Search Results - "KENJI MORIKAMI" :: K.UTB vyhledávací portál | TBU Library Retrieval Portal

Disruption of CRAF-Mediated MEK Activation Is Required for Effective MEK Inhibition in KRAS Mutant Tumors

Disruption of CRAF-Mediated MEK Activation Is Required for Effective MEK Inhibition in KRAS Mutant Tumors

by Lito, Piro, Saborowski, Anna, Yue, Jingyin, Solomon, Martha, Joseph, Eric, Gadal, Sunyana, Saborowski, Michael, Kastenhuber, Edward, Fellmann, Christof, Ohara, Kazuhiro, Morikami, Kenji, Miura, Takaaki, Lukacs, Christine, Ishii, Nobuya, Lowe, Scott, Rosen, Neal
Published in Cancer cell (12.05.2014)

Get full text

Journal Article

Halogen Bonding at the Active Sites of Human Cathepsin L and MEK1 Kinase: Efficient Interactions in Different Environments

Halogen Bonding at the Active Sites of Human Cathepsin L and MEK1 Kinase: Efficient Interactions in Different Environments

by Hardegger, Leo A., Kuhn, Bernd, Spinnler, Beat, Anselm, Lilli, Ecabert, Robert, Stihle, Martine, Gsell, Bernard, Thoma, Ralf, Diez, Joachim, Benz, Jörg, Plancher, Jean-Marc, Hartmann, Guido, Isshiki, Yoshiaki, Morikami, Kenji, Shimma, Nobuo, Haap, Wolfgang, Banner, David W., Diederich, François
Published in ChemMedChem (04.11.2011)

Get full text

Journal Article

Discovery and biological activity of a novel class I PI3K inhibitor, CH5132799

Discovery and biological activity of a novel class I PI3K inhibitor, CH5132799

by Ohwada, Jun, Ebiike, Hirosato, Kawada, Hatsuo, Tsukazaki, Masao, Nakamura, Mitsuaki, Miyazaki, Takuya, Morikami, Kenji, Yoshinari, Kiyoshi, Yoshida, Miyuki, Kondoh, Osamu, Kuramoto, Shino, Ogawa, Kotaro, Aoki, Yuko, Shimma, Nobuo
Published in Bioorganic & medicinal chemistry letters (15.03.2011)

Get full text

Journal Article

Development of a Method for Converting a TAK1 Type I Inhibitor into a Type II or c-Helix-Out Inhibitor by Structure-Based Drug Design (SBDD)

Development of a Method for Converting a TAK1 Type I Inhibitor into a Type II or c-Helix-Out Inhibitor by Structure-Based Drug Design (SBDD)

by Muraoka, Terushige, Ide, Mitsuaki, Irie, Machiko, Morikami, Kenji, Miura, Takaaki, Nishihara, Masamichi, Kashiwagi, Hirotaka
Published in Chemical & pharmaceutical bulletin (2016)

Get full text

Journal Article

Monte Carlo Simulations on Atropisomerism of Thienotriazolodiazepines Applicable to Slow Transition Phenomena Using Potential Energy Surfaces by ab initio Molecular Orbital Calculations

Monte Carlo Simulations on Atropisomerism of Thienotriazolodiazepines Applicable to Slow Transition Phenomena Using Potential Energy Surfaces by ab initio Molecular Orbital Calculations

by Morikami, Kenji, Itezono, Yoshiko, Nishimoto, Masahiro, Ohta, Masateru
Published in Chemical & pharmaceutical bulletin (2014)

Get full text

Journal Article

Effects of fluorines on nonsecosteroidal vitamin D receptor agonists

Effects of fluorines on nonsecosteroidal vitamin D receptor agonists

by Kashiwagi, Hirotaka, Ohta, Masateru, Ono, Yoshiyuki, Morikami, Kenji, Itoh, Susumu, Sato, Hideki, Takahashi, Tadakatsu
Published in Bioorganic & medicinal chemistry (01.02.2013)

Get full text

Journal Article

Synthesis and biological activities of benzofuran antifungal agents targeting fungal N-myristoyltransferase

Synthesis and biological activities of benzofuran antifungal agents targeting fungal N-myristoyltransferase

by Masubuchi, Miyako, Ebiike, Hirosato, Kawasaki, Ken-ichi, Sogabe, Satoshi, Morikami, Kenji, Shiratori, Yasuhiko, Tsujii, Shinji, Fujii, Toshihiko, Sakata, Kiyoaki, Hayase, Michiko, Shindoh, Hidetoshi, Aoki, Yuko, Ohtsuka, Tatsuo, Shimma, Nobuo
Published in Bioorganic & medicinal chemistry (01.10.2003)

