Novel Carboxamide-Based Allosteric MEK Inhibitors: Discovery and Optimization Efforts toward XL518 (GDC-0973)
Rice, Kenneth D, Aay, Naing, Anand, Neel K, Blazey, Charles M, Bowles, Owen J, Bussenius, Joerg, Costanzo, Simona, Curtis, Jeffry K, Defina, Steven C, Dubenko, Larisa, Engst, Stefan, Joshi, Anagha A, Kennedy, Abigail R, Kim, Angie I, Koltun, Elena S, Lougheed, Julie C, Manalo, Jean-Claire L, Martini, Jean-Francois, Nuss, John M, Peto, Csaba J, Tsang, Tsze H, Yu, Peiwen, Johnston, Stuart
Published in ACS medicinal chemistry letters (10.05.2012)
Published in ACS medicinal chemistry letters (10.05.2012)
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Journal Article
Discovery of XL888: A novel tropane-derived small molecule inhibitor of HSP90
Bussenius, Joerg, Blazey, Charles M., Aay, Naing, Anand, Neel K., Arcalas, Arlyn, Baik, TaeGon, Bowles, Owen J., Buhr, Chris A., Costanzo, Simona, Curtis, Jeffrey K., DeFina, Steven C., Dubenko, Larisa, Heuer, Timothy S., Huang, Ping, Jaeger, Christopher, Joshi, Anagha, Kennedy, Abigail R., Kim, Angie I., Lara, Katherine, Lee, Jae, Li, Jonathan, Lougheed, Julie C., Ma, Sunghoon, Malek, Shiva, Manalo, Jean-Claire L., Martini, Jean-Francois, McGrath, Garth, Nicoll, Monique, Nuss, John M., Pack, Michael, Peto, Csaba J., Tsang, Tsze H., Wang, Longcheng, Womble, Scott W., Yakes, Michael, Zhang, Wentao, Rice, Kenneth D.
Published in Bioorganic & medicinal chemistry letters (01.09.2012)
Published in Bioorganic & medicinal chemistry letters (01.09.2012)
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Journal Article
The First Formal Asymmetric Synthesis of Phorbol
Wender, Paul A, Rice, Kenneth D, Schnute, Mark E
Published in Journal of the American Chemical Society (20.08.1997)
Published in Journal of the American Chemical Society (20.08.1997)
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Journal Article
Pyrazolopyrimidines as dual Akt/p70S6K inhibitors
Rice, Kenneth D., Kim, Moon H., Bussenius, Joerg, Anand, Neel K., Blazey, Charles M., Bowles, Owen J., Canne-Bannen, Lynne, Chan, Diva S.-M., Chen, Baili, Co, Erick W., Costanzo, Simona, DeFina, Steven C., Dubenko, Larisa, Engst, Stefan, Franzini, Maurizio, Huang, Ping, Jammalamadaka, Vasu, Khoury, Richard G., Klein, Rhett R., Laird, A.Douglas, Le, Donna T., Mac, Morrison B., Matthews, David J., Markby, David, Miller, Nicole, Nuss, John M., Parks, Jason J., Tsang, Tsze H., Tsuhako, Amy L., Wang, Yong, Xu, Wei
Published in Bioorganic & medicinal chemistry letters (15.04.2012)
Published in Bioorganic & medicinal chemistry letters (15.04.2012)
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Journal Article
Design and evaluation of a series of pyrazolopyrimidines as p70S6K inhibitors
Bussenius, Joerg, Anand, Neel K., Blazey, Charles M., Bowles, Owen J., Bannen, Lynne Canne, Chan, Diva S.-M., Chen, Baili, Co, Erick W., Costanzo, Simona, DeFina, Steven C., Dubenko, Larisa, Engst, Stefan, Franzini, Maurizio, Huang, Ping, Jammalamadaka, Vasu, Khoury, Richard G., Kim, Moon H., Klein, Rhett R., Laird, Douglas, Le, Donna T., Mac, Morrison B., Matthews, David J., Markby, David, Miller, Nicole, Nuss, John M., Parks, Jason J., Tsang, Tsze H., Tsuhako, Amy L., Wang, Yong, Xu, Wei, Rice, Kenneth D.
Published in Bioorganic & medicinal chemistry letters (15.03.2012)
Published in Bioorganic & medicinal chemistry letters (15.03.2012)
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Journal Article
Dibasic inhibitors of human mast cell tryptase. Part 2: Structure–activity relationships and requirements for potent activity
Rice, Kenneth D, Wang, Vivian R, Gangloff, Anthony R, Kuo, Elaine Y.-L, Dener, Jeffrey M, Newcomb, William S, Young, Wendy B, Putnam, Daun, Cregar, Lynne, Wong, Martin, Simpson, Paul J
Published in Bioorganic & medicinal chemistry letters (16.10.2000)
Published in Bioorganic & medicinal chemistry letters (16.10.2000)
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Journal Article
Dibasic inhibitors of human mast cell tryptase. Part 1: Synthesis and optimization of a novel class of inhibitors
Rice, Kenneth D, Gangloff, Anthony R, Kuo, Elaine Y.-L, Dener, Jeffrey M, Wang, Vivian R, Lum, Robert, Newcomb, William S, Havel, Chris, Putnam, Daun, Cregar, Lynne, Wong, Martin, Warne, Robert L
Published in Bioorganic & medicinal chemistry letters (16.10.2000)
Published in Bioorganic & medicinal chemistry letters (16.10.2000)
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Journal Article
Dibasic Inhibitors of Human Mast Cell Tryptase. Part 3: Identification of a Series of Potent and Selective Inhibitors Containing the Benzamidine Functionality
Dener, Jeffrey M., Rice, Kenneth D., Newcomb, William S., Wang, Vivian R., Young, Wendy B., Gangloff, Anthony R., Kuo, Elaine Y.-L., Cregar, Lynne, Putnam, Daun, Wong, Martin
Published in Bioorganic & medicinal chemistry letters (09.07.2001)
Published in Bioorganic & medicinal chemistry letters (09.07.2001)
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Journal Article
Monocharged inhibitors of mast cell tryptase derived from potent and selective dibasic inhibitors
Dener, Jeffrey M, Wang, Vivian R, Rice, Kenneth D, Gangloff, Anthony R, Kuo, Elaine Y.-L, Newcomb, William S, Putnam, Daun, Wong, Martin
Published in Bioorganic & medicinal chemistry letters (03.09.2001)
Published in Bioorganic & medicinal chemistry letters (03.09.2001)
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Journal Article
Inhibitors of tryptase for the treatment of mast cell-mediated diseases
Rice, K D, Tanaka, R D, Katz, B A, Numerof, R P, Moore, W R
Published in Current pharmaceutical design (01.10.1998)
Published in Current pharmaceutical design (01.10.1998)
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