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The human early-life exposome (HELIX): project rationale and design
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Published in Environmental health perspectives (01.06.2014)
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High-resolution magic-angle-spinning NMR spectroscopy for metabolic profiling of intact tissues
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Published in Nature protocols (01.06.2010)
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The early-life exposome and epigenetic age acceleration in children
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Published in Environment international (01.10.2021)
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The potential and challenges of targeting MTAP-negative cancers beyond synthetic lethality
Bray, Chandler, Balcells, Cristina, McNeish, Iain A., Keun, Hector C.
Published in Frontiers in oncology (19.09.2023)
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Determinants of the urinary and serum metabolome in children from six European populations
Lau, Chung-Ho E, Siskos, Alexandros P, Maitre, Léa, Robinson, Oliver, Athersuch, Toby J, Want, Elizabeth J, Urquiza, Jose, Casas, Maribel, Vafeiadi, Marina, Roumeliotaki, Theano, McEachan, Rosemary R C, Azad, Rafaq, Haug, Line S, Meltzer, Helle M, Andrusaityte, Sandra, Petraviciene, Inga, Grazuleviciene, Regina, Thomsen, Cathrine, Wright, John, Slama, Remy, Chatzi, Leda, Vrijheid, Martine, Keun, Hector C, Coen, Muireann
Published in BMC medicine (08.11.2018)
Published in BMC medicine (08.11.2018)
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Metabolic Profiling of Human Colorectal Cancer Using High-Resolution Magic Angle Spinning Nuclear Magnetic Resonance (HR-MAS NMR) Spectroscopy and Gas Chromatography Mass Spectrometry (GC/MS)
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Inhibition of monocarboxyate transporter 1 by AZD3965 as a novel therapeutic approach for diffuse large B-cell lymphoma and Burkitt lymphoma
Noble, Richard A, Bell, Natalie, Blair, Helen, Sikka, Arti, Thomas, Huw, Phillips, Nicole, Nakjang, Sirintra, Miwa, Satomi, Crossland, Rachel, Rand, Vikki, Televantou, Despina, Long, Anna, Keun, Hector C, Bacon, Chris M, Bomken, Simon, Critchlow, Susan E, Wedge, Stephen R
Published in Haematologica (Roma) (01.07.2017)
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Alterations of choline phospholipid metabolism in endometrial cancer are caused by choline kinase alpha overexpression and a hyperactivated deacylation pathway
Trousil, Sebastian, Lee, Patrizia, Pinato, David J, Ellis, James K, Dina, Roberto, Aboagye, Eric O, Keun, Hector C, Sharma, Rohini
Published in Cancer research (Chicago, Ill.) (01.12.2014)
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Indisulam targets RNA splicing and metabolism to serve as a therapeutic strategy for high-risk neuroblastoma
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Published in Nature communications (16.03.2022)
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Predictive modelling using pathway scores: robustness and significance of pathway collections
Segura-Lepe, Marcelo P, Keun, Hector C, Ebbels, Timothy M D
Published in BMC bioinformatics (04.11.2019)
Published in BMC bioinformatics (04.11.2019)
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Pharmacological depletion of RNA splicing factor RBM39 by indisulam synergizes with PARP inhibitors in high-grade serous ovarian carcinoma
Xu, Yuewei, Spear, Sarah, Ma, Yurui, Lorentzen, Marc P., Gruet, Michael, McKinney, Flora, Xu, Yitao, Wickremesinghe, Chiharu, Shepherd, Madelen R., McNeish, Iain, Keun, Hector C., Nijhuis, Anke
Published in Cell reports (Cambridge) (31.10.2023)
Published in Cell reports (Cambridge) (31.10.2023)
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Suppression of MTHFD2 in MCF‑7 Breast Cancer Cells Increases Glycolysis, Dependency on Exogenous Glycine, and Sensitivity to Folate Depletion
Koufaris, Costas, Gallage, Suchira, Yang, Tianlai, Lau, Chung-Ho, Valbuena, Gabriel N, Keun, Hector C
Published in Journal of proteome research (05.08.2016)
Published in Journal of proteome research (05.08.2016)
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Prospective analysis of circulating metabolites and endometrial cancer risk
Dossus, Laure, Kouloura, Eirini, Biessy, Carine, Viallon, Vivian, Siskos, Alexandros P., Dimou, Niki, Rinaldi, Sabina, Merritt, Melissa A., Allen, Naomi, Fortner, Renee, Kaaks, Rudolf, Weiderpass, Elisabete, Gram, Inger T., Rothwell, Joseph A., Lécuyer, Lucie, Severi, Gianluca, Schulze, Matthias B., Nøst, Therese Haugdahl, Crous-Bou, Marta, Sánchez, Maria-Jose, Amiano, Pilar, Colorado-Yohar, Sandra M., Gurrea, Aurelio Barricarte, Schmidt, Julie A., Palli, Domenico, Agnoli, Claudia, Tumino, Rosario, Sacerdote, Carlotta, Mattiello, Amalia, Vermeulen, Roel, Heath, Alicia K., Christakoudi, Sofia, Tsilidis, Konstantinos K., Travis, Ruth C., Gunter, Marc J., Keun, Hector C.
