Approach for targeting Ras with small molecules that activate SOS-mediated nucleotide exchange
Burns, Michael C., Qi Sun, Daniels, R. Nathan, Camper, DeMarco, Kennedy, J. Phillip, Phan, Jason, Olejniczak, Edward T., Lee, Taekyu, Waterson, Alex G., Rossanese, Olivia W., Fesik, Stephen W.
Published in Proceedings of the National Academy of Sciences - PNAS (04.03.2014)
Published in Proceedings of the National Academy of Sciences - PNAS (04.03.2014)
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Loss of Phosphatase and Tensin Homologue Deleted on Chromosome 10 Engages ErbB3 and Insulin-Like Growth Factor-I Receptor Signaling to Promote Antiestrogen Resistance in Breast Cancer
MILLER MARIANELA PEREZ-TORRES, Todd W, NARASANNA, Archana, ARTEAGA, Carlos L, GUIX, Marta, STAL, Olle, PEREZ-TENORIO, Gizeh, GONZALEZ-ANGULO, Ana M, HENNESSY, Bryan T, MILLS, Gordon B, KENNEDY, J. Phillip, LINDSLEY, Craig W
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Published in Cancer research (Chicago, Ill.) (15.05.2009)
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Centrally Active Allosteric Potentiators of the M4 Muscarinic Acetylcholine Receptor Reverse Amphetamine-Induced Hyperlocomotor Activity in Rats
Brady, Ashley E, Jones, Carrie K, Bridges, Thomas M, Kennedy, J Phillip, Thompson, Analisa D, Heiman, Justin U, Breininger, Micah L, Gentry, Patrick R, Yin, Huiyong, Jadhav, Satyawan B, Shirey, Jana K, Conn, P Jeffrey, Lindsley, Craig W
Published in The Journal of pharmacology and experimental therapeutics (01.12.2008)
Published in The Journal of pharmacology and experimental therapeutics (01.12.2008)
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Inhibition of Mammalian Target of Rapamycin Is Required for Optimal Antitumor Effect of HER2 Inhibitors against HER2-Overexpressing Cancer Cells
MILLER, Todd W, FORBES, James T, COOK, Rebecca S, KENNEDY, J. Phillip, LINDSLEY, Craig W, ARTEAGA, Carlos L, SHAH, Chirayu, WYATT, Shelby K, MANNING, H. Charles, OLIVARES, Maria G, SANCHEZ, Violeta, DUGGER, Teresa C, DE MATOS GRANJA, Nara, NARASANNA, Archana
Published in Clinical cancer research (01.12.2009)
Published in Clinical cancer research (01.12.2009)
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Insulin reveals Akt signaling as a novel regulator of norepinephrine transporter trafficking and norepinephrine homeostasis
Robertson, Sabrina D, Matthies, Heinrich J G, Owens, W Anthony, Sathananthan, Vidiya, Christianson, Nicole S Bibus, Kennedy, J Phillip, Lindsley, Craig W, Daws, Lynette C, Galli, Aurelio
Published in The Journal of neuroscience (25.08.2010)
Published in The Journal of neuroscience (25.08.2010)
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Chemical lead optimization of a pan Gq mAChR M1, M3, M5 positive allosteric modulator (PAM) lead. Part II: Development of a potent and highly selective M1 PAM
BRIDGES, Thomas M, PHILLIP KENNEDY, J, NOETZEL, Meredith J, BREININGER, Micah L, GENTRY, Patrick R, CONN, P. Jeffrey, LINDSLEY, Craig W
Published in Bioorganic & medicinal chemistry letters (15.03.2010)
Published in Bioorganic & medicinal chemistry letters (15.03.2010)
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A novel class of H3 antagonists derived from the natural product guided synthesis of unnatural analogs of the marine bromopyrrole alkaloid dispyrin
KENNEDY, J. Phillip, CONN, P. Jeffrey, LINDSLEY, Craig W
Published in Bioorganic & medicinal chemistry letters (15.06.2009)
Published in Bioorganic & medicinal chemistry letters (15.06.2009)
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Synthesis and SAR of analogues of the M1 allosteric agonist TBPB. Part I: Exploration of alternative benzyl and privileged structure moieties
Bridges, Thomas M., Brady, Ashley E., Phillip Kennedy, J., Nathan Daniels, R., Miller, Nicole R., Kim, Kwango, Breininger, Micah L., Gentry, Patrick R., Brogan, John T., Jones, Carrie K., Jeffrey Conn, P., Lindsley, Craig W.
