Activation of metabotropic glutamate (mGlu)2 receptors suppresses histamine release in limbic brain regions following acute ketamine challenge
Fell, Matthew J., Katner, Jason S., Johnson, Bryan G., Khilevich, Albert, Schkeryantz, Jeffrey M., Perry, Kenneth W., Svensson, Kjell A.
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Published in Neuropharmacology (01.03.2010)
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Effects of Substitution on 9-(3-Bromo-4-fluorophenyl)-5,9-dihydro-3H,4H-2,6-dioxa-4- azacyclopenta[b]naphthalene-1,8-dione, a Dihydropyridine ATP-Sensitive Potassium Channel Opener
Altenbach, Robert J, Brune, Michael E, Buckner, Steven A, Coghlan, Michael J, Daza, Anthony V, Fabiyi, Adebola, Gopalakrishnan, Murali, Henry, Rodger F, Khilevich, Albert, Kort, Michael E, Milicic, Ivan, Scott, Victoria E, Smith, Jamie C, Whiteaker, Kristi L, Carroll, William A
Published in Journal of medicinal chemistry (16.11.2006)
Published in Journal of medicinal chemistry (16.11.2006)
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Synthesis, Chromatographic Resolution, and Anti-Human Immunodeficiency Virus Activity of (±)-Calanolide A and Its Enantiomers
Flavin, Michael T, Rizzo, John D, Khilevich, Albert, Kucherenko, Alla, Sheinkman, Abram K, Vilaychack, Vilayphone, Lin, Chen, Wei, Greenwood, Eugenia Mata, Pengsuparp, Thitima, Pezzuto, John M, Hughes, Stephen H, Flavin, Thomas M, Cibulski, Michael, Boulanger, William A, Shone, Robert L, Xu, Ze-Qi
Published in Journal of medicinal chemistry (15.03.1996)
Published in Journal of medicinal chemistry (15.03.1996)
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Discovery of the First α‑Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid (AMPA) Receptor Antagonist Dependent upon Transmembrane AMPA Receptor Regulatory Protein (TARP) γ‑8
Gardinier, Kevin M, Gernert, Douglas L, Porter, Warren J, Reel, Jon K, Ornstein, Paul L, Spinazze, Patrick, Stevens, F. Craig, Hahn, Patric, Hollinshead, Sean P, Mayhugh, Daniel, Schkeryantz, Jeff, Khilevich, Albert, De Frutos, Oscar, Gleason, Scott D, Kato, Akihiko S, Luffer-Atlas, Debra, Desai, Prashant V, Swanson, Steven, Burris, Kevin D, Ding, Chunjin, Heinz, Beverly A, Need, Anne B, Barth, Vanessa N, Stephenson, Gregory A, Diseroad, Benjamin A, Woods, Tim A, Yu, Hong, Bredt, David, Witkin, Jeffrey M
Published in Journal of medicinal chemistry (26.05.2016)
Published in Journal of medicinal chemistry (26.05.2016)
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Synthesis of (+)-calanolide A, an anti-HIV agent, Via enzyme-catalyzed resolution of the aldol products
Khilevich, Albert, Mar, Aye, Flavin, Michael T., Rizzo, John D., Lin, Lin, Dzekhtser, Sergey, Brankovic, Darko, Zhang, Heping, Chen, Wei, Liao, Shuyuan, Zembower, David E., Xu, Ze-Qi
Published in Tetrahedron: asymmetry (01.11.1996)
Published in Tetrahedron: asymmetry (01.11.1996)
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N-(4-((2-(trifluoromethyl)-3-hydroxy-4-(isobutyryl)phenoxy)methyl)benzyl)-1-methyl-1H-imidazole-4-carboxamide (THIIC), a novel metabotropic glutamate 2 potentiator with potential anxiolytic/antidepressant properties: in vivo profiling suggests a link between behavioral and central nervous system neurochemical changes
Fell, Matthew J, Witkin, Jeffrey M, Falcone, Julie F, Katner, Jason S, Perry, Kenneth W, Hart, John, Rorick-Kehn, Linda, Overshiner, Carl D, Rasmussen, Kurt, Chaney, Stephen F, Benvenga, Mark J, Li, Xia, Marlow, Deanna L, Thompson, Linda K, Luecke, Susan K, Wafford, Keith A, Seidel, Wesley F, Edgar, Dale M, Quets, Anne T, Felder, Christian C, Wang, XuShan, Heinz, Beverly A, Nikolayev, Alexander, Kuo, Ming-Shang, Mayhugh, Daniel, Khilevich, Albert, Zhang, Deyi, Ebert, Philip J, Eckstein, James A, Ackermann, Bradley L, Swanson, Steven P, Catlow, John T, Dean, Robert A, Jackson, Kimberley, Tauscher-Wisniewski, Sitra, Marek, Gerard J, Schkeryantz, Jeffrey M, Svensson, Kjell A
Published in The Journal of pharmacology and experimental therapeutics (01.01.2011)
Published in The Journal of pharmacology and experimental therapeutics (01.01.2011)
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Discovery of dual positive allosteric modulators (PAMs) of the metabotropic glutamate 2 receptor and CysLT1 antagonists for treating migraine headache
Blanco, Maria-Jesus, Benesh, Dana R., Knobelsdorf, James A., Khilevich, Albert, Cortez, Guillermo S., Mokube, Fese, Aicher, Thomas D., Groendyke, Todd M., Marmsater, Fredrik P., Tang, Tony P., Johnson, Kirk W., Clemens-Smith, Amy, Muhlhauser, Mark A., Swanson, Steven, Catlow, John, Emkey, Renee, Johnson, Michael P., Schkeryantz, Jeffrey M.
