A Practical Approach for Enantio- and Diastereocontrol in the Synthesis of 2,3-Disubstituted Succinic Acid Esters: Synthesis of the pan-Notch Inhibitor BMS-906024
Quesnelle, Claude A., Gill, Patrice, Kim, Soong-Hoon, Chen, Libing, Zhao, Yufen, Fink, Brian E., Saulnier, Mark, Frennesson, David, DeMartino, Michael P., Baran, Phil S., Gavai, Ashvinikumar V.
Published in Synlett (19.09.2016)
Published in Synlett (19.09.2016)
Get more information
Journal Article
Structure-based design of potent and selective inhibitors of collagenase-3 (MMP-13)
Kim, Soong-Hoon, Pudzianowski, Andrew T., Leavitt, Kenneth J., Barbosa, Joseph, McDonnell, Patricia A., Metzler, William J., Rankin, Bruce M., Liu, Richard, Vaccaro, Wayne, Pitts, William
Published in Bioorganic & medicinal chemistry letters (15.02.2005)
Published in Bioorganic & medicinal chemistry letters (15.02.2005)
Get full text
Journal Article
Hyperdynamic microtubules, cognitive deficits, and pathology are improved in tau transgenic mice with low doses of the microtubule-stabilizing agent BMS-241027
Barten, Donna M, Fanara, Patrizia, Andorfer, Cathy, Hoque, Nina, Wong, P Y Anne, Husted, Kristofor H, Cadelina, Gregory W, Decarr, Lynn B, Yang, Ling, Liu, Victoria, Fessler, Chancy, Protassio, Joan, Riff, Timothy, Turner, Holly, Janus, Christopher G, Sankaranarayanan, Sethu, Polson, Craig, Meredith, Jere E, Gray, Gemma, Hanna, Amanda, Olson, Richard E, Kim, Soong-Hoon, Vite, Gregory D, Lee, Francis Y, Albright, Charles F
Published in The Journal of neuroscience (23.05.2012)
Published in The Journal of neuroscience (23.05.2012)
Get full text
Journal Article
Catalytic Ring Closing Metathesis of Dienynes: Construction of Fused Bicyclic Rings
Kim, Soong-Hoon, Bowden, Ned, Grubbs, Robert H
Published in Journal of the American Chemical Society (01.11.1994)
Published in Journal of the American Chemical Society (01.11.1994)
Get full text
Journal Article
New dual inhibitors of EGFR and HER2 protein tyrosine kinases
Fink, Brian E., Vite, Gregory D., Mastalerz, Harold, Kadow, John F., Kim, Soong-Hoon, Leavitt, Kenneth J., Du, Karen, Crews, Donald, Mitt, Toomas, Wong, Tai W., Hunt, John T., Vyas, Dolatrai M., Tokarski, John S.
Published in Bioorganic & medicinal chemistry letters (01.11.2005)
Published in Bioorganic & medicinal chemistry letters (01.11.2005)
Get full text
Journal Article
Discovery of a Hydroxypyridinone APJ Receptor Agonist as a Clinical Candidate
Johnson, James A, Kim, Soong-Hoon, Jiang, Ji, Phillips, Monique, Schumacher, William A, Bostwick, Jeffrey S, Gargalovic, Peter S, Onorato, Joelle M, Luk, Chiuwa E, Generaux, Claudia, He, Yan, Chen, Xue-Qing, Xu, Carrie, Galella, Michael A, Wang, Tao, Gordon, David A, Wexler, Ruth R, Finlay, Heather J
Published in Journal of medicinal chemistry (25.03.2021)
Published in Journal of medicinal chemistry (25.03.2021)
Get full text
Journal Article
Catalytic Ring Closing Metathesis of Dienynes: Construction of Fused Bicyclic [ n . m.0] Rings
Kim, Soong-Hoon, Zuercher, William J, Bowden, Ned B, Grubbs, Robert H
Published in Journal of organic chemistry (09.02.1996)
Published in Journal of organic chemistry (09.02.1996)
Get full text
Journal Article
Synthesis, Structure Proof, and Biological Activity of Epothilone Cyclopropanes
