Structure of the BTB domain of Keap1 and its interaction with the triterpenoid antagonist CDDO
Cleasby, Anne, Yon, Jeff, Day, Philip J, Richardson, Caroline, Tickle, Ian J, Williams, Pamela A, Callahan, James F, Carr, Robin, Concha, Nestor, Kerns, Jeffrey K, Qi, Hongwei, Sweitzer, Thomas, Ward, Paris, Davies, Thomas G
Published in PloS one (04.06.2014)
Published in PloS one (04.06.2014)
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Keap Calm, and Carry on Covalently
Wilson, Anthony J, Kerns, Jeffrey K, Callahan, James F, Moody, Christopher J
Published in Journal of medicinal chemistry (10.10.2013)
Published in Journal of medicinal chemistry (10.10.2013)
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Monoacidic Inhibitors of the Kelch-like ECH-Associated Protein 1: Nuclear Factor Erythroid 2‑Related Factor 2 (KEAP1:NRF2) Protein–Protein Interaction with High Cell Potency Identified by Fragment-Based Discovery
Davies, Thomas G, Wixted, William E, Coyle, Joseph E, Griffiths-Jones, Charlotte, Hearn, Keisha, McMenamin, Rachel, Norton, David, Rich, Sharna J, Richardson, Caroline, Saxty, Gordon, Willems, Henriëtte M. G, Woolford, Alison J.-A, Cottom, Joshua E, Kou, Jen-Pyng, Yonchuk, John G, Feldser, Heidi G, Sanchez, Yolanda, Foley, Joseph P, Bolognese, Brian J, Logan, Gregory, Podolin, Patricia L, Yan, Hongxing, Callahan, James F, Heightman, Tom D, Kerns, Jeffrey K
Published in Journal of medicinal chemistry (28.04.2016)
Published in Journal of medicinal chemistry (28.04.2016)
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Journal Article
Structure–Activity and Structure–Conformation Relationships of Aryl Propionic Acid Inhibitors of the Kelch-like ECH-Associated Protein 1/Nuclear Factor Erythroid 2‑Related Factor 2 (KEAP1/NRF2) Protein–Protein Interaction
Heightman, Tom D, Callahan, James F, Chiarparin, Elisabetta, Coyle, Joseph E, Griffiths-Jones, Charlotte, Lakdawala, Ami S, McMenamin, Rachel, Mortenson, Paul N, Norton, David, Peakman, Torren M, Rich, Sharna J, Richardson, Caroline, Rumsey, William L, Sanchez, Yolanda, Saxty, Gordon, Willems, Henriëtte M. G, Wolfe, Lawrence, Woolford, Alison J.-A, Wu, Zining, Yan, Hongxing, Kerns, Jeffrey K, Davies, Thomas G
Published in Journal of medicinal chemistry (09.05.2019)
Published in Journal of medicinal chemistry (09.05.2019)
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Journal Article
The Spongistatins: Architecturally Complex Natural Products-Part Two: Synthesis of the C(29-51) Subunit, Fragment Assembly, and Final Elaboration to (+)-Spongistatin 2
Smith III, Amos B., Lin, Qiyan, Doughty, Victoria A., Zhuang, Linghang, McBriar, Mark D., Kerns, Jeffrey K., Brook, Christopher S., Murase, Noriaki, Nakayama, Kiyoshi
Published in Angewandte Chemie (International ed.) (05.01.2001)
Published in Angewandte Chemie (International ed.) (05.01.2001)
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Journal Article
Fragment-Guided Discovery of Pyrazole Carboxylic Acid Inhibitors of the Kelch-like ECH-Associated Protein 1: Nuclear Factor Erythroid 2 Related Factor 2 (KEAP1:NRF2) Protein−Protein Interaction
Norton, David, Bonnette, William G, Callahan, James F, Carr, Maria G, Griffiths-Jones, Charlotte M, Heightman, Tom D, Kerns, Jeffrey K, Nie, Hong, Rich, Sharna J, Richardson, Caroline, Rumsey, William, Sanchez, Yolanda, Verdonk, Marcel L, Willems, Henriëtte M. G, Wixted, William E, Woolford, Alison J.-A, Wu, Zining, Davies, Thomas G
Published in Journal of medicinal chemistry (11.11.2021)
Published in Journal of medicinal chemistry (11.11.2021)
