Deep Mutational Scanning of SARS-CoV-2 Receptor Binding Domain Reveals Constraints on Folding and ACE2 Binding
Starr, Tyler N., Greaney, Allison J., Hilton, Sarah K., Ellis, Daniel, Crawford, Katharine H.D., Dingens, Adam S., Navarro, Mary Jane, Bowen, John E., Tortorici, M. Alejandra, Walls, Alexandra C., King, Neil P., Veesler, David, Bloom, Jesse D.
Published in Cell (03.09.2020)
Published in Cell (03.09.2020)
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Accurate design of megadalton-scale two-component icosahedral protein complexes
Bale, Jacob B., Gonen, Shane, Liu, Yuxi, Sheffler, William, Ellis, Daniel, Thomas, Chantz, Cascio, Duilio, Yeates, Todd O., Gonen, Tamir, King, Neil P., Baker, David
Published in Science (American Association for the Advancement of Science) (22.07.2016)
Published in Science (American Association for the Advancement of Science) (22.07.2016)
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Functional SARS-CoV-2-Specific Immune Memory Persists after Mild COVID-19
Rodda, Lauren B., Netland, Jason, Shehata, Laila, Pruner, Kurt B., Morawski, Peter A., Thouvenel, Christopher D., Takehara, Kennidy K., Eggenberger, Julie, Hemann, Emily A., Waterman, Hayley R., Fahning, Mitchell L., Chen, Yu, Hale, Malika, Rathe, Jennifer, Stokes, Caleb, Wrenn, Samuel, Fiala, Brooke, Carter, Lauren, Hamerman, Jessica A., King, Neil P., Gale, Michael, Campbell, Daniel J., Rawlings, David J., Pepper, Marion
Published in Cell (07.01.2021)
Published in Cell (07.01.2021)
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Dynamics of Neutralizing Antibody Titers in the Months After Severe Acute Respiratory Syndrome Coronavirus 2 Infection
Crawford, Katharine H D, Dingens, Adam S, Eguia, Rachel, Wolf, Caitlin R, Wilcox, Naomi, Logue, Jennifer K, Shuey, Kiel, Casto, Amanda M, Fiala, Brooke, Wrenn, Samuel, Pettie, Deleah, King, Neil P, Greninger, Alexander L, Chu, Helen Y, Bloom, Jesse D
Published in The Journal of infectious diseases (03.02.2021)
Published in The Journal of infectious diseases (03.02.2021)
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Protocol and Reagents for Pseudotyping Lentiviral Particles with SARS-CoV-2 Spike Protein for Neutralization Assays
Crawford, Katharine H D, Eguia, Rachel, Dingens, Adam S, Loes, Andrea N, Malone, Keara D, Wolf, Caitlin R, Chu, Helen Y, Tortorici, M Alejandra, Veesler, David, Murphy, Michael, Pettie, Deleah, King, Neil P, Balazs, Alejandro B, Bloom, Jesse D
Published in Viruses (06.05.2020)
Published in Viruses (06.05.2020)
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Induction of Potent Neutralizing Antibody Responses by a Designed Protein Nanoparticle Vaccine for Respiratory Syncytial Virus
Marcandalli, Jessica, Fiala, Brooke, Ols, Sebastian, Perotti, Michela, de van der Schueren, Willem, Snijder, Joost, Hodge, Edgar, Benhaim, Mark, Ravichandran, Rashmi, Carter, Lauren, Sheffler, Will, Brunner, Livia, Lawrenz, Maria, Dubois, Patrice, Lanzavecchia, Antonio, Sallusto, Federica, Lee, Kelly K., Veesler, David, Correnti, Colin E., Stewart, Lance J., Baker, David, Loré, Karin, Perez, Laurent, King, Neil P.
Published in Cell (07.03.2019)
Published in Cell (07.03.2019)
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Complete and cooperative in vitro assembly of computationally designed self-assembling protein nanomaterials
Wargacki, Adam J., Wörner, Tobias P., van de Waterbeemd, Michiel, Ellis, Daniel, Heck, Albert J. R., King, Neil P.
