, Takayoshi, Hashimoto, Takuma, Sogabe, Yuri, Fukada, Harumi, Matsumoto, Takashi, Sawa, Masaaki
Published in Biochemical and biophysical research communications (04.11.2017)
Published in Biochemical and biophysical research communications (04.11.2017)
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The juxtamembrane region of TrkA kinase is critical for inhibitor selectivity
Furuya, Noritaka, Momose, Takaki, Katsuno, Kenji, Fushimi, Nobuhiko, Muranaka, Hideyuki, Handa, Chiaki, Ozawa, Tomonaga, Kinoshita, Takayoshi
Published in Bioorganic & medicinal chemistry letters (01.03.2017)
Published in Bioorganic & medicinal chemistry letters (01.03.2017)
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A crucial role of Cys218 in configuring an unprecedented auto-inhibition form of MAP2K7
Sogabe, Yuri, Hashimoto, Takuma, Matsumoto, Takashi, Kirii, Yasuyuki, Sawa, Masaaki, Kinoshita, Takayoshi
Published in Biochemical and biophysical research communications (29.04.2016)
Published in Biochemical and biophysical research communications (29.04.2016)
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Cell-based screen identifies a new potent and highly selective CK2 inhibitor for modulation of circadian rhythms and cancer cell growth
Oshima, Tsuyoshi, Niwa, Yoshimi, Kuwata, Keiko, Srivastava, Ashutosh, Hyoda, Tomoko, Tsuchiya, Yoshiki, Kumagai, Megumi, Tsuyuguchi, Masato, Tamaru, Teruya, Sugiyama, Akiko, Ono, Natsuko, Zolboot, Norjin, Aikawa, Yoshiki, Oishi, Shunsuke, Nonami, Atsushi, Arai, Fumio, Hagihara, Shinya, Yamaguchi, Junichiro, Tama, Florence, Kunisaki, Yuya, Yagita, Kazuhiro, Ikeda, Masaaki, Kinoshita, Takayoshi, Kay, Steve A, Itami, Kenichiro, Hirota, Tsuyoshi
Published in Science advances (01.01.2019)
Published in Science advances (01.01.2019)
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Structure–activity relationship study of 4-(thiazol-5-yl)benzoic acid derivatives as potent protein kinase CK2 inhibitors
Ohno, Hiroaki, Minamiguchi, Daiki, Nakamura, Shinya, Shu, Keito, Okazaki, Shiho, Honda, Maho, Misu, Ryosuke, Moriwaki, Hirotomo, Nakanishi, Shinsuke, Oishi, Shinya, Kinoshita, Takayoshi, Nakanishi, Isao, Fujii, Nobutaka
Published in Bioorganic & medicinal chemistry (01.03.2016)
Published in Bioorganic & medicinal chemistry (01.03.2016)
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A promiscuous kinase inhibitor delineates the conspicuous structural features of protein kinase CK2a1
Tsuyuguchi, Masato, Nakaniwa, Tetsuko, Sawa, Masaaki, Nakanishi, Isao, Kinoshita, Takayoshi
Published in Acta crystallographica. Section F, Structural biology communications (01.07.2019)
Published in Acta crystallographica. Section F, Structural biology communications (01.07.2019)
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Identification of a selective ERK inhibitor and structural determination of the inhibitor–ERK2 complex
Ohori, Makoto, Kinoshita, Takayoshi, Okubo, Mitsuru, Sato, Kentaro, Yamazaki, Akiko, Arakawa, Hiroyuki, Nishimura, Shintaro, Inamura, Noriaki, Nakajima, Hidenori, Neya, Masahiro, Miyake, Hiroshi, Fujii, Takashi
Published in Biochemical and biophysical research communications (14.10.2005)
Published in Biochemical and biophysical research communications (14.10.2005)
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Combined High-Resolution Neutron and X-ray Analysis of Inhibited Elastase Confirms the Active-Site Oxyanion Hole but Rules against a Low-Barrier Hydrogen Bond
