Discovery of Potent and Selective Adamantane-Based Small-Molecule P2X7 Receptor Antagonists/Interleukin-1β Inhibitors
Furber, Mark, Alcaraz, Lilian, Bent, Janice E, Beyerbach, Armin, Bowers, Keith, Braddock, Martin, Caffrey, Moya V, Cladingboel, David, Collington, John, Donald, David K, Fagura, Malbinder, Ince, Frank, Kinchin, Elizabeth C, Laurent, Celine, Lawson, Mandy, Luker, Timothy J, Mortimore, Michael M. P, Pimm, Austen D, Riley, Robert J, Roberts, Nicola, Robertson, Mark, Theaker, Jill, Thorne, Philip V, Weaver, Richard, Webborn, Peter, Willis, Paul
Published in Journal of medicinal chemistry (29.11.2007)
Published in Journal of medicinal chemistry (29.11.2007)
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Journal Article
Dual D2-Receptor and β2-Adrenoceptor Agonists for the Treatment of Airway Diseases. 1. Discovery and Biological Evaluation of Some 7-(2-Aminoethyl)- 4-hydroxybenzothiazol-2(3H)-one Analogues
Bonnert, Roger V, Brown, Roger C, Chapman, David, Cheshire, David R, Dixon, John, Ince, Francis, Kinchin, Elizabeth C, Lyons, Amanda J, Davis, Andrew M, Hallam, Catherine, Harper, Stephen T, Unitt, John F, Dougall, Iain G, Jackson, Dale M, McKechnie, Kenneth, Young, Alan, Simpson, Wilfred T
Published in Journal of medicinal chemistry (03.12.1998)
Published in Journal of medicinal chemistry (03.12.1998)
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Journal Article
Cathepsin C Inhibitors: Property Optimization and Identification of a Clinical Candidate
Furber, Mark, Tiden, Anna-Karin, Gardiner, Philip, Mete, Antonio, Ford, Rhonan, Millichip, Ian, Stein, Linda, Mather, Andrew, Kinchin, Elizabeth, Luckhurst, Christopher, Barber, Simon, Cage, Peter, Sanganee, Hitesh, Austin, Rupert, Chohan, Kamaldeep, Beri, Raj, Thong, Bob, Wallace, Alan, Oreffo, Victor, Hutchinson, Ray, Harper, Steve, Debreczeni, Judit, Breed, Jason, Wissler, Lisa, Edman, Karl
Published in Journal of medicinal chemistry (27.03.2014)
Published in Journal of medicinal chemistry (27.03.2014)
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Journal Article
Discovery of potent and selective adamantane-based small-molecule P2X(7) receptor antagonists/interleukin-1 beta,6 inhibitors
Furber, Mark, Alcaraz, Lilian, Bent, Janice E., Beyerbach, Armin, Bowers, Keith, Braddock, Martin, Caffrey, Moya V., Cladingboel, David, Collington, John, Donald, David K., Fagura, Malbinder, Ince, Frank, Kinchin, Elizabeth C., Laurent, Celine, Lawson, Mandy, Luker, Timothy J., Mortimore, Michael M. P., Pimm, Austen D., Riley, Robert J., Roberts, Nicola, Robertson, Mark, Theaker, Jill, Thorne, Philip V., Weaver, Richard, Webborn, Peter, Willis, Paul
Published in Journal of medicinal chemistry (29.11.2007)
Published in Journal of medicinal chemistry (29.11.2007)
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Journal Article
Discovery of Potent and Selective Adamantane-Based Small-Molecule P2X 7 Receptor Antagonists/Interleukin-1β Inhibitors
Furber, Mark, Alcaraz, Lilian, Bent, Janice E., Beyerbach, Armin, Bowers, Keith, Braddock, Martin, Caffrey, Moya V., Cladingboel, David, Collington, John, Donald, David K., Fagura, Malbinder, Ince, Frank, Kinchin, Elizabeth C., Laurent, Celine, Lawson, Mandy, Luker, Timothy J., Mortimore, Michael M. P., Pimm, Austen D., Riley, Robert J., Roberts, Nicola, Robertson, Mark, Theaker, Jill, Thorne, Philip V., Weaver, Richard, Webborn, Peter, Willis, Paul
