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The Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of a TYK2/JAK1 Inhibitor (PF-06700841) in Healthy Subjects and Patients With Plaque Psoriasis
Banfield, Christopher, Scaramozza, Matthew, Zhang, Weidong, Kieras, Elizabeth, Page, Karen M, Fensome, Andrew, Vincent, Michael, Dowty, Martin E, Goteti, Kosalaram, Winkle, Peter J, Peeva, Elena
Published in Journal of clinical pharmacology (01.04.2018)
Published in Journal of clinical pharmacology (01.04.2018)
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Pharmacokinetics, mass balance, and metabolism of [14C]envonalkib (TQ-B3139), a novel ALK tyrosine kinase inhibitor, in healthy Chinese subjects
Ma, Sheng, Wang, Xin, Yan, Shu, Miao, Liyan, Wan, Xiaojing, Ding, Dawei, Yu, Ding, Diao, Xingxing, Wang, Xunqiang, Zhang, Hua
Published in Cancer chemotherapy and pharmacology (01.11.2024)
Published in Cancer chemotherapy and pharmacology (01.11.2024)
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Understanding LRRK2 kinase activity in preclinical models and human subjects through quantitative analysis of LRRK2 and pT73 Rab10
Wang, Xiang, Negrou, Elvira, Maloney, Michael T., Bondar, Vitaliy V., Andrews, Shan V., Montalban, Manuel, Llapashtica, Ceyda, Maciuca, Romeo, Nguyen, Hoang, Solanoy, Hilda, Arguello, Annie, Przybyla, Laralynne, Moerke, Nathan J., Huntwork-Rodriguez, Sarah, Henry, Anastasia G.
Published in Scientific reports (18.06.2021)
Published in Scientific reports (18.06.2021)
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The Lysin Motif Receptor-like Kinase (LysM-RLK) CERK1 Is a Major Chitin-binding Protein in Arabidopsis thaliana and Subject to Chitin-induced Phosphorylation
Petutschnig, Elena K., Jones, Alexandra M.E., Serazetdinova, Liliya, Lipka, Ulrike, Lipka, Volker
Published in The Journal of biological chemistry (10.09.2010)
Published in The Journal of biological chemistry (10.09.2010)
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Evaluation of Bruton’s Tyrosine Kinase (BTK) inhibition with alternative doses of ibrutinib in subjects with Chronic Lymphocytic Leukemia (CLL)
Ouerdani, Aziz, Valenzuela, Belén, Treijtel, Nicoline, Haddish-Berhane, Nahor, Desphande, Sanjay, Srinivasan, Srimathi, Smith, Emma, Perez Ruixo, Juan José
Published in Cancer chemotherapy and pharmacology (01.12.2025)
Published in Cancer chemotherapy and pharmacology (01.12.2025)
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Evaluation of a Janus kinase 1 inhibitor, PF‐04965842, in healthy subjects: A phase 1, randomized, placebo‐controlled, dose‐escalation study
Peeva, Elena, Hodge, Martin R., Kieras, Elizabeth, Vazquez, Michael L., Goteti, Kosalaram, Tarabar, Sanela G., Alvey, Christine W., Banfield, Christopher
Published in British journal of clinical pharmacology (01.08.2018)
Published in British journal of clinical pharmacology (01.08.2018)
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Pharmacokinetics, Mass Balance, and Biotransformation of [14C]tinengotinib, A Novel Multi-target Kinase Inhibitor, in Healthy Subjects
Ni, Shumao, Ma, Sheng, Yu, Yingying, Yu, Zhenwen, Zhu, Yujia, Sun, Xiaofen, Li, Lin, Sun, Caixia, Wang, Hui, Peng, Peng, Gu, Zheming, Zhang, Hua, Wu, Frank, Miao, Liyan, Fan, Jean
Published in Drugs in R&D (01.09.2024)
Published in Drugs in R&D (01.09.2024)
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Dysregulated phosphorylation of Ca2+/calmodulin‐dependent protein kinase II‐α in the hippocampus of subjects with mild cognitive impairment and Alzheimer’s disease
Reese, Lindsay C., Laezza, Fernanda, Woltjer, Randall, Taglialatela, Giulio
Published in Journal of neurochemistry (01.11.2011)
Published in Journal of neurochemistry (01.11.2011)
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Mass balance, metabolic disposition, and pharmacokinetics of [14C]ensartinib, a novel potent anaplastic lymphoma kinase (ALK) inhibitor, in healthy subjects following oral administration
Zhou, Sufeng, Liu, Wei, Zhou, Chen, Zhang, Lingling, Xie, Lijun, Xu, Zhaoqiang, Wang, Lu, Zhao, Yuqing, Guo, Lian, Chen, Juan, Ding, Lieming, Mao, Li, Tao, Yi, Zhang, Chen, Ding, Sijia, Shao, Feng
Published in Cancer chemotherapy and pharmacology (01.12.2020)
Published in Cancer chemotherapy and pharmacology (01.12.2020)
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Expression of protein kinase HIPK2 is subject to a quality control mechanism that acts during translation and requires its kinase activity to prevent degradation of nascent HIPK2
Müller, Jan Paul, Scholl, Stephan, Kunick, Conrad, Klempnauer, Karl-Heinz
