A next-generation cleaved, soluble HIV-1 Env trimer, BG505 SOSIP.664 gp140, expresses multiple epitopes for broadly neutralizing but not non-neutralizing antibodies
Sanders, Rogier W, Derking, Ronald, Cupo, Albert, Julien, Jean-Philippe, Yasmeen, Anila, de Val, Natalia, Kim, Helen J, Blattner, Claudia, de la Peña, Alba Torrents, Korzun, Jacob, Golabek, Michael, de Los Reyes, Kevin, Ketas, Thomas J, van Gils, Marit J, King, C Richter, Wilson, Ian A, Ward, Andrew B, Klasse, P J, Moore, John P
Published in PLoS pathogens (01.09.2013)
Published in PLoS pathogens (01.09.2013)
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Sequential and Simultaneous Immunization of Rabbits with HIV-1 Envelope Glycoprotein SOSIP.664 Trimers from Clades A, B and C
Klasse, P J, LaBranche, Celia C, Ketas, Thomas J, Ozorowski, Gabriel, Cupo, Albert, Pugach, Pavel, Ringe, Rajesh P, Golabek, Michael, van Gils, Marit J, Guttman, Miklos, Lee, Kelly K, Wilson, Ian A, Butera, Salvatore T, Ward, Andrew B, Montefiori, David C, Sanders, Rogier W, Moore, John P
Published in PLoS pathogens (01.09.2016)
Published in PLoS pathogens (01.09.2016)
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HIV-1 neutralizing antibodies induced by native-like envelope trimers
Sanders, Rogier W., van Gils, Marit J., Derking, Ronald, Sok, Devin, Ketas, Thomas J., Burger, Judith A., Ozorowski, Gabriel, Cupo, Albert, Simonich, Cassandra, Goo, Leslie, Arendt, Heather, Kim, Helen J., Lee, Jeong Hyun, Pugach, Pavel, Williams, Melissa, Debnath, Gargi, Moldt, Brian, van Breemen, Mariëlle J., Isik, Gözde, Medina-Ramírez, Max, Back, Jaap Willem, Koff, Wayne C., Julien, Jean-Philippe, Rakasz, Eva G., Seaman, Michael S., Guttman, Miklos, Lee, Kelly K., Klasse, Per Johan, LaBranche, Celia, Schief, William R., Wilson, Ian A., Overbaugh, Julie, Burton, Dennis R., Ward, Andrew B., Montefiori, David C., Dean, Hansi, Moore, John P.
Published in Science (American Association for the Advancement of Science) (10.07.2015)
Published in Science (American Association for the Advancement of Science) (10.07.2015)
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Structural and functional evaluation of de novo-designed, two-component nanoparticle carriers for HIV Env trimer immunogens
Antanasijevic, Aleksandar, Ueda, George, Brouwer, Philip J M, Copps, Jeffrey, Huang, Deli, Allen, Joel D, Cottrell, Christopher A, Yasmeen, Anila, Sewall, Leigh M, Bontjer, Ilja, Ketas, Thomas J, Turner, Hannah L, Berndsen, Zachary T, Montefiori, David C, Klasse, Per Johan, Crispin, Max, Nemazee, David, Moore, John P, Sanders, Rogier W, King, Neil P, Baker, David, Ward, Andrew B
Published in PLoS pathogens (11.08.2020)
Published in PLoS pathogens (11.08.2020)
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Enhancing and shaping the immunogenicity of native-like HIV-1 envelope trimers with a two-component protein nanoparticle
Brouwer, Philip J. M., Antanasijevic, Aleksandar, Berndsen, Zachary, Yasmeen, Anila, Fiala, Brooke, Bijl, Tom P. L., Bontjer, Ilja, Bale, Jacob B., Sheffler, William, Allen, Joel D., Schorcht, Anna, Burger, Judith A., Camacho, Miguel, Ellis, Daniel, Cottrell, Christopher A., Behrens, Anna-Janina, Catalano, Marco, del Moral-Sánchez, Iván, Ketas, Thomas J., LaBranche, Celia, van Gils, Marit J., Sliepen, Kwinten, Stewart, Lance J., Crispin, Max, Montefiori, David C., Baker, David, Moore, John P., Klasse, Per Johan, Ward, Andrew B., King, Neil P., Sanders, Rogier W.
