CRISPR screens in cancer spheroids identify 3D growth-specific vulnerabilities
Han, Kyuho, Pierce, Sarah E, Li, Amy, Spees, Kaitlyn, Anderson, Gray R, Seoane, Jose A, Lo, Yuan-Hung, Dubreuil, Michael, Olivas, Micah, Kamber, Roarke A, Wainberg, Michael, Kostyrko, Kaja, Kelly, Marcus R, Yousefi, Maryam, Simpkins, Scott W, Yao, David, Lee, Keonil, Kuo, Calvin J, Jackson, Peter K, Sweet-Cordero, Alejandro, Kundaje, Anshul, Gentles, Andrew J, Curtis, Christina, Winslow, Monte M, Bassik, Michael C
Published in Nature (London) (01.04.2020)
Published in Nature (London) (01.04.2020)
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The ciliopathy-associated CPLANE proteins direct basal body recruitment of intraflagellar transport machinery
Toriyama, Michinori, Lee, Chanjae, Taylor, S Paige, Duran, Ivan, Cohn, Daniel H, Bruel, Ange-Line, Tabler, Jacqueline M, Drew, Kevin, Kelly, Marcus R, Kim, Sukyoung, Park, Tae Joo, Braun, Daniela A, Pierquin, Ghislaine, Biver, Armand, Wagner, Kerstin, Malfroot, Anne, Panigrahi, Inusha, Franco, Brunella, Al-Lami, Hadeel Adel, Yeung, Yvonne, Choi, Yeon Ja, Duffourd, Yannis, Faivre, Laurence, Rivière, Jean-Baptiste, Chen, Jiang, Liu, Karen J, Marcotte, Edward M, Hildebrandt, Friedhelm, Thauvin-Robinet, Christel, Krakow, Deborah, Jackson, Peter K, Wallingford, John B
Published in Nature genetics (01.06.2016)
Published in Nature genetics (01.06.2016)
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Bispecific Antibodies and Antibody-Drug Conjugates (ADCs) Bridging HER2 and Prolactin Receptor Improve Efficacy of HER2 ADCs
Andreev, Julian, Thambi, Nithya, Perez Bay, Andres E, Delfino, Frank, Martin, Joel, Kelly, Marcus P, Kirshner, Jessica R, Rafique, Ashique, Kunz, Arthur, Nittoli, Thomas, MacDonald, Douglas, Daly, Christopher, Olson, William, Thurston, Gavin
Published in Molecular cancer therapeutics (01.04.2017)
Published in Molecular cancer therapeutics (01.04.2017)
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Journal Article
RAD-TGTs: high-throughput measurement of cellular mechanotype via rupture and delivery of DNA tension probes
Pawlak, Matthew R, Smiley, Adam T, Ramirez, Maria Paz, Kelly, Marcus D, Shamsan, Ghaidan A, Anderson, Sarah M, Smeester, Branden A, Largaespada, David A, Odde, David J, Gordon, Wendy R
Published in Nature communications (28.04.2023)
Published in Nature communications (28.04.2023)
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Journal Article
A Mucin 16 bispecific T cell-engaging antibody for the treatment of ovarian cancer
Crawford, Alison, Haber, Lauric, Kelly, Marcus P, Vazzana, Kristin, Canova, Lauren, Ram, Priyanka, Pawashe, Arpita, Finney, Jennifer, Jalal, Sumreen, Chiu, Danica, Colleton, Curtis A, Garnova, Elena, Makonnen, Sosina, Hickey, Carlos, Krueger, Pamela, DelFino, Frank, Potocky, Terra, Kuhnert, Jessica, Godin, Stephen, Retter, Marc W, Duramad, Paurene, MacDonald, Douglas, Olson, William C, Fairhurst, Jeanette, Huang, Tammy, Martin, Joel, Lin, John C, Smith, Eric, Thurston, Gavin, Kirshner, Jessica R
Published in Science translational medicine (19.06.2019)
Published in Science translational medicine (19.06.2019)
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Comparative Proteomics Reveals Strain-Specific β-TrCP Degradation via Rotavirus NSP1 Hijacking a Host Cullin-3-Rbx1 Complex
Ding, Siyuan, Mooney, Nancie, Li, Bin, Kelly, Marcus R, Feng, Ningguo, Loktev, Alexander V, Sen, Adrish, Patton, John T, Jackson, Peter K, Greenberg, Harry B
Published in PLoS pathogens (01.10.2016)
Published in PLoS pathogens (01.10.2016)