Published in Nature communications (09.02.2021)
Published in Nature communications (09.02.2021)
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Designed proteins induce the formation of nanocage-containing extracellular vesicles
Votteler, Jörg, Ogohara, Cassandra, Yi, Sue, Hsia, Yang, Nattermann, Una, Belnap, David M., King, Neil P., Sundquist, Wesley I.
Published in Nature (London) (08.12.2016)
Published in Nature (London) (08.12.2016)
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Enhancing and shaping the immunogenicity of native-like HIV-1 envelope trimers with a two-component protein nanoparticle
Brouwer, Philip J. M., Antanasijevic, Aleksandar, Berndsen, Zachary, Yasmeen, Anila, Fiala, Brooke, Bijl, Tom P. L., Bontjer, Ilja, Bale, Jacob B., Sheffler, William, Allen, Joel D., Schorcht, Anna, Burger, Judith A., Camacho, Miguel, Ellis, Daniel, Cottrell, Christopher A., Behrens, Anna-Janina, Catalano, Marco, del Moral-Sánchez, Iván, Ketas, Thomas J., LaBranche, Celia, van Gils, Marit J., Sliepen, Kwinten, Stewart, Lance J., Crispin, Max, Montefiori, David C., Baker, David, Moore, John P., Klasse, Per Johan, Ward, Andrew B., King, Neil P., Sanders, Rogier W.
Published in Nature communications (19.09.2019)
Published in Nature communications (19.09.2019)
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De novo design of tunable, pH-driven conformational changes
Boyken, Scott E, Benhaim, Mark A, Busch, Florian, Jia, Mengxuan, Bick, Matthew J, Choi, Heejun, Klima, Jason C, Chen, Zibo, Walkey, Carl, Mileant, Alexander, Sahasrabuddhe, Aniruddha, Wei, Kathy Y, Hodge, Edgar A, Byron, Sarah, Quijano-Rubio, Alfredo, Sankaran, Banumathi, King, Neil P, Lippincott-Schwartz, Jennifer, Wysocki, Vicki H, Lee, Kelly K, Baker, David
Published in Science (American Association for the Advancement of Science) (17.05.2019)
Published in Science (American Association for the Advancement of Science) (17.05.2019)
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Tailored design of protein nanoparticle scaffolds for multivalent presentation of viral glycoprotein antigens
Ueda, George, Antanasijevic, Aleksandar, Fallas, Jorge A, Sheffler, William, Copps, Jeffrey, Ellis, Daniel, Hutchinson, Geoffrey B, Moyer, Adam, Yasmeen, Anila, Tsybovsky, Yaroslav, Park, Young-Jun, Bick, Matthew J, Sankaran, Banumathi, Gillespie, Rebecca A, Brouwer, Philip Jm, Zwart, Peter H, Veesler, David, Kanekiyo, Masaru, Graham, Barney S, Sanders, Rogier W, Moore, John P, Klasse, Per Johan, Ward, Andrew B, King, Neil P, Baker, David
Published in eLife (04.08.2020)
Published in eLife (04.08.2020)
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Serological identification of SARS-CoV-2 infections among children visiting a hospital during the initial Seattle outbreak
Dingens, Adam S., Crawford, Katharine H. D., Adler, Amanda, Steele, Sarah L., Lacombe, Kirsten, Eguia, Rachel, Amanat, Fatima, Walls, Alexandra C., Wolf, Caitlin R., Murphy, Michael, Pettie, Deleah, Carter, Lauren, Qin, Xuan, King, Neil P., Veesler, David, Krammer, Florian, Dickerson, Jane A., Chu, Helen Y., Englund, Janet A., Bloom, Jesse D.
