Pharmacodynamic Response of the MET/HGF Receptor to Small-Molecule Tyrosine Kinase Inhibitors Examined with Validated, Fit-for-Clinic Immunoassays
Srivastava, Apurva K, Hollingshead, Melinda G, Weiner, Jennifer, Navas, Tony, Evrard, Yvonne A, Khin, Sonny A, Ji, Jiuping Jay, Zhang, Yiping, Borgel, Suzanne, Pfister, Thomas D, Kinders, Robert J, Bottaro, Donald P, Linehan, W Marston, Tomaszewski, Joseph E, Doroshow, James H, Parchment, Ralph E
Published in Clinical cancer research (15.07.2016)
Published in Clinical cancer research (15.07.2016)
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Topoisomerase I levels in the NCI-60 cancer cell line panel determined by validated ELISA and microarray analysis and correlation with indenoisoquinoline sensitivity
Pfister, Thomas D, Reinhold, William C, Agama, Keli, Gupta, Shalu, Khin, Sonny A, Kinders, Robert J, Parchment, Ralph E, Tomaszewski, Joseph E, Doroshow, James H, Pommier, Yves
Published in Molecular cancer therapeutics (01.07.2009)
Published in Molecular cancer therapeutics (01.07.2009)
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Intravenous 5-fluoro-2′-deoxycytidine administered with tetrahydrouridine increases the proportion of p16-expressing circulating tumor cells in patients with advanced solid tumors
Coyne, Geraldine O.’Sullivan, Wang, Lihua, Zlott, Jennifer, Juwara, Lamin, Covey, Joseph M., Beumer, Jan H., Cristea, Mihaela C., Newman, Edward M., Koehler, Stephen, Nieva, Jorge J., Garcia, Agustin A., Gandara, David R., Miller, Brandon, Khin, Sonny, Miller, Sarah B., Steinberg, Seth M., Rubinstein, Larry, Parchment, Ralph E., Kinders, Robert J., Piekarz, Richard L., Kummar, Shivaani, Chen, Alice P., Doroshow, James H.
Published in Cancer chemotherapy and pharmacology (01.05.2020)
Published in Cancer chemotherapy and pharmacology (01.05.2020)
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Development and validation of an immunoassay for quantification of topoisomerase I in solid tumor tissues
Pfister, Thomas D, Hollingshead, Melinda, Kinders, Robert J, Zhang, Yiping, Evrard, Yvonne A, Ji, Jiuping, Khin, Sonny A, Borgel, Suzanne, Stotler, Howard, Carter, John, Divelbiss, Raymond, Kummar, Shivaani, Pommier, Yves, Parchment, Ralph E, Tomaszewski, Joseph E, Doroshow, James H
Published in PloS one (28.12.2012)
Published in PloS one (28.12.2012)
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Preclinical Modeling of a Phase 0 Clinical Trial: Qualification of a Pharmacodynamic Assay of Poly (ADP-Ribose) Polymerase in Tumor Biopsies of Mouse Xenografts
KINDERS, Robert J, HOLLINGSHEAD, Melinda, KHIN, Sonny, RUBINSTEIN, Larry, TOMASZEWSKI, Joseph E, DOROSHOW, James H, PARCHMENT, Ralph E
Published in Clinical cancer research (01.11.2008)
Published in Clinical cancer research (01.11.2008)
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Biomarker-driven phase 2 study of MK-2206 and selumetinib (AZD6244, ARRY-142886) in patients with colorectal cancer
Do, Khanh, Speranza, Giovanna, Bishop, Rachel, Khin, Sonny, Rubinstein, Larry, Kinders, Robert J., Datiles, Manuel, Eugeni, Michelle, Lam, Michael H., Doyle, L. Austin, Doroshow, James H., Kummar, Shivaani
Published in Investigational new drugs (01.06.2015)
Published in Investigational new drugs (01.06.2015)
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Abstract B018: Restoration of p16INK4A expression in circulating tumor cells in patients with advanced solid tumors treated with deoxycytidine analogs and associated dynamic EMT phenotypic changes
Wang, Lihua, Miller, Brandon, Khin, Sonny, O’Sullivan-Coyne, Geraldine, Chen, Alice P., Kummar, Shivaani, Takebe, Naoko, Ferry-Galow, Kate, Parchment, Ralph E., Rubinstein, Larry, Piekarz, Richard, Newman, Edward M., Doroshow, James H., Kinders, Robert J.
Published in Molecular cancer therapeutics (01.12.2019)
Published in Molecular cancer therapeutics (01.12.2019)
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Abstract LB-B20: Characterization and Enumeration of Multiple Circulating Tumor Cell Phenotypes Using Two Distinct Platforms Establishes Presence of Epithelial-Mesenchymal Transition CTCs in Patients
Wang, Lihua, Owusu, Francis, Khin, Sonny, Parchment, Ralph, Chen, Alice, Kummar, Shivaani, Doroshow, James H., Kinders, Robert J.
