Uncovering the functional anatomy of the human insula during speech
Woolnough, Oscar, Forseth, Kiefer James, Rollo, Patrick Sarahan, Tandon, Nitin
Published in eLife (19.12.2019)
Published in eLife (19.12.2019)
Get full text
Journal Article
An inhibitor of KDM5 demethylases reduces survival of drug-tolerant cancer cells
Vinogradova, Maia, Gehling, Victor S, Gustafson, Amy, Arora, Shilpi, Tindell, Charles A, Wilson, Catherine, Williamson, Kaylyn E, Guler, Gulfem D, Gangurde, Pranoti, Manieri, Wanda, Busby, Jennifer, Flynn, E Megan, Lan, Fei, Kim, Hyo-jin, Odate, Shobu, Cochran, Andrea G, Liu, Yichin, Wongchenko, Matthew, Yang, Yibin, Cheung, Tommy K, Maile, Tobias M, Lau, Ted, Costa, Michael, Hegde, Ganapati V, Jackson, Erica, Pitti, Robert, Arnott, David, Bailey, Christopher, Bellon, Steve, Cummings, Richard T, Albrecht, Brian K, Harmange, Jean-Christophe, Kiefer, James R, Trojer, Patrick, Classon, Marie
Published in Nature chemical biology (01.07.2016)
Published in Nature chemical biology (01.07.2016)
Get full text
Journal Article
Structural basis for dual-mode inhibition of the ABC transporter MsbA
Ho, Hoangdung, Miu, Anh, Alexander, Mary Kate, Garcia, Natalie K., Oh, Angela, Zilberleyb, Inna, Reichelt, Mike, Austin, Cary D., Tam, Christine, Shriver, Stephanie, Hu, Huiyong, Labadie, Sharada S., Liang, Jun, Wang, Lan, Wang, Jian, Lu, Yan, Purkey, Hans E., Quinn, John, Franke, Yvonne, Clark, Kevin, Beresini, Maureen H., Tan, Man-Wah, Sellers, Benjamin D., Maurer, Till, Koehler, Michael F. T., Wecksler, Aaron T., Kiefer, James R., Verma, Vishal, Xu, Yiming, Nishiyama, Mireille, Payandeh, Jian, Koth, Christopher M.
Published in Nature (London) (01.05.2018)
Published in Nature (London) (01.05.2018)
Get full text
Journal Article
Molecular Basis for Cyclooxygenase Inhibition by the Non-steroidal Anti-inflammatory Drug Naproxen
Duggan, Kelsey C., Walters, Matthew J., Musee, Joel, Harp, Joel M., Kiefer, James R., Oates, John A., Marnett, Lawrence J.
Published in The Journal of biological chemistry (05.11.2010)
Published in The Journal of biological chemistry (05.11.2010)
Get full text
Journal Article
GDC-9545 (Giredestrant): A Potent and Orally Bioavailable Selective Estrogen Receptor Antagonist and Degrader with an Exceptional Preclinical Profile for ER+ Breast Cancer
Liang, Jun, Zbieg, Jason R., Blake, Robert A., Chang, Jae H., Daly, Stephen, DiPasquale, Antonio G., Friedman, Lori S., Gelzleichter, Thomas, Gill, Matthew, Giltnane, Jennifer M., Goodacre, Simon, Guan, Jane, Hartman, Steven J., Ingalla, Ellen Rei, Kategaya, Lorn, Kiefer, James R., Kleinheinz, Tracy, Labadie, Sharada S., Lai, Tommy, Li, Jun, Liao, Jiangpeng, Liu, Zhiguo, Mody, Vidhi, McLean, Neville, Metcalfe, Ciara, Nannini, Michelle A., Oeh, Jason, O’Rourke, Martin G., Ortwine, Daniel F., Ran, Yingqing, Ray, Nicholas C., Roussel, Fabien, Sambrone, Amy, Sampath, Deepak, Schutt, Leah K., Vinogradova, Maia, Wai, John, Wang, Tao, Wertz, Ingrid E., White, Jonathan R., Yeap, Siew Kuen, Young, Amy, Zhang, Birong, Zheng, Xiaoping, Zhou, Wei, Zhong, Yu, Wang, Xiaojing
Published in Journal of medicinal chemistry (26.08.2021)
Published in Journal of medicinal chemistry (26.08.2021)
Get full text
Journal Article
The novel benzopyran class of selective cyclooxygenase-2 inhibitors. Part 2: The second clinical candidate having a shorter and favorable human half-life
Wang, Jane L., Limburg, David, Graneto, Matthew J., Springer, John, Hamper, Joseph Rogier Bruce, Liao, Subo, Pawlitz, Jennifer L., Kurumbail, Ravi G., Maziasz, Timothy, Talley, John J., Kiefer, James R., Carter, Jeffery
Published in Bioorganic & medicinal chemistry letters (01.12.2010)
Published in Bioorganic & medicinal chemistry letters (01.12.2010)
Get full text
Journal Article
Discovery of GDC-0077 (Inavolisib), a Highly Selective Inhibitor and Degrader of Mutant PI3Kα
Hanan, Emily J., Braun, Marie-Gabrielle, Heald, Robert A., MacLeod, Calum, Chan, Connie, Clausen, Saundra, Edgar, Kyle A., Eigenbrot, Charles, Elliott, Richard, Endres, Nicholas, Friedman, Lori S., Gogol, Emily, Gu, Xiao-Hui, Thibodeau, Rebecca Hong, Jackson, Philip S., Kiefer, James R., Knight, Jamie D., Nannini, Michelle, Narukulla, Raman, Pace, Amanda, Pang, Jodie, Purkey, Hans E., Salphati, Laurent, Sampath, Deepak, Schmidt, Stephen, Sideris, Steve, Song, Kyung, Sujatha-Bhaskar, Swathi, Ultsch, Mark, Wallweber, Heidi, Xin, Jianfeng, Yeap, SiewKuen, Young, Amy, Zhong, Yu, Staben, Steven T.
