Targeted inhibition of the COP9 signalosome for treatment of cancer
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Published in Nature communications (24.10.2016)
Published in Nature communications (24.10.2016)
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Discovery of Novel Dot1L Inhibitors through a Structure-Based Fragmentation Approach
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Published in ACS medicinal chemistry letters (11.08.2016)
Published in ACS medicinal chemistry letters (11.08.2016)
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Discovery of Roblitinib (FGF401) as a Reversible-Covalent Inhibitor of the Kinase Activity of Fibroblast Growth Factor Receptor 4
Fairhurst, Robin A, Knoepfel, Thomas, Buschmann, Nicole, Leblanc, Catherine, Mah, Robert, Todorov, Milen, Nimsgern, Pierre, Ripoche, Sebastien, Niklaus, Michel, Warin, Nicolas, Luu, Van Huy, Madoerin, Mario, Wirth, Jasmin, Graus-Porta, Diana, Weiss, Andreas, Kiffe, Michael, Wartmann, Markus, Kinyamu-Akunda, Jacqueline, Sterker, Dario, Stamm, Christelle, Adler, Flavia, Buhles, Alexandra, Schadt, Heiko, Couttet, Philippe, Blank, Jutta, Galuba, Inga, Trappe, Jörg, Voshol, Johannes, Ostermann, Nils, Zou, Chao, Berghausen, Jörg, Del Rio Espinola, Alberto, Jahnke, Wolfgang, Furet, Pascal
Published in Journal of medicinal chemistry (12.11.2020)
Published in Journal of medicinal chemistry (12.11.2020)
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FGF401, A First-In-Class Highly Selective and Potent FGFR4 Inhibitor for the Treatment of FGF19-Driven Hepatocellular Cancer
Weiss, Andreas, Adler, Flavia, Buhles, Alexandra, Stamm, Christelle, Fairhurst, Robin A, Kiffe, Michael, Sterker, Dario, Centeleghe, Mario, Wartmann, Markus, Kinyamu-Akunda, Jacqueline, Schadt, Heiko S, Couttet, Philippe, Wolf, Armin, Wang, Youzhen, Barzaghi-Rinaudo, Patrizia, Murakami, Masato, Kauffmann, Audrey, Knoepfel, Thomas, Buschmann, Nicole, Leblanc, Catherine, Mah, Robert, Furet, Pascal, Blank, Jutta, Hofmann, Francesco, Sellers, William R, Graus Porta, Diana
Published in Molecular cancer therapeutics (01.12.2019)
Published in Molecular cancer therapeutics (01.12.2019)
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Structure-Guided Elaboration of a Fragment-Like Hit into an Orally Efficacious Leukotriene A4 Hydrolase Inhibitor
Thoma, Gebhard, Miltz, Wolfgang, Srinivas, Honnappa, Penno, Carlos A., Kiffe, Michael, Gajewska, Monika, Klein, Kai, Evans, Amanda, Beerli, Christian, Röhn, Till A.
Published in Journal of medicinal chemistry (28.03.2024)
Published in Journal of medicinal chemistry (28.03.2024)
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Discovery of Amino Alcohols as Highly Potent, Selective, and Orally Efficacious Inhibitors of Leukotriene A4 Hydrolase
Thoma, Gebhard, Markert, Christian, Lueoend, Rainer, Miltz, Wolfgang, Spanka, Carsten, Bollbuck, Birgit, Wolf, Romain M., Srinivas, Honnappa, Penno, Carlos A., Kiffe, Michael, Gajewska, Monika, Bednarczyk, Dallas, Wieczorek, Grazyna, Evans, Amanda, Beerli, Christian, Röhn, Till A.