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UHRF1 is a mediator of KRAS driven oncogenesis in lung adenocarcinoma
Kostyrko, Kaja, Román, Marta, Lee, Alex G, Simpson, David R, Dinh, Phuong T, Leung, Stanley G, Marini, Kieren D, Kelly, Marcus R, Broyde, Joshua, Califano, Andrea, Jackson, Peter K, Sweet-Cordero, E Alejandro
Published in Nature communications (05.07.2023)
Published in Nature communications (05.07.2023)
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A multi-scale map of cell structure fusing protein images and interactions
Qin, Yue, Huttlin, Edward L, Winsnes, Casper F, Gosztyla, Maya L, Wacheul, Ludivine, Kelly, Marcus R, Blue, Steven M, Zheng, Fan, Chen, Michael, Schaffer, Leah V, Licon, Katherine, Bäckström, Anna, Vaites, Laura Pontano, Lee, John J, Ouyang, Wei, Liu, Sophie N, Zhang, Tian, Silva, Erica, Park, Jisoo, Pitea, Adriana, Kreisberg, Jason F, Gygi, Steven P, Ma, Jianzhu, Harper, J Wade, Yeo, Gene W, Lafontaine, Denis L J, Lundberg, Emma, Ideker, Trey
Published in Nature (London) (16.12.2021)
Published in Nature (London) (16.12.2021)
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Dystrophin missense mutations alter focal adhesion tension and mechanotransduction
Ramirez, Maria Paz, Anderson, Michael J M, Kelly, Marcus D, Sundby, Lauren J, Hagerty, Anthony R, Wenthe, Sophia J, Odde, David J, Ervasti, James M, Gordon, Wendy R
Published in Proceedings of the National Academy of Sciences - PNAS (21.06.2022)
Published in Proceedings of the National Academy of Sciences - PNAS (21.06.2022)
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Drebrin restricts rotavirus entry by inhibiting dynamin-mediated endocytosis
Li, Bin, Ding, Siyuan, Feng, Ningguo, Mooney, Nancie, Ooi, Yaw Shin, Ren, Lili, Diep, Jonathan, Kelly, Marcus R., Yasukawa, Linda L., Patton, John T., Yamazaki, Hiroyuki, Shirao, Tomoaki, Jackson, Peter K., Greenberg, Harry B.
Published in Proceedings of the National Academy of Sciences - PNAS (02.05.2017)
Published in Proceedings of the National Academy of Sciences - PNAS (02.05.2017)
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A Biparatopic Antibody-Drug Conjugate to Treat MET-Expressing Cancers, Including Those that Are Unresponsive to MET Pathway Blockade
DaSilva, John O, Yang, Katie, Surriga, Oliver, Nittoli, Thomas, Kunz, Arthur, Franklin, Matthew C, Delfino, Frank J, Mao, Shu, Zhao, Feng, Giurleo, Jason T, Kelly, Marcus P, Makonnen, Sosina, Hickey, Carlos, Krueger, Pamela, Foster, Randi, Chen, Zhaoyuan, Retter, Marc W, Slim, Rabih, Young, Tara M, Olson, William C, Thurston, Gavin, Daly, Christopher
Published in Molecular cancer therapeutics (01.10.2021)
Published in Molecular cancer therapeutics (01.10.2021)
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Combined Proteomic and Genetic Interaction Mapping Reveals New RAS Effector Pathways and Susceptibilities
Kelly, Marcus R, Kostyrko, Kaja, Han, Kyuho, Mooney, Nancie A, Jeng, Edwin E, Spees, Kaitlyn, Dinh, Phuong T, Abbott, Keene L, Gwinn, Dana M, Sweet-Cordero, E Alejandro, Bassik, Michael C, Jackson, Peter K
Published in Cancer discovery (01.12.2020)
Published in Cancer discovery (01.12.2020)
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Interpretation of cancer mutations using a multiscale map of protein systems
Zheng, Fan, Kelly, Marcus R, Ramms, Dana J, Heintschel, Marissa L, Tao, Kai, Tutuncuoglu, Beril, Lee, John J, Ono, Keiichiro, Foussard, Helene, Chen, Michael, Herrington, Kari A, Silva, Erica, Liu, Sophie N, Chen, Jing, Churas, Christopher, Wilson, Nicholas, Kratz, Anton, Pillich, Rudolf T, Patel, Devin N, Park, Jisoo, Kuenzi, Brent, Yu, Michael K, Licon, Katherine, Pratt, Dexter, Kreisberg, Jason F, Kim, Minkyu, Swaney, Danielle L, Nan, Xiaolin, Fraley, Stephanie I, Gutkind, J Silvio, Krogan, Nevan J, Ideker, Trey