Johnson, James, Kim, Soong-Hoon, Bifano, Marc, DiMarco, John, Fairchild, Craig, Gougoutas, Jack, Lee, Francis, Long, Byron, Tokarski, John, Vite, Gregory
Published in Organic letters (01.06.2000)
Published in Organic letters (01.06.2000)
Get full text
Journal Article
Identification of Reversible Small Molecule Inhibitors of Endothelial Lipase (EL) That Demonstrate HDL‑C Increase In Vivo
Tora, George, Kim, Soong-Hoon, Pi, Zulan, Johnson, James A, Jiang, Ji, Phillips, Monique, Lloyd, John, Abell, Lynn M, Lu, Hao, Locke, Gregory, Adam, Leonard P, Taylor, David S, Yin, Xiaohong, Behnia, Kamelia, Zhao, Lei, Yang, Richard, Basso, Michael, Caporuscio, Christian, Chen, Alice Ye, Liu, Eddie, Kirshgessner, Todd, Onorato, Joelle M, Ryan, Carol, Traeger, Sarah C, Gordon, David, Wexler, Ruth R, Finlay, Heather J
Published in Journal of medicinal chemistry (27.02.2020)
Published in Journal of medicinal chemistry (27.02.2020)
Get full text
Journal Article
Identification of substituted benzothiazole sulfones as potent and selective inhibitors of endothelial lipase
Kim, Soong-Hoon, Johnson, James A., Jiang, Ji, Parkhurst, Brandon, Phillips, Monique, Pi, Zulan, Qiao, Jennifer X., Tora, George, Ye Chen, Alice, Liu, Eddie, Yin, Xiaohong, Yang, Richard, Zhao, Lei, Taylor, David S., Basso, Michael, Behnia, Kamelia, Onorato, Joelle, Chen, Xue-Qing, Abell, Lynn M., Lu, Hao, Locke, Gregory, Caporuscio, Christian, Adam, Leonard P., Gordon, David, Wexler, Ruth R., Finlay, Heather J.
Published in Bioorganic & medicinal chemistry letters (01.08.2019)
Published in Bioorganic & medicinal chemistry letters (01.08.2019)
Get full text
Journal Article
Corrigendum to “Identification of substituted benzothiazole sulfones as potent and selective inhibitors of endothelial lipase” [Bioorg. Med. Chem. Lett. 29 (2019) 1918–1921]
Kim, Soong-Hoon, Johnson, James A., Jiang, Ji, Parkhurst, Brandon, Phillips, Monique, Pi, Zulan, Qiao, Jennifer X., Tora, George, Ye Chen, Alice, Liu, Eddie, Yin, Xiaohong, Yang, Richard, Zhao, Lei, Taylor, David S., Basso, Michael, Behnia, Kamelia, Onorato, Joelle, Chen, Xue-Qing, Abell, Lynn M., Lu, Hao, Locke, Gregory, Caporuscio, Christian, Adam, Leonard P., Gordon, David, Wexler, Ruth R., Finlay, Heather J.
Published in Bioorganic & medicinal chemistry letters (01.09.2019)
Published in Bioorganic & medicinal chemistry letters (01.09.2019)
Get full text
Journal Article
Novel pyrrolo[2,1- f][1,2,4]triazin-4-amines: Dual inhibitors of EGFR and HER2 protein tyrosine kinases
Fink, Brian E., Norris, Derek, Mastalerz, Harold, Chen, Ping, Goyal, Bindu, Zhao, Yufen, Kim, Soong-Hoon, Vite, Gregory D., Lee, Francis Y., Zhang, Hongjian, Oppenheimer, Simone, Tokarski, John S., Wong, Tai W., Gavai, Ashvinikumar V.
Published in Bioorganic & medicinal chemistry letters (15.01.2011)
Published in Bioorganic & medicinal chemistry letters (15.01.2011)
Get full text
Journal Article
Regioselective synthesis of folate receptor-targeted agents derived from epothilone analogs and folic acid
Vlahov, Iontcho R., Vite, Gregory D., Kleindl, Paul J., Wang, Yu, Santhapuram, Hari Krishna R., You, Fei, Howard, Stephen J., Kim, Soong-Hoon, Lee, Francis F.Y., Leamon, Christopher P.
