Search Results - "KELLEHER, EUGENE W" :: K.UTB vyhledávací portál | TBU Library Retrieval Portal

Discovery and Optimization of a STING Agonist Platform for Application in Antibody Drug Conjugates

Discovery and Optimization of a STING Agonist Platform for Application in Antibody Drug Conjugates

by Duvall, Jeremy R., Thomas, Joshua D., Bukhalid, Raghida A., Catcott, Kalli C., Bentley, Keith W., Collins, Scott D., Eitas, Timothy, Jones, Brian D., Kelleher, Eugene W., Lancaster, Kelly, Protopopova, Marina, Ray, Soumya S., Ter-Ovanesyan, Elena, Xu, Ling, Yang, Liping, Zurita, Jeffrey, Damelin, Marc, Toader, Dorin, Lowinger, Timothy B.
Published in Journal of medicinal chemistry (10.08.2023)

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Journal Article

Discovery of 3‑(3-(4-(1-Aminocyclobutyl)phenyl)-5-phenyl‑3H‑imidazo[4,5‑b]pyridin-2-yl)pyridin-2-amine (ARQ 092): An Orally Bioavailable, Selective, and Potent Allosteric AKT Inhibitor

Discovery of 3‑(3-(4-(1-Aminocyclobutyl)phenyl)-5-phenyl‑3H‑imidazo[4,5‑b]pyridin-2-yl)pyridin-2-amine (ARQ 092): An Orally Bioavailable, Selective, and Potent Allosteric AKT Inhibitor

by Lapierre, Jean-Marc, Eathiraj, Sudharshan, Vensel, David, Liu, Yanbin, Bull, Cathy O, Cornell-Kennon, Susan, Iimura, Shin, Kelleher, Eugene W, Kizer, Darin E, Koerner, Steffi, Makhija, Sapna, Matsuda, Akihisa, Moussa, Magdi, Namdev, Nivedita, Savage, Ronald E, Szwaya, Jeff, Volckova, Erika, Westlund, Neil, Wu, Hui, Schwartz, Brian
Published in Journal of medicinal chemistry (14.07.2016)

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Journal Article

암 치료를 위한 STING 작용제로서의 비스-[N--1H-벤조[D]이미다졸-2-일)-피라졸-5-카복사미드] 유도체 및 관련 화합물

암 치료를 위한 STING 작용제로서의 비스-[N--1H-벤조[D]이미다졸-2-일)-피라졸-5-카복사미드] 유도체 및 관련 화합물

by TOADER DORIN, DUVALL JEREMY R, KELLEHER EUGENE W, RAY SOUMYA S, JONES BRIAN D, THOMAS JOSHUA D, BENTLEY KEITH W
Year of Publication 04.05.2022

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Patent

스팅 효능제를 포함하는 항체 약물 접합체

스팅 효능제를 포함하는 항체 약물 접합체

by TOADER DORIN, DUVALL JEREMY R, KELLEHER EUGENE W, BUKHALID RAGHIDA A, LOWINGER TIMOTHY B, XU LING, THOMAS JOSHUA D, BENTLEY KEITH W, CETINBAS NANIYE, DAMELIN MARC I, YANG LIPING
Year of Publication 09.01.2023

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Patent

Abstract 1738: XMT-2056, a well-tolerated, Immunosynthen-based STING-agonist antibody-drug conjugate which induces anti-tumor immune activity

Abstract 1738: XMT-2056, a well-tolerated, Immunosynthen-based STING-agonist antibody-drug conjugate which induces anti-tumor immune activity

by Duvall, Jeremy R., Bukhalid, Raghida A., Cetinbas, Naniye M., Catcott, Kalli C., Slocum, Kelly, Avocetien, Kenneth, Bentley, Keith W., Bradley, Stephen, Clardy, Susan, Collins, Scott D., Ditty, Elizabeth, Eitas, Timothy, Jones, Brian D., Kelleher, Eugene W., Lee, Winnie, Monnell, Travis, Mosher, Rebecca, Protopopova, Marina, Qin, LiuLiang, Shaw, Pamela, Ter-Ovanesyan, Elena, Thomas, Joshua D., Wongthida, Phonphimon, Xu, Ling, Yang, Liping, Zurita, Jeffrey, Toader, Dorin, Damelin, Marc, Lowinger, Timothy B.
Published in Cancer research (Chicago, Ill.) (01.07.2021)

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Journal Article

Abstract 6706: Systemic administration of STING agonist antibody-drug conjugates elicit potent anti-tumor immune responses with minimal induction of circulating cytokines

