Potent S1P receptor agonists replicate the pharmacologic actions of the novel immune modulator FTY720
Hale, Jeffrey J., Neway, William, Mills, Sander G., Hajdu, Richard, Ann Keohane, Carol, Rosenbach, Mark, Milligan, James, Shei, Gan-Ju, Chrebet, Gary, Bergstrom, James, Card, Deborah, Koo, Gloria C., Koprak, Sam L., Jackson, Jesse J., Rosen, Hugh, Mandala, Suzanne
Published in Bioorganic & medicinal chemistry letters (21.06.2004)
Published in Bioorganic & medicinal chemistry letters (21.06.2004)
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Journal Article
Mice Deficient in Sphingosine Kinase 1 Are Rendered Lymphopenic by FTY720
Allende, Maria L, Sasaki, Teiji, Kawai, Hiromichi, Olivera, Ana, Mi, Yide, van Echten-Deckert, Gerhild, Hajdu, Richard, Rosenbach, Mark, Keohane, Carol Ann, Mandala, Suzanne, Spiegel, Sarah, Proia, Richard L
Published in The Journal of biological chemistry (10.12.2004)
Published in The Journal of biological chemistry (10.12.2004)
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Identification of Metabolites of a Substance P (Neurokinin 1 Receptor) Antagonist in Rat Hepatocytes and Rat Plasma
HOP, Cornelis E. C. A, YANFENG WANG, CURTIS, Neil, ELLIOTT, Jason, GERHARD, Ute, LOCKER, Karen, MORRISON, Denise, MORTISHIRE-SMITH, Russell, THOMAS, Steven, WATT, Alan P, EVANS, David C, KUMAR, Sanjeev, SILVA ELIPE, Maria Victoria, RAAB, Conrad E, DEAN, Dennis C, POON, Grace K, KEOHANE, Carol-Ann, STRAUSS, John, CHIU, Shuet-Hing L
Published in Drug metabolism and disposition (01.08.2002)
Published in Drug metabolism and disposition (01.08.2002)
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Journal Article
Sphingosine 1-phosphate receptor agonist FTY720-phosphate causes marginal zone B cell displacement
Vora, Kalpit A., Nichols, Elizabeth, Porter, Gene, Cui, Yan, Keohane, Carol Ann, Hajdu, Richard, Hale, Jeffery, Neway, William, Zaller, Dennis, Mandala, Suzanne
Published in Journal of leukocyte biology (01.08.2005)
Published in Journal of leukocyte biology (01.08.2005)
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Journal Article
Selecting against S1P3 enhances the acute cardiovascular tolerability of 3-(N-benzyl)aminopropylphosphonic acid S1P receptor agonists
Hale, Jeffrey J., Doherty, George, Toth, Leslie, Mills, Sander G., Hajdu, Richard, Ann Keohane, Carol, Rosenbach, Mark, Milligan, James, Shei, Gan-Ju, Chrebet, Gary, Bergstrom, James, Card, Deborah, Forrest, Michael, Sun, Shu-Yu, West, Sarah, Xie, Huijuan, Nomura, Naomi, Rosen, Hugh, Mandala, Suzanne
Published in Bioorganic & medicinal chemistry letters (05.07.2004)
Published in Bioorganic & medicinal chemistry letters (05.07.2004)
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Journal Article
The discovery of 3-(N-alkyl)aminopropylphosphonic acids as potent S1P receptor agonists
Hale, Jeffrey J., Doherty, George, Toth, Leslie, Li, Zhen, Mills, Sander G., Hajdu, Richard, Ann Keohane, Carol, Rosenbach, Mark, Milligan, James, Shei, Gan-Ju, Chrebet, Gary, Bergstrom, James, Card, Deborah, Rosen, Hugh, Mandala, Suzanne
Published in Bioorganic & medicinal chemistry letters (05.07.2004)
Published in Bioorganic & medicinal chemistry letters (05.07.2004)
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Journal Article
Genetic deletion and pharmacological inhibition of phosphodiesterase 10A protects mice from diet-induced obesity and insulin resistance
Nawrocki, Andrea R, Rodriguez, Carlos G, Toolan, Dawn M, Price, Olga, Henry, Melanie, Forrest, Gail, Szeto, Daphne, Keohane, Carol Ann, Pan, Yie, Smith, Karen M, Raheem, Izzat T, Cox, Christopher D, Hwa, Joyce, Renger, John J, Smith, Sean M