Published in Journal of medicinal chemistry (22.12.2022)
Published in Journal of medicinal chemistry (22.12.2022)
Get full text
Journal Article
Discovery of a Potent and Selective in Vivo Probe (GNE-272) for the Bromodomains of CBP/EP300
Crawford, Terry D, Romero, F. Anthony, Lai, Kwong Wah, Tsui, Vickie, Taylor, Alexander M, de Leon Boenig, Gladys, Noland, Cameron L, Murray, Jeremy, Ly, Justin, Choo, Edna F, Hunsaker, Thomas L, Chan, Emily W, Merchant, Mark, Kharbanda, Samir, Gascoigne, Karen E, Kaufman, Susan, Beresini, Maureen H, Liao, Jiangpeng, Liu, Wenfeng, Chen, Kevin X, Chen, Zhongguo, Conery, Andrew R, Côté, Alexandre, Jayaram, Hariharan, Jiang, Ying, Kiefer, James R, Kleinheinz, Tracy, Li, Yingjie, Maher, Jonathan, Pardo, Eneida, Poy, Florence, Spillane, Kerry L, Wang, Fei, Wang, Jian, Wei, Xiaocang, Xu, Zhaowu, Xu, Zhongya, Yen, Ivana, Zawadzke, Laura, Zhu, Xiaoyu, Bellon, Steven, Cummings, Richard, Cochran, Andrea G, Albrecht, Brian K, Magnuson, Steven
Published in Journal of medicinal chemistry (08.12.2016)
Published in Journal of medicinal chemistry (08.12.2016)
Get full text
Journal Article
Trastuzumab does not bind rat or mouse ErbB2/neu: implications for selection of non-clinical safety models for trastuzumab-based therapeutics
Lewis Phillips, Gail, Guo, Jun, Kiefer, James R., Proctor, William, Bumbaca Yadav, Daniela, Dybdal, Noel, Shen, Ben-Quan
Published in Breast cancer research and treatment (01.01.2022)
Published in Breast cancer research and treatment (01.01.2022)
Get full text
Journal Article
Fluorescent indomethacin-dansyl conjugates utilize the membrane-binding domain of cyclooxygenase-2 to block the opening to the active site
Xu, Shu, Uddin, Md. Jashim, Banerjee, Surajit, Duggan, Kelsey, Musee, Joel, Kiefer, James R., Ghebreselasie, Kebreab, Rouzer, Carol A., Marnett, Lawrence J.
Published in The Journal of biological chemistry (31.05.2019)
Published in The Journal of biological chemistry (31.05.2019)
Get full text
Journal Article
Development of an 18F-labeled anti-human CD8 VHH for same-day immunoPET imaging
Sriraman, Shravan Kumar, Davies, Christopher W., Gill, Herman, Kiefer, James R., Yin, Jianping, Ogasawara, Annie, Urrutia, Alejandra, Javinal, Vincent, Lin, Zhonghua, Seshasayee, Dhaya, Abraham, Ryan, Haas, Phil, Koth, Christopher, Marik, Jan, Koerber, James T., Williams, Simon Peter
Published in European journal of nuclear medicine and molecular imaging (01.02.2023)
Published in European journal of nuclear medicine and molecular imaging (01.02.2023)
Get full text
Journal Article
Discovery of Potent, Selective, and Orally Available IRE1α Inhibitors Demonstrating Comparable PD Modulation to IRE1 Knockdown in a Multiple Myeloma Model
Braun, Marie-Gabrielle, Ashkenazi, Avi, Beveridge, Ramsay E., Castanedo, Georgette, Wallweber, Heidi Ackerly, Beresini, Maureen H., Clark, Kevin R., De Bruyn, Tom, Fu, Liqiang, Gibbons, Paul, Jiang, Fan, Kaufman, Susan, Kan, David, Kiefer, James R., Leclerc, Jean-Philippe, Lemire, Alexandre, Ly, Cuong, Segal, Ehud, Sims, Jessica, Wang, Weiru, Wei, Wentao, Zhao, Liang, Schwarz, Jacob B., Rudolph, Joachim
Published in Journal of medicinal chemistry (13.06.2024)
Published in Journal of medicinal chemistry (13.06.2024)
Get full text
Journal Article
A BCMA/CD16A bispecific innate cell engager for the treatment of multiple myeloma
Kakiuchi-Kiyota, Satoko, Ross, Thorsten, Wallweber, Heidi Ackerly, Kiefer, James R., Schutten, Melissa M., Adedeji, Adeyemi O., Cai, Hao, Hendricks, Robert, Cohen, Sivan, Myneni, Srividya, Liu, Luna, Fullerton, Aaron, Corr, Nicholas, Yu, Lanlan, de Almeida Nagata, Denise, Zhong, Shelly, Leong, Steven R., Li, Ji, Nakamura, Rin, Sumiyoshi, Teiko, Li, Jinze, Ovacik, Ayse Meric, Zheng, Bing, Dillon, Mike, Spiess, Christoph, Wingert, Susanne, Rajkovic, Erich, Ellwanger, Kristina, Reusch, Uwe, Polson, Andrew G.
