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Brivaracetam: Rationale for discovery and preclinical profile of a selective SV2A ligand for epilepsy treatment

by Klitgaard, Henrik, Matagne, Alain, Nicolas, Jean‐Marie, Gillard, Michel, Lamberty, Yves, De Ryck, Marc, Kaminski, Rafal M., Leclercq, Karine, Niespodziany, Isabelle, Wolff, Christian, Wood, Martyn, Hannestad, Jonas, Kervyn, Sophie, Kenda, Benoit
Published in Epilepsia (Copenhagen) (01.04.2016)

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Journal Article

SV2A protein is a broad-spectrum anticonvulsant target: Functional correlation between protein binding and seizure protection in models of both partial and generalized epilepsy

SV2A protein is a broad-spectrum anticonvulsant target: Functional correlation between protein binding and seizure protection in models of both partial and generalized epilepsy

by Kaminski, Rafal M., Matagne, Alain, Leclercq, Karine, Gillard, Michel, Michel, Philippe, Kenda, Benoit, Talaga, Patrice, Klitgaard, Henrik
Published in Neuropharmacology (01.03.2008)

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Journal Article

Discovery of Heterocyclic Nonacetamide Synaptic Vesicle Protein 2A (SV2A) Ligands with Single-Digit Nanomolar Potency: Opening Avenues towards the First SV2A Positron Emission Tomography (PET) Ligands

Discovery of Heterocyclic Nonacetamide Synaptic Vesicle Protein 2A (SV2A) Ligands with Single-Digit Nanomolar Potency: Opening Avenues towards the First SV2A Positron Emission Tomography (PET) Ligands

by Mercier, Joël, Archen, Laurence, Bollu, Véronique, Carré, Stéphane, Evrard, Yves, Jnoff, Eric, Kenda, Benoît, Lallemand, Bénédicte, Michel, Philippe, Montel, Florian, Moureau, Florence, Price, Nathalie, Quesnel, Yannick, Sauvage, Xavier, Valade, Anne, Provins, Laurent
Published in ChemMedChem (01.04.2014)

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Journal Article

Discovery of 4-Substituted Pyrrolidone Butanamides as New Agents with Significant Antiepileptic Activity

Discovery of 4-Substituted Pyrrolidone Butanamides as New Agents with Significant Antiepileptic Activity

by Kenda, Benoit M, Matagne, Alain C, Talaga, Patrice E, Pasau, Patrick M, Differding, Edmond, Lallemand, Bénédicte I, Frycia, Anne M, Moureau, Florence G, Klitgaard, Henrik V, Gillard, Michel R, Fuks, Bruno, Michel, Philippe
Published in Journal of medicinal chemistry (29.01.2004)

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Journal Article

Profile of the new pyrrolidone derivative seletracetam (ucb 44212) in animal models of epilepsy

by Matagne, Alain, Margineanu, Doru-Georg, Potschka, Heidrun, Löscher, Wolfgang, Michel, Philippe, Kenda, Benoit, Klitgaard, Henrik
Published in European journal of pharmacology (01.07.2009)

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Journal Article

Discovery of Heterocyclic Nonacetamide Synaptic Vesicle Protein2A (SV2A) Ligands with Single-Digit Nanomolar Potency: Opening Avenues towards the First SV2A Positron Emission Tomography (PET) Ligands

Discovery of Heterocyclic Nonacetamide Synaptic Vesicle Protein2A (SV2A) Ligands with Single-Digit Nanomolar Potency: Opening Avenues towards the First SV2A Positron Emission Tomography (PET) Ligands

by Mercier, Joël, Archen, Laurence, Bollu, Véronique, Carre, Stéphane, Evrard, Yves, Jnoff, Eric, Kenda, Benoît, Lallemand, Bénédicte, Michel, Philippe, Montel, Florian, Moureau, Florence, Price, Nathalie, Quesnel, Yannick, Sauvage, Xavier, Valade, Anne, Provins, Laurent
Published in ChemMedChem (01.04.2014)

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Journal Article

[ super(11)C]UCB-A, a novel PET tracer for synaptic vesicle protein 2 A

[ super(11)C]UCB-A, a novel PET tracer for synaptic vesicle protein 2 A

by Estradaa, Sergio, Lubberinkb, Mark, Thibblinb, Alf, Sprychad, Margareta, Buchanane, Tim, Mestdaghe, Nathalie, Kendae, Benoit, Merciere, Joel, Provinse, Laurent, Gillarde, Michel, Tytgate, Dominique, Antonia, Gunnar
Published in Nuclear medicine and biology (01.06.2016)

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Journal Article

Brivaracetam: Rationale for discovery and preclinical profile of a selective SV 2A ligand for epilepsy treatment

by Klitgaard, Henrik, Matagne, Alain, Nicolas, Jean‐Marie, Gillard, Michel, Lamberty, Yves, De Ryck, Marc, Kaminski, Rafal M., Leclercq, Karine, Niespodziany, Isabelle, Wolff, Christian, Wood, Martyn, Hannestad, Jonas, Kervyn, Sophie, Kenda, Benoit
Published in Epilepsia (Copenhagen) (01.04.2016)