Published in Bioorganic & medicinal chemistry letters (15.01.2017)
Published in Bioorganic & medicinal chemistry letters (15.01.2017)
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BTK 억제제 화합물
PARTRIDGE KATHERINE MARIE, KUKLISH STEVEN LEE, HENRY KENNETH JAMES JR, QUIMBY STEVEN JAMES, KHILEVICH ALBERT
Year of Publication 29.05.2020
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Year of Publication 29.05.2020
Patent
Novel bicyclo[3.1.0]hexane analogs as antagonists of metabotropic glutamate 2/3 receptors for the treatment of depression
Dressman, Bruce A., Tromiczak, Eric G., Chappell, Mark D., Tripp, Allie E., Quimby, Steven J., Vetman, Tatiana, Fivush, Adam M., Matt, James, Jaramillo, Carlos, Li, Renhua, Khilevich, Albert, Blanco, Maria-Jesus, Smith, Stephon C., Carpintero, Mercedes, de Diego, José Eugenio, Barberis, Mario, García-Cerrada, Susana, Soriano, José F., Schkeryantz, Jeffrey M., Witkin, Jeffrey M., Wafford, Keith A., Seidel, Wesley, Britton, Thomas, Overshiner, Carl D., Li, Xia, Wang, Xu-Shan, Heinz, Beverly A., Catlow, John T., Swanson, Steven, Bedwell, David, Ornstein, Paul L., Mitch, Charles H.
Published in Bioorganic & medicinal chemistry letters (01.12.2016)
Published in Bioorganic & medicinal chemistry letters (01.12.2016)
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Synthesis of pyrazoles and isoxazoles as potent αvβ3 receptor antagonists
PENNING, Thomas D, KHILEVICH, Albert, HANNEKE, Melanie L, KEENE, Jeffery L, KLOVER, Jon A, NICKOLS, G. Allen, NICKOLS, Maureen A, RADER, Randall K, SETTLE, Steven L, SHANNON, Kristen E, STEININGER, Christina N, WESTLIN, Marisa M, CHEN, Barbara B, WESTLIN, William F, RUSSELL, Mark A, BOYS, Mark L, YAPING WANG, DUFFIN, Tiffany, ENGLEMAN, V. Wayne, FINN, Mary Beth, FREEMAN, Sandra K
Published in Bioorganic & medicinal chemistry letters (15.06.2006)
Published in Bioorganic & medicinal chemistry letters (15.06.2006)
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TARP- 8 AMPA 6--3H-13--2- 6-SUBSTITUTED-3H-13-BENZOTHIAZOL-2-ONE COMPOUNDS AS TARP-GAMMA 8 DEPENDENT AMPA RECEPTOR ANTAGONISTS
SPINAZZE PATRICK GIANPIETRO, REEL JON KEVIN, ORNSTEIN PAUL LESLIE, MAYHUGH DANIEL RAY, PORTER WARREN JAYE, STEVENS FREDDIE CRAIG, WITKIN JEFFREY MICHAEL, HOLLINSHEAD SEAN PATRICK, KHILEVICH ALBERT, SCHKERYANTZ JEFFREY MICHAEL, GERNERT DOUGLAS LINN, HAHN PATRIC JAMES, GARDINIER KEVIN MATTHEW
Year of Publication 09.12.2016
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Year of Publication 09.12.2016
Patent
N -(4-((2-(trifluoromethyl)-3-hydroxy-4-(isobutyryl)phenoxy)methyl)benzyl)-1-methyl-1 H -imidazole-4-carboxamide (THIIC), a Novel Metabotropic Glutamate 2 Potentiator with Potential Anxiolytic/Antidepressant Properties: In Vivo Profiling Suggests a Link between Behavioral and Central Nervous System Neurochemical Changes
Fell, Matthew J., Witkin, Jeffrey M., Falcone, Julie F., Katner, Jason S., Perry, Kenneth W., Hart, John, Rorick-Kehn, Linda, Overshiner, Carl D., Rasmussen, Kurt, Chaney, Stephen F., Benvenga, Mark J., Li, Xia, Marlow, Deanna L., Thompson, Linda K., Luecke, Susan K., Wafford, Keith A., Seidel, Wesley F., Edgar, Dale M., Quets, Anne T., Felder, Christian C., Wang, XuShan, Heinz, Beverly A., Nikolayev, Alexander, Kuo, Ming-Shang, Mayhugh, Daniel, Khilevich, Albert, Zhang, Deyi, Ebert, Philip J., Eckstein, James A., Ackermann, Bradley L., Swanson, Steven P., Catlow, John T., Dean, Robert A., Jackson, Kimberley, Tauscher-Wisniewski, Sitra, Marek, Gerard J., Schkeryantz, Jeffrey M., Svensson, Kjell A.
