ABT-263: a potent and orally bioavailable Bcl-2 family inhibitor
Tse, Christin, Shoemaker, Alexander R, Adickes, Jessica, Anderson, Mark G, Chen, Jun, Jin, Sha, Johnson, Eric F, Marsh, Kennan C, Mitten, Michael J, Nimmer, Paul, Roberts, Lisa, Tahir, Stephen K, Xiao, Yu, Yang, Xiufen, Zhang, Haichao, Fesik, Stephen, Rosenberg, Saul H, Elmore, Steven W
Published in Cancer research (Chicago, Ill.) (01.05.2008)
Published in Cancer research (Chicago, Ill.) (01.05.2008)
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Discovery of an Orally Bioavailable Small Molecule Inhibitor of Prosurvival B-Cell Lymphoma 2 Proteins
Park, Cheol-Min, Bruncko, Milan, Adickes, Jessica, Bauch, Joy, Ding, Hong, Kunzer, Aaron, Marsh, Kennan C, Nimmer, Paul, Shoemaker, Alexander R, Song, Xiaohong, Tahir, Stephen K, Tse, Christin, Wang, Xilu, Wendt, Michael D, Yang, Xiufen, Zhang, Haichao, Fesik, Stephen W, Rosenberg, Saul H, Elmore, Steven W
Published in Journal of medicinal chemistry (13.11.2008)
Published in Journal of medicinal chemistry (13.11.2008)
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Discovery of the Poly(ADP-ribose) Polymerase (PARP) Inhibitor 2-[(R)-2-methylpyrrolidin-2-yl]-1H-benzimidazole-4-carboxamide (ABT-888) for the Treatment of Cancer
Penning, Thomas D, Zhu, Gui-Dong, Gandhi, Viraj B, Gong, Jianchun, Liu, Xuesong, Shi, Yan, Klinghofer, Vered, Johnson, Eric F, Donawho, Cherrie K, Frost, David J, Bontcheva-Diaz, Velitchka, Bouska, Jennifer J, Osterling, Donald J, Olson, Amanda M, Marsh, Kennan C, Luo, Yan, Giranda, Vincent L
Published in Journal of medicinal chemistry (22.01.2009)
Published in Journal of medicinal chemistry (22.01.2009)
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Journal Article
Validation of Diacyl Glycerolacyltransferase I as a Novel Target for the Treatment of Obesity and Dyslipidemia Using a Potent and Selective Small Molecule Inhibitor
Zhao, Gang, Souers, Andrew J, Voorbach, Martin, Falls, H. Doug, Droz, Brian, Brodjian, Sevan, Lau, Yau Yi, Iyengar, Rajesh R, Gao, Ju, Judd, Andrew S, Wagaw, Seble H, Ravn, Matthew M, Engstrom, Kenneth M, Lynch, John K, Mulhern, Mathew M, Freeman, Jennifer, Dayton, Brian D, Wang, Xiaojun, Grihalde, Nelson, Fry, Dennis, Beno, David W. A, Marsh, Kennan C, Su, Zhi, Diaz, Gilbert J, Collins, Christine A, Sham, Hing, Reilly, Regina M, Brune, Michael E, Kym, Philip R
Published in Journal of medicinal chemistry (14.02.2008)
Published in Journal of medicinal chemistry (14.02.2008)
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4-(2-[2-(2(R)-Methylpyrrolidin-1-yl)ethyl]benzofuran-5-yl)benzonitrile and Related 2-Aminoethylbenzofuran H3 Receptor Antagonists Potently Enhance Cognition and Attention
Cowart, Marlon, Faghih, Ramin, Curtis, Michael P, Gfesser, Gregory A, Bennani, Youssef L, Black, Lawrence A, Pan, Liping, Marsh, Kennan C, Sullivan, James P, Esbenshade, Timothy A, Fox, Gerard B, Hancock, Arthur A
Published in Journal of medicinal chemistry (13.01.2005)
Published in Journal of medicinal chemistry (13.01.2005)