Published in Journal of medicinal chemistry (29.11.2007)
Published in Journal of medicinal chemistry (29.11.2007)
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Journal Article
Hit-to-Lead studies: The discovery of potent, orally bioavailable thiazolopyrimidine CXCR2 receptor antagonists
Baxter, Andrew, Cooper, Anne, Kinchin, Elizabeth, Moakes, Kerry, Unitt, John, Wallace, Alan
Published in Bioorganic & medicinal chemistry letters (15.02.2006)
Published in Bioorganic & medicinal chemistry letters (15.02.2006)
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Journal Article
Discovery and evolution of phenoxypiperidine hydroxyamide dual CCR3/H-1 antagonists. Part II: Optimising in vivo clearance
Furber, Mark, Alcaraz, Lilian, Luckhurst, Christopher, Bahl, Ash, Beaton, Haydn, Bowers, Keith, Collington, John, Denton, Rebecca, Donald, David, Kinchin, Elizabeth, MacDonald, Cathy, Rigby, Aaron, Riley, Rob, Soars, Matt, Springthorpe, Brian, Webborn, Peter
Published in Bioorganic & medicinal chemistry letters (15.12.2012)
Published in Bioorganic & medicinal chemistry letters (15.12.2012)
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Journal Article
Discovery and evolution of phenoxypiperidine hydroxyamide dual CCR3/H-1 antagonists. Part I
Furber, Mark, Alcaraz, Lilian, Luckhurst, Christopher, Bahl, Ash, Beaton, Haydn, Bowers, Keith, Collington, John, Denton, Rebecca, Donald, David, Kinchin, Elizabeth, MacDonald, Cathy, Rigby, Aaron, Riley, Rob, Soars, Matt, Springthorpe, Brian, Webborn, Peter
Published in Bioorganic & medicinal chemistry letters (15.12.2012)
Published in Bioorganic & medicinal chemistry letters (15.12.2012)
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Journal Article
Discovery and evolution of phenoxypiperidine hydroxyamide dual CCR3/H1 antagonists. Part I
Furber, Mark, Alcaraz, Lilian, Luckhurst, Christopher, Bahl, Ash, Beaton, Haydn, Bowers, Keith, Collington, John, Denton, Rebecca, Donald, David, Kinchin, Elizabeth, MacDonald, Cathy, Rigby, Aaron, Riley, Rob, Soars, Matt, Springthorpe, Brian, Webborn, Peter
Published in Bioorganic & medicinal chemistry letters (15.12.2012)
Published in Bioorganic & medicinal chemistry letters (15.12.2012)
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Journal Article
Discovery and evolution of phenoxypiperidine hydroxyamide dual CCR3/H1 antagonists. Part II: Optimising in vivo clearance
Furber, Mark, Alcaraz, Lilian, Luckhurst, Christopher, Bahl, Ash, Beaton, Haydn, Bowers, Keith, Collington, John, Denton, Rebecca, Donald, David, Kinchin, Elizabeth, MacDonald, Cathy, Rigby, Aaron, Riley, Rob, Soars, Matt, Springthorpe, Brian, Webborn, Peter
Published in Bioorganic & medicinal chemistry letters (15.12.2012)
Published in Bioorganic & medicinal chemistry letters (15.12.2012)
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Journal Article
Hit-to-Lead studies: The discovery of potent, orally bioavailable triazolethiol CXCR2 receptor antagonists