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Journal Article
Characterization of the Potent, Selective Nrf2 Activator, 3-(Pyridin-3-Ylsulfonyl)-5-(Trifluoromethyl)-2H-Chromen-2-One, in Cellular and In Vivo Models of Pulmonary Oxidative Stress
Yonchuk, John G, Foley, Joseph P, Bolognese, Brian J, Logan, Gregory, Wixted, William E, Kou, Jen-Pyng, Chalupowicz, Diana G, Feldser, Heidi G, Sanchez, Yolanda, Nie, Hong, Callahan, James F, Kerns, Jeffrey K, Podolin, Patricia L
Published in The Journal of pharmacology and experimental therapeutics (01.10.2017)
Published in The Journal of pharmacology and experimental therapeutics (01.10.2017)
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Journal Article
Characterization of the Potent, Selective Nrf2 Activator, 3-(Pyridin-3-Ylsulfonyl)-5-(Trifluoromethyl)-2 H -Chromen-2-One, in Cellular and In Vivo Models of Pulmonary Oxidative Stress
Yonchuk, John G, Foley, Joseph P, Bolognese, Brian J, Logan, Gregory, Wixted, William E, Kou, Jen-Pyng, Chalupowicz, Diana G, Feldser, Heidi G, Sanchez, Yolanda, Nie, Hong, Callahan, James F, Kerns, Jeffrey K, Podolin, Patricia L
Published in The Journal of pharmacology and experimental therapeutics (01.10.2017)
Published in The Journal of pharmacology and experimental therapeutics (01.10.2017)
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Journal Article
3,5-Disubstituted-indole-7-carboxamides as IKKβ Inhibitors: Optimization of Oral Activity via the C3 Substituent
Kerns, Jeffrey K, Busch-Petersen, Jakob, Fu, Wei, Boehm, Jeffrey C, Nie, Hong, Muratore, Michael, Bullion, Ann, Lin, Guoliang, Li, Huijie, Davis, Roderick, Lin, Xichen, Lakdawala, Ami S, Cousins, Rick, Field, Rita, Payne, Jeremy, Miller, David D, Bamborough, Paul, Christopher, John A, Baldwin, Ian, Osborn, Ruth R, Yonchuk, John, Webb, Edward, Rumsey, William L
Published in ACS medicinal chemistry letters (13.12.2018)
Published in ACS medicinal chemistry letters (13.12.2018)
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Discovery of 6-Aryl-7-alkoxyisoquinoline Inhibitors of IκB Kinase-β (IKK-β)
Christopher, John A, Bamborough, Paul, Alder, Catherine, Campbell, Amanda, Cutler, Geoffrey J, Down, Kenneth, Hamadi, Ahmed M, Jolly, Adrian M, Kerns, Jeffrey K, Lucas, Fiona S, Mellor, Geoffrey W, Miller, David D, Morse, Mary A, Pancholi, Kiritkant D, Rumsey, William, Solanke, Yemisi E, Williamson, Rick
Published in Journal of medicinal chemistry (14.05.2009)
Published in Journal of medicinal chemistry (14.05.2009)
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Journal Article
The discovery of 2-amino-3,5-diarylbenzamide inhibitors of IKK-α and IKK-β kinases
Christopher, John A., Avitabile, Barbara G., Bamborough, Paul, Champigny, Aurelie C., Cutler, Geoffrey J., Dyos, Susan L., Grace, Ken G., Kerns, Jeffrey K., Kitson, Jeremy D., Mellor, Geoffrey W., Morey, James V., Morse, Mary A., O’Malley, Carolyn F., Patel, Champa B., Probst, Nicholas, Rumsey, William, Smith, Clive A., Wilson, Michael J.
Published in Bioorganic & medicinal chemistry letters (15.07.2007)
Published in Bioorganic & medicinal chemistry letters (15.07.2007)
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Journal Article
Spongipyran synthetic studies. Total synthesis of (+)-spongistatin 2
Smith, Amos B., Lin, Qiyan, Doughty, Victoria A., Zhuang, Linghang, McBriar, Mark D., Kerns, Jeffrey K., Boldi, Armen M., Murase, Noriaki, Moser, William H., Brook, Christopher S., Bennett, Clay S., Nakayama, Kiyoshi, Sobukawa, Masao, Lee Trout, Robert E.