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Evoked Changes in Cardiovascular Function in Rats by Infusion of Levosimendan, OR-1896 [(R)-N-(4-(4-Methyl-6-oxo-1,4,5,6-tetrahydropyridazin-3-yl)phenyl)acetamide], OR-1855 [(R)-6-(4-Aminophenyl)-5-methyl-4,5-dihydropyridazin-3(2H)-one], Dobutamine, and Milrinone: Comparative Effects on Peripheral Resistance, Cardiac Output, dP/dt, Pulse Rate, and Blood Pressure
Segreti, Jason A, Marsh, Kennan C, Polakowski, James S, Fryer, Ryan M
Published in The Journal of pharmacology and experimental therapeutics (01.04.2008)
Published in The Journal of pharmacology and experimental therapeutics (01.04.2008)
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Journal Article
Discovery of 4-(5-(4-Chlorophenyl)-2-methyl-3-propionyl-1H-pyrrol-1-yl)benzenesulfonamide (A-867744) as a Novel Positive Allosteric Modulator of the α7 Nicotinic Acetylcholine Receptor
Faghih, Ramin, Gopalakrishnan, Sujatha M, Gronlien, Jens Halvard, Malysz, John, Briggs, Clark A, Wetterstrand, Caroline, Ween, Hilde, Curtis, Michael P, Sarris, Kathy A, Gfesser, Gregory A, El-Kouhen, Rachid, Robb, Holly M, Radek, Richard J, Marsh, Kennan C, Bunnelle, William H, Gopalakrishnan, Murali
Published in Journal of medicinal chemistry (28.05.2009)
Published in Journal of medicinal chemistry (28.05.2009)
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Thrombospondin-1 Mimetic Peptide Inhibitors of Angiogenesis and Tumor Growth: Design, Synthesis, and Optimization of Pharmacokinetics and Biological Activities
Haviv, Fortuna, Bradley, Michael F, Kalvin, Douglas M, Schneider, Andrew J, Davidson, Donald J, Majest, Sandra M, McKay, Laura M, Haskell, Catherine J, Bell, Randy L, Nguyen, Bach, Marsh, Kennan C, Surber, Bruce W, Uchic, John T, Ferrero, James, Wang, Yi-Chun, Leal, Juan, Record, Rae D, Hodde, Jason, Badylak, Stephen F, Lesniewski, Richard R, Henkin, Jack
Published in Journal of medicinal chemistry (21.04.2005)
Published in Journal of medicinal chemistry (21.04.2005)
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Discovery of Novel p-Arylthio Cinnamides as Antagonists of Leukocyte Function-Associated Antigen-1/Intracellular Adhesion Molecule-1 Interaction. 1. Identification of an Additional Binding Pocket Based on an Anilino Diaryl Sulfide Lead
Liu, Gang, Link, J. T, Pei, Zhonghua, Reilly, Edward B, Leitza, Sandra, Nguyen, Bach, Marsh, Kennan C, Okasinski, Gregory F, von Geldern, Thomas W, Ormes, Mark, Fowler, Kerry, Gallatin, Mike
Published in Journal of medicinal chemistry (19.10.2000)
Published in Journal of medicinal chemistry (19.10.2000)
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Journal Article
Venetoclax pharmacokinetics in participants with end‐stage renal disease undergoing haemodialysis
Noorani, Behnam, Menon, Rajeev M., Chen, Xin, Marsh, Kennan C., Huang, Weize, Gupta, Shelly, Dobkowska, Edyta, Marbury, Thomas, Salem, Ahmed Hamed
Published in British journal of clinical pharmacology (01.03.2024)