Published in Nature communications (19.09.2019)
Published in Nature communications (19.09.2019)
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Epitopes for neutralizing antibodies induced by HIV-1 envelope glycoprotein BG505 SOSIP trimers in rabbits and macaques
Klasse, P J, Ketas, Thomas J, Cottrell, Christopher A, Ozorowski, Gabriel, Debnath, Gargi, Camara, Diawoye, Francomano, Erik, Pugach, Pavel, Ringe, Rajesh P, LaBranche, Celia C, van Gils, Marit J, Bricault, Christine A, Barouch, Dan H, Crotty, Shane, Silvestri, Guido, Kasturi, Sudhir, Pulendran, Bali, Wilson, Ian A, Montefiori, David C, Sanders, Rogier W, Ward, Andrew B, Moore, John P
Published in PLoS pathogens (23.02.2018)
Published in PLoS pathogens (23.02.2018)
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A native-like SOSIP.664 trimer based on an HIV-1 subtype B env gene
Pugach, Pavel, Ozorowski, Gabriel, Cupo, Albert, Ringe, Rajesh, Yasmeen, Anila, de Val, Natalia, Derking, Ronald, Kim, Helen J, Korzun, Jacob, Golabek, Michael, de Los Reyes, Kevin, Ketas, Thomas J, Julien, Jean-Philippe, Burton, Dennis R, Wilson, Ian A, Sanders, Rogier W, Klasse, P J, Ward, Andrew B, Moore, John P
Published in Journal of virology (01.03.2015)
Published in Journal of virology (01.03.2015)
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T cell-inducing vaccine durably prevents mucosal SHIV infection even with lower neutralizing antibody titers
Arunachalam, Prabhu S., Charles, Tysheena P., Joag, Vineet, Bollimpelli, Venkata S., Scott, Madeleine K. D., Wimmers, Florian, Burton, Samantha L., Labranche, Celia C., Petitdemange, Caroline, Gangadhara, Sailaja, Styles, Tiffany M., Quarnstrom, Clare F., Walter, Korey A., Ketas, Thomas J., Legere, Traci, Jagadeesh Reddy, Pradeep Babu, Kasturi, Sudhir Pai, Tsai, Anthony, Yeung, Bertrand Z., Gupta, Shakti, Tomai, Mark, Vasilakos, John, Shaw, George M., Kang, Chil-Yong, Moore, John P., Subramaniam, Shankar, Khatri, Purvesh, Montefiori, David, Kozlowski, Pamela A., Derdeyn, Cynthia A., Hunter, Eric, Masopust, David, Amara, Rama R., Pulendran, Bali
Published in Nature medicine (01.06.2020)
Published in Nature medicine (01.06.2020)
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Protection of Rhesus Macaques from Vaginal Infection by Vaginally Delivered Maraviroc, an Inhibitor of HIV-1 Entry via the CCR5 Co-Receptor
Veazey, Ronald S., Ketas, Thomas J., Dufour, Jason, Moroney-Rasmussen, Terri, Green, Linda C., Klasse, P. J., Moore, John P.
Published in The Journal of infectious diseases (01.09.2010)
Published in The Journal of infectious diseases (01.09.2010)
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Improving the Immunogenicity of Native-like HIV-1 Envelope Trimers by Hyperstabilization
Torrents de la Peña, Alba, Julien, Jean-Philippe, de Taeye, Steven W., Garces, Fernando, Guttman, Miklos, Ozorowski, Gabriel, Pritchard, Laura K., Behrens, Anna-Janina, Go, Eden P., Burger, Judith A., Schermer, Edith E., Sliepen, Kwinten, Ketas, Thomas J., Pugach, Pavel, Yasmeen, Anila, Cottrell, Christopher A., Torres, Jonathan L., Vavourakis, Charlotte D., van Gils, Marit J., LaBranche, Celia, Montefiori, David C., Desaire, Heather, Crispin, Max, Klasse, Per Johan, Lee, Kelly K., Moore, John P., Ward, Andrew B., Wilson, Ian A., Sanders, Rogier W.