Published in Tetrahedron (15.08.2009)
Published in Tetrahedron (15.08.2009)
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Journal Article
3,5-Disubstituted-indole-7-carboxamides: The discovery of a novel series of potent, selective inhibitors of IKK-β
Miller, David D., Bamborough, Paul, Christopher, John A., Baldwin, Ian R., Champigny, Aurelie C., Cutler, Geoffrey J., Kerns, Jeffrey K., Longstaff, Timothy, Mellor, Geoffrey W., Morey, James V., Morse, Mary A., Nie, Hong, Rumsey, William L., Taggart, John J.
Published in Bioorganic & medicinal chemistry letters (15.04.2011)
Published in Bioorganic & medicinal chemistry letters (15.04.2011)
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Azepanone-based inhibitors of human cathepsin S: Optimization of selectivity via the P2 substituent
Kerns, Jeffrey K., Nie, Hong, Bondinell, William, Widdowson, Katherine L., Yamashita, Dennis S., Rahman, Attiq, Podolin, Patricia L., Carpenter, Donald C., Jin, Qi, Riflade, Benoit, Dong, Xiaoyang, Nevins, Neysa, Keller, Paul M., Mitchell, Laura, Tomaszek, Thaddeus
Published in Bioorganic & medicinal chemistry letters (01.08.2011)
Published in Bioorganic & medicinal chemistry letters (01.08.2011)
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3-Arylamino-2H-1,2,4-benzothiadiazin-5-ol 1,1-dioxides as novel and selective CXCR2 antagonists
Wang, Yonghui, Busch-Petersen, Jakob, Wang, Feng, Ma, Lanping, Fu, Wei, Kerns, Jeffrey K, Jin, Jian, Palovich, Michael R, Shen, Jing-Kang, Burman, Miriam, Foley, James J, Schmidt, Dulcie B, Hunsberger, Gerald E, Sarau, Henry M, Widdowson, Katherine L
Published in Bioorganic & medicinal chemistry letters (15.07.2007)
Published in Bioorganic & medicinal chemistry letters (15.07.2007)
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3-(2,3-디히드로-1H-인덴-5-일)프로판산 유도체 및 NRF2 조절제로서의 그의 용도
CALLAHAN JAMES FRANCIS, HEIGHTMAN THOMAS DANIEL, WOOLFORD ALISON JO ANNE, KERNS JEFFREY K, BOEHM JEFFREY CHARLES, YAN HONGXING
Year of Publication 26.07.2019
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Year of Publication 26.07.2019
Patent
NRF2 조절제
CALLAHAN JAMES FRANCIS, HEIGHTMAN THOMAS DANIEL, WOOLFORD ALISON JO ANNE, KERNS JEFFREY K, BOEHM JEFFREY CHARLES, YAN HONGXING
Year of Publication 21.02.2018
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Year of Publication 21.02.2018
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NRF2 조절제
HEIGHTMAN THOMAS DANIEL, GRIFFITHS JONES CHARLOTTE MARY, WOOLFORD ALISON JO ANNE, KERNS JEFFREY K, LI TINDY, YAN HONGXING, WILLEMS HENDRIKA MARIA GERARDA
Year of Publication 20.02.2018
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Year of Publication 20.02.2018
Patent
A Highly Convergent Synthesis of 2-Phenyl Quinoline as Dual Antagonists for NK2 and NK3 Receptors
Yan, Hongxing, Kerns, Jeffrey K., Jin, Qi, Zhu, Chongjie, Barnette, Mary S., Callahan, James F., Hay, Douglas W. P., Jolivette, Larry J., Luttmann, Mark A., Sarau, Henry M., Ward, Keith W., Widdowson, Katherine L., Wan, Zehong
Published in Synthetic communications (01.12.2005)
Published in Synthetic communications (01.12.2005)
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Journal Article
NRF2 조절제
GRIFFITHS JONES CHARLOTTE MARY, WOOLFORD ALISON JO ANNE, BOEHM JEFFREY CHARLES, YAN HONGXING, DAVIS RODERICK S, HAMILTON PARIS L, NORTON DAVID, CALLAHAN JAMES FRANCIS, HEIGHTMAN THOMAS DANIEL, LAKDAWALA SHAH AMI, KERNS JEFFREY K, GOODWIN NICOLE CATHLEEN, LI TINDY, JIN YUN
Year of Publication 21.02.2018
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Year of Publication 21.02.2018
Patent