Amyloid-related imaging abnormalities in patients with Alzheimer's disease treated with bapineuzumab: a retrospective analysis
Sperling, Reisa, Dr, Salloway, Stephen, Prof, Brooks, David J, Prof, Tampieri, Donatella, MD, Barakos, Jerome, MD, Fox, Nick C, Prof, Raskind, Murray, Prof, Sabbagh, Marwan, MD, Honig, Lawrence S, MD, Porsteinsson, Anton P, Prof, Lieberburg, Ivan, MD, Arrighi, H Michael, PhD, Morris, Kristen A, MS, Lu, Yuan, MS, Liu, Enchi, PhD, Gregg, Keith M, PhD, Brashear, H Robert, MD, Kinney, Gene G, PhD, Black, Ronald, MD, Grundman, Michael, MD
Published in Lancet neurology (01.03.2012)
Published in Lancet neurology (01.03.2012)
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Novel conformation-specific monoclonal antibodies against amyloidogenic forms of transthyretin
Higaki, Jeffrey N., Chakrabartty, Avi, Galant, Natalie J., Hadley, Kevin C., Hammerson, Bradley, Nijjar, Tarlochan, Torres, Ronald, Tapia, Jose R., Salmans, Joshua, Barbour, Robin, Tam, Stephen J., Flanagan, Ken, Zago, Wagner, Kinney, Gene G.
Published in Amyloid (01.06.2016)
Published in Amyloid (01.06.2016)
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A Novel Selective Positive Allosteric Modulator of Metabotropic Glutamate Receptor Subtype 5 Has in Vivo Activity and Antipsychotic-Like Effects in Rat Behavioral Models
Kinney, Gene G, O'Brien, Julie A, Lemaire, Wei, Burno, Maryann, Bickel, Denise J, Clements, Michelle K, Chen, Tsing-Bau, Wisnoski, David D, Lindsley, Craig W, Tiller, Philip R, Smith, Sheri, Jacobson, Marlene A, Sur, Cyrille, Duggan, Mark E, Pettibone, Douglas J, Conn, P Jeffrey, Williams, Jr, David L
Published in The Journal of pharmacology and experimental therapeutics (01.04.2005)
Published in The Journal of pharmacology and experimental therapeutics (01.04.2005)
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Journal Article
Metabotropic Glutamate Subtype 5 Receptors Modulate Locomotor Activity and Sensorimotor Gating in Rodents
Kinney, Gene G, Burno, Maryann, Campbell, Una C, Hernandez, Lisa M, Rodriguez, Dana, Bristow, Linda J, Conn, P Jeffrey
Published in The Journal of pharmacology and experimental therapeutics (01.07.2003)
Published in The Journal of pharmacology and experimental therapeutics (01.07.2003)
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Journal Article
Allosteric Modulation of Group III Metabotropic Glutamate Receptor 4: A Potential Approach to Parkinson's Disease Treatment
Marino, Michael J., Williams, David L., O'Brien, Julie A., Valenti, Ornella, McDonald, Terrence P., Clements, Michelle K., Wang, Ruiping, DiLella, Anthony G., Hess, J. Fred, Kinney, Gene G., Conn, P. Jeffrey
Published in Proceedings of the National Academy of Sciences - PNAS (11.11.2003)
Published in Proceedings of the National Academy of Sciences - PNAS (11.11.2003)
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First‐in‐human assessment of PRX002, an anti–α‐synuclein monoclonal antibody, in healthy volunteers
Schenk, Dale B., Koller, Martin, Ness, Daniel K., Griffith, Sue G., Grundman, Michael, Zago, Wagner, Soto, Jay, Atiee, George, Ostrowitzki, Susanne, Kinney, Gene G.
Published in Movement disorders (01.02.2017)
Published in Movement disorders (01.02.2017)
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First-in-human assessment of PRX002, an anti-[alpha]-synuclein monoclonal antibody, in healthy volunteers
Schenk, Dale B, Koller, Martin, Ness, Daniel K, Griffith, Sue G, Grundman, Michael, Zago, Wagner, Soto, Jay, Atiee, George, Ostrowitzki, Susanne, Kinney, Gene G
Published in Movement disorders (01.02.2017)
Published in Movement disorders (01.02.2017)
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First-in-Human Phase I/II Study of NEOD001 in Patients With Light Chain Amyloidosis and Persistent Organ Dysfunction
Gertz, Morie A, Landau, Heather, Comenzo, Raymond L, Seldin, David, Weiss, Brendan, Zonder, Jeffrey, Merlini, Giampaolo, Schönland, Stefan, Walling, Jackie, Kinney, Gene G, Koller, Martin, Schenk, Dale B, Guthrie, Spencer D, Liedtke, Michaela
Published in Journal of clinical oncology (01.04.2016)
Published in Journal of clinical oncology (01.04.2016)
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Journal Article
The mechanism of action, pharmacological characteristics, and clinical utility of the amyloid depleter birtamimab for the potential treatment of AL amyloidosis
Palladini, Giovanni, Liedtke, Michaela, Zago, Wagner, Dolan, Phil, Kinney, Gene G, Gertz, Morie A
Published in Leukemia & lymphoma (02.07.2024)
Published in Leukemia & lymphoma (02.07.2024)
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Birtamimab plus standard of care in light-chain amyloidosis: the phase 3 randomized placebo-controlled VITAL trial
Gertz, Morie A., Cohen, Adam D., Comenzo, Raymond L., Kastritis, Efstathios, Landau, Heather J., Libby, Edward N., Liedtke, Michaela, Sanchorawala, Vaishali, Schönland, Stefan, Wechalekar, Ashutosh, Zonder, Jeffrey A., Palladini, Giovanni, Walling, Jackie, Guthrie, Spencer, Nie, Christie, Karp, Carol, Jin, Yuying, Kinney, Gene G., Merlini, Giampaolo
Published in Blood (05.10.2023)
Published in Blood (05.10.2023)
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Journal Article
Discovery of N-{[1-(propylsulfonyl)-4-pyridin-2-ylpiperidin-4-yl]methyl}benzamides as novel, selective and potent GlyT1 inhibitors
Zhao, Zhijian, Leister, William H., O’Brien, Julie A., Lemaire, Wei, Williams, David L., Jacobson, Marlene A., Sur, Cyrille, Kinney, Gene G., Pettibone, Doug J., Tiller, Philip R., Smith, Sheri, Hartman, George D., Lindsley, Craig W., Wolkenberg, Scott E.
