Lithium Promotes Longevity through GSK3/NRF2-Dependent Hormesis
Castillo-Quan, Jorge Iván, Li, Li, Kinghorn, Kerri J., Ivanov, Dobril K., Tain, Luke S., Slack, Cathy, Kerr, Fiona, Nespital, Tobias, Thornton, Janet, Hardy, John, Bjedov, Ivana, Partridge, Linda
Published in Cell reports (Cambridge) (19.04.2016)
Published in Cell reports (Cambridge) (19.04.2016)
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Journal Article
Autophagic dysfunction and gut microbiota dysbiosis cause chronic immune activation in a Drosophila model of Gaucher disease
Atilano, Magda L, Hull, Alexander, Romila, Catalina-Andreea, Adams, Mirjam L, Wildfire, Jacob, Ureña, Enric, Dyson, Miranda, Ivan-Castillo-Quan, Jorge, Partridge, Linda, Kinghorn, Kerri J
Published in PLoS genetics (01.12.2023)
Published in PLoS genetics (01.12.2023)
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Journal Article
Fine-tuning autophagy maximises lifespan and is associated with changes in mitochondrial gene expression in Drosophila
Bjedov, Ivana, Cochemé, Helena M, Foley, Andrea, Wieser, Daniela, Woodling, Nathaniel S, Castillo-Quan, Jorge Iván, Norvaisas, Povilas, Lujan, Celia, Regan, Jennifer C, Toivonen, Janne M, Murphy, Michael P, Thornton, Janet, Kinghorn, Kerri J, Neufeld, Thomas P, Cabreiro, Filipe, Partridge, Linda
Published in PLoS genetics (30.11.2020)
Published in PLoS genetics (30.11.2020)
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Journal Article
Lysosomal storage, impaired autophagy and innate immunity in Gaucher and Parkinson's diseases: insights for drug discovery
Hull, Alexander, Atilano, Magda L, Gergi, Laith, Kinghorn, Kerri J
Published in Philosophical transactions of the Royal Society of London. Series B. Biological sciences (08.04.2024)
Published in Philosophical transactions of the Royal Society of London. Series B. Biological sciences (08.04.2024)
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Journal Article
A triple drug combination targeting components of the nutrient-sensing network maximizes longevity
Castillo-Quan, Jorge Iván, Tain, Luke S., Kinghorn, Kerri J., Li, Li, Grönke, Sebastian, Hinze, Yvonne, Blackwell, T. Keith, Bjedov, Ivana, Partridge, Linda
Published in Proceedings of the National Academy of Sciences - PNAS (15.10.2019)
Published in Proceedings of the National Academy of Sciences - PNAS (15.10.2019)
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Journal Article
A Drosophila Model of Neuronopathic Gaucher Disease Demonstrates Lysosomal-Autophagic Defects and Altered mTOR Signalling and Is Functionally Rescued by Rapamycin
Kinghorn, Kerri J, Grönke, Sebastian, Castillo-Quan, Jorge Iván, Woodling, Nathaniel S, Li, Li, Sirka, Ernestas, Gegg, Matthew, Mills, Kevin, Hardy, John, Bjedov, Ivana, Partridge, Linda
Published in The Journal of neuroscience (16.11.2016)
Published in The Journal of neuroscience (16.11.2016)
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Journal Article
Loss of PLA2G6 leads to elevated mitochondrial lipid peroxidation and mitochondrial dysfunction
Kinghorn, Kerri J, Castillo-Quan, Jorge Iván, Bartolome, Fernando, Angelova, Plamena R, Li, Li, Pope, Simon, Cochemé, Helena M, Khan, Shabana, Asghari, Shabnam, Bhatia, Kailash P, Hardy, John, Abramov, Andrey Y, Partridge, Linda
Published in Brain (London, England : 1878) (01.07.2015)
Published in Brain (London, England : 1878) (01.07.2015)
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Journal Article
Autophagic dysregulation triggers innate immune activation in glucocerebrosidase deficiency
Atilano, Magda L., Hull, Alexander J., Kinghorn, Kerri J.
Published in Autophagy reports (31.12.2024)
Published in Autophagy reports (31.12.2024)
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Journal Article
Genetics and Pharmacology of Longevity: The Road to Therapeutics for Healthy Aging
Castillo-Quan, Jorge Iván, Kinghorn, Kerri J, Bjedov, Ivana
Published in Advances in Genetics (2015)
Published in Advances in Genetics (2015)
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Book Chapter
Journal Article
Misfolded PrP impairs the UPS by interaction with the 20S proteasome and inhibition of substrate entry
Deriziotis, Pelagia, André, Ralph, Smith, David M, Goold, Rob, Kinghorn, Kerri J, Kristiansen, Mark, Nathan, James A, Rosenzweig, Rina, Krutauz, Dasha, Glickman, Michael H, Collinge, John, Goldberg, Alfred L, Tabrizi, Sarah J
Published in The EMBO journal (03.08.2011)
Published in The EMBO journal (03.08.2011)
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Journal Article
Reply: Glial mitochondropathy in infantile neuroaxonal dystrophy: pathophysiological and therapeutic implications
Kinghorn, Kerri J, Castillo-Quan, Jorge Iván, Li, Li, Bhatia, Kailash P, Abramov, Andrey Y, Hardy, John, Partridge, Linda
Published in Brain (London, England : 1878) (01.12.2016)
Published in Brain (London, England : 1878) (01.12.2016)
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Journal Article
Neuroserpin Binds Aβ and Is a Neuroprotective Component of Amyloid Plaques in Alzheimer Disease
Kinghorn, Kerri J., Crowther, Damian C., Sharp, Lynda K., Nerelius, Charlotte, Davis, Richard L., Chang, Howard T., Green, Clare, Gubb, David C., Johansson, Jan, Lomas, David A.
Published in The Journal of biological chemistry (29.09.2006)
Published in The Journal of biological chemistry (29.09.2006)
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Journal Article
Sugar and alcohol molecules provide a therapeutic strategy for the serpinopathies that cause dementia and cirrhosis
Sharp, Lynda K., Mallya, Meera, Kinghorn, Kerri J., Wang, Zhen, Crowther, Damian C., Huntington, James A., Belorgey, Didier, Lomas, David A.
Published in The FEBS journal (01.06.2006)
Published in The FEBS journal (01.06.2006)
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Journal Article
Therapeutic targets from a Drosophila model of Alzheimer’s disease
Crowther, Damian C, Kinghorn, Kerri J, Page, Richard, Lomas, David A
Published in Current opinion in pharmacology (01.10.2004)
Published in Current opinion in pharmacology (01.10.2004)
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Journal Article