Published in Diabetes (New York, N.Y.) (01.01.2014)
Published in Diabetes (New York, N.Y.) (01.01.2014)
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Journal Article
Alteration of Lymphocyte Trafficking by Sphingosine-1-Phosphate Receptor Agonists
Mandala, Suzanne, Hajdu, Richard, Bergstrom, James, Quackenbush, Elizabeth, Xie, Jenny, Milligan, James, Thornton, Rosemary, Shei, Gan-Ju, Card, Deborah, Keohane, CarolAnn, Rosenbach, Mark, Hale, Jeffrey, Lynch, Christopher L., Rupprecht, Kathleen, Parsons, William, Rosen, Hugh
Published in Science (American Association for the Advancement of Science) (12.04.2002)
Published in Science (American Association for the Advancement of Science) (12.04.2002)
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A novel approach to assess the spontaneous gastrointestinal bleeding risk of antithrombotic agents using Apc(min/+) mice
Wei, Huijun, Shang, Jin, Keohane, CarolAnn, Wang, Min, Li, Qiu, Ni, Weihua, O'Neill, Kim, Chintala, Madhu
Published in Thrombosis and haemostasis (01.06.2014)
Published in Thrombosis and haemostasis (01.06.2014)
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Discovery of Potent 3,5-Diphenyl-1,2,4-oxadiazole Sphingosine-1-phosphate-1 (S1P1) Receptor Agonists with Exceptional Selectivity against S1P2 and S1P3
Li, Zhen, Chen, Weirong, Hale, Jeffrey J, Lynch, Christopher L, Mills, Sander G, Hajdu, Richard, Keohane, Carol Ann, Rosenbach, Mark J, Milligan, James A, Shei, Gan-Ju, Chrebet, Gary, Parent, Stephen A, Bergstrom, James, Card, Deborah, Forrest, Michael, Quackenbush, Elizabeth J, Wickham, L. Alexandra, Vargas, Hugo, Evans, Rose M, Rosen, Hugh, Mandala, Suzanne
Published in Journal of medicinal chemistry (06.10.2005)
Published in Journal of medicinal chemistry (06.10.2005)
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Journal Article
A Rational Utilization of High-Throughput Screening Affords Selective, Orally Bioavailable 1-Benzyl-3-carboxyazetidine Sphingosine-1-phosphate-1 Receptor Agonists
Hale, Jeffrey J, Lynch, Christopher L, Neway, William, Mills, Sander G, Hajdu, Richard, Keohane, Carol Ann, Rosenbach, Mark J, Milligan, James A, Shei, Gan-Ju, Parent, Stephen A, Chrebet, Gary, Bergstrom, James, Card, Deborah, Ferrer, Marc, Hodder, Peter, Strulovici, Berta, Rosen, Hugh, Mandala, Suzanne
Published in Journal of medicinal chemistry (30.12.2004)
Published in Journal of medicinal chemistry (30.12.2004)
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Journal Article
2,5-Disubstituted pyrrolidine carboxylates as potent, orally active sphingosine-1-phosphate (S1P) receptor agonists
Colandrea, Vincent J., Legiec, Irene E., Huo, Pei, Yan, Lin, Hale, Jeffrey J., Mills, Sander G., Bergstrom, James, Card, Deborah, Chebret, Gary, Hajdu, Richard, Keohane, Carol Ann, Milligan, James A., Rosenbach, Mark J., Shei, Gan-Ju, Mandala, Suzanne M.
Published in Bioorganic & medicinal chemistry letters (01.06.2006)
Published in Bioorganic & medicinal chemistry letters (01.06.2006)
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Journal Article
Design and synthesis of conformationally constrained 3-( N-alkylamino)propylphosphonic acids as potent agonists of sphingosine-1-phosphate (S1P) receptors
Yan, Lin, Hale, Jeffrey J., Lynch, Christopher L., Budhu, Richard, Gentry, Amy, Mills, Sander G., Hajdu, Richard, Keohane, Carol Ann, Rosenbach, Mark J., Milligan, James A., Shei, Gan-Ju, Chrebet, Gary, Bergstrom, James, Card, Deborah, Rosen, Hugh, Mandala, Suzanne M.