Published in Biochimica et biophysica acta. Molecular cell research (01.01.2021)
Published in Biochimica et biophysica acta. Molecular cell research (01.01.2021)
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Effects of a topical treatment with spleen tyrosine kinase inhibitor in healthy subjects and patients with cold urticaria or chronic spontaneous urticaria: Results of a phase 1a/b randomised double‐blind placebo‐controlled study
Dickson, Marion C., Walker, Alexandra, Grattan, Clive, Perry, Hayley, Williams, Nicola, Ratia, Nirav, Dewit, Odile, Gisbert, Sophie, Metz, Martin, Maurer, Marcus
Published in British journal of clinical pharmacology (01.12.2021)
Published in British journal of clinical pharmacology (01.12.2021)
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Pharmacokinetics and Safety of the Tyrosine Kinase 2 Inhibitor Deucravacitinib in Healthy Chinese Subjects
Jing, Shan, Lin, Yang, Dockens, Randy, Marchisin, David, He, Bing, Girgis, Ihab G., Chimalakonda, Anjaneya, Murthy, Bindu, Aras, Urvi
Published in Dermatology and therapy (01.12.2023)
Published in Dermatology and therapy (01.12.2023)
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The Ankyrin Repeat and Kinase Domain Containing 1 Gene Polymorphism (ANKK1 Taq1A) and Personality Traits in Addicted Subjects
Grzywacz, Anna, Chmielowiec, Jolanta, Chmielowiec, Krzysztof, Mroczek, Bożena, Masiak, Jolanta, Suchanecka, Aleksandra, Sipak-Szmigiel, Olimpia, Szumilas, Kamila, Trybek, Grzegorz
Published in International journal of environmental research and public health (27.07.2019)
Published in International journal of environmental research and public health (27.07.2019)
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Pharmacokinetics, Safety, and Tolerability of Selonsertib, an Apoptosis Signal-Regulating Kinase 1 (ASK1) Inhibitor, Following First-in-Human Single and Multiple Ascending Doses in Healthy Subjects
Nelson, Cara H., Etchevers, Kim, Yi, Saili, Breckenridge, David, Hepner, Mischa, Patel, Uptal, Ling, John, Mathias, Anita
Published in Clinical pharmacokinetics (01.09.2020)
Published in Clinical pharmacokinetics (01.09.2020)
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Effects of Food on the Pharmacokinetics and Safety of HA121-28 Tablet, a Novel Multi-Targeting Tyrosine Kinase Inhibitor, in Healthy Chinese Subjects: A Phase I Clinical Trial
Liu, Yixian, Li, Xiaoyu, Zhang, Mengyu, Men, Yuchun, Wang, Ying, Zhu, Xiaohong, Zheng, Li
Published in Drug design, development and therapy (01.01.2025)
Published in Drug design, development and therapy (01.01.2025)
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Metformin Increases AMP-Activated Protein Kinase Activity in Skeletal Muscle of Subjects With Type 2 Diabetes
Musi, Nicolas, Hirshman, Michael F., Nygren, Jonas, Svanfeldt, Monika, Bavenholm, Peter, Rooyackers, Olav, Zhou, Gaochao, Williamson, Joanne M., Ljunqvist, Olle, Efendic, Suad, Moller, David E., Thorell, Anders, Goodyear, Laurie J.
Published in Diabetes (New York, N.Y.) (01.07.2002)
Published in Diabetes (New York, N.Y.) (01.07.2002)
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Enhancement of cutaneous immunity during aging by blocking p38 mitogen-activated protein (MAP) kinase–induced inflammation
Vukmanovic-Stejic, Milica, Chambers, Emma S., Suárez-Fariñas, Mayte, Sandhu, Daisy, Fuentes-Duculan, Judilyn, Patel, Neil, Agius, Elaine, Lacy, Katie E., Turner, Carolin T., Larbi, Anis, Birault, Veronique, Noursadeghi, Mahdad, Mabbott, Neil A., Rustin, Malcolm H.A., Krueger, James G., Akbar, Arne N.
Published in Journal of allergy and clinical immunology (01.09.2018)
Published in Journal of allergy and clinical immunology (01.09.2018)
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The effect of food on the pharmacokinetics of Sutetinib maleate capsule, an irreversible EGFR tyrosine kinase inhibitor, in healthy Chinese subjects
Cao, Bei, Ma, Tingting, Zhang, Yuqiang, Huang, Lei, Lin, Hui, Jiang, Huanhuan, Zhao, Yu, Geng, Yan, Yang, Yuanxun, Cao, Sumin, Li, Juan
Published in Investigational new drugs (01.06.2024)
Published in Investigational new drugs (01.06.2024)
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Absolute bioavailability, biotransformation, and excretion of the bruton tyrosine kinase inhibitor TL-895 in healthy human subjects
Podoll, Terry, Allard, Martine, Krejsa, Cecile, Khorlin, Nick, Fong, Jonathan, Masten, Sue, Slatter, J. Greg
Published in Drug metabolism and pharmacokinetics (01.06.2025)
Published in Drug metabolism and pharmacokinetics (01.06.2025)
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