Prediction of Human Hepatic Clearance from in Vivo Animal Experiments and in Vitro Metabolic Studies with Liver Microsomes from Animals and Humans
NARITOMI, Yoichi, TERASHITA, Shigeyuki, KIMURA, Sumihisa, SUZUKI, Akira, KAGAYAMA, Akira, SUGIYAMA, Yuichi
Published in Drug metabolism and disposition (01.10.2001)
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Published in Drug metabolism and disposition (01.10.2001)
Journal Article
Osteotropic Drug Delivery System (ODDS) Based on Bisphosphonic Prodrug. V. Biological Disposition and Targeting Characteristics of Osteotropic Estradiol
FUJISAKI, Jiro, TOKUNAGA, Yuji, TAKAHASHI, Toshiya, KIMURA, Sumihisa, SHIMOJO, Fumio, HATA, Takehisa
Published in Biological & pharmaceutical bulletin (1997)
Published in Biological & pharmaceutical bulletin (1997)
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Journal Article
Development of a Novel Drug Release System, Time-Controlled Explosion System (TES). II. Design of Multiparticulate TES and in Vitro Drug Release Properties
UEDA, Satoshi, YAMAGUCHI, Hisami, KOTANI, Masateru, Kimura, Sumihisa, TOKUNAGA, Yuji, KAGAYAMA, Akira, HATA, Takehisa
Published in Chemical & pharmaceutical bulletin (1994)
Published in Chemical & pharmaceutical bulletin (1994)
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Journal Article
Osteotropic drug delivery system (ODDS) based on bisphosphonic prodrug. III: Pharmacokinetics and targeting characteristics of osteotropic carboxyfluorescein
Fujisaki, J, Tokunaga, Y, Sawamoto, T, Takahashi, T, Kimura, S, Shimojo, F, Hata, T
Published in Journal of drug targeting (1996)
Published in Journal of drug targeting (1996)
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Journal Article
Investigation of the electrochemical oxidation products of zotepine and their fragmentation using on-line electrochemistry/electrospray ionization mass spectrometry
Nozaki, Kazuyoshi, Kitagawa, Hiroshi, Kimura, Sumihisa, Kagayama, Akira, Arakawa, Ryuichi
Published in Journal of mass spectrometry. (01.05.2006)
Published in Journal of mass spectrometry. (01.05.2006)
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Journal Article
Bone-specific delivery and sustained release of diclofenac, a non-steroidal anti-inflammatory drug, via bisphosphonic prodrug based on the Osteotropic Drug Delivery System (ODDS)
Hirabayashi, Hideki, Takahashi, Toshiya, Fujisaki, Jiro, Masunaga, Taro, Sato, Sachio, Hiroi, Jun, Tokunaga, Yuji, Kimura, Sumihisa, Hata, Takehisa
Published in Journal of controlled release (29.01.2001)
Published in Journal of controlled release (29.01.2001)
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Journal Article
Relationship between physicochemical and Osteotropic properties of bisphosphonic derivatives : Rational design for Osteotropic Drug Delivery System (ODDS)
HIRABAYASHI, Hideki, SAWAMOTO, Taiji, FUJISAKI, Jiro, TOKUNAGA, Yuji, KIMURA, Sumihisa, HATA, Takehisa
Published in Pharmaceutical research (01.05.2001)
Published in Pharmaceutical research (01.05.2001)
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Journal Article
Dose-dependent pharmacokinetics and disposition of bisphosphonic prodrug of diclofenac based on osteotropic drug delivery system (ODDS)
Hirabayashi, Hideki, Sawamoto, Taiji, Fujisaki, Jiro, Tokunaga, Yuji, Kimura, Sumihisa, Hata, Takehisa
Published in Biopharmaceutics & drug disposition (01.11.2002)
Published in Biopharmaceutics & drug disposition (01.11.2002)
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Journal Article
PERCUTANEOUSLY ABSORBABLE PREPARATION
ASAKURA, SOTOO, KIMURA, SUMIHISA, HATA, TAKEHISA, KADO, KAZUTAKE, OHISHI, YOSHIKO
Year of Publication 16.02.1995
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Year of Publication 16.02.1995
Patent
PROLONGED-ACTION PHARMACEUTICAL PREPARATION
KAGAYAMA, AKIRA, KIMURA, SUMIHISA, MURATA, SABURO, HATA, TAKEHISA, TANIMOTO, SACHIYO
Year of Publication 26.05.1994
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Year of Publication 26.05.1994
Patent
LONG-ACTING PHARMACEUTICAL PREPARATION
KAGAYAMA, AKIRA, KIMURA, SUMIHISA, MURATA, SABURO, HATA, TAKEHISA, UEDA, SATOSHI
Year of Publication 01.10.1992
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Year of Publication 01.10.1992
Patent
Osteotropic drug delivery system (ODDS) based on bisphosphonic prodrug. I.v. effects of osteotropic estradiol on bone mineral density and uterine weight in ovariectomized rats
Fujisaki, J, Tokunaga, Y, Takahashi, T, Shimojo, F, Kimura, S, Hata, T
Published in Journal of drug targeting (1998)
Published in Journal of drug targeting (1998)
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Journal Article
MEDICINAL COMPOSITION
IBUKI, RINTA, OHNISHI, NORIO, SHIMOJO, FUMIO, KIMURA, SUMIHISA, UEDA, SATOSHI, HIROSE, TAKEO
Year of Publication 22.10.1998
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Year of Publication 22.10.1998
Patent
MEDICINAL COMPOSITION
SHIMOJO, FUMIO, KIMURA, SUMIHISA, HATA, TAKEHISA, TOKUNAGA, YUJI, UEDA, SATOSHI, HIROSE, TAKEO
Year of Publication 11.06.1998
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Year of Publication 11.06.1998
Patent
ANALGESIC, ANTICONJUNCTIVITIC OR CHRONIC RHEUMATISM REMEDY CONTAINING QUINOLIZINONE COMPOUND OR SALT THEREOF, AND PREPARATION FOR TOPICAL APPLICATION THEREOF
KAGAYAMA, AKIRA, KIMURA, SUMIHISA, HIROI, JUN, HATA, TAKEHISA, UEDA, SATOSHI, SHIMOMURA, KYOICHI, SAWAI, SEIJI
Year of Publication 14.04.1994
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Year of Publication 14.04.1994
Patent