Published in Science (American Association for the Advancement of Science) (01.10.2021)
Published in Science (American Association for the Advancement of Science) (01.10.2021)
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Antibody-targeted NY-ESO-1 to mannose receptor or DEC-205 in vitro elicits dual human CD8+ and CD4+ T cell responses with broad antigen specificity
Tsuji, Takemasa, Matsuzaki, Junko, Kelly, Marcus P, Ramakrishna, Venky, Vitale, Laura, He, Li-Zhen, Keler, Tibor, Odunsi, Kunle, Old, Lloyd J, Ritter, Gerd, Gnjatic, Sacha
Published in The Journal of immunology (1950) (15.01.2011)
Published in The Journal of immunology (1950) (15.01.2011)
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WRN inhibition leads to its chromatin-associated degradation via the PIAS4-RNF4-p97/VCP axis
Rodríguez Pérez, Fernando, Natwick, Dean, Schiff, Lauren, McSwiggen, David, Heckert, Alec, Huey, Melina, Morrison, Huntly, Loo, Mandy, Miranda, Rafael G, Filbin, John, Ortega, Jose, Van Buren, Kayla, Murnock, Danny, Tao, Arnold, Butler, Renee, Cheng, Kylie, Tarvestad, William, Zhang, Zhengjian, Gonzalez, Eric, Miller, Rand M, Kelly, Marcus, Tang, Yangzhong, Ho, Jaclyn, Anderson, Daniel, Bashore, Charlene, Basham, Stephen
Published in Nature communications (18.07.2024)
Published in Nature communications (18.07.2024)
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The OTX2 Gene Induces Tumor Growth and Triggers Leptomeningeal Metastasis by Regulating the mTORC2 Signaling Pathway in Group 3 Medulloblastomas
Ampudia-Mesias, Elisabet, Cameron, Charles S, Yoo, Eunjae, Kelly, Marcus, Anderson, Sarah M, Manning, Riley, Abrahante Lloréns, Juan E, Moertel, Christopher L, Yim, Hyungshin, Odde, David J, Saydam, Nurten, Saydam, Okay
Published in International journal of molecular sciences (17.04.2024)
Published in International journal of molecular sciences (17.04.2024)
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Antibody drug conjugates of cleavable amino-alkyl and aryl maytansinoids
Nittoli, Thomas, Kelly, Marcus P., Delfino, Frank, Rudge, John, Kunz, Arthur, Markotan, Thomas, Spink, Jan, Chen, Zhaoyuan, Shan, Jing, Navarro, Elizabeth, Tait, Michele, Provoncha, Kathleen, Giurleo, Jason, Zhao, Feng, Jiang, Xiaobo, Hylton, Donna, Makonnen, Sosina, Hickey, Carlos, Kirshner, Jessica R., Thurston, Gavin, Papadopoulos, Nicholas
Published in Bioorganic & medicinal chemistry (15.05.2018)
Published in Bioorganic & medicinal chemistry (15.05.2018)
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Preclinical Activity of the Novel Anti-Prolactin Receptor (PRLR) Antibody-Drug Conjugate REGN2878-DM1 in PRLR-Positive Breast Cancers
Kelly, Marcus P, Hickey, Carlos, Makonnen, Sosina, Coetzee, Sandra, Jalal, Sumreen, Wang, Yu, Delfino, Frank, Shan, Jing, Potocky, Terra B, Chatterjee, Ishita, Andreev, Julian, Kunz, Arthur, D'Souza, Christopher, Giurleo, Jason T, Nittoli, Thomas, Trail, Pamela A, Thurston, Gavin, Kirshner, Jessica R
Published in Molecular cancer therapeutics (01.07.2017)
Published in Molecular cancer therapeutics (01.07.2017)
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Mutual antagonism between CD44 and integrins in glioblastoma cell traction and migration
Kelly, Marcus D., Pawlak, Matthew R., Zhan, Kevin H., Shamsan, Ghaidan A., Gordon, Wendy R., Odde, David J.
Published in APL bioengineering (01.09.2024)
Published in APL bioengineering (01.09.2024)
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