Published in Journal of medicinal chemistry (14.12.2023)
Published in Journal of medicinal chemistry (14.12.2023)
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Discovery of the Clinical Candidate MAK683: An EED-Directed, Allosteric, and Selective PRC2 Inhibitor for the Treatment of Advanced Malignancies
Huang, Ying, Sendzik, Martin, Zhang, Jeff, Gao, Zhenting, Sun, Yongfeng, Wang, Long, Gu, Justin, Zhao, Kehao, Yu, Zhengtian, Zhang, Lijun, Zhang, Qiong, Blanz, Joachim, Chen, Zijun, Dubost, Valérie, Fang, Douglas, Feng, Lijian, Fu, Xingnian, Kiffe, Michael, Li, Ling, Luo, Fangjun, Luo, Xiao, Mi, Yuan, Mistry, Prakash, Pearson, David, Piaia, Alessandro, Scheufler, Clemens, Terranova, Remi, Weiss, Andreas, Zeng, Jue, Zhang, Hailong, Zhang, Jiangwei, Zhao, Mengxi, Dillon, Michael P, Jeay, Sebastien, Qi, Wei, Moggs, Jonathan, Pissot-Soldermann, Carole, Li, En, Atadja, Peter, Lingel, Andreas, Oyang, Counde
Published in Journal of medicinal chemistry (14.04.2022)
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Identification of NVP-CLR457 as an Orally Bioavailable Non-CNS-Penetrant pan-Class IA Phosphoinositol-3-Kinase Inhibitor
Fairhurst, Robin A., Furet, Pascal, Imbach-Weese, Patricia, Stauffer, Frédéric, Rueeger, Heinrich, McCarthy, Clive, Ripoche, Sebastien, Oswald, Susanne, Arnaud, Bertrand, Jary, Aline, Maira, Michel, Schnell, Christian, Guthy, Daniel A., Wartmann, Markus, Kiffe, Michael, Desrayaud, Sandrine, Blasco, Francesca, Widmer, Toni, Seiler, Frank, Gutmann, Sascha, Knapp, Mark, Caravatti, Giorgio
Published in Journal of medicinal chemistry (23.06.2022)
Published in Journal of medicinal chemistry (23.06.2022)
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Efficacy and safety of MAS825 (anti-IL-1β/IL-18) in COVID-19 patients with pneumonia and impaired respiratory function
Hakim, Alex D, Awili, Mustafa, O’Neal, Hollis R, Siddiqi, Omar, Jaffrani, Naseem, Lee, Richard, Overcash, Jeffrey S, Chauffe, Ann, Hammond, Terese C, Patel, Bela, Waters, Michael, Criner, Gerard J, Pachori, Alok, Junge, Guido, Levitch, Rafael, Watts, Jen, Koo, Philip, Sengupta, Tirtha, Yu, Lili, Kiffe, Michael, Pinck, Anne, Stein, Richard R, Bendrick-Peart, Jamie, Jenkins, Janet, Rowlands, Marianna, Waldron-Lynch, Frank, Matthews, Jesse
Published in Clinical and experimental immunology (13.10.2023)
Published in Clinical and experimental immunology (13.10.2023)
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Preclinical pharmacokinetics and metabolism of MAK683, a clinical stage selective oral embryonic ectoderm development (EED) inhibitor for cancer treatment
Zhang, Ji Yue (Jeff), Zhang, Jiangwei, Kiffe, Michael, Walles, Markus, Jin, Yi, Blanz, Joachim, Dayer, Jerôme, Sanchez, Arevalo, Zhang, Chunye, Zhang, Lijun, Huang, Ying, Oyang, Counde
Published in Xenobiotica (02.01.2022)
Published in Xenobiotica (02.01.2022)
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Abstract 1770: A new DOT1L inhibitor with in vivo activity in mouse models of MLL-translocated leukemia
Weiss, Andreas, Stauffer, Frederic, Clemens, Clemens, Möbitz, Henrik, Ragot, Christian, Beyer, Kim S., Calkins, Keith, Thoma, Claudio, Guthy, Daniel, Kiffe, Michael, Van Eerdenbrugh, Bernard, Sellers, William R., Hofmann, Francesco, Tiedt, Ralph, Gaul, Christoph
Published in Cancer research (Chicago, Ill.) (15.08.2020)
Published in Cancer research (Chicago, Ill.) (15.08.2020)
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Discovery of MAP855, an Efficacious and Selective MEK1/2 Inhibitor with an ATP-Competitive Mode of Action