Published in Nature communications (01.09.2020)
Published in Nature communications (01.09.2020)
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A broadly generalizable stabilization strategy for sarbecovirus fusion machinery vaccines
Lee, Jimin, Stewart, Cameron, Schäfer, Alexandra, Leaf, Elizabeth M., Park, Young-Jun, Asarnow, Daniel, Powers, John M., Treichel, Catherine, Sprouse, Kaitlin R., Corti, Davide, Baric, Ralph, King, Neil P., Veesler, David
Published in Nature communications (28.06.2024)
Published in Nature communications (28.06.2024)
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Induction of cross-neutralizing antibodies by a permuted hepatitis C virus glycoprotein nanoparticle vaccine candidate
Sliepen, Kwinten, Radić, Laura, Capella-Pujol, Joan, Watanabe, Yasunori, Zon, Ian, Chumbe, Ana, Lee, Wen-Hsin, de Gast, Marlon, Koopsen, Jelle, Koekkoek, Sylvie, del Moral-Sánchez, Iván, Brouwer, Philip J. M., Ravichandran, Rashmi, Ozorowski, Gabriel, King, Neil P., Ward, Andrew B., van Gils, Marit J., Crispin, Max, Schinkel, Janke, Sanders, Rogier W.
Published in Nature communications (25.11.2022)
Published in Nature communications (25.11.2022)
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Polyclonal antibody responses to HIV Env immunogens resolved using cryoEM
Antanasijevic, Aleksandar, Sewall, Leigh M., Cottrell, Christopher A., Carnathan, Diane G., Jimenez, Luis E., Ngo, Julia T., Silverman, Jennifer B., Groschel, Bettina, Georgeson, Erik, Bhiman, Jinal, Bastidas, Raiza, LaBranche, Celia, Allen, Joel D., Copps, Jeffrey, Perrett, Hailee R., Rantalainen, Kimmo, Cannac, Fabien, Yang, Yuhe R., de la Peña, Alba Torrents, Rocha, Rebeca Froes, Berndsen, Zachary T., Baker, David, King, Neil P., Sanders, Rogier W., Moore, John P., Crotty, Shane, Crispin, Max, Montefiori, David C., Burton, Dennis R., Schief, William R., Silvestri, Guido, Ward, Andrew B.
Published in Nature communications (10.08.2021)
Published in Nature communications (10.08.2021)
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Structural and functional evaluation of de novo-designed, two-component nanoparticle carriers for HIV Env trimer immunogens
Antanasijevic, Aleksandar, Ueda, George, Brouwer, Philip J M, Copps, Jeffrey, Huang, Deli, Allen, Joel D, Cottrell, Christopher A, Yasmeen, Anila, Sewall, Leigh M, Bontjer, Ilja, Ketas, Thomas J, Turner, Hannah L, Berndsen, Zachary T, Montefiori, David C, Klasse, Per Johan, Crispin, Max, Nemazee, David, Moore, John P, Sanders, Rogier W, King, Neil P, Baker, David, Ward, Andrew B
Published in PLoS pathogens (11.08.2020)
Published in PLoS pathogens (11.08.2020)
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Structure-based design of stabilized recombinant influenza neuraminidase tetramers
Ellis, Daniel, Lederhofer, Julia, Acton, Oliver J., Tsybovsky, Yaroslav, Kephart, Sally, Yap, Christina, Gillespie, Rebecca A., Creanga, Adrian, Olshefsky, Audrey, Stephens, Tyler, Pettie, Deleah, Murphy, Michael, Sydeman, Claire, Ahlrichs, Maggie, Chan, Sidney, Borst, Andrew J., Park, Young-Jun, Lee, Kelly K., Graham, Barney S., Veesler, David, King, Neil P., Kanekiyo, Masaru
Published in Nature communications (05.04.2022)
Published in Nature communications (05.04.2022)
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Growing Glycans in Rosetta: Accurate de novo glycan modeling, density fitting, and rational sequon design
Adolf-Bryfogle, Jared, Labonte, Jason W, Kraft, John C, Shapovalov, Maxim, Raemisch, Sebastian, Lütteke, Thomas, DiMaio, Frank, Bahl, Christopher D, Pallesen, Jesper, King, Neil P, Gray, Jeffrey J, Kulp, Daniel W, Schief, William R
Published in PLoS computational biology (24.06.2024)
Published in PLoS computational biology (24.06.2024)
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