Published in The Journal of pharmacology and experimental therapeutics (01.01.2011)
Published in The Journal of pharmacology and experimental therapeutics (01.01.2011)
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IMIDAZOLE CARBOXAMIDES
LIU BIN, ZHANG DEYI, KHILEVICH ALBERT, SCHKERYANTZ JEFFREY MICHAEL, MAYHUGH DANIEL RAY
Year of Publication 07.03.2011
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Year of Publication 07.03.2011
Patent
Effects of Substitution on 9-(3-Bromo-4-fluorophenyl)-5,9-dihydro-3 H ,4 H -2,6-dioxa-4- azacyclopenta[ b ]naphthalene-1,8-dione, a Dihydropyridine ATP-Sensitive Potassium Channel Opener
Altenbach, Robert J., Brune, Michael E., Buckner, Steven A., Coghlan, Michael J., Daza, Anthony V., Fabiyi, Adebola, Gopalakrishnan, Murali, Henry, Rodger F., Khilevich, Albert, Kort, Michael E., Milicic, Ivan, Scott, Victoria E., Smith, Jamie C., Whiteaker, Kristi L., Carroll, William A.
Published in Journal of medicinal chemistry (01.11.2006)
Published in Journal of medicinal chemistry (01.11.2006)
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Btk inhibitor compounds
Henry, Kenneth James, Partridge, Katherine Marie, Kuklish, Steven, Khilevich, Albert, Quimby, Steven
Year of Publication 29.09.2023
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Year of Publication 29.09.2023
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BTK inhibitor compounds
Quimby, Steven James, Partridge, Katherine Marie, Kuklish, Steven Lee, Henry, Jr., Kenneth James, Khilevich, Albert
Year of Publication 03.01.2023
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Year of Publication 03.01.2023
Patent
BTK INHIBITOR COMPOUNDS
KHILEVICH, Albert, HENRY, Kenneth James, QUIMBY, Steven, PARTRIDGE, Katherine, KUKLISH, Steven
Year of Publication 28.06.2022
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Year of Publication 28.06.2022
Patent
BTK INHIBITOR COMPOUNDS
Quimby, Steven James, Partridge, Katherine Marie, Henry, Kenneth James, Jr, Kuklish, Steven Lee, Khilevich, Albert
Year of Publication 29.04.2022
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Year of Publication 29.04.2022
Patent
Synthesis of pyrazoles and isoxazoles as potent alpha(v)beta3 receptor antagonists
Penning, Thomas D, Khilevich, Albert, Chen, Barbara B, Russell, Mark A, Boys, Mark L, Wang, Yaping, Duffin, Tiffany, Engleman, V Wayne, Finn, Mary Beth, Freeman, Sandra K, Hanneke, Melanie L, Keene, Jeffery L, Klover, Jon A, Nickols, G Allen, Nickols, Maureen A, Rader, Randall K, Settle, Steven L, Shannon, Kristen E, Steininger, Christina N, Westlin, Marisa M, Westlin, William F
Published in Bioorganic & medicinal chemistry letters (15.06.2006)
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Published in Bioorganic & medicinal chemistry letters (15.06.2006)
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