Published in Gynecologic oncology (01.08.2021)
Published in Gynecologic oncology (01.08.2021)
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The coordinated action of VCP/p97 and GCN2 regulates cancer cell metabolism and proteostasis during nutrient limitation
Parzych, Katarzyna, Saavedra-García, Paula, Valbuena, Gabriel N., Al-Sadah, Hibah A., Robinson, Mark E., Penfold, Lucy, Kuzeva, Desislava M., Ruiz-Tellez, Angie, Loaiza, Sandra, Holzmann, Viktoria, Caputo, Valentina, Johnson, David C., Kaiser, Martin F., Karadimitris, Anastasios, Lam, Eric W-F, Chevet, Eric, Feldhahn, Niklas, Keun, Hector C., Auner, Holger W.
Published in Oncogene (01.04.2019)
Published in Oncogene (01.04.2019)
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Metabolic profiling detects early effects of environmental and lifestyle exposure to cadmium in a human population
Ellis, James K, Athersuch, Toby J, Thomas, Laura D K, Teichert, Friederike, Pérez-Trujillo, Miriam, Svendsen, Claus, Spurgeon, David J, Singh, Rajinder, Järup, Lars, Bundy, Jacob G, Keun, Hector C
Published in BMC medicine (19.06.2012)
Published in BMC medicine (19.06.2012)
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Variability of multi-omics profiles in a population-based child cohort
Gallego-Paüls, Marta, Hernández-Ferrer, Carles, Bustamante, Mariona, Basagaña, Xavier, Barrera-Gómez, Jose, Lau, Chung-Ho E, Siskos, Alexandros P, Vives-Usano, Marta, Ruiz-Arenas, Carlos, Wright, John, Slama, Remy, Heude, Barbara, Casas, Maribel, Grazuleviciene, Regina, Chatzi, Leda, Borràs, Eva, Sabidó, Eduard, Carracedo, Ángel, Estivill, Xavier, Urquiza, Jose, Coen, Muireann, Keun, Hector C, González, Juan R, Vrijheid, Martine, Maitre, Léa
Published in BMC medicine (22.07.2021)
Published in BMC medicine (22.07.2021)
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Choline-releasing glycerophosphodiesterase EDI3 drives tumor cell migration and metastasis
Stewart, Joanna D, Marchan, Rosemarie, Lesjak, Michaela S, Lambert, Joerg, Hergenroeder, Roland, Ellis, James K, Lau, Chung-Ho, Keun, Hector C, Schmitz, Gerd, Schiller, Juergen, Eibisch, Mandy, Hedberg, Christian, Waldmann, Herbert, Lausch, Ekkehart, Tanner, Berno, Sehouli, Jalid, Sagemueller, Jens, Staude, Hagen, Steiner, Eric, Hengstler, Jan G
Published in Proceedings of the National Academy of Sciences - PNAS (22.05.2012)
Published in Proceedings of the National Academy of Sciences - PNAS (22.05.2012)
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