BH3-Mimetic Drugs: Blazing the Trail for New Cancer Medicines
Merino, Delphine, Kelly, Gemma L., Lessene, Guillaume, Wei, Andrew H., Roberts, Andrew W., Strasser, Andreas
Published in Cancer cell (10.12.2018)
Published in Cancer cell (10.12.2018)
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Journal Article
The manipulation of apoptosis for cancer therapy using BH3-mimetic drugs
Diepstraten, Sarah T, Anderson, Mary Ann, Czabotar, Peter E, Lessene, Guillaume, Strasser, Andreas, Kelly, Gemma L
Published in Nature reviews. Cancer (01.01.2022)
Published in Nature reviews. Cancer (01.01.2022)
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Journal Article
An Inducible Lentiviral Guide RNA Platform Enables the Identification of Tumor-Essential Genes and Tumor-Promoting Mutations In Vivo
Aubrey, Brandon J., Kelly, Gemma L., Kueh, Andrew J., Brennan, Margs S., O’Connor, Liam, Milla, Liz, Wilcox, Stephen, Tai, Lin, Strasser, Andreas, Herold, Marco J.
Published in Cell reports (Cambridge) (03.03.2015)
Published in Cell reports (Cambridge) (03.03.2015)
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Journal Article
Intact TP-53 function is essential for sustaining durable responses to BH3-mimetic drugs in leukemias
Thijssen, Rachel, Diepstraten, Sarah T., Moujalled, Donia, Chew, Edward, Flensburg, Christoffer, Shi, Melissa X., Dengler, Michael A., Litalien, Veronique, MacRaild, Sarah, Chen, Maoshan, Anstee, Natasha S., Reljić, Boris, Gabriel, Sarah S., Djajawi, Tirta M., Riffkin, Chris D., Aubrey, Brandon J., Chang, Catherine, Tai, Lin, Xu, Zhen, Morley, Thomas, Pomilio, Giovanna, Bruedigam, Claudia, Kallies, Axel, Stroud, David A., Bajel, Ashish, Kluck, Ruth M., Lane, Steven W., Schoumacher, Marie, Banquet, Sébastien, Majewski, Ian J., Strasser, Andreas, Roberts, Andrew W., Huang, David C.S., Brown, Fiona C., Kelly, Gemma L., Wei, Andrew H.
Published in Blood (20.05.2021)
Published in Blood (20.05.2021)
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Journal Article
The anti-cancer agent APR-246 can activate several programmed cell death processes to kill malignant cells
Wang, Zilu, Hu, Huimin, Heitink, Luuk, Rogers, Kelly, You, Yue, Tan, Tao, Suen, Connie Li Wai, Garnham, Alex, Chen, Hao, Lieschke, Elizabeth, Diepstraten, Sarah T, Chang, Catherine, Chen, Tianwei, Moujalled, Diane, Sutherland, Kate, Lessene, Guillaume, Sieber, Oliver M, Visvader, Jane, Kelly, Gemma L, Strasser, Andreas
Published in Cell death and differentiation (01.04.2023)
Published in Cell death and differentiation (01.04.2023)
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Journal Article
VDAC2 enables BAX to mediate apoptosis and limit tumor development
Chin, Hui San, Li, Mark X, Tan, Iris K L, Ninnis, Robert L, Reljic, Boris, Scicluna, Kristen, Dagley, Laura F, Sandow, Jarrod J, Kelly, Gemma L, Samson, Andre L, Chappaz, Stephane, Khaw, Seong L, Chang, Catherine, Morokoff, Andrew, Brinkmann, Kerstin, Webb, Andrew, Hockings, Colin, Hall, Cathrine M, Kueh, Andrew J, Ryan, Michael T, Kluck, Ruth M, Bouillet, Philippe, Herold, Marco J, Gray, Daniel H D, Huang, David C S, van Delft, Mark F, Dewson, Grant
Published in Nature communications (26.11.2018)
Published in Nature communications (26.11.2018)
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Generation of a CRISPR activation mouse that enables modelling of aggressive lymphoma and interrogation of venetoclax resistance
Deng, Yexuan, Diepstraten, Sarah T, Potts, Margaret A, Giner, Göknur, Trezise, Stephanie, Ng, Ashley P, Healey, Gerry, Kane, Serena R, Cooray, Amali, Behrens, Kira, Heidersbach, Amy, Kueh, Andrew J, Pal, Martin, Wilcox, Stephen, Tai, Lin, Alexander, Warren S, Visvader, Jane E, Nutt, Stephen L, Strasser, Andreas, Haley, Benjamin, Zhao, Quan, Kelly, Gemma L, Herold, Marco J
Published in Nature communications (12.08.2022)
Published in Nature communications (12.08.2022)
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Journal Article
