Pharmacokinetic enhancement of inhibitors of the human immunodeficiency virus protease by coadministration with ritonavir
KEMPF, D. J, MARSH, K. C, SUN, E, PIZZUTI, D, PLATTNER, J. J, NORBECK, D. W, LEONARD, J. M, KUMAR, G, RODRIGUES, A. D, DENISSEN, J. F, MCDONALD, E, KUKULKA, M. J, HSU, A, GRANNEMAN, G. R, BAROLDI, P. A
Published in Antimicrobial Agents and Chemotherapy (01.03.1997)
Published in Antimicrobial Agents and Chemotherapy (01.03.1997)
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Journal Article
Identification of Genotypic Changes in Human Immunodeficiency Virus Protease That Correlate with Reduced Susceptibility to the Protease Inhibitor Lopinavir among Viral Isolates from Protease Inhibitor-Experienced Patients
Kempf, D J, Isaacson, J D, King, M S, Brun, S C, Xu, Y, Real, K, Bernstein, B M, Japour, A J, Sun, E, Rode, R A
Published in Journal of Virology (01.08.2001)
Published in Journal of Virology (01.08.2001)
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Journal Article
ABT-378, a Highly Potent Inhibitor of the Human Immunodeficiency Virus Protease
SHAM, H. L, KEMPF, D. J, BETEBENNER, D, KORNEYEVA, M, VASAVANONDA, S, MCDONALD, E, SALDIVAR, A, WIDEBURG, N, XIAOOI CHEN, PING NIU, CHANG PARK, JAYANTI, V, MOLLA, A, GRABOWSKI, B, GRANNEMAN, G. R, SUN, E, JAPOUR, A. J, LEONARD, J. M, PLATTNER, J. J, NORBECK, D. W, MARSH, K. C, KUMAR, G. N, CHEN, C.-M, KATI, W, STEWART, K, LAL, R, HSU, A
Published in Antimicrobial Agents and Chemotherapy (01.12.1998)
Published in Antimicrobial Agents and Chemotherapy (01.12.1998)
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Journal Article
The duration of viral suppression during protease inhibitor therapy for HIV-1 infection is predicted by plasma HIV-1 RNA at the nadir
KEMPF, D. J, RODE, R. A, LEONARD, J. M, YI XU, SUN, E, HEATH-CHIOZZI, M. E, VALDES, J, JAPOUR, A. J, DANNER, S, BOUCHER, C, MOLLA, A
Published in AIDS (London) (26.03.1998)
Published in AIDS (London) (26.03.1998)
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Journal Article
ABT-538 is a Potent Inhibitor of Human Immunodeficiency Virus Protease and has High Oral Bioavailability in Humans
Kempf, Dale J., Marsh, Kennan C., Denissen, Jon F., McDonald, Edith, Vasavanonda, Sudthida, Flentge, Charles A., Green, Brian E., Fino, Lynnmarie, Park, Chang H., Kong, Xiang-Peng, Wideburg, Norman E., Saldivar, Ayda, Ruiz, Lisa, Kati, Warren M., Sham, Hing L., Robins, Terry, Stewart, Kent D., Hsu, Ann, Plattner, Jacob J., Leonard, John M., Norbeck, Daniel W.
Published in Proceedings of the National Academy of Sciences - PNAS (28.03.1995)
Published in Proceedings of the National Academy of Sciences - PNAS (28.03.1995)
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Journal Article
Partial inhibition of the human immunodeficiency virus type 1 protease results in aberrant virus assembly and the formation of noninfectious particles
KAPLAN, A. H, ZACK, J. A, KNIGGE, M, PAUL, D. A, KEMPF, D. J, NORBECK, D. W, SWANSTROM, R
Published in Journal of Virology (01.07.1993)
Published in Journal of Virology (01.07.1993)
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Journal Article
Ritonavir and saquinavir combination therapy for the treatment of HIV infection
CAMERON, D. W, JAPOUR, A. J, ANGEL, Jon B, MCMAHON, D, HO, D, DEVANARAYAN, V, RODE, R, SALGO, M. P, KEMPF, D. J, GRANNEMAN, R, LEONARD, J. M, SUN, E, YI XU, ANN HSU, MELLORS, J, FARTHING, C, COHEN, C, PORETZ, D, MARKOWITZ, M, FOLLANSBEE, S
Published in AIDS (London) (04.02.1999)
Published in AIDS (London) (04.02.1999)
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Journal Article
Characterization of human immunodeficiency virus type 1 variants with increased resistance to a C2-symmetric protease inhibitor
HO, D. D, TOYOSHIMA, T, HONGMEI MO, KEMPF, D. J, NORBECK, D, CHIH-MING CHEN, WIDEBURG, N. E, BURT, S. K, ERICKSON, J. W, SINGH, M. K
Published in Journal of Virology (01.03.1994)
Published in Journal of Virology (01.03.1994)
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Journal Article
Discovery of Ritonavir, a Potent Inhibitor of HIV Protease with High Oral Bioavailability and Clinical Efficacy
Kempf, Dale J, Sham, Hing L, Marsh, Kennan C, Flentge, Charles A, Betebenner, David, Green, Brian E, McDonald, Edith, Vasavanonda, Sudthida, Saldivar, Ayda, Wideburg, Norman E, Kati, Warren M, Ruiz, Lisa, Zhao, Chen, Fino, LynnMarie, Patterson, Jean, Molla, Akhteruzzaman, Plattner, Jacob J, Norbeck, Daniel W