Published in Bioorganic & medicinal chemistry letters (01.03.2009)
Published in Bioorganic & medicinal chemistry letters (01.03.2009)
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PRX004 in variant amyloid transthyretin (ATTRv) amyloidosis: results of a phase 1, open-label, dose-escalation study
Suhr, Ole B, Grogan, Martha, Silva, Ana Martins da, Karam, Chafic, Garcia-Pavia, Pablo, Drachman, Brian, Zago, Wagner, Tripuraneni, Radhika, Kinney, Gene G
Published in Amyloid (29.10.2024)
Published in Amyloid (29.10.2024)
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Alzheimer's disease-type neuronal tau hyperphosphorylation induced by Aβ oligomers
De Felice, Fernanda G, Wu, Diana, Lambert, Mary P, Fernandez, Sara J, Velasco, Pauline T, Lacor, Pascale N, Bigio, Eileen H, Jerecic, Jasna, Acton, Paul J, Shughrue, Paul J, Chen-Dodson, Elizabeth, Kinney, Gene G, Klein, William L
Published in Neurobiology of aging (01.09.2008)
Published in Neurobiology of aging (01.09.2008)
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Journal Article
PRX012 induces microglia‐mediated clearance of pyroglutamate‐modified Aβ in Alzheimer’s Disease brain tissue
Tam, Stephen, Zhang, Gang, Li, Lauri, Elmaarouf, Abderrahman, Skov, Michael, Dolan, Philip, Kinney, Gene G, Campbell, Brian, Zago, Wagner M
Published in Alzheimer's & dementia (01.12.2021)
Published in Alzheimer's & dementia (01.12.2021)
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Journal Article
Inhibition of Calcineurin-mediated Endocytosis and α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid (AMPA) Receptors Prevents Amyloid β Oligomer-induced Synaptic Disruption
Zhao, Wei-Qin, Santini, Francesca, Breese, Robert, Ross, Dave, Zhang, Xiaohua Douglas, Stone, David J., Ferrer, Marc, Townsend, Matthew, Wolfe, Abigail L., Seager, Matthew A., Kinney, Gene G., Shughrue, Paul J., Ray, William J.
Published in The Journal of biological chemistry (05.03.2010)
Published in The Journal of biological chemistry (05.03.2010)
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Journal Article
Sustained levels of antibodies against Aβ in amyloid-rich regions of the CNS following intravenous dosing in human APP transgenic mice
Bard, Frédérique, Fox, Michael, Friedrich, Stuart, Seubert, Peter, Schenk, Dale, Kinney, Gene G., Yednock, Ted
Published in Experimental neurology (01.11.2012)
Published in Experimental neurology (01.11.2012)
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Journal Article
Design, Synthesis, and In Vivo Efficacy of Glycine Transporter-1 (GlyT1) Inhibitors Derived from a Series of [4-Phenyl-1-(propylsulfonyl)piperidin-4-yl]methyl Benzamides
Lindsley, Craig W., Zhao, Zhijian, Leister, William H., O'Brien, Julie, Lemaire, Wei, Williams Jr, David L., Chen, Tsing-Bau, Chang, Raymond S. L., Burno, Maryann, Jacobson, Marlene A., Sur, Cyrille, Kinney, Gene G., Pettibone, Douglas J., Tiller, Philip R., Smith, Sheri, Tsou, Nancy N., Duggan, Mark E., Conn, P. Jeffrey, Hartman, George D.
Published in ChemMedChem (11.08.2006)
Published in ChemMedChem (11.08.2006)
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Neutralization of soluble, synaptotoxic amyloid β species by antibodies is epitope specific
Zago, Wagner, Buttini, Manuel, Comery, Thomas A, Nishioka, Christopher, Gardai, Shyra J, Seubert, Peter, Games, Dora, Bard, Frédérique, Schenk, Dale, Kinney, Gene G
Published in The Journal of neuroscience (22.02.2012)
Published in The Journal of neuroscience (22.02.2012)
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Journal Article
Vascular alterations in PDAPP mice after anti-Aβ immunotherapy: Implications for amyloid-related imaging abnormalities
Zago, Wagner, Schroeter, Sally, Guido, Teresa, Khan, Karen, Seubert, Peter, Yednock, Ted, Schenk, Dale, Gregg, Keith M, Games, Dora, Bard, Frédérique, Kinney, Gene G
Published in Alzheimer's & dementia (01.10.2013)
Published in Alzheimer's & dementia (01.10.2013)
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