Tamada, Taro, Kinoshita, Takayoshi, Kurihara, Kazuo, Adachi, Motoyasu, Ohhara, Takashi, Imai, Keisuke, Kuroki, Ryota, Tada, Toshiji
Published in Journal of the American Chemical Society (12.08.2009)
Published in Journal of the American Chemical Society (12.08.2009)
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Crystal and solution structures disclose a putative transient state of mitogen-activated protein kinase kinase 4
Matsumoto, Takashi, Kinoshita, Takayoshi, Kirii, Yasuyuki, Tada, Toshiji, Yamano, Akihito
Published in Biochemical and biophysical research communications (24.08.2012)
Published in Biochemical and biophysical research communications (24.08.2012)
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Bioconversion of FR901459, a novel derivative of cyclosporin A, by Lentzea sp. 7887
Sasamura, Satoshi, Kobayashi, Motoo, Muramatsu, Hideyuki, Yoshimura, Seiji, Kinoshita, Takayoshi, Ohki, Hidenori, Okada, Kazuki, Deai, Yoko, Yamagishi, Yukiko, Hashimoto, Michizane
Published in Journal of antibiotics (01.08.2015)
Published in Journal of antibiotics (01.08.2015)
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Identification of protein kinase CK2 inhibitors using solvent dipole ordering virtual screening
Nakanishi, Isao, Murata, Katsumi, Nagata, Naoya, Kurono, Masakuni, Kinoshita, Takayoshi, Yasue, Misato, Miyazaki, Takako, Takei, Yoshinori, Nakamura, Shinya, Sakurai, Atsushi, Iwamoto, Nobuko, Nishiwaki, Keiji, Nakaniwa, Tetsuko, Sekiguchi, Yusuke, Hirasawa, Akira, Tsujimoto, Gozoh, Kitaura, Kazuo
Published in European journal of medicinal chemistry (26.05.2015)
Published in European journal of medicinal chemistry (26.05.2015)
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Seven Cysteine-Deficient Mutants Depict the Interplay between Thermal and Chemical Stabilities of Individual Cysteine Residues in Mitogen-Activated Protein Kinase c‑Jun N‑Terminal Kinase 1
Nakaniwa, Tetsuko, Fukada, Harumi, Inoue, Tatsuya, Gouda, Masaki, Nakai, Ryoko, Kirii, Yasuyuki, Adachi, Motoyasu, Tamada, Taro, Segawa, Shin-ichi, Kuroki, Ryota, Tada, Toshiji, Kinoshita, Takayoshi
Published in Biochemistry (Easton) (23.10.2012)
Published in Biochemistry (Easton) (23.10.2012)
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The in silico screening and X-ray structure analysis of the inhibitor complex of Plasmodium falciparum orotidine 5'-monophosphate decarboxylase
Takashima, Yasuhide, Mizohata, Eiichi, Krungkrai, Sudaratana R, Fukunishi, Yoshifumi, Kinoshita, Takayoshi, Sakata, Tsuneaki, Matsumura, Hiroyoshi, Krungkrai, Jerapan, Horii, Toshihiro, Inoue, Tsuyoshi
Published in Journal of biochemistry (Tokyo) (01.08.2012)
Published in Journal of biochemistry (Tokyo) (01.08.2012)
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A detailed thermodynamic profile of cyclopentyl and isopropyl derivatives binding to CK2 kinase
Kinoshita, Takayoshi, Sekiguchi, Yusuke, Fukada, Harumi, Nakaniwa, Tetsuko, Tada, Toshiji, Nakamura, Shinya, Kitaura, Kazuo, Ohno, Hiroaki, Suzuki, Yamato, Hirasawa, Akira, Nakanishi, Isao, Tsujimoto, Gozoh
Published in Molecular and cellular biochemistry (01.10.2011)
Published in Molecular and cellular biochemistry (01.10.2011)
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