MEF2C haploinsufficiency caused by either microdeletion of the 5q14.3 region or mutation is responsible for severe mental retardation with stereotypic movements, epilepsy and/or cerebral malformations
Le Meur, N, Holder-Espinasse, M, Jaillard, S, Goldenberg, A, Joriot, S, Amati-Bonneau, P, Guichet, A, Barth, M, Charollais, A, Journel, H, Auvin, S, Boucher, C, Kerckaert, J-P, David, V, Manouvrier-Hanu, S, Saugier-Veber, P, Frébourg, T, Dubourg, C, Andrieux, J, Bonneau, D
Published in Journal of medical genetics (01.01.2010)
Published in Journal of medical genetics (01.01.2010)
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Autocrine induction of invasion and metastasis by tumor-associated trypsin inhibitor in human colon cancer cells
Gouyer, V, Fontaine, D, Dumont, P, de Wever, O, Fontayne-Devaud, H, Leteurtre, E, Truant, S, Delacour, D, Drobecq, H, Kerckaert, J-P, de Launoit, Y, Bracke, M, Gespach, C, Desseyn, J-L, Huet, G
Published in Oncogene (03.07.2008)
Published in Oncogene (03.07.2008)
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Recurrent genomic aberrations combined with deletions of various tumour suppressor genes may deregulate the G1 S transition in CD4+CD56+ haematodermic neoplasms and contribute to the aggressiveness of the disease
Jardin, F, Callanan, M, Penther, D, Ruminy, P, Troussard, X, Kerckaert, J P, Figeac, M, Parmentier, F, Rainville, V, Vaida, I, Bertrand, P, Duval, A B, Picquenot, J M, Chaperot, L, Marolleau, J P, Plumas, J, Tilly, H, Bastard, C
Published in Leukemia (01.04.2009)
Published in Leukemia (01.04.2009)
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The LAZ3(BCL-6) oncoprotein recruits a SMRT/mSIN3A/histone deacetylase containing complex to mediate transcriptional repression
Dhordain, Philippe, Quief, Sabine, Lantoine, Danièle, Kerckaert, Jean-Pierre, Albagli, Olivier, Lin, Richard J., Evans, Ronald M.
Published in Nucleic acids research (15.10.1998)
Published in Nucleic acids research (15.10.1998)
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LAZ3, a novel zinc-finger encoding gene, is disrupted by recurring chromosome 3q27 translocations in human lymphomas
Kerckaert, J P, Deweindt, C, Tilly, H, Quief, S, Lecocq, G, Bastard, C
Published in Nature genetics (01.09.1993)
Published in Nature genetics (01.09.1993)
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Genotype–phenotype correlation of 30 patients with Smith-Magenis syndrome (SMS) using comparative genome hybridisation array: cleft palate in SMS is associated with larger deletions
Andrieux, J, Villenet, C, Quief, S, Lignon, S, Geffroy, S, Roumier, C, de Leersnyder, H, de Blois, M-C, Manouvrier, S, Delobel, B, Benzacken, B, Bitoun, P, Attie-Bitach, T, Thomas, S, Lyonnet, S, Vekemans, M, Kerckaert, J-P
Published in Journal of medical genetics (01.08.2007)
Published in Journal of medical genetics (01.08.2007)
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Nonrandom 4p13 rearrangements of the RhoH/TTF gene, encoding a GTP-binding protein, in non-Hodgkin's lymphoma and multiple myeloma
PREUDHOMME, C, ROUMIER, C, KERCKAERT, J. P, GALIEGUE-ZOUITINA, S, HILDEBRAND, M. P, DALLERY-PRUDHOMME, E, LANTOINE, D, LAÏ, J. L, DAUDIGNON, A, ADENIS, C, BAUTERS, F, FENAUX, P
Published in Oncogene (13.04.2000)
Published in Oncogene (13.04.2000)
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Corepressor SMRT Binds the BTB/POZ Repressing Domain of the LAZ3/BCL6 Oncoprotein
Dhordain, Philippe, Albagli, Olivier, Lin, Richard J., Ansieau, Stephane, Quief, Sabine, Leutz, Achim, Kerckaert, Jean-Pierre, Evans, Ronald M., Leprince, Dominique
Published in Proceedings of the National Academy of Sciences - PNAS (30.09.1997)
Published in Proceedings of the National Academy of Sciences - PNAS (30.09.1997)
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Overexpressed BCL6 (LAZ3) oncoprotein triggers apoptosis, delays S phase progression and associates with replication foci
ALBAGLI, O, LANTOINE, D, QUIEF, S, QUIGNON, F, ENGLERT, C, KERCKAERT, J.-P, MONTARRAS, D, PINSET, C, LINDON, C
Published in Oncogene (09.09.1999)
Published in Oncogene (09.09.1999)
