Discovery of PiragliatinFirst Glucokinase Activator Studied in Type 2 Diabetic Patients
Sarabu, Ramakanth, Bizzarro, Fred T, Corbett, Wendy L, Dvorozniak, Mark T, Geng, Wanping, Grippo, Joseph F, Haynes, Nancy-Ellen, Hutchings, Stanley, Garofalo, Lisa, Guertin, Kevin R, Hilliard, Darryl W, Kabat, Marek, Kester, Robert F, Ka, Wang, Liang, Zhenmin, Mahaney, Paige E, Marcus, Linda, Matschinsky, Franz M, Moore, David, Racha, Jagdish, Radinov, Roumen, Ren, Yi, Qi, Lida, Pignatello, Michael, Spence, Cheryl L, Steele, Thomas, Tengi, John, Grimsby, Joseph
Published in Journal of medicinal chemistry (23.08.2012)
Published in Journal of medicinal chemistry (23.08.2012)
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Journal Article
PROTAC-mediated NR4A1 degradation as a novel strategy for cancer immunotherapy
Wang, Lei, Xiao, Yufeng, Luo, Yuewan, Master, Rohan P, Mo, Jiao, Kim, Myung-Chul, Liu, Yi, Maharjan, Chandra K, Patel, Urvi M, De, Umasankar, Carelock, Madison E, Tithi, Tanzia Islam, Li, Xiangming, Shaffer, Donald R, Guertin, Kevin R, Zhuang, Haoyang, Moser, Emily, Smalley, Keiran S M, Lv, Dongwen, Zhou, Daohong, Zheng, Guangrong, Zhang, Weizhou
Published in The Journal of experimental medicine (04.03.2024)
Published in The Journal of experimental medicine (04.03.2024)
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Journal Article
Allosteric Activators of Glucokinase: Potential Role in Diabetes Therapy
Grimsby, Joseph, Sarabu, Ramakanth, Corbett, Wendy L., Haynes, Nancy-Ellen, Bizzarro, Fred T., Coffey, John W., Guertin, Kevin R., Hilliard, Darryl W., Kester, Robert F., Mahaney, Paige E., Marcus, Linda, Qi, Lida, Spence, Cheryl L., Tengi, John, Magnuson, Mark A., Chu, Chang An, Dvorozniak, Mark T., Matschinsky, Franz M., Grippo, Joseph F.
Published in Science (American Association for the Advancement of Science) (18.07.2003)
Published in Science (American Association for the Advancement of Science) (18.07.2003)
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Journal Article
Discovery, Structure−Activity Relationships, Pharmacokinetics, and Efficacy of Glucokinase Activator (2R)-3-Cyclopentyl-2-(4-methanesulfonylphenyl)-N-thiazol-2-yl-propionamide (RO0281675)
Haynes, Nancy-Ellen, Corbett, Wendy L, Bizzarro, Fred T, Guertin, Kevin R, Hilliard, Darryl W, Holland, George W, Kester, Robert F, Mahaney, Paige E, Qi, Lida, Spence, Cheryl L, Tengi, John, Dvorozniak, Mark T, Railkar, Aruna, Matschinsky, Franz M, Grippo, Joseph F, Grimsby, Joseph, Sarabu, Ramakanth
Published in Journal of medicinal chemistry (13.05.2010)
Published in Journal of medicinal chemistry (13.05.2010)
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Journal Article
MetAP2 inhibition modifies hemoglobin S to delay polymerization and improves blood flow in sickle cell disease
Demers, Melanie, Sturtevant, Sarah, Guertin, Kevin R., Gupta, Dipti, Desai, Kunal, Vieira, Benjamin F., Li, Wenjing, Hicks, Alexandra, Ismail, Ayman, Gonçalves, Bronner P., Di Caprio, Giuseppe, Schonbrun, Ethan, Hansen, Scott, Musayev, Faik N., Safo, Martin K., Wood, David K., Higgins, John M., Light, David R.
Published in Blood advances (09.03.2021)
Published in Blood advances (09.03.2021)
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Journal Article
Discovery of camphor-derived pyrazolones as 11β-hydroxysteroid dehydrogenase type 1 inhibitors
Gillespie, Paul, Pietranico-Cole, Sherrie, Myers, Michael, Bilotta, Joseph A., Conde-Knape, Karin, Fotouhi, Nader, Goodnow, Robert A., Guertin, Kevin R., Hamilton, Matthew M., Haynes, Nancy-Ellen, Liu, Baolian, Qi, Lida, Ren, Yonglin, Scott, Nathan R., So, Sung-Sau, Spence, Cheryl, Taub, Rebecca, Thakkar, Kshitij, Tilley, Jefferson W., Zwingelstein, Catherine
Published in Bioorganic & medicinal chemistry letters (15.06.2014)
Published in Bioorganic & medicinal chemistry letters (15.06.2014)
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Journal Article
Identification of RO4597014, a Glucokinase Activator Studied in the Clinic for the Treatment of Type 2 Diabetes
Qian, Yimin, Corbett, Wendy L, Berthel, Steven J, Choi, Duk Soon, Dvorozniak, Mark T, Geng, Wanping, Gillespie, Paul, Guertin, Kevin R, Haynes, Nancy-Ellen, Kester, Robert F, Mennona, Francis A, Moore, David, Racha, Jagdish, Radinov, Roumen, Sarabu, Ramakanth, Scott, Nathan R, Grimsby, Joseph, Mallalieu, Navita L
Published in ACS medicinal chemistry letters (11.04.2013)
Published in ACS medicinal chemistry letters (11.04.2013)
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Journal Article
Identification of a novel class of orally active pyrimido[5,4-3][1,2,4]triazine-5,7-diamine-based hypoglycemic agents with protein tyrosine phosphatase inhibitory activity
Guertin, Kevin R., Setti, Lina, Qi, Lida, Dunsdon, Rachel M., Dymock, Brian W., Jones, Philip S., Overton, Hilary, Taylor, Mathew, Williams, Glyn, Sergi, Joseph A., Wang, Karen, Peng, Ying, Renzetti, Marcia, Boyce, Rogely, Falcioni, Fiorenza, Garippa, Ralph, Olivier, Andrée R.