Baxter, Andrew, Bennion, Colin, Bent, Janice, Boden, Kerry, Brough, Steve, Cooper, Anne, Kinchin, Elizabeth, Kindon, Nicholas, McInally, Tom, Mortimore, Mike, Roberts, Bryan, Unitt, John
Published in Bioorganic & medicinal chemistry letters (18.08.2003)
Published in Bioorganic & medicinal chemistry letters (18.08.2003)
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Journal Article
Novel Enantioselective Synthesis of 1,3-Butadien-2-ylmethanols via Tandem Alkylbromide-epoxide Vinylations Using Dimethylsulfonium Methylide
Alcaraz, Lilian, Cox, Katherine, Cridland, Andrew P, Kinchin, Elizabeth, Morris, James, Thompson, Stewart P
Published in Organic letters (31.03.2005)
Published in Organic letters (31.03.2005)
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Journal Article
Discovery of potent and selective adamantane-based small-molecule P2X(7) receptor antagonists/interleukin-1beta inhibitors
Furber, Mark, Alcaraz, Lilian, Bent, Janice E, Beyerbach, Armin, Bowers, Keith, Braddock, Martin, Caffrey, Moya V, Cladingboel, David, Collington, John, Donald, David K, Fagura, Malbinder, Ince, Frank, Kinchin, Elizabeth C, Laurent, Celine, Lawson, Mandy, Luker, Timothy J, Mortimore, Michael M P, Pimm, Austen D, Riley, Robert J, Roberts, Nicola, Robertson, Mark, Theaker, Jill, Thorne, Philip V, Weaver, Richard, Webborn, Peter, Willis, Paul
Published in Journal of medicinal chemistry (29.11.2007)
Get full text
Published in Journal of medicinal chemistry (29.11.2007)
Journal Article
Dual D 2 -Receptor and β 2 -Adrenoceptor Agonists for the Treatment of Airway Diseases. 1. Discovery and Biological Evaluation of Some 7-(2-Aminoethyl)- 4-hydroxybenzothiazol-2(3 H )-one Analogues
Bonnert, Roger V., Brown, Roger C., Chapman, David, Cheshire, David R., Dixon, John, Ince, Francis, Kinchin, Elizabeth C., Lyons, Amanda J., Davis, Andrew M., Hallam, Catherine, Harper, Stephen T., Unitt, John F., Dougall, Iain G., Jackson, Dale M., McKechnie, Kenneth, Young, Alan, Simpson, Wilfred T.
Published in Journal of medicinal chemistry (01.12.1998)
Published in Journal of medicinal chemistry (01.12.1998)
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Journal Article
SUBSTITUTED N-[1-CYANO-2-(PHENYL)ETHYL] 1-AMINOCYCLOALK-1-YLCARBOXAMIDE COMPOUNDS - 760
MATHER, ANDREW, METE, ANTONIO, STANIER, ANDREW GEOFFREY, KINCHIN, ELIZABETH, MILLICHIP, IAN, FORD, RHONAN
Year of Publication 15.12.2011
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Year of Publication 15.12.2011
Patent
Piperidines as chemokine modulators (CCR)
Alcaraz, Lilian, Cage, Peter, Furber, Mark, Kinchin, Elizabeth, Luckhurst, Christopher, Rigby, Aaron
Year of Publication 07.06.2011
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Year of Publication 07.06.2011
Patent
Piperidines as chemokine modulators (CCR)
CAGE PETER, ALCARAZ LILIAN, LUCKHURST CHRISTOPHER, RIGBY AARON, KINCHIN ELIZABETH, FURBER MARK
Year of Publication 07.06.2011
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Year of Publication 07.06.2011
Patent
SULPHONAMIDE DERIVATES AS MODULATORS OF THE GLUCOCORTICOID RECEPTOR
KINCHIN, ELIZABETH, BLADH, HAAKAN, HANSSON, THOMAS, BENGTSSON, MALENA
Year of Publication 11.10.2007
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Year of Publication 11.10.2007
Patent