Published in Molecular cancer therapeutics (01.12.2015)
Published in Molecular cancer therapeutics (01.12.2015)
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Validation of a hypoxia-inducible factor-1 alpha specimen collection procedure and quantitative enzyme-linked immunosorbent assay in solid tumor tissues
Park, Sook Ryun, Kinders, Robert J., Khin, Sonny, Hollingshead, Melinda, Antony, Smitha, Parchment, Ralph E., Tomaszewski, Joseph E., Kummar, Shivaani, Doroshow, James H.
Published in Analytical biochemistry (15.08.2014)
Published in Analytical biochemistry (15.08.2014)
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Vascular permeability in experimental diabetes is associated with reduced endothelial occludin content : Vascular endothelial growth factor decreases occludin in retinal endothelial cells
ANTONETTI, D. A, BARBER, A. J, KHIN, S, LIETH, E, TARBELL, J. M, GARDNER, T. W
Published in Diabetes (New York, N.Y.) (01.12.1998)
Published in Diabetes (New York, N.Y.) (01.12.1998)
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Validation of a Hypoxia-Inducible Factor-1α Specimen Collection Procedure and Quantitative ELISA in Solid Tumor Tissues
Park, Sook Ryun, Kinders, Robert J., Khin, Sonny, Hollingshead, Melinda, Antony, Smitha, Parchment, Ralph E., Tomaszewski, Joseph E., Kummar, Shivaani, Doroshow, James H.
Published in Analytical biochemistry (04.05.2014)
Published in Analytical biochemistry (04.05.2014)
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Abstract 3616: Validation and fitness testing of a quantitative immunoassay for HIF1α in biopsy specimens
Park, Sook Ryun, Kinders, Robert J., Khin, Sonny, Hollingshead, Melinda, Parchment, Ralph E., Tomaszewski, Joseph E., Doroshow, James H.
Published in Cancer research (Chicago, Ill.) (15.04.2012)
Published in Cancer research (Chicago, Ill.) (15.04.2012)
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Abstract C3: Validation and fitness testing of a quantitative immunoassay for HIF1α in biopsy specimens
Kinders, Robert J., Park, Sook Ryun, Khin, Sonny, Hollingshead, Melinda G., Parchment, Ralph E., Tomaszewski, Joseph E., Doroshow, James H.
Published in Molecular cancer therapeutics (12.11.2011)
Published in Molecular cancer therapeutics (12.11.2011)
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Phase l study assessing a two-consecutive-day (QD x 2) dosing schedule of the HSP90 inhibitor, AT13387, in patients with advanced solid tumors
Do, Khanh Tu, Speranza, Giovanna, Chen, Alice P., Trepel, Jane B., Lee, Min-Jung, Lee, Sunmin, Phillips, Larry, Collins, Jerry M., Weil, Marcie K., Kinders, Robert J., Khin, Sonny, Allen, Deborah, Parthasarathy, Ramya, Doroshow, James H., Kummar, Shivaani
Published in Journal of clinical oncology (20.05.2012)
Published in Journal of clinical oncology (20.05.2012)
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Pharmacodynamic biomarker-driven trial of MK-2206, an AKT inhibitor, with AZD6244 (selumetinib), a MEK inhibitor, in patients with advanced colorectal carcinoma (CRC)
Speranza, Giovanna, Kinders, Robert J., Khin, Sonny, Weil, Marcie K., Do, Khanh Tu, Horneffer, Yvonne, Juwara, Lamin, Allen, Deborah, Williams, P. Mickey, Lih, Chih Jian, Rubinstein, Larry, Doyle, Laurence A, Doroshow, James H., Kummar, Shivaani
Published in Journal of clinical oncology (20.05.2012)
Published in Journal of clinical oncology (20.05.2012)
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Abstract A106: Investigation of 5-fluorodeoxycytidine with tetrahydrouracil as a demethylation regimen in solid tumors
Kinders, Robert J., Wang, Lihua, Kummar, Shivaani, Khin, Sonny, Balasubramanian, Priya, Zhu, Weimin, Parchment, Ralph E., Newman, Edward, Tomaszewski, Joseph E., Doroshow, James H.
Published in Molecular cancer therapeutics (12.11.2011)
Published in Molecular cancer therapeutics (12.11.2011)
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Abstract C224: A novel validated quantitative pharmacodynamic topoisomerase I covalent-complex immunoassay
Pfister, Thomas D., Khin, Sonny A., Agama, Keli, Hollingshead, Melinda, Sooryakumar, Dhriti, Pommier, Yves, Parchment, Ralph E., Tomaszewski, Joseph E., Doroshow, James H., Kinders, Robert J.
Published in Molecular cancer therapeutics (10.12.2009)
Published in Molecular cancer therapeutics (10.12.2009)
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