SARM1 is a metabolic sensor activated by an increased NMN/NAD+ ratio to trigger axon degeneration
Figley, Matthew D., Gu, Weixi, Nanson, Jeffrey D., Shi, Yun, Sasaki, Yo, Cunnea, Katie, Malde, Alpeshkumar K., Jia, Xinying, Luo, Zhenyao, Saikot, Forhad K., Mosaiab, Tamim, Masic, Veronika, Holt, Stephanie, Hartley-Tassell, Lauren, McGuinness, Helen Y., Manik, Mohammad K., Bosanac, Todd, Landsberg, Michael J., Kerry, Philip S., Mobli, Mehdi, Hughes, Robert O., Milbrandt, Jeffrey, Kobe, Bostjan, DiAntonio, Aaron, Ve, Thomas
Published in Neuron (Cambridge, Mass.) (07.04.2021)
Published in Neuron (Cambridge, Mass.) (07.04.2021)
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Journal Article
Structural basis of SARM1 activation, substrate recognition, and inhibition by small molecules
Shi, Yun, Kerry, Philip S., Nanson, Jeffrey D., Bosanac, Todd, Sasaki, Yo, Krauss, Raul, Saikot, Forhad K., Adams, Sarah E., Mosaiab, Tamim, Masic, Veronika, Mao, Xianrong, Rose, Faith, Vasquez, Eduardo, Furrer, Marieke, Cunnea, Katie, Brearley, Andrew, Gu, Weixi, Luo, Zhenyao, Brillault, Lou, Landsberg, Michael J., DiAntonio, Aaron, Kobe, Bostjan, Milbrandt, Jeffrey, Hughes, Robert O., Ve, Thomas
Published in Molecular cell (05.05.2022)
Published in Molecular cell (05.05.2022)
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Journal Article
Structure of influenza hemagglutinin in complex with an inhibitor of membrane fusion
Russell, Rupert J, Kerry, Philip S, Stevens, David J, Steinhauer, David A, Martin, Stephen R, Gamblin, Steven J, Skehel, John J
Published in Proceedings of the National Academy of Sciences - PNAS (18.11.2008)
Published in Proceedings of the National Academy of Sciences - PNAS (18.11.2008)
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Journal Article
Serendipitous Discovery of a Potent Influenza Virus A Neuraminidase Inhibitor
Mohan, Sankar, Kerry, Philip S., Bance, Nicole, Niikura, Masahiro, Pinto, B. Mario
Published in Angewandte Chemie International Edition (20.01.2014)
Published in Angewandte Chemie International Edition (20.01.2014)
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Journal Article
PROTACs Targeting BRM (SMARCA2) Afford Selective In Vivo Degradation over BRG1 (SMARCA4) and Are Active in BRG1 Mutant Xenograft Tumor Models
Berlin, Michael, Cantley, Jennifer, Bookbinder, Mark, Bortolon, Elizabeth, Broccatelli, Fabio, Cadelina, Greg, Chan, Emily W., Chen, Huifen, Chen, Xin, Cheng, Yunxing, Cheung, Tommy K., Davenport, Kim, DiNicola, Dean, Gordon, Debbie, Hamman, Brian D., Harbin, Alicia, Haskell, Roy, He, Mingtao, Hole, Alison J., Januario, Thomas, Kerry, Philip S., Koenig, Stefan G., Li, Limei, Merchant, Mark, Pérez-Dorado, Inmaculada, Pizzano, Jennifer, Quinn, Connor, Rose, Christopher M., Rousseau, Emma, Soto, Leofal, Staben, Leanna R., Sun, Hongming, Tian, Qingping, Wang, Jing, Wang, Weifeng, Ye, Crystal S., Ye, Xiaofen, Zhang, Penghong, Zhou, Yuhui, Yauch, Robert, Dragovich, Peter S.
