Unique Preclinical Characteristics of GG745, A Potent Dual Inhibitor of 5AR
Bramson, H N, Hermann, D, Batchelor, K W, Lee, F W, James, M K, Frye, S V
Published in The Journal of pharmacology and experimental therapeutics (01.09.1997)
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Published in The Journal of pharmacology and experimental therapeutics (01.09.1997)
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Pharmacokinetic parameters and mechanisms of inhibition of rat type 1 and 2 steroid 5α-reductases : determinants for different in vivo activities of GI198745 and finasteride in the rat
STUART, J. Darren, LEE, Frank W, BRAMSON, H. Neal, NOEL, Deborah Simpson, KADWELL, Sue H, OVERTON, Laurie K, HOFFMAN, Christine R, KOST, Thomas A, TIPPIN, Timothy K, YEAGER, Russell L, BATCHELOR, Kenneth W
Published in Biochemical pharmacology (01.10.2001)
Published in Biochemical pharmacology (01.10.2001)
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3-[4-(1,2-Diphenylbut-1-enyl)phenyl]acrylic Acid: A Non-Steroidal Estrogen with Functional Selectivity for Bone over Uterus in Rats
Willson, Timothy M, Henke, Brad R, Momtahen, Tanya M, Charifson, Paul S, Batchelor, Kenneth W, Lubahn, Dennis B, Moore, Linda B, Oliver, Beverly B, Sauls, Howard R, Triantafillou, James A, Wolfe, Steven G, Baer, Philip G
Published in Journal of medicinal chemistry (01.05.1994)
Published in Journal of medicinal chemistry (01.05.1994)
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Structure-Activity Relationships for Inhibition of Type 1 and 2 Human 5.alpha.-Reductase and Human Adrenal 3.beta.-Hydroxy-.DELTA.5-steroid Dehydrogenase/3-Keto-.DELTA.5-steroid Isomerase by 6-Azaandrost-4-en-3-ones: Optimization of the C17 Substituent
Frye, Stephen V, Haffner, Curt D, Maloney, Patrick R, Hiner, Roger N, Dorsey, George F, Noe, Robert A, Unwalla, Rayomand J, Batchelor, Kenneth W, Bramson, H. Neal, Stuart, J. Darren, Schweiker, Stephanie L, Van Arnold, John, Bickett, D. Mark, Moss, Marcia L, Tian, Gaochoa, Lee, Frank W, Tippin, Timothy K, James, Michael K, Grizzle, Mary K, Long, James E, Croom, Dallas K
Published in Journal of medicinal chemistry (01.07.1995)
Published in Journal of medicinal chemistry (01.07.1995)
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6-Azasteroids: potent dual inhibitors of human type 1 and 2 steroid 5.alpha.-reductase
Frye, Stephen V, Haffner, Curt D, Maloney, Patrick R, Mook, Robert A, Dorsey, G. F, Hiner, Roger N, Batchelor, Kenneth W, Bramson, H. Neal, Stuart, J. Darren
Published in Journal of medicinal chemistry (01.12.1993)
Published in Journal of medicinal chemistry (01.12.1993)
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Pharmacokinetic parameters and mechanisms of inhibition of rat type 1 and 2 steroid 5α-reductases: determinants for different in vivo activities of GI198745 and finasteride in the rat 3 3Abbreviations: r5AR1, rat 5α-reductase 1; r5AR2, rat 5α-reductase 2; and DHT, dihydrotestosterone
Darren Stuart, J., Lee, Frank W., Simpson Noel, Deborah, Kadwell, Sue H., Overton, Laurie K., Hoffman, Christine R., Kost, Thomas A., Tippin, Timothy K., Yeager, Russell L., Batchelor, Kenneth W., Neal Bramson, H.
Published in Biochemical pharmacology (01.10.2001)
Published in Biochemical pharmacology (01.10.2001)
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17β-(N-tert-butylcarbamoyl)-4-aza-5α-androstan-1-en-3-one is an active site-directed slow time-dependent inhibitor of human steroid 5α-reductase 1
GAOCHAO TIAN, STUART, J. D, FRYE, S. V, BATCHELOR, K. W, WISEMAN, J. S, MOSS, M. L, DOMANICO, P. L, BRAMSON, H. N, PATEL, I. R, KADWELL, S. H, OVERTON, L. K, KOST, T. A, MOOK, R. A
Published in Biochemistry (Easton) (01.03.1994)
Published in Biochemistry (Easton) (01.03.1994)
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6-AZASTEROIDS - POTENT DUAL INHIBITORS OF HUMAN TYPE-1 AND 2 STEROID 5-ALPHA-REDUCTASE
FRYE, SV, HAFFNER, CD, MALONEY, PR, MOOK, RA, HINER, RN, BATCHELOR, KW, BRAMSON, HN, STUART, JD, SCHWEIKER, SL, VANARNOLD, J, BICKETT, DM, MOSS, ML, TIAN, GC, UNWALLA, RJ, LEE, FW, TIPPIN, TK, JAMES, MK, GRIZZLE, MK, LONG, JE, SCHUSTER, SV, DORSEY, GF
Published in Journal of medicinal chemistry (24.12.1993)
Published in Journal of medicinal chemistry (24.12.1993)
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