Affinity chromatography reveals direct binding of the GATA4–NKX2-5 interaction inhibitor (3i-1000) with GATA4
Jumppanen, Mikael, Kinnunen, Sini M., Zore, Matej, Välimäki, Mika J., Talman, Virpi, Gennäs, Gustav Boije af, Ruskoaho, Heikki J., Yli-Kauhaluoma, Jari
Published in Scientific reports (18.04.2024)
Published in Scientific reports (18.04.2024)
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Discovery of Small Molecules Targeting the Synergy of Cardiac Transcription Factors GATA4 and NKX2‑5
Välimäki, Mika J, Tölli, Marja A, Kinnunen, Sini M, Aro, Jani, Serpi, Raisa, Pohjolainen, Lotta, Talman, Virpi, Poso, Antti, Ruskoaho, Heikki J
Published in Journal of medicinal chemistry (28.09.2017)
Published in Journal of medicinal chemistry (28.09.2017)
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Journal Article
Synthesis, Identification, and Structure–Activity Relationship Analysis of GATA4 and NKX2‑5 Protein–Protein Interaction Modulators
Jumppanen, Mikael, Kinnunen, Sini M, Välimäki, Mika J, Talman, Virpi, Auno, Samuli, Bruun, Tanja, Boije af Gennäs, Gustav, Xhaard, Henri, Aumüller, Ingo B, Ruskoaho, Heikki, Yli-Kauhaluoma, Jari
Published in Journal of medicinal chemistry (12.09.2019)
Published in Journal of medicinal chemistry (12.09.2019)
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GSK3β Serine 389 Phosphorylation Modulates Cardiomyocyte Hypertrophy and Ischemic Injury
Vainio, Laura, Taponen, Saija, Kinnunen, Sini M, Halmetoja, Eveliina, Szabo, Zoltan, Alakoski, Tarja, Ulvila, Johanna, Junttila, Juhani, Lakkisto, Päivi, Magga, Johanna, Kerkelä, Risto
Published in International journal of molecular sciences (18.12.2021)
Published in International journal of molecular sciences (18.12.2021)
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Journal Article
Switching of hypertrophic signalling towards enhanced cardiomyocyte identity and maturity by a GATA4-targeted compound
Pohjolainen, Lotta, Kinnunen, Sini M, Auno, Samuli, Kiriazis, Alexandros, Pohjavaara, Saana, Kari-Koskinen, Julia, Zore, Matej, Jumppanen, Mikael, Yli-Kauhaluoma, Jari, Talman, Virpi, Ruskoaho, Heikki, Välimäki, Mika J
Published in Stem cell research & therapy (02.01.2024)
Published in Stem cell research & therapy (02.01.2024)
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In vitro and in vivo assessment of heart-homing porous silicon nanoparticles
Ferreira, Mónica P.A, Ranjan, Sanjeev, Correia, Alexandra M.R, Mäkilä, Ermei M, Kinnunen, Sini M, Zhang, Hongbo, Shahbazi, Mohammad-Ali, Almeida, Patrick V, Salonen, Jarno J, Ruskoaho, Heikki J, Airaksinen, Anu J, Hirvonen, Jouni T, Santos, Hélder A
Published in Biomaterials (01.07.2016)
Published in Biomaterials (01.07.2016)
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Journal Article
Cardiac Actions of a Small Molecule Inhibitor Targeting GATA4–NKX2-5 Interaction
Kinnunen, Sini M., Tölli, Marja, Välimäki, Mika J., Gao, Erhe, Szabo, Zoltan, Rysä, Jaana, Ferreira, Mónica P. A., Ohukainen, Pauli, Serpi, Raisa, Correia, Alexandra, Mäkilä, Ermei, Salonen, Jarno, Hirvonen, Jouni, Santos, Hélder A., Ruskoaho, Heikki
Published in Scientific reports (15.03.2018)
Published in Scientific reports (15.03.2018)
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GATA4-targeted compound exhibits cardioprotective actions against doxorubicin-induced toxicity in vitro and in vivo: establishment of a chronic cardiotoxicity model using human iPSC-derived cardiomyocytes
Karhu, S. Tuuli, Kinnunen, Sini M., Tölli, Marja, Välimäki, Mika J., Szabó, Zoltán, Talman, Virpi, Ruskoaho, Heikki
Published in Archives of toxicology (01.06.2020)
Published in Archives of toxicology (01.06.2020)
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Journal Article
GATA-targeted compounds modulate cardiac subtype cell differentiation in dual reporter stem cell line
Välimäki, Mika J, Leigh, Robert S, Kinnunen, Sini M, March, Alexander R, de Sande, Ana Hernández, Kinnunen, Matias, Varjosalo, Markku, Heinäniemi, Merja, Kaynak, Bogac L, Ruskoaho, Heikki
Published in Stem cell research & therapy (18.03.2021)
Published in Stem cell research & therapy (18.03.2021)
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In vivo biocompatibility of porous silicon biomaterials for drug delivery to the heart