Get full text

Journal Article

Optimizing the Physicochemical Properties of Raf/MEK Inhibitors by Nitrogen Scanning

Optimizing the Physicochemical Properties of Raf/MEK Inhibitors by Nitrogen Scanning

by Aoki, Toshihiro, Hyohdoh, Ikumi, Furuichi, Noriyuki, Ozawa, Sawako, Watanabe, Fumio, Matsushita, Masayuki, Sakaitani, Masahiro, Morikami, Kenji, Takanashi, Kenji, Harada, Naoki, Tomii, Yasushi, Shiraki, Koji, Furumoto, Kentaro, Tabo, Mitsuyasu, Yoshinari, Kiyoshi, Ori, Kazutomo, Aoki, Yuko, Shimma, Nobuo, Iikura, Hitoshi
Published in ACS medicinal chemistry letters (10.04.2014)

Get full text

Journal Article

Design and synthesis of novel benzofurans as a new class of antifungal agents targeting fungal N-myristoyltransferase. Part 3

Design and synthesis of novel benzofurans as a new class of antifungal agents targeting fungal N-myristoyltransferase. Part 3

by Kawasaki, Ken-ichi, Masubuchi, Miyako, Morikami, Kenji, Sogabe, Satoshi, Aoyama, Tsunehisa, Ebiike, Hirosato, Niizuma, Satoshi, Hayase, Michiko, Fujii, Toshihiko, Sakata, Kiyoaki, Shindoh, Hidetoshi, Shiratori, Yasuhiko, Aoki, Yuko, Ohtsuka, Tatsuo, Shimma, Nobuo
Published in Bioorganic & medicinal chemistry letters (06.01.2003)

Get full text

Journal Article

Development of a Method for Converting a TAK1 Type I Inhibitor into a Type II or c-Helix-Out Inhibitor by Structure-Based Drug Design (SBDD)

Development of a Method for Converting a TAK1 Type I Inhibitor into a Type II or c-Helix-Out Inhibitor by Structure-Based Drug Design (SBDD)

by Terushige Muraokaa, Mitsuaki Idea, Machiko Irieb, Kenji Morikamia, Takaaki Miurab, Masamichi Nishiharaa, Hirotaka Kashiwagia
Published in Chemical and Pharmaceutical Bulletin (01.11.2016)

Get full text

Journal Article

The fibroblast growth factor receptor genetic status as a potential predictor of the sensitivity to CH5183284/Debio 1347, a novel selective FGFR inhibitor

The fibroblast growth factor receptor genetic status as a potential predictor of the sensitivity to CH5183284/Debio 1347, a novel selective FGFR inhibitor

by Nakanishi, Yoshito, Akiyama, Nukinori, Tsukaguchi, Toshiyuki, Fujii, Toshihiko, Sakata, Kiyoaki, Sase, Hitoshi, Isobe, Takehito, Morikami, Kenji, Shindoh, Hidetoshi, Mio, Toshiyuki, Ebiike, Hirosato, Taka, Naoki, Aoki, Yuko, Ishii, Nobuya
Published in Molecular cancer therapeutics (01.11.2014)

Get full text

Journal Article

Discovery of [5-Amino-1-(2-methyl‑3H‑benzimidazol-5-yl)pyrazol-4-yl]-(1H‑indol-2-yl)methanone (CH5183284/Debio 1347), An Orally Available and Selective Fibroblast Growth Factor Receptor (FGFR) Inhibitor

Discovery of [5-Amino-1-(2-methyl‑3H‑benzimidazol-5-yl)pyrazol-4-yl]-(1H‑indol-2-yl)methanone (CH5183284/Debio 1347), An Orally Available and Selective Fibroblast Growth Factor Receptor (FGFR) Inhibitor

by Ebiike, Hirosato, Taka, Naoki, Matsushita, Masayuki, Ohmori, Masayuki, Takami, Kyoko, Hyohdoh, Ikumi, Kohchi, Masami, Hayase, Tadakatsu, Nishii, Hiroki, Morikami, Kenji, Nakanishi, Yoshito, Akiyama, Nukinori, Shindoh, Hidetoshi, Ishii, Nobuya, Isobe, Takehito, Matsuoka, Hiroharu
Published in Journal of medicinal chemistry (08.12.2016)

Get full text

Journal Article

Discovery of a potent and highly selective transforming growth factor β receptor-associated kinase 1 (TAK1) inhibitor by structure based drug design (SBDD)