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Journal Article

[11C]UCB-A, a novel PET tracer for synaptic vesicle protein 2A

[11C]UCB-A, a novel PET tracer for synaptic vesicle protein 2A

by Estrada, Sergio, Lubberink, Mark, Thibblin, Alf, Sprycha, Margareta, Buchanan, Tim, Mestdagh, Nathalie, Kenda, Benoit, Mercier, Joel, Provins, Laurent, Gillard, Michel, Tytgat, Dominique, Antoni, Gunnar
Published in Nuclear medicine and biology (01.06.2016)

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Journal Article

[11 C]UCB-A, a n3ovel PET tracer for synaptic vesicle protein 2A

[11 C]UCB-A, a n3ovel PET tracer for synaptic vesicle protein 2A

by Estrada, Sergio, Lubberink, Mark, Thibblin, Alf, Sprycha, Margareta, Buchanan, Tim, Mestdagh, Nathalie, Kenda, Benoit, Mercier, Joel, Provins, Laurent, Gillard, Michel, Tytgat, Dominique, Antoni, Gunnar
Published in Nuclear medicine and biology (2016)

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Journal Article

2-Oxo-1-pyrrolidine derivatives, process of their preparation and their use

2-Oxo-1-pyrrolidine derivatives, process of their preparation and their use

by DIFFERDING EDMOND, LALLEMAND BÉNÉDICTE, MICHEL PHILLIPPE, PASAU PATRICK, MATAGNE ALAIN, KENDA BENOIT KENDA, TALAGA PATRICE
Year of Publication 30.04.2014

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Patent

2-Oxo-1-pyrrolidine derivatives, process of their preparation and their use

2-Oxo-1-pyrrolidine derivatives, process of their preparation and their use

by DIFFERDING EDMOND, MICHEL PHILLIPPE, PASAU PATRICK, MATAGNE ALAIN, LALLEMAND BENEDICTE, KENDA BENOIT KENDA, TALAGA PATRICE
Year of Publication 12.02.2003

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Patent

Discovery of Indolone Acetamides as Novel SV2A Ligands with Improved Potency Toward Seizure Suppression

Discovery of Indolone Acetamides as Novel SV2A Ligands with Improved Potency Toward Seizure Suppression

by Frycia, Anne, Starck, Jean-Philippe, Jadot, Sophie, Lallemand, Bénédicte, Leclercq, Karine, Lo Brutto, Patrick, Matagne, Alain, Verbois, Valérie, Mercier, Joël, Kenda, Benoit
Published in ChemMedChem (01.02.2010)

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Journal Article

Cover Picture: Discovery of Indolone Acetamides as Novel SV2A Ligands with Improved Potency Toward Seizure Suppression (ChemMedChem 2/2010)

Cover Picture: Discovery of Indolone Acetamides as Novel SV2A Ligands with Improved Potency Toward Seizure Suppression (ChemMedChem 2/2010)

by Frycia, Anne, Starck, Jean-Philippe, Jadot, Sophie, Lallemand, Bénédicte, Leclercq, Karine, Lo Brutto, Patrick, Matagne, Alain, Verbois, Valérie, Mercier, Joël, Kenda, Benoit
Published in ChemMedChem (01.02.2010)

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Journal Article

CRM1 inhibitors for treating epilepsy

CRM1 inhibitors for treating epilepsy

by Lee, Margaret, Leclercq, Karine, Tamir, Sharon, Kenda, Benoit, De Ryck, Marc, Kaminski, Rafal M
Year of Publication 14.03.2023

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Patent

Stereoselective syntheses of 1,2-dialkyl-1-phenyl cyclopentanes involving intramolecular carbolithiation of olefins

Stereoselective syntheses of 1,2-dialkyl-1-phenyl cyclopentanes involving intramolecular carbolithiation of olefins

by Krief, Alain, Kenda, Benoît, Maertens, Christophe, Remacle, Bruno
Published in Tetrahedron (20.05.1996)

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Journal Article

COMPOUNDS FOR ENHANCING THE COGNITIVE FUNCTION

COMPOUNDS FOR ENHANCING THE COGNITIVE FUNCTION

by JNOFF, ERIC, KENDA, BENOIT
Year of Publication 23.01.2014

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Patent

Methods for Enhancing the Cognitive Function

Methods for Enhancing the Cognitive Function

by MATAGNE ALAIN, KENDA BENOIT
Year of Publication 05.07.2012

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Patent

METHODS FOR ENHANCING THE COGNITIVE FUNCTION

METHODS FOR ENHANCING THE COGNITIVE FUNCTION

by MATAGNE, ALAIN, KENDA, BENOIT
Year of Publication 13.06.2012

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Patent

CRM1 INHIBITORS FOR TREATING EPILEPSY

CRM1 INHIBITORS FOR TREATING EPILEPSY

by Lee, Margaret, Leclercq, Karine, Tamir, Sharon, Kenda, Benoit, De Ryck, Marc, Kaminski, Rafal M
Year of Publication 12.12.2019

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Patent

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