Published in British journal of clinical pharmacology (01.03.2024)
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Central Mechanisms Regulating Penile Erection in Conscious Rats: The Dopaminergic Systems Related to the Proerectile Effect of Apomorphine
Hsieh, Gin C, Hollingsworth, Peter R, Martino, Brenda, Chang, Renjie, Terranova, Marc A, O'Neill, Alyssa B, Lynch, James J, Moreland, Robert B, Donnelly-Roberts, Diana L, Kolasa, Teodozyi, Mikusa, Joseph P, McVey, Jill M, Marsh, Kennan C, Sullivan, James P, Brioni, Jorge D
Published in The Journal of pharmacology and experimental therapeutics (01.01.2004)
Published in The Journal of pharmacology and experimental therapeutics (01.01.2004)
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Journal Article
Design of a New Histamine H3 Receptor Antagonist Chemotype: (3aR,6aR)-5-Alkyl-1-aryl-octahydropyrrolo[3,4-b]pyrroles, Synthesis, and Structure−Activity Relationships
Zhao, Chen, Sun, Minghua, Bennani, Youssef L, Miller, Thomas R, Witte, David G, Esbenshade, Timothy A, Wetter, Jill, Marsh, Kennan C, Hancock, Arthur A, Brioni, Jorge D, Cowart, Marlon D
Published in Journal of medicinal chemistry (13.08.2009)
Published in Journal of medicinal chemistry (13.08.2009)
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UCT943, a Next-Generation Plasmodium falciparum PI4K Inhibitor Preclinical Candidate for the Treatment of Malaria
Brunschwig, Christel, Lawrence, Nina, Taylor, Dale, Abay, Efrem, Njoroge, Mathew, Basarab, Gregory S, Le Manach, Claire, Paquet, Tanya, Cabrera, Diego Gonzàlez, Nchinda, Aloysius T, de Kock, Carmen, Wiesner, Lubbe, Denti, Paolo, Waterson, David, Blasco, Benjamin, Leroy, Didier, Witty, Michael J, Donini, Cristina, Duffy, James, Wittlin, Sergio, White, Karen L, Charman, Susan A, Jiménez-Díaz, Maria Belén, Angulo-Barturen, Iñigo, Herreros, Esperanza, Gamo, Francisco Javier, Rochford, Rosemary, Mancama, Dalu, Coetzer, Theresa L, van der Watt, Mariëtte E, Reader, Janette, Birkholtz, Lyn-Marie, Marsh, Kennan C, Solapure, Suresh M, Burke, John E, McPhail, Jacob A, Vanaerschot, Manu, Fidock, David A, Fish, Paul V, Siegl, Peter, Smith, Dennis A, Wirjanata, Grennady, Noviyanti, Rintis, Price, Ric N, Marfurt, Jutta, Silue, Kigbafori D, Street, Leslie J, Chibale, Kelly
Published in Antimicrobial agents and chemotherapy (01.09.2018)
Published in Antimicrobial agents and chemotherapy (01.09.2018)
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Bumped Kinase Inhibitors as therapy for apicomplexan parasitic diseases: lessons learned
Choi, Ryan, Hulverson, Matthew A., Huang, Wenlin, Vidadala, Rama S.R., Whitman, Grant R., Barrett, Lynn K., Schaefer, Deborah A., Betzer, Dana P., Riggs, Michael W., Doggett, J. Stone, Hemphill, Andrew, Ortega-Mora, Luis Miguel, McCloskey, Molly C., Arnold, Samuel L.M., Hackman, Robert C., Marsh, Kennan C., Lynch, James J., Freiberg, Gail M., Leroy, Bruce E., Kempf, Dale J., Choy, Robert K.M., de Hostos, Eugenio L., Maly, Dustin J., Fan, Erkang, Ojo, Kayode K., Van Voorhis, Wesley C.