Discovery of a potent and highly selective transforming growth factor β receptor-associated kinase 1 (TAK1) inhibitor by structure based drug design (SBDD)

by Muraoka, Terushige, Ide, Mitsuaki, Morikami, Kenji, Irie, Machiko, Nakamura, Mitsuaki, Miura, Takaaki, Kamikawa, Takayuki, Nishihara, Masamichi, Kashiwagi, Hirotaka
Published in Bioorganic & medicinal chemistry (15.09.2016)

Get full text

Journal Article

Identification of a selective inhibitor of transforming growth factor β-activated kinase 1 by biosensor-based screening of focused libraries

Identification of a selective inhibitor of transforming growth factor β-activated kinase 1 by biosensor-based screening of focused libraries

by Miura, Takaaki, Matsuo, Atsushi, Muraoka, Terushige, Ide, Mitsuaki, Morikami, Kenji, Kamikawa, Takayuki, Nishihara, Masamichi, Kashiwagi, Hirotaka
Published in Bioorganic & medicinal chemistry letters (15.02.2017)

Get full text

Journal Article

Discovery of 6-benzyloxyquinolines as c-Met selective kinase inhibitors

Discovery of 6-benzyloxyquinolines as c-Met selective kinase inhibitors

by Nishii, Hiroki, Chiba, Takashi, Morikami, Kenji, Fukami, Takaaki A., Sakamoto, Hiroshi, Ko, Kwangseok, Koyano, Hiroshi
Published in Bioorganic & medicinal chemistry letters (15.02.2010)

Get full text

Journal Article

Modification of a dihydropyrrolopyrimidine phosphoinositide 3-kinase (PI3K) inhibitor to improve oral bioavailability

Modification of a dihydropyrrolopyrimidine phosphoinositide 3-kinase (PI3K) inhibitor to improve oral bioavailability

by Kawada, Hatsuo, Ebiike, Hirosato, Tsukazaki, Masao, Yamamoto, Shun, Koyama, Kohei, Nakamura, Mitsuaki, Morikami, Kenji, Yoshinari, Kiyoshi, Yoshida, Miyuki, Ogawa, Kotaro, Shinma, Nobuo, Tsukuda, Takuo, Ohwada, Jun
Published in Bioorganic & medicinal chemistry (15.12.2015)

Get full text

Journal Article

Systematic SAR study of the side chain of nonsecosteroidal vitamin D3 analogs

Systematic SAR study of the side chain of nonsecosteroidal vitamin D3 analogs

by Kashiwagi, Hirotaka, Ono, Yoshiyuki, Ohta, Masateru, Morikami, Kenji, Takahashi, Tadakatsu
Published in Bioorganic & medicinal chemistry (15.07.2012)

Get full text

Journal Article

Discovery of novel tetracyclic compounds as anaplastic lymphoma kinase inhibitors

Discovery of novel tetracyclic compounds as anaplastic lymphoma kinase inhibitors

by Kinoshita, Kazutomo, Ono, Yoshiyuki, Emura, Takashi, Asoh, Kohsuke, Furuichi, Noriyuki, Ito, Toshiya, Kawada, Hatsuo, Tanaka, Shota, Morikami, Kenji, Tsukaguchi, Toshiyuki, Sakamoto, Hiroshi, Tsukuda, Takuo, Oikawa, Nobuhiro
Published in Bioorganic & medicinal chemistry letters (15.06.2011)

Get full text

Journal Article

Optimization of the phenylurea moiety in a phosphoinositide 3-kinase (PI3K) inhibitor to improve water solubility and the PK profile by introducing a solubilizing group and ortho substituents

by Kawada, Hatsuo, Ebiike, Hirosato, Tsukazaki, Masao, Yamamoto, Shun, Koyama, Kohei, Nakamura, Mitsuaki, Morikami, Kenji, Yoshinari, Kiyoshi, Yoshida, Miyuki, Ogawa, Kotaro, Shimma, Nobuo, Tsukuda, Takuo, Ohwada, Jun
Published in Bioorganic & medicinal chemistry (01.07.2016)

Get full text

Journal Article

Abstract 4758: Disruption of CRAF-mediated MEK activation is required for effective MEK inhibition in KRAS mutant tumors

Abstract 4758: Disruption of CRAF-mediated MEK activation is required for effective MEK inhibition in KRAS mutant tumors

by Lito, Piro, Saborowski, Anna, Yue, Jingyin, Solomon, Martha, Joseph, Eric, Fellman, Christof, Ohara, Kazuhiro, Morikami, Kenji, Miura, Takaaki, Lucas, Christine, Ishii, Nobuya, Lowe, Scott, Rosen, Neal
Published in Cancer research (Chicago, Ill.) (01.10.2014)

Get full text

Journal Article

1
2
3
4
5
6
7
8
9
Next
[9]