New IDH1 mutant inhibitors for treatment of acute myeloid leukemia
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Published in Nature chemical biology (01.11.2015)
Published in Nature chemical biology (01.11.2015)
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Identification of a Pharmacophore for Thrombopoietic Activity of Small, Non-Peptidyl Molecules. 1. Discovery and Optimization of Salicylaldehyde Thiosemicarbazone Thrombopoietin Mimics
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Published in Journal of medicinal chemistry (15.08.2002)
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Identification of a Pharmacophore for Thrombopoietic Activity of Small, Non-Peptidyl Molecules. 2. Rational Design of Naphtho[1,2-d]imidazole Thrombopoietin Mimics
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Published in Journal of medicinal chemistry (15.08.2002)
Published in Journal of medicinal chemistry (15.08.2002)
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3-(1,1-Dioxo-2H-(1,2,4)-benzothiadiazin-3-yl)-4-hydroxy-2(1H)-quinolinones, Potent Inhibitors of Hepatitis C Virus RNA-Dependent RNA Polymerase
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Published in Journal of medicinal chemistry (09.02.2006)
Published in Journal of medicinal chemistry (09.02.2006)
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Substituted benzothiadizine inhibitors of Hepatitis C virus polymerase
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Published in Bioorganic & medicinal chemistry letters (01.08.2009)
Published in Bioorganic & medicinal chemistry letters (01.08.2009)
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Synthesis and biological activity of heteroaryl 3-(1,1-dioxo-2H-(1,2,4)-benzothiadizin-3-yl)-4-hydroxy-2(1H)-quinolinone derivatives as hepatitis C virus NS5B polymerase inhibitors
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Published in Bioorganic & medicinal chemistry letters (01.08.2009)
Published in Bioorganic & medicinal chemistry letters (01.08.2009)
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Hydrazinonaphthalene and Azonaphthalene Thrombopoietin Mimics Are Nonpeptidyl Promoters of Megakaryocytopoiesis
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Published in Journal of medicinal chemistry (25.10.2001)
Published in Journal of medicinal chemistry (25.10.2001)
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Reversible inhibitors of the gastric (H+/K+)-ATPase. 3. 3-Substituted-4-(phenylamino)quinolines
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Published in Journal of medicinal chemistry (01.09.1992)
Published in Journal of medicinal chemistry (01.09.1992)
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Reversible inhibitors of the gastric (H+/K+)-ATPase. 2. 1-Arylpyrrolo[3,2-c]quinolines: effect of the 4-substituent
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Published in Journal of medicinal chemistry (01.05.1992)
Published in Journal of medicinal chemistry (01.05.1992)
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Reversible Inhibitors of the Gastric (H+/K+)-ATPase. 4. Identification of an Inhibitor with an Intermediate Duration of Action
Leach, Colin A, Brown, Thomas H, Ife, Robert J, Keeling, David J, Parsons, Michael E, Theobald, Colin J, Wiggall, Kenneth J
Published in Journal of medicinal chemistry (01.07.1995)
Published in Journal of medicinal chemistry (01.07.1995)
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Reversible inhibitors of the gastric (H+/K+)-ATPase. 1. 1-Aryl-4-methylpyrrolo[3,2-c]quinolines as conformationally restrained analogs of 4-(arylamino)quinolines
Brown, Thomas H, Ife, Robert J, Keeling, David J, Laing, Shiona M, Leach, Colin A, Parsons, Michael E, Price, Carolyn A, Reavill, David R, Wiggall, Kenneth J
Published in Journal of medicinal chemistry (01.02.1990)
Published in Journal of medicinal chemistry (01.02.1990)
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New IDH1 mutant inhibitors for treatment of acute myeloid leukemiaf
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Published in Nature chemical biology (01.11.2015)
Published in Nature chemical biology (01.11.2015)
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Journal Article
Novel IDH1 Mutant Inhibitors for Treatment of Acute Myeloid Leukemia
Okoye-Okafor, Ujunwa C., Bartholdy, Boris, Cartier, Jessy, Gao, Enoch, Pietrak, Beth, Rendina, Alan R., Rominger, Cynthia, Quinn, Chad, Smallwood, Angela, Wiggall, Kenneth J., Reif, Alexander J., Schmidt, Stanley J., Qi, Hongwei, Zhao, Huizhen, Joberty, Gerard, Faelth-Savitski, Maria, Bantscheff, Marcus, Drewes, Gerard, Duraiswami, Chaya, Brady, Pat, Groy, Arthur, Narayanagari, Swathi-Rao, Antony-Debre, Ileana, Mitchell, Kelly, Wang, Heng Rui, Kao, Yun-Ruei, Christopeit, Maximilian, Carvajal, Luis, Barreyro, Laura, Paietta, Elisabeth, Makishima, Hideki, Will, Britta, Concha, Nestor, Adams, Nicholas D., Schwartz, Benjamin, McCabe, Michael T., Maciejewski, Jaroslav, Verma, Amit, Steidl, Ulrich
Published in Nature chemical biology (05.10.2015)
Published in Nature chemical biology (05.10.2015)
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Journal Article
Synthesis and biological activity of heteroaryl 3-(1,1-dioxo-2H-(1,2,4)-benzo-thiadizin-3-yl)-4-hydroxy-2(1H)-quinolinone derivatives as hepatitis C virus NS5B polymerase inhibitors
TEDESCO, Rosanna, DEPING CHAI, SHAW, Antony N, VALKO, Klara L, WIGGALL, Kenneth J, ZIMMERMAN, Michael N, DUFFY, Kevin J, DARCY, Michael G, DHANAK, Dashyant, FITCH, Duke M, GATES, Adam, JOHNSTON, Victor K, KEENAN, Richard M, LIN-GOERKE, Juili, SARISKY, Robert T
Published in Bioorganic & medicinal chemistry letters (2009)
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Published in Bioorganic & medicinal chemistry letters (2009)
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Discovery of SB-497115, a Small-Molecule Thrombopoietin (TPO) Receptor Agonist for the Treatment of Thrombocytopenia
Luengo, Juan I., Duffy, Kevin J., Shaw, Anthony N., Delorme, Evelyne, Wiggall, Kenneth J., Giampa, Leslie, Liu, Nannan, Smith, Heather, Tian, Shin-Shay, Miller, Stephen G., Keenan, Richard M., Rosen, Jon, Dillon, Susan B., Lamb, Peter, Erickson-Miller, Connie L.
Published in Blood (16.11.2004)
Published in Blood (16.11.2004)
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PROLYL HYDROXYLASE INHIBITORS
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Year of Publication 29.06.2011
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Year of Publication 29.06.2011
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PROLYL HYDROXYLASE INHIBITORS
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Year of Publication 28.04.2011
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Year of Publication 28.04.2011
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PROLYL HYDROXYLASE INHIBITORS
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Year of Publication 13.04.2011
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Year of Publication 13.04.2011
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PROLYL HYDROXYLASE INHIBITORS
WANG, YONGHUI, BRACKLEY, JAMES A., III, TEDESCO, ROSANNA, WIGGALL, KENNETH J, SHAW, ANTONY NICHOLAS, YU, HONGYI
Year of Publication 30.12.2009
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Year of Publication 30.12.2009
Patent
ANTI-INFECTIVES
ZIMMERMAN, MICHAEL, N, DUFFY, KEVIN, J, FITCH, DUKE, M, WIGGALL, KENNETH, J, TEDESCO, ROSANNA, CHAI, DEPING, SHAW, ANTONY, N
Year of Publication 02.08.2007
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Year of Publication 02.08.2007
Patent