Published in International journal for parasitology (01.05.2020)
Published in International journal for parasitology (01.05.2020)
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Novel heterocyclic-substituted benzofuran histamine H3 receptor antagonists: in vitro properties, drug-likeness, and behavioral activity
Cowart, Marlon, Gfesser, Gregory A, Browman, Kaitlin E, Faghih, Ramin, Miller, Thomas R, Milicic, Ivan, Baranowski, John L, Krueger, Kathleen M, Witte, David G, Molesky, Angela L, Komater, Victoria A, Buckley, Michael J, Diaz, Gilbert J, Gagne, Gerard D, Zhou, Deliang, Deng, Xiaoqing, Pan, Liping, Roberts, Ellen M, Diehl, Marilyn S, Wetter, Jill M, Marsh, Kennan C, Fox, Gerard B, Brioni, Jorge D, Esbenshade, Timothy A, Hancock, Arthur A
Published in Biochemical pharmacology (15.04.2007)
Published in Biochemical pharmacology (15.04.2007)
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Comparison of Toxicities among Different Bumped Kinase Inhibitor Analogs for Treatment of Cryptosporidiosis
Hulverson, Matthew A, Choi, Ryan, Schaefer, Deborah A, Betzer, Dana P, McCloskey, Molly C, Whitman, Grant R, Huang, Wenlin, Lee, Sangun, Pranata, Andy, McLeod, Malcolm D, Marsh, Kennan C, Kempf, Dale J, LeRoy, Bruce E, Zafiratos, Mark T, Bielinski, Aimee L, Hackman, Robert C, Ojo, Kayode K, Arnold, Samuel L M, Barrett, Lynn K, Tzipori, Saul, Riggs, Michael W, Fan, Erkang, Van Voorhis, Wesley C
Published in Antimicrobial agents and chemotherapy (18.04.2023)
Published in Antimicrobial agents and chemotherapy (18.04.2023)
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A Phase-I pharmacokinetic, safety and food-effect study on flubentylosin, a novel analog of Tylosin-A having potent anti-Wolbachia and antifilarial activity
Alami, Negar, Carter, David C, Kwatra, Nisha V, Zhao, Weihan, Snodgrass, Linda, Porcalla, Ariel R, Klein, Cheri E, Cohen, Daniel E, Gallenberg, Loretta, Neenan, Melina, Carr, Robert A, Marsh, Kennan C, Kempf, Dale J
Published in PLoS neglected tropical diseases (10.07.2023)
Published in PLoS neglected tropical diseases (10.07.2023)
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AhR activation underlies the CYP1A autoinduction by A-998679 in rats
Liguori, Michael J, Lee, Chih-Hung, Liu, Hong, Ciurlionis, Rita, Ditewig, Amy C, Doktor, Stella, Andracki, Mark E, Gagne, Gerard D, Waring, Jeffrey F, Marsh, Kennan C, Gopalakrishnan, Murali, Blomme, Eric A G, Yang, Yi
Published in Frontiers in genetics (2012)
Published in Frontiers in genetics (2012)
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Expanding the Repertoire for "Large Small Molecules": Prodrug ABBV-167 Efficiently Converts to Venetoclax with Reduced Food Effect in Healthy Volunteers
Salem, Ahmed Hamed, Tao, Zhi-Fu, Bueno, Orlando F, Chen, Jie, Chen, Shuang, Edalji, Rohinton, Elmore, Steven W, Fournier, Keith M, Harper, Kaid C, Hong, Richard, Jenkins, Gary J, Ji, Jianguo, Judge, Russell A, Kalvass, John C, Klix, Russell C, Ku, Yi-Yin, Leverson, Joel D, Marks, Richard A, Marsh, Kennan C, Menon, Rajeev M, Park, Chang H, Phillips, Darren C, Pu, Yu-Ming, Rosenberg, Saul H, Sanzgiri, Yeshwant D, Sheikh, Ahmad Y, Shi, Yi, Stolarik, Deanne, Suleiman, Ahmed A, Wang, Xilu, Zhang, Geoff G Z, Catron, Nathaniel D, Souers, Andrew J
Published in Molecular cancer therapeutics (01.06.2021)
Published in Molecular cancer therapeutics (01.06.2021)
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