Tölli, Marja A, Ferreira, Mónica P.A, Kinnunen, Sini M, Rysä, Jaana, Mäkilä, Ermei M, Szabó, Zoltán, Serpi, Raisa E, Ohukainen, Pauli J, Välimäki, Mika J, Correia, Alexandra M.R, Salonen, Jarno J, Hirvonen, Jouni T, Ruskoaho, Heikki J, Santos, Hélder A
Published in Biomaterials (01.09.2014)
Published in Biomaterials (01.09.2014)
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Journal Article
Stem cells are the most sensitive screening tool to identify toxicity of GATA4-targeted novel small-molecule compounds
Karhu, S. Tuuli, Välimäki, Mika J., Jumppanen, Mikael, Kinnunen, Sini M., Pohjolainen, Lotta, Leigh, Robert S., Auno, Samuli, Földes, Gábor, Boije af Gennäs, Gustav, Yli-Kauhaluoma, Jari, Ruskoaho, Heikki, Talman, Virpi
Published in Archives of toxicology (01.09.2018)
Published in Archives of toxicology (01.09.2018)
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A Framework for Creating Value from Fleet Data at Ecosystem Level
Kinnunen, Sini-Kaisu, Hanski, Jyri, Marttonen-Arola, Salla, Kärri, Timo
Published in Management systems in production engineering (26.09.2017)
Published in Management systems in production engineering (26.09.2017)
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Towards sustainable feasibility studies for P2X investments
Matinmikko, Jan, Kinnunen, Sini-Kaisu, Sinkkonen, Tiina, Kärri, Timo
Published in Journal of cleaner production (10.09.2022)
Published in Journal of cleaner production (10.09.2022)
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Abstract 781: Doxorubicin-Induced Cardiotoxicity and Novel GATA4-Targeted Compounds
Karhu, Tuuli, Kinnunen, Sini, Talman, Virpi, Ruskoaho, Heikki
Published in Circulation research (02.08.2019)
Published in Circulation research (02.08.2019)
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Journal Article
Drug‐Loaded Multifunctional Nanoparticles Targeted to the Endocardial Layer of the Injured Heart Modulate Hypertrophic Signaling
Ferreira, Mónica P. A., Ranjan, Sanjeev, Kinnunen, Sini, Correia, Alexandra, Talman, Virpi, Mäkilä, Ermei, Barrios‐Lopez, Brianda, Kemell, Marianna, Balasubramanian, Vimalkumar, Salonen, Jarno, Hirvonen, Jouni, Ruskoaho, Heikki, Airaksinen, Anu J., Santos, Hélder A.
Published in Small (Weinheim an der Bergstrasse, Germany) (01.09.2017)
Published in Small (Weinheim an der Bergstrasse, Germany) (01.09.2017)
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Identification of cardiomyocyte-enriched long non-coding RNAs as potential targets for induction of cardiac regeneration
Pohjolainen, Lotta M, Kinnunen, Sini, Ruskoaho, Heikki, Talman, Virpi
Published in Proceedings for Annual Meeting of The Japanese Pharmacological Society (2018)
Published in Proceedings for Annual Meeting of The Japanese Pharmacological Society (2018)
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Journal Article
Discovery of Small Molecules Targeting the Synergy of Cardiac Transcription Factors GATA4 and NKX2-5
Ruskoaho, Heikki J, Aro, Jani, Serpi, Raisa, Pohjolainen, Lotta, Talman, Virpi, Poso, Antti, Rysa, Jaana, Kinnunen, Sini, Tolli, Marja, Valimaki, Mika
Published in Proceedings for Annual Meeting of The Japanese Pharmacological Society (2018)
Published in Proceedings for Annual Meeting of The Japanese Pharmacological Society (2018)
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Drug Delivery: Drug‐Loaded Multifunctional Nanoparticles Targeted to the Endocardial Layer of the Injured Heart Modulate Hypertrophic Signaling (Small 33/2017)
Ferreira, Mónica P. A., Ranjan, Sanjeev, Kinnunen, Sini, Correia, Alexandra, Talman, Virpi, Mäkilä, Ermei, Barrios‐Lopez, Brianda, Kemell, Marianna, Balasubramanian, Vimalkumar, Salonen, Jarno, Hirvonen, Jouni, Ruskoaho, Heikki, Airaksinen, Anu J., Santos, Hélder A.
Published in Small (Weinheim an der Bergstrasse, Germany) (01.09.2017)
Published in Small (Weinheim an der Bergstrasse, Germany) (01.09.2017)
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Journal Article
Nuclear Receptor-Like Structure and Interaction of Congenital Heart Disease-Associated Factors GATA4 and NKX2-5: e0144145
Kinnunen, Sini, Vaelimaeki, Mika, Tolli, Marja, Wohlfahrt, Gerd, Darwich, Rami, Komati, Hiba, Nemer, Mona, Ruskoaho, Heikki
Published in PloS one (01.12.2015)
Published in PloS one (01.12.2015)
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