Poddutoori, Ramulu, Aardalen, Kimberly, Aithal, Kiran, Barahagar, Sanjeev Surendranath, Belliappa, Charamanna, Bock, Mark, Chelur, Shekar, Gerken, Andrea, Gopinath, Sreevalsam, Gruenenfelder, Bjoern, Kiffe, Michael, Krishnaswami, Maithreyi, Langowski, John, Madapa, Sudharshan, Narayanan, Kishore, Pandit, Chetan, Panigrahi, Sunil Kumar, Perrone, Mark, Potakamuri, Ravi Kumar, Ramachandra, Murali, Ramanathan, Anuradha, Ramos, Rita, Sager, Emine, Samajdar, Susanta, Subramanya, Hosahalli S, Thimmasandra, Devaraja Seethappa, Venetsanakos, Eleni, Möbitz, Henrik
Published in Journal of medicinal chemistry (10.03.2022)
Published in Journal of medicinal chemistry (10.03.2022)
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NLRC4-GOF 염증복합체병증의 치료에 사용하기 위한 이중특이적 항체
JUNGE GUIDO, STEIN RICHARD, WALDRON LYNCH FRANK, KIFFE MICHAEL, KOVARIK JIRI
Year of Publication 21.07.2023
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Year of Publication 21.07.2023
Patent
New Potent DOT1L Inhibitors for in Vivo Evaluation in Mouse
Stauffer, Frédéric, Weiss, Andreas, Scheufler, Clemens, Möbitz, Henrik, Ragot, Christian, Beyer, Kim S, Calkins, Keith, Guthy, Daniel, Kiffe, Michael, Van Eerdenbrugh, Bernard, Tiedt, Ralph, Gaul, Christoph
Published in ACS medicinal chemistry letters (12.12.2019)
Published in ACS medicinal chemistry letters (12.12.2019)
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Pharmacological Characterization of a Novel 5-Hydroxybenzothiazolone-Derived β 2 -Adrenoceptor Agonist with Functional Selectivity for Anabolic Effects on Skeletal Muscle Resulting in a Wider Cardiovascular Safety Window in Preclinical Studies
Koziczak-Holbro, Magdalena, Rigel, Dean F, Dumotier, Bérengère, Sykes, David A, Tsao, Jeffrey, Nguyen, Ngoc-Hong, Bösch, Julian, Jourdain, Marie, Flotte, Ludivine, Adachi, Yuichiro, Kiffe, Michael, Azria, Moïse, Fairhurst, Robin A, Charlton, Steven J, Richardson, Brian P, Lach-Trifilieff, Estelle, Glass, David J, Ullrich, Thomas, Hatakeyama, Shinji
Published in The Journal of pharmacology and experimental therapeutics (01.05.2019)
Published in The Journal of pharmacology and experimental therapeutics (01.05.2019)
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Comparison of a two-dimensional liquid chromatography/mass spectrometry approach with a chip-based nanoelectrospray device for structural elucidation of metabolites in a human ADME study using a quadrupole time-of-flight mass spectrometer
Trunzer, Markus, Graf, Daniel, Kiffe, Michael
Published in Rapid communications in mass spectrometry (01.01.2007)
Published in Rapid communications in mass spectrometry (01.01.2007)
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Cytostar-T plates—A valid alternative for microplate scintillation counting of low radioactivity in combination with high-performance liquid chromatography in drug metabolism studies?
Kiffe, Michael, Nufer, Robert, Trunzer, Markus, Graf, Daniel
Published in Journal of Chromatography A (20.07.2007)
Published in Journal of Chromatography A (20.07.2007)
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Journal Article
Combination of High-Performance Liquid Chromatography and Microplate Scintillation Counting for Crop and Animal Metabolism Studies: A Comparison with Classical On-Line and Thin-Layer Chromatography Radioactivity Detection
Kiffe, Michael, Jehle, Andrea, Ruembeli, Robert
Published in Analytical chemistry (Washington) (15.02.2003)
Published in Analytical chemistry (Washington) (15.02.2003)
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