Published in Bioorganic & medicinal chemistry letters (01.08.2010)
Published in Bioorganic & medicinal chemistry letters (01.08.2010)
Get full text
Journal Article
Discovery and Preclinical Evaluation of [4-[[1-(3-fluorophenyl)methyl]-1H-indazol-5-ylamino]-5-methylpyrrolo[2,1-f][1,2,4]triazin-6-yl]carbamic Acid, (3S)-3-Morpholinylmethyl Ester (BMS-599626), a Selective and Orally Efficacious Inhibitor of Human Epidermal Growth Factor Receptor 1 and 2 Kinases
Gavai, Ashvinikumar V, Fink, Brian E, Fairfax, David J, Martin, Gregory S, Rossiter, Lana M, Holst, Christian L, Kim, Soong-Hoon, Leavitt, Kenneth J, Mastalerz, Harold, Han, Wen-Ching, Norris, Derek, Goyal, Bindu, Swaminathan, Shankar, Patel, Bharat, Mathur, Arvind, Vyas, Dolatrai M, Tokarski, John S, Yu, Chiang, Oppenheimer, Simone, Zhang, Hongjian, Marathe, Punit, Fargnoli, Joseph, Lee, Francis Y, Wong, Tai W, Vite, Gregory D
Published in Journal of medicinal chemistry (12.11.2009)
Published in Journal of medicinal chemistry (12.11.2009)
Get full text
Journal Article
Discovery of low nanomolar non-hydroxamate inhibitors of tumor necrosis factor-α converting enzyme (TACE)
Duan, James J.-W., Chen, Lihua, Lu, Zhonghui, Jiang, Bin, Asakawa, Naoyuki, Sheppeck, James E., Liu, Rui-Qin, Covington, Maryanne B., Pitts, William, Kim, Soong-Hoon, Decicco, Carl P.
Published in Bioorganic & medicinal chemistry letters (2007)
Published in Bioorganic & medicinal chemistry letters (2007)
Get full text
Journal Article
Design, synthesis, functional and structural characterization of an inhibitor of N-acetylneuraminate-9-phosphate phosphatase: Observation of extensive dynamics in an enzyme/inhibitor complex
Kim, Soong-Hoon, Constantine, Keith L., Duke, Gerald J., Goldfarb, Valentina, Hunt, John T., Johnson, Stephen, Kish, Kevin, Klei, Herbert E., McDonnell, Patricia A., Metzler, William J., Mueller, Luciano, Poss, Michael A., Fairchild, Craig R., Bhide, Rajeev S.
Published in Bioorganic & medicinal chemistry letters (15.07.2013)
Published in Bioorganic & medicinal chemistry letters (15.07.2013)
Get full text
Journal Article
Identification of 2-amino-5-(thioaryl)thiazoles as inhibitors of nerve growth factor receptor TrkA
Kim, Soong-Hoon, Tokarski, John S., Leavitt, Kenneth J., Fink, Brian E., Salvati, Mark E., Moquin, Robert, Obermeier, Mary T., Trainor, George L., Vite, Gregory G., Stadnick, Linda K., Lippy, Jonathan S., You, Dan, Lorenzi, Matthew V., Chen, Ping
Published in Bioorganic & medicinal chemistry (15.01.2008)
Published in Bioorganic & medicinal chemistry (15.01.2008)
Get full text
Journal Article
Discovery of (R)-7-Cyano-2,3,4,5-tetrahydro-1-(1H-imidazol-4-ylmethyl)-3- (phenylmethyl)-4-(2-thienylsulfonyl)-1H-1,4-benzodiazepine (BMS-214662), a Farnesyltransferase Inhibitor with Potent Preclinical Antitumor Activity
Hunt, John T, Ding, Charles Z, Batorsky, Roberta, Bednarz, Mark, Bhide, Rajeev, Cho, Young, Chong, Saeho, Chao, Sam, Gullo-Brown, Johnni, Guo, Peng, Kim, Soong Hoon, Lee, Francis Y. F, Leftheris, Katerina, Miller, Arthur, Mitt, Toomas, Patel, Manorama, Penhallow, Becky A, Ricca, Carol, Rose, William C, Schmidt, Robert, Slusarchyk, William A, Vite, Gregory, Manne, Veeraswamy
Published in Journal of medicinal chemistry (05.10.2000)
Published in Journal of medicinal chemistry (05.10.2000)
Get full text
Journal Article
Synthesis, Chromatographic Purification, and Isolation of Epothilone–Folic Acid Conjugate BMS-753493
Kim, Soong-Hoon, de Mas, Nuria, Parlanti, Luca, Lyngberg, Olav K, Ströhlein, Guido, Guo, Zhenrong, Dambalas, Konstantinos, Rosso, Victor W, Yang, Bing-Shiou, Girard, Kevin P, Manaloto, Zerene A, D’Arasmo, Germano, Frigerio, Riccardo E, Wang, Wei, Lu, Xujin, Bolgar, Mark S, Gokhale, Madhushree, Thakur, Ajit B
Published in Organic process research & development (15.07.2011)
Published in Organic process research & development (15.07.2011)
Get full text
Journal Article