Published in Bioorganic & medicinal chemistry letters (01.09.2003)
Published in Bioorganic & medicinal chemistry letters (01.09.2003)
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Journal Article
Functional analysis of the Pseudomonas aeruginosa autoinducer PAI
Passador, L, Tucker, K D, Guertin, K R, Journet, M P, Kende, A S, Iglewski, B H
Published in Journal of Bacteriology (01.10.1996)
Published in Journal of Bacteriology (01.10.1996)
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Journal Article
Optimization of the β-Aminoester class of factor Xa inhibitors. part 2: Identification of FXV673 as a potent and selective inhibitor with excellent In vivo anticoagulant activity
Guertin, Kevin R, Gardner, Charles J, Klein, Scott I, Zulli, Allison L, Czekaj, Mark, Gong, Yong, Spada, Alfred P, Cheney, Daniel L, Maignan, Sebastian, Guilloteau, Jean-Pierre, Brown, Karen D, Colussi, Dennis J, Chu, Valeria, Heran, Christopher L, Morgan, Suzanne R, Bentley, Ross G, Dunwiddie, Christopher T, Leadley, Robert J, Pauls, Henry W
Published in Bioorganic & medicinal chemistry letters (17.06.2002)
Published in Bioorganic & medicinal chemistry letters (17.06.2002)
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Journal Article
Optimization of the β-aminoester class of factor Xa inhibitors. Part 1: P4 and side-chain modifications for improved in vitro potency
CZEKAJ, Mark, KLEIN, Scott I, CHU, Valeria, LEADLEY, Robert J, DUNWIDDIE, Christopher T, GUERTIN, Kevin R, GARDNER, Charles J, ZULLI, Allison L, PAULS, Henry W, SPADA, Alfred P, CHENEY, Daniel L, BROWN, Karen D, COLUSSI, Dennis J
Published in Bioorganic & medicinal chemistry letters (17.06.2002)
Published in Bioorganic & medicinal chemistry letters (17.06.2002)
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Journal Article
Identification and Initial Structure−Activity Relationships of a Novel Class of Nonpeptide Inhibitors of Blood Coagulation Factor Xa
Klein, Scott I, Czekaj, Mark, Gardner, Charles J, Guertin, Kevin R, Cheney, Daniel L, Spada, Alfred P, Bolton, Scott A, Brown, Karen, Colussi, Dennis, Heran, Christopher L, Morgan, Suzanne R, Leadley, Robert J, Dunwiddie, Christopher T, Perrone, Mark H, Chu, Valeria
Published in Journal of medicinal chemistry (12.02.1998)
Published in Journal of medicinal chemistry (12.02.1998)
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Journal Article
Unleashing the Power of NR4A1 Degradation as a Novel Strategy for Cancer Immunotherapy
Wang, Lei, Xiao, Yufeng, Luo, Yuewan, Master, Rohan P, Mo, Jiao, Kim, Myung-Chul, Liu, Yi, Patel, Urvi M, Li, Xiangming, Shaffer, Donald, Guertin, Kevin R, Moser, Emily, Smalley, Keiran S, Zhou, Daohong, Zheng, Guangrong, Zhang, Weizhou
Published in bioRxiv : the preprint server for biology (13.08.2023)
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Published in bioRxiv : the preprint server for biology (13.08.2023)
Journal Article
Optimization of the β-Aminoester class of factor Xa inhibitors. part 1: P 4 and side-Chain modifications for improved In vitro potency
Czekaj, Mark, Klein, Scott I, Guertin, Kevin R, Gardner, Charles J, Zulli, Allison L, Pauls, Henry W, Spada, Alfred P, Cheney, Daniel L, Brown, Karen D, Colussi, Dennis J, Chu, Valeria, Leadley, Robert J, Dunwiddie, Christopher T
Published in Bioorganic & medicinal chemistry letters (17.06.2002)
Published in Bioorganic & medicinal chemistry letters (17.06.2002)
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Journal Article
Optimization of the beta-aminoester class of factor Xa inhibitors. Part 1: P(4) and side-chain modifications for improved in vitro potency
Czekaj, Mark, Klein, Scott I, Guertin, Kevin R, Gardner, Charles J, Zulli, Allison L, Pauls, Henry W, Spada, Alfred P, Cheney, Daniel L, Brown, Karen D, Colussi, Dennis J, Chu, Valeria, Leadley, Robert J, Dunwiddie, Christopher T
Published in Bioorganic & medicinal chemistry letters (17.06.2002)
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Published in Bioorganic & medicinal chemistry letters (17.06.2002)
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