Published in Leukemia (01.04.2022)
Published in Leukemia (01.04.2022)
Get full text
Journal Article
Water molecules in protein–ligand interfaces. Evaluation of software tools and SAR comparison
Nittinger, Eva, Gibbons, Paul, Eigenbrot, Charles, Davies, Doug R., Maurer, Brigitte, Yu, Christine L., Kiefer, James R., Kuglstatter, Andreas, Murray, Jeremy, Ortwine, Daniel F., Tang, Yong, Tsui, Vickie
Published in Journal of computer-aided molecular design (01.03.2019)
Published in Journal of computer-aided molecular design (01.03.2019)
Get full text
Journal Article
Diving into the Water: Inducible Binding Conformations for BRD4, TAF1(2), BRD9, and CECR2 Bromodomains
Crawford, Terry D, Tsui, Vickie, Flynn, E. Megan, Wang, Shumei, Taylor, Alexander M, Côté, Alexandre, Audia, James E, Beresini, Maureen H, Burdick, Daniel J, Cummings, Richard, Dakin, Les A, Duplessis, Martin, Good, Andrew C, Hewitt, Michael C, Huang, Hon-Ren, Jayaram, Hariharan, Kiefer, James R, Jiang, Ying, Murray, Jeremy, Nasveschuk, Christopher G, Pardo, Eneida, Poy, Florence, Romero, F. Anthony, Tang, Yong, Wang, Jian, Xu, Zhaowu, Zawadzke, Laura E, Zhu, Xiaoyu, Albrecht, Brian K, Magnuson, Steven R, Bellon, Steve, Cochran, Andrea G
Published in Journal of medicinal chemistry (09.06.2016)
Published in Journal of medicinal chemistry (09.06.2016)
Get full text
Journal Article
Structure of mammalian poly(ADP-ribose) glycohydrolase reveals a flexible tyrosine clasp as a substrate-binding element
Kim, In-Kwon, Kiefer, James R, Ho, Chris M W, Stegeman, Roderick A, Classen, Scott, Tainer, John A, Ellenberger, Tom
Published in Nature structural & molecular biology (01.06.2012)
Published in Nature structural & molecular biology (01.06.2012)
Get full text
Journal Article
Development of Potent and Selective Pyrazolopyrimidine IRAK4 Inhibitors
Bryan, Marian C, Drobnick, Joy, Gobbi, Alberto, Kolesnikov, Aleksandr, Chen, Yongsheng, Rajapaksa, Naomi, Ndubaku, Chudi, Feng, Jianwen, Chang, Willy, Francis, Ross, Yu, Christine, Choo, Edna F, DeMent, Kevin, Ran, Yingqing, An, Le, Emson, Claire, Huang, Zhiyu, Sujatha-Bhaskar, Swathi, Brightbill, Hans, DiPasquale, Antonio, Maher, Jonathan, Wai, John, McKenzie, Brent S, Lupardus, Patrick J, Zarrin, Ali A, Kiefer, James R
Published in Journal of medicinal chemistry (11.07.2019)
Published in Journal of medicinal chemistry (11.07.2019)
Get full text
Journal Article
From a novel HTS hit to potent, selective, and orally bioavailable KDM5 inhibitors
Liang, Jun, Labadie, Sharada, Zhang, Birong, Ortwine, Daniel F., Patel, Snahel, Vinogradova, Maia, Kiefer, James R., Mauer, Till, Gehling, Victor S., Harmange, Jean-Christophe, Cummings, Richard, Lai, Tommy, Liao, Jiangpeng, Zheng, Xiaoping, Liu, Yichin, Gustafson, Amy, Van der Porten, Erica, Mao, Weifeng, Liederer, Bianca M., Deshmukh, Gauri, An, Le, Ran, Yingqing, Classon, Marie, Trojer, Patrick, Dragovich, Peter S., Murray, Lesley
Published in Bioorganic & medicinal chemistry letters (01.07.2017)
Published in Bioorganic & medicinal chemistry letters (01.07.2017)
Get full text
Journal Article