Published in Cell reports (Cambridge) (22.08.2017)
Published in Cell reports (Cambridge) (22.08.2017)
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Structural and biological mimicry of protein surface recognition by α/β-peptide foldamers
Horne, W. Seth, Johnson, Lisa M, Ketas, Thomas J, Klasse, Per Johan, Lu, Min, Moore, John P, Gellman, Samuel H
Published in Proceedings of the National Academy of Sciences - PNAS (01.09.2009)
Published in Proceedings of the National Academy of Sciences - PNAS (01.09.2009)
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Limited or no protection by weakly or nonneutralizing antibodies against vaginal SHIV challenge of macaques compared with a strongly neutralizing antibody
Burton, Dennis R, Hessell, Ann J, Keele, Brandon F, Klasse, Per Johan, Ketas, Thomas A, Moldt, Brian, Dunlop, D. Cameron, Poignard, Pascal, Doyle, Lara A, Cavacini, Lisa, Veazey, Ronald S, Moore, John P
Published in Proceedings of the National Academy of Sciences - PNAS (05.07.2011)
Published in Proceedings of the National Academy of Sciences - PNAS (05.07.2011)
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Effects of Adjuvants on HIV-1 Envelope Glycoprotein SOSIP Trimers In Vitro
Ozorowski, Gabriel, Cupo, Albert, Golabek, Michael, LoPiccolo, Michelle, Ketas, Thomas A, Cavallary, Matt, Cottrell, Christopher A, Klasse, P J, Ward, Andrew B, Moore, John P
Published in Journal of virology (01.07.2018)
Published in Journal of virology (01.07.2018)
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Antibody Responses to SARS-CoV-2 mRNA Vaccines Are Detectable in Saliva
Ketas, Thomas J, Chaturbhuj, Devidas, Portillo, Victor M Cruz, Francomano, Erik, Golden, Encouse, Chandrasekhar, Sharanya, Debnath, Gargi, Díaz-Tapia, Randy, Yasmeen, Anila, Kramer, Kyle D, Munawar, Tarek, Leconet, Wilhelm, Zhao, Zhen, Brouwer, Philip J M, Cushing, Melissa M, Sanders, Rogier W, Cupo, Albert, Klasse, Per Johan, Formenti, Silvia C, Moore, John P
Published in Pathogens & immunity (07.06.2021)
Published in Pathogens & immunity (07.06.2021)
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SARS-CoV-2 vaccination, booster, and infection in pregnant population enhances passive immunity in neonates
Murphy, Elisabeth A., Guzman-Cardozo, Camila, Sukhu, Ashley C., Parks, Debby J., Prabhu, Malavika, Mohammed, Iman, Jurkiewicz, Magdalena, Ketas, Thomas J., Singh, Sunidhi, Canis, Marie, Bednarski, Eva, Hollingsworth, Alexis, Thompson, Embree M., Eng, Dorothy, Bieniasz, Paul D., Riley, Laura E., Hatziioannou, Theodora, Yang, Yawei J.
Published in Nature communications (10.08.2023)
Published in Nature communications (10.08.2023)
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cGMP production and analysis of BG505 SOSIP.664, an extensively glycosylated, trimeric HIV‐1 envelope glycoprotein vaccine candidate
Dey, Antu K., Cupo, Albert, Ozorowski, Gabriel, Sharma, Vaneet K., Behrens, Anna‐Janina, Go, Eden P., Ketas, Thomas J., Yasmeen, Anila, Klasse, Per J., Sayeed, Eddy, Desaire, Heather, Crispin, Max, Wilson, Ian A., Sanders, Rogier W., Hassell, Thomas, Ward, Andrew B., Moore, John P.
Published in Biotechnology and bioengineering (01.04.2018)
Published in Biotechnology and bioengineering (01.04.2018)
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Closing and Opening Holes in the Glycan Shield of HIV-1 Envelope Glycoprotein SOSIP Trimers Can Redirect the Neutralizing Antibody Response to the Newly Unmasked Epitopes
Ringe, Rajesh P, Pugach, Pavel, Cottrell, Christopher A, LaBranche, Celia C, Seabright, Gemma E, Ketas, Thomas J, Ozorowski, Gabriel, Kumar, Sonu, Schorcht, Anna, van Gils, Marit J, Crispin, Max, Montefiori, David C, Wilson, Ian A, Ward, Andrew B, Sanders, Rogier W, Klasse, P J, Moore, John P
Published in Journal of virology (15.02.2019)
Published in Journal of virology (15.02.2019)
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Influences on the Design and Purification of Soluble, Recombinant Native-Like HIV-1 Envelope Glycoprotein Trimers
Ringe, Rajesh P, Yasmeen, Anila, Ozorowski, Gabriel, Go, Eden P, Pritchard, Laura K, Guttman, Miklos, Ketas, Thomas A, Cottrell, Christopher A, Wilson, Ian A, Sanders, Rogier W, Cupo, Albert, Crispin, Max, Lee, Kelly K, Desaire, Heather, Ward, Andrew B, Klasse, P J, Moore, John P
Published in Journal of virology (01.12.2015)
Published in Journal of virology (01.12.2015)
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Addition of a cholesterol group to an HIV-1 peptide fusion inhibitor dramatically increases its antiviral potency
Ingallinella, Paolo, Bianchi, Elisabetta, Ladwa, Neal A, Wang, Ying-Jie, Hrin, Renee, Veneziano, Maria, Bonelli, Fabio, Ketas, Thomas J, Moore, John P, Miller, Michael D, Pessi, Antonello
Published in Proceedings of the National Academy of Sciences - PNAS (07.04.2009)
Published in Proceedings of the National Academy of Sciences - PNAS (07.04.2009)
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HIV-1 evades virus-specific IgG2 and IgA responses by targeting systemic and intestinal B cells via long-range intercellular conduits
Xu, Weifeng, Santini, Paul A, Sullivan, John S, He, Bing, Shan, Meimei, Ball, Susan C, Dyer, Wayne B, Ketas, Thomas J, Chadburn, Amy, Cohen-Gould, Leona, Knowles, Daniel M, Chiu, April, Sanders, Rogier W, Chen, Kang, Cerutti, Andrea
Published in Nature immunology (01.09.2009)
Published in Nature immunology (01.09.2009)
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