Published in Journal of medicinal chemistry (25.01.2024)
Published in Journal of medicinal chemistry (25.01.2024)
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Journal Article
Structural insights into phosphoinositide 3-kinase activation by the influenza A virus NS1 protein
Hale, Benjamin G, Kerry, Philip S, Jackson, David, Precious, Bernard L, Gray, Alexander, Killip, Marian J, Randall, Richard E, Russell, Rupert J
Published in Proceedings of the National Academy of Sciences - PNAS (02.02.2010)
Published in Proceedings of the National Academy of Sciences - PNAS (02.02.2010)
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Journal Article
A transient homotypic interaction model for the influenza A virus NS1 protein effector domain
Kerry, Philip S, Ayllon, Juan, Taylor, Margaret A, Hass, Claudia, Lewis, Andrew, García-Sastre, Adolfo, Randall, Richard E, Hale, Benjamin G, Russell, Rupert J
Published in PloS one (28.03.2011)
Published in PloS one (28.03.2011)
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Journal Article
Novel Bat Influenza Virus NS1 Proteins Bind Double-Stranded RNA and Antagonize Host Innate Immunity
Turkington, Hannah L, Juozapaitis, Mindaugas, Kerry, Philip S, Aydillo, Teresa, Ayllon, Juan, García-Sastre, Adolfo, Schwemmle, Martin, Hale, Benjamin G
Published in Journal of virology (01.10.2015)
Published in Journal of virology (01.10.2015)
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Journal Article
Novel sialic acid derivatives lock open the 150-loop of an influenza A virus group-1 sialidase
von Itzstein, Mark, Rudrawar, Santosh, Dyason, Jeffrey C, Rameix-Welti, Marie-Anne, Rose, Faith J, Kerry, Philip S, Russell, Rupert J. M, van der Werf, Sylvie, Thomson, Robin J, Naffakh, Nadia
Published in Nature communications (16.11.2010)
Published in Nature communications (16.11.2010)
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Journal Article
Structural basis for a class of nanomolar influenza A neuraminidase inhibitors
Kerry, Philip S., Mohan, Sankar, Russell, Rupert J. M., Bance, Nicole, Niikura, Masahiro, Pinto, B. Mario
Published in Scientific reports (16.10.2013)
Published in Scientific reports (16.10.2013)
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Journal Article
Synthesis, structure and inhibitory activity of a stereoisomer of oseltamivir carboxylate
Sartori, Andrea, Dell'Amico, Luca, Battistini, Lucia, Curti, Claudio, Rivara, Silvia, Pala, Daniele, Kerry, Philip S., Pelosi, Giorgio, Casiraghi, Giovanni, Rassu, Gloria, Zanardi, Franca
Published in Organic & biomolecular chemistry (14.03.2014)
Published in Organic & biomolecular chemistry (14.03.2014)
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Journal Article
Synthesis and evaluation of novel 3-C-alkylated-Neu5Ac2en derivatives as probes of influenza virus sialidase 150-loop flexibility
Rudrawar, Santosh, Kerry, Philip S., Rameix-Welti, Marie-Anne, Maggioni, Andrea, Dyason, Jeffrey C., Rose, Faith J., van der Werf, Sylvie, Thomson, Robin J., Naffakh, Nadia, Russell, Rupert J. M., von Itzstein, Mark
Published in Organic & biomolecular chemistry (21.11.2012)
Published in Organic & biomolecular chemistry (21.11.2012)
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Journal Article
A cluster of conserved basic amino acids near the C-terminus of the PB1 subunit of the influenza virus RNA polymerase is involved in the regulation of viral transcription
Kerry, Philip S, Willsher, Nicholas, Fodor, Ervin
Published in Virology (New York, N.Y.) (30.03.2008)
Published in Virology (New York, N.Y.) (30.03.2008)
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Journal Article
The specific monocarboxylate transporter-1 (MCT-1) inhibitor, AR-C117977, induces donor-specific suppression, reducing acute and chronic allograft rejection in the rat
Ekberg, Henrik, Qi, Zhongquan, Pahlman, Clara, Veress, Béla, Bundick, Robert V, Craggs, Robert I, Holness, Elain, Edwards, Susan, Murray, Clare M, Ferguson, Douglas, Kerry, Philip J, Wilson, Elaine, Donald, David K
Published in Transplantation (15.11.2007)
Published in Transplantation (15.11.2007)
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Journal Article
Serendipitous Discovery of a Potent Influenza Virus A Neuraminidase Inhibitor
Mohan, Sankar, Kerry, Philip S., Bance, Nicole, Niikura, Masahiro, Pinto, B. Mario
Published in Angewandte Chemie (20.01.2014)
Published in Angewandte Chemie (20.01.2014)
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Journal Article
Conservation of a crystallographic interface suggests a role for β-sheet augmentation in influenza virus NS1 multifunctionality
Kerry, Philip S., Long, Elizabeth, Taylor, Margaret A., Russell, Rupert J. M.
Published in Acta crystallographica. Section F, Structural biology and crystallization communications (01.08.2011)
Published in Acta crystallographica. Section F, Structural biology and crystallization communications (01.08.2011)
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Journal Article
Uncovering the molecular basis for SARM1 activation
Kerry, Philip S., Brearley, Andrew, Furrer, Marieke, Cunnea, Katie
Published in Acta crystallographica. Section A, Foundations and advances (07.07.2023)
Published in Acta crystallographica. Section A, Foundations and advances (07.07.2023)
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Journal Article
Development of a Selective Inhibitor of Protein Arginine Deiminase 2
Muth, Aaron, Subramanian, Venkataraman, Beaumont, Edward, Nagar, Mitesh, Kerry, Philip, McEwan, Paul, Srinath, Hema, Clancy, Kathleen, Parelkar, Sangram, Thompson, Paul R
Published in Journal of medicinal chemistry (13.04.2017)
Published in Journal of medicinal chemistry (13.04.2017)
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