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LAZ3 Rearrangements in Non-Hodgkin’s Lymphoma: Correlation With Histology, Immunophenotype, Karyotype, and Clinical Outcome in 217 Patients
Bastard, Christian, Deweindt, Clotilde, Kerckaert, Jean Pierre, Lenormand, Bernard, Rossi, Annick, Pezzella, Francesco, Fruchart, Christophe, Duval, Christian, Monconduit, Mathieu, Tilly, Hervé
Published in Blood (01.05.1994)
Published in Blood (01.05.1994)
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The BTB/POZ domain targets the LAZ3/BCL6 oncoprotein to nuclear dots and mediates homomerisation in vivo
Dhordain, P, Albagli, O, Ansieau, S, Koken, M H, Deweindt, C, Quief, S, Lantoine, D, Leutz, A, Kerckaert, J P, Leprince, D
Published in Oncogene (21.12.1995)
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Published in Oncogene (21.12.1995)
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Small deletions occur in highly conserved regions of the LAZ3/BCL6 major translocation cluster in one case of non-Hodgkin's lymphoma without 3q27 translocation
BERNARDIN, F, COLLYN-D'HOOGHE, M, QUIEF, S, BASTARD, C, LEPRINCE, D, KERCKAERT, J.-P
Published in Oncogene (20.02.1997)
Published in Oncogene (20.02.1997)
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Splicing with inverted order of exons occurs proximal to large introns
Cocquerelle, C., Daubersies, P., Majérus, M.A., Kerckaert, J.P., Bailleul, B.
Published in The EMBO journal (01.03.1992)
Published in The EMBO journal (01.03.1992)
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A novel 9-base pair duplication in RET exon 8 in familial medullary thyroid carcinoma
PIGNY, P, BAUTERS, C, PORCHET, N, WEMEAU, J.-L, HOUCKE, M. L, CREPIN, M, CARON, P, GIRAUD, S, CALENDER, A, BUISINE, M.-P, KERCKAERT, J.-P
Published in The journal of clinical endocrinology and metabolism (01.05.1999)
Published in The journal of clinical endocrinology and metabolism (01.05.1999)
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Analysis of LAZ3 (BCL-6) Status in B-Cell Non-Hodgkin's Lymphomas: Results of Rearrangement and Gene Expression Studies and a Mutational Analysis of Coding Region Sequences
Otsuki, Takemi, Yano, Takahiro, Clark, Helen M., Bastard, Christian, Kerckaert, Jean Pierre, Jaffe, Elaine S., Raffeld, Mark
Published in Blood (15.05.1995)
Published in Blood (15.05.1995)
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Therostasin, a Novel Clotting Factor Xa Inhibitor from the Rhynchobdellid Leech, Theromyzon tessulatum
Chopin, Vincent, Salzet, Michel, Baert, Jean-luc, Vandenbulcke, Franck, Sautière, Pierre-Eric, Kerckaert, Jean-Pierre, Malecha, Jean
Published in The Journal of biological chemistry (20.10.2000)
Published in The Journal of biological chemistry (20.10.2000)
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Waved aCGH: to smooth or not to smooth
Leprêtre, F, Villenet, C, Quief, S, Nibourel, O, Jacquemin, C, Troussard, X, Jardin, F, Gibson, F, Kerckaert, J.P, Roumier, C, Figeac, M
Published in Nucleic acids research (01.04.2010)
Published in Nucleic acids research (01.04.2010)
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The B cell transcriptional coactivator BOB1/OBF1 gene fuses to the LAZ3/BCL6 gene by t(3;11)(q27;q23.1) chromosomal translocation in a B cell leukemia line (Karpas 231)
Galiègue Zouitina, S, Quief, S, Hildebrand, M P, Denis, C, Lecocq, G, Collyn-d'Hooghe, M, Bastard, C, Yuille, M, Dyer, M J, Kerckaert, J P
Published in Leukemia (01.04.1996)
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Published in Leukemia (01.04.1996)
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High incidence of biallelic point mutations in the Runt domain of the AML1/PEBP2αB gene in Mo acute myeloid leukemia and in myeloid malignancies with acquired trisomy 21
Preudhomme, Claude, Warot-Loze, Delphine, Roumier, Christophe, Grardel-Duflos, Nalthalie, Garand, Richard, Lai, Jean Luc, Dastugue, Nicole, Macintyre, Elizabeth, Denis, Claude, Bauters, Francis, Kerckaert, Jean Pierre, Cosson, Alain, Fenaux, Pierre
Published in Blood (15.10.2000)
Published in Blood (15.10.2000)
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