Published in Journal of medicinal chemistry (12.02.1998)
Published in Journal of medicinal chemistry (12.02.1998)
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Journal Article
NMR-Based Discovery of Lead Inhibitors That Block DNA Binding of the Human Papillomavirus E2 Protein
Hajduk, Philip J, Dinges, Jürgen, Miknis, Gregory F, Merlock, Megan, Middleton, Tim, Kempf, Dale J, Egan, David A, Walter, Karl A, Robins, Terry S, Shuker, Suzy B, Holzman, Thomas F, Fesik, Stephen W
Published in Journal of medicinal chemistry (26.09.1997)
Published in Journal of medicinal chemistry (26.09.1997)
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Journal Article
Recent developments in HIV protease inhibitor therapy
Molla, Akhteruzzaman, Richard Granneman, G, Sun, Eugene, Kempf, Dale J
Published in Antiviral Research (01.07.1998)
Published in Antiviral Research (01.07.1998)
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Book Review
Journal Article
Selection of Multiple Human Immunodeficiency Virus Type 1 Variants that Encode Viral Proteases with Decreased Sensitivity to an Inhibitor of the Viral Protease
Kaplan, Andrew H., Michael, Scott F., Wehbie, Robert S., Knigge, Mark F., Paul, Deborah A., Everitt, Lorraine, Kempf, Dale J., Norbeck, Daniel W., Erickson, John W., Swanstrom, Ronald
Published in Proceedings of the National Academy of Sciences - PNAS (07.06.1994)
Published in Proceedings of the National Academy of Sciences - PNAS (07.06.1994)
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Journal Article
Symmetry-based inhibitors of HIV protease. Structure-activity studies of acylated 2,4-diamino-1,5-diphenyl-3-hydroxypentane and 2,5-diamino-1,6-diphenylhexane-3,4-diol
Kempf, Dale J, Codacovi, Lynnmarie, Wang, Xiu Chun, Kohlbrenner, William E, Wideburg, Norman E, Saldivar, Ayda, Vasavanonda, Sudthida, Marsh, Kennan C, Bryant, Pamela
Published in Journal of medicinal chemistry (01.02.1993)
Published in Journal of medicinal chemistry (01.02.1993)
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Journal Article
Antiviral and pharmacokinetic properties of C2 symmetric inhibitors of the human immunodeficiency virus type 1 protease
Kempf, D J, Marsh, K C, Paul, D A, Knigge, M F, Norbeck, D W, Kohlbrenner, W E, Codacovi, L, Vasavanonda, S, Bryant, P, Wang, X C
Published in Antimicrobial Agents and Chemotherapy (01.11.1991)
Published in Antimicrobial Agents and Chemotherapy (01.11.1991)
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Journal Article
In vitro metabolism of the HIV-1 protease inhibitor ABT-378: Species comparison and metabolite identification
KUMAR, G. N, JAYANTI, V, KEMPF, D. J, DENISSEN, J. F, LEE, R. D, WHITTERN, D. N, UCHIC, J, THOMAS, S, JOHNSON, P, GRABOWSKI, B, SHAM, H, BETEBENNER, D
Published in Drug metabolism and disposition (1999)
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Published in Drug metabolism and disposition (1999)
Journal Article
Incidence of Resistance in a Double-Blind Study Comparing Lopinavir/Ritonavir Plus Stavudine and Lamivudine to Nelfinavir plus Stavudine and Lamivudine
Kempf, Dale J., King, Martin S., Bernstein, Barry, Cernohous, Paul, Bauer, Eric, Moseley, Jennifer, Gu, Kai, Hsu, Ann, Brun, Scott, Sun, Eugene
Published in The Journal of infectious diseases (01.01.2004)
Published in The Journal of infectious diseases (01.01.2004)
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Journal Article
Human immunodeficiency virus type 1 virions composed of unprocessed Gag and Gag-Pol precursors are capable of reverse transcribing viral genomic RNA
KAPLAN, A. H, KROGSTAD, P, KEMPF, D. J, NORBECK, D. W, SWANSTROM, R
Published in Antimicrobial Agents and Chemotherapy (01.12.1994)
Published in Antimicrobial Agents and Chemotherapy (01.12.1994)
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Journal Article
In vitro inhibition of human immunodeficiency virus (HIV) type 1 replication by C2 symmetry-based HIV protease inhibitors as single agents or in combinations
KAGEYAMA, S, WEINSTEIN, J. N, SHIRASAKA, T, KEMPF, D. J, NORBECK, D. W, PLATTNER, J. J, ERICKSON, J, MITSUYA, H
Published in Antimicrobial Agents and Chemotherapy (01.05.1992)
Published in Antimicrobial Agents and Chemotherapy (01.05.1992)
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Journal Article