Published in Bioorganic & medicinal chemistry letters (04.10.2004)
Published in Bioorganic & medicinal chemistry letters (04.10.2004)
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Journal Article
Discovery of Potent 3,5-Diphenyl-1,2,4-oxadiazole Sphingosine-1-phosphate-1 (S1P 1 ) Receptor Agonists with Exceptional Selectivity against S1P 2 and S1P 3
Li, Zhen, Chen, Weirong, Hale, Jeffrey J., Lynch, Christopher L., Mills, Sander G., Hajdu, Richard, Keohane, Carol Ann, Rosenbach, Mark J., Milligan, James A., Shei, Gan-Ju, Chrebet, Gary, Parent, Stephen A., Bergstrom, James, Card, Deborah, Forrest, Michael, Quackenbush, Elizabeth J., Wickham, L. Alexandra, Vargas, Hugo, Evans, Rose M., Rosen, Hugh, Mandala, Suzanne
Published in Journal of medicinal chemistry (01.10.2005)
Published in Journal of medicinal chemistry (01.10.2005)
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Journal Article
Selecting against S1P3 enhances the acute cardiovascular tolerability of 3-(N-benzyl)aminopropylphosphonic acid S1P receptor agonists
HALE, Jeffrey J, DOHERTY, George, BERGSTROM, James, CARD, Deborah, FORREST, Michael, SUN, Shu-Yu, WEST, Sarah, HUIJUAN XIE, NOMURA, Naomi, ROSEN, Hugh, MANDALA, Suzanne, TOTH, Leslie, MILLS, Sander G, HAJDU, Richard, KEOHANE, Carol Ann, ROSENBACH, Mark, MILLIGAN, James, SHEI, Gan-Ju, CHREBET, Gary
Published in Bioorganic & medicinal chemistry letters (05.07.2004)
Published in Bioorganic & medicinal chemistry letters (05.07.2004)
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Journal Article
The pharmacokinetics of a thiazole benzenesulfonamide β3-adrenergic receptor agonist and its analogs in rats, dogs, and monkeys: Improving oral bioavailability
STEARNS, Ralph A, MILLER, Randy R, COLLETTI, Adria E, STRAUSS, John R, KEOHANE, Carol Ann, FEENEY, William P, ILIFF, Susan A, CHIU, Shuet-Hing Lee, WEI TANG, KWEI, Gloria Y, TANG, Frank S, MATHVINK, Robert J, NAYLOR, Elizabeth M, CHITTY, Dawn, COLANDREA, Vincent J, WEBER, Ann E
Published in Drug metabolism and disposition (2002)
Published in Drug metabolism and disposition (2002)
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Journal Article
Selecting against S1P 3 enhances the acute cardiovascular tolerability of 3-(N-benzyl)aminopropylphosphonic acid S1P receptor agonists
Hale, Jeffrey J., Doherty, George, Toth, Leslie, Mills, Sander G., Hajdu, Richard, Ann Keohane, Carol, Rosenbach, Mark, Milligan, James, Shei, Gan-Ju, Chrebet, Gary, Bergstrom, James, Card, Deborah, Forrest, Michael, Sun, Shu-Yu, West, Sarah, Xie, Huijuan, Nomura, Naomi, Rosen, Hugh, Mandala, Suzanne
Published in Bioorganic & medicinal chemistry letters (2004)
Published in Bioorganic & medicinal chemistry letters (2004)
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Journal Article
The Pharmacokinetics of a Thiazole Benzenesulfonamide β3-Adrenergic Receptor Agonist and Its Analogs in Rats, Dogs, and Monkeys: Improving Oral Bioavailability
Ralph A. Stearns, Randy R. Miller, Wei Tang, Gloria Y. Kwei, Frank S. Tang, Robert J. Mathvink, Elizabeth M. Naylor, Dawn Chitty, Vincent J. Colandrea, Ann E. Weber, Adria E. Colletti, John R. Strauss, Carol Ann Keohane, William P. Feeney, Susan A. Iliff, Shuet-Hing Lee Chiu
Published in Drug metabolism and disposition (01.07.2002)
Published in Drug metabolism and disposition (01.07.2002)
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Journal Article
The pharmacokinetics of a thiazole benzenesulfonamide beta 3-adrenergic receptor agonist and its analogs in rats, dogs, and monkeys: improving oral bioavailability
Stearns, Ralph A, Miller, Randy R, Tang, Wei, Kwei, Gloria Y, Tang, Frank S, Mathvink, Robert J, Naylor, Elizabeth M, Chitty, Dawn, Colandrea, Vincent J, Weber, Ann E, Colletti, Adria E, Strauss, John R, Keohane, Carol Ann, Feeney, William P, Iliff, Susan A, Chiu, Shuet-Hing Lee
Published in Drug metabolism and disposition (01.07.2002)
Published in Drug metabolism and disposition (01.07.2002)
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