Published in Bioorganic & medicinal chemistry (15.10.2008)
Published in Bioorganic & medicinal chemistry (15.10.2008)
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Synthesis and Structure–Activity Relationships of Allosteric Potentiators of the M4 Muscarinic Acetylcholine Receptor
Kennedy, J. Phillip, Bridges, Thomas M., Gentry, Patrick R., Brogan, John T., Kane, Alexander S., Jones, Carrie K., Brady, Ashley E., Shirey, Jana K., Conn, P. Jeffrey, Lindsley, Craig W.
Published in ChemMedChem (05.10.2009)
Published in ChemMedChem (05.10.2009)
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Discovery of Aminopiperidine Indoles That Activate the Guanine Nucleotide Exchange Factor SOS1 and Modulate RAS Signaling
Abbott, Jason R, Hodges, Timothy R, Daniels, R. Nathan, Patel, Pratiq A, Kennedy, J. Phillip, Howes, Jennifer E, Akan, Denis T, Burns, Michael C, Sai, Jiqing, Sobolik, Tammy, Beesetty, Yugandhar, Lee, Taekyu, Rossanese, Olivia W, Phan, Jason, Waterson, Alex G, Fesik, Stephen W
Published in Journal of medicinal chemistry (26.07.2018)
Published in Journal of medicinal chemistry (26.07.2018)
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A Selective Allosteric Potentiator of the M1 Muscarinic Acetylcholine Receptor Increases Activity of Medial Prefrontal Cortical Neurons and Restores Impairments in Reversal Learning
Shirey, Jana K, Brady, Ashley E, Jones, Paulianda J, Davis, Albert A, Bridges, Thomas M, Kennedy, J. Phillip, Jadhav, Satyawan B, Menon, Usha N, Xiang, Zixiu, Watson, Mona L, Christian, Edward P, Doherty, James J, Quirk, Michael C, Snyder, Dean H, Lah, James J, Levey, Allan I, Nicolle, Michelle M, Lindsley, Craig W, Conn, P. Jeffrey
Published in The Journal of neuroscience (11.11.2009)
Published in The Journal of neuroscience (11.11.2009)
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Discovery of a Potent Inhibitor of Replication Protein A Protein–Protein Interactions Using a Fragment-Linking Approach
Frank, Andreas O, Feldkamp, Michael D, Kennedy, J. Phillip, Waterson, Alex G, Pelz, Nicholas F, Patrone, James D, Vangamudi, Bhavatarini, Camper, DeMarco V, Rossanese, Olivia W, Chazin, Walter J, Fesik, Stephen W
Published in Journal of medicinal chemistry (27.11.2013)
Published in Journal of medicinal chemistry (27.11.2013)
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Novel Selective Allosteric Activator of the M1 Muscarinic Acetylcholine Receptor Regulates Amyloid Processing and Produces Antipsychotic-Like Activity in Rats
Jones, Carrie K, Brady, Ashley E, Davis, Albert A, Xiang, Zixiu, Bubser, Michael, Tantawy, Mohammed Noor, Kane, Alexander S, Bridges, Thomas M, Kennedy, J. Phillip, Bradley, Stefania R, Peterson, Todd E, Ansari, M. Sib, Baldwin, Ronald M, Kessler, Robert M, Deutch, Ariel Y, Lah, James J, Levey, Allan I, Lindsley, Craig W, Conn, P. Jeffrey
Published in The Journal of neuroscience (08.10.2008)
Published in The Journal of neuroscience (08.10.2008)
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Discovery of Quinazolines That Activate SOS1-Mediated Nucleotide Exchange on RAS
Abbott, Jason R, Patel, Pratiq A, Howes, Jennifer E, Akan, Denis T, Kennedy, J. Phillip, Burns, Michael C, Browning, Carrie F, Sun, Qi, Rossanese, Olivia W, Phan, Jason, Waterson, Alex G, Fesik, Stephen W
Published in ACS medicinal chemistry letters (13.09.2018)
Published in ACS medicinal chemistry letters (13.09.2018)
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Total synthesis of Eudistomins Y 1–Y 6
Phillip Kennedy, J., Breininger, Micah L., Lindsley, Craig W.
Published in Tetrahedron letters (16.12.2009)
Published in Tetrahedron letters (16.12.2009)
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