An Epstein-Barr virus anti-apoptotic protein constitutively expressed in transformed cells and implicated in burkitt lymphomagenesis: the Wp/BHRF1 link
Kelly, Gemma L, Long, Heather M, Stylianou, Julianna, Thomas, Wendy A, Leese, Alison, Bell, Andrew I, Bornkamm, Georg W, Mautner, Josef, Rickinson, Alan B, Rowe, Martin
Published in PLoS pathogens (01.03.2009)
Published in PLoS pathogens (01.03.2009)
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Journal Article
A Drosophila chemical screen reveals synergistic effect of MEK and DGKα inhibition in Ras-driven cancer
La Marca, John E, Ely, Robert W, Diepstraten, Sarah T, Burke, Peter, Kelly, Gemma L, Humbert, Patrick O, Richardson, Helena E
Published in Disease models & mechanisms (01.03.2023)
Published in Disease models & mechanisms (01.03.2023)
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Journal Article
Therapeutic Response to Non-genotoxic Activation of p53 by Nutlin3a Is Driven by PUMA-Mediated Apoptosis in Lymphoma Cells
Valente, Liz J., Aubrey, Brandon J., Herold, Marco J., Kelly, Gemma L., Happo, Lina, Scott, Clare L., Newbold, Andrea, Johnstone, Ricky W., Huang, David C.S., Vassilev, Lyubomir T., Strasser, Andreas
Published in Cell reports (Cambridge) (01.03.2016)
Published in Cell reports (Cambridge) (01.03.2016)
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Journal Article
Author Correction: Generation of a CRISPR activation mouse that enables modelling of aggressive lymphoma and interrogation of venetoclax resistance
Deng, Yexuan, Diepstraten, Sarah T, Potts, Margaret A, Giner, Göknur, Trezise, Stephanie, Ng, Ashley P, Healey, Gerry, Kane, Serena R, Cooray, Amali, Behrens, Kira, Heidersbach, Amy, Kueh, Andrew J, Pal, Martin, Wilcox, Stephen, Tai, Lin, Alexander, Warren S, Visvader, Jane E, Nutt, Stephen L, Strasser, Andreas, Haley, Benjamin, Zhao, Quan, Kelly, Gemma L, Herold, Marco J
Published in Nature communications (25.08.2022)
Published in Nature communications (25.08.2022)
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Journal Article
BCL-2 protein family: attractive targets for cancer therapy
Kaloni, Deeksha, Diepstraten, Sarah T, Strasser, Andreas, Kelly, Gemma L
Published in Apoptosis (London) (01.02.2023)
Published in Apoptosis (London) (01.02.2023)
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Journal Article
The Transcription Factor ASCIZ and Its Target DYNLL1 Are Essential for the Development and Expansion of MYC-Driven B Cell Lymphoma
Wong, David M., Li, Lingli, Jurado, Sabine, King, Ashleigh, Bamford, Rebecca, Wall, Meaghan, Walia, Mannu K., Kelly, Gemma L., Walkley, Carl R., Tarlinton, David M., Strasser, Andreas, Heierhorst, Jörg
Published in Cell reports (Cambridge) (16.02.2016)
Published in Cell reports (Cambridge) (16.02.2016)
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Journal Article
Different Patterns of Epstein-Barr Virus Latency in Endemic Burkitt Lymphoma (BL) Lead to Distinct Variants within the BL-Associated Gene Expression Signature
Kelly, Gemma L, Stylianou, Julianna, Rasaiyaah, Jane, Wei, Wenbin, Thomas, Wendy, Croom-Carter, Deborah, Kohler, Christian, Spang, Rainer, Woodman, Ciaran, Kellam, Paul, Rickinson, Alan B, Bell, Andrew I
Published in Journal of Virology (01.03.2013)
Published in Journal of Virology (01.03.2013)
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Journal Article
How does p53 induce apoptosis and how does this relate to p53-mediated tumour suppression?
Aubrey, Brandon J, Kelly, Gemma L, Janic, Ana, Herold, Marco J, Strasser, Andreas
Published in Cell death and differentiation (01.01.2018)
Published in Cell death and differentiation (01.01.2018)
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Journal Article
Should mutant TP53 be targeted for cancer therapy?
Wang, Zilu, Strasser, Andreas, Kelly, Gemma L
Published in Cell death and differentiation (01.05.2022)
Published in Cell death and differentiation (01.05.2022)
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