Abstract 6706: Systemic administration of STING agonist antibody-drug conjugates elicit potent anti-tumor immune responses with minimal induction of circulating cytokines

by Bukhalid, Raghida A., Duvall, Jeremy R., Cetinbas, Naniye Malli, Catcott, Kalli C., Avocetien, Kenneth, Bentley, Keith W., Bradley, Stephen, Carter, Tyler, Chin, Chen-Ni, Clardy, Susan, Collins, Scott D., Eitas, Timothy, Jones, Brian D., Kelleher, Eugene W., Mosher, Rebecca, Nazzaro, Mark, Protopopova, Marina, Shaw, Pamela, Slocum, Kelly, Ter-Ovanesyan, Elena, Qin, LiuLiang, Thomas, Joshua D., Xu, Ling, Yang, Liping, Zurita, Jeffrey, Toader, Dorin, Damelin, Marc, Lowinger, Timothy B.
Published in Cancer research (Chicago, Ill.) (15.08.2020)

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Journal Article

Discovery of 3-(3-(4-(1-Aminocyclobutyl)phenyl)-5-phenyl-3 H -imidazo[4,5- b ]pyridin-2-yl)pyridin-2-amine (ARQ 092): An Orally Bioavailable, Selective, and Potent Allosteric AKT Inhibitor

Discovery of 3-(3-(4-(1-Aminocyclobutyl)phenyl)-5-phenyl-3 H -imidazo[4,5- b ]pyridin-2-yl)pyridin-2-amine (ARQ 092): An Orally Bioavailable, Selective, and Potent Allosteric AKT Inhibitor

by Lapierre, Jean-Marc, Eathiraj, Sudharshan, Vensel, David, Liu, Yanbin, Bull, Cathy O., Cornell-Kennon, Susan, Iimura, Shin, Kelleher, Eugene W., Kizer, Darin E., Koerner, Steffi, Makhija, Sapna, Matsuda, Akihisa, Moussa, Magdi, Namdev, Nivedita, Savage, Ronald E., Szwaya, Jeff, Volckova, Erika, Westlund, Neil, Wu, Hui, Schwartz, Brian
Published in Journal of medicinal chemistry (14.07.2016)

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Journal Article

Abstract 3503: XMT-2056, a HER2-targeted Immunosynthen STING-agonist antibody-drug conjugate, binds a novel epitope of HER2 and shows increased anti-tumor activity in combination with trastuzumab and pertuzumab

Abstract 3503: XMT-2056, a HER2-targeted Immunosynthen STING-agonist antibody-drug conjugate, binds a novel epitope of HER2 and shows increased anti-tumor activity in combination with trastuzumab and pertuzumab

by Duvall, Jeremy R., Bukhalid, Raghida A., Cetinbas, Naniye M., Catcott, Kalli C., Lancaster, Kelly, Bentley, Keith W., Clark, Suzanna, Clardy, Susan, Collins, Scott D., Dirksen, Anouk, Ditty, Elizabeth, Du, Bingfan, Kelleher, Eugene W., Monnell, Travis, Protopopova, Marina, Routhier, Caitlin, Stevenson, Cheri, Ter-Ovanesyan, Elena, Thomas, Joshua D., Uttard, Alex, Wang, Jason, Wongthida, Phonphimon, Xu, Ling, Yau, Annika, Zurita, Jeffrey, Toader, Dorin, Damelin, Marc, Lowinger, Timothy B.
Published in Cancer research (Chicago, Ill.) (15.06.2022)

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Journal Article

BIS-[N-((5-CARBAMOYL)-1H-BENZO[D]IMIDAZOL-2-YL)-PYRAZOL-5-CARBOXAMIDE] DERIVATIVES AND RELATED COMPOUNDS AS STING (STIMULATOR OF INTERFERON GENES) AGONISTS FOR THE TREATMENT OF CANCER

BIS-[N-((5-CARBAMOYL)-1H-BENZO[D]IMIDAZOL-2-YL)-PYRAZOL-5-CARBOXAMIDE] DERIVATIVES AND RELATED COMPOUNDS AS STING (STIMULATOR OF INTERFERON GENES) AGONISTS FOR THE TREATMENT OF CANCER

by KELLEHER, Eugene W, RAY, Soumya S, THOMAS, Joshua D, BENTLEY, Keith W, DUVALL, Jeremy R, TOADER, Dorin, JONES, Brian D
Year of Publication 31.07.2024

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Patent

Sting agonist compounds and methods of use

Sting agonist compounds and methods of use

by Kelleher, Eugene W, Duvall, Jeremy R, Jones, Brian D, Ray, Soumya S, Thomas, Joshua D, Toader, Dorin, Bentley, Keith W
Year of Publication 26.03.2024

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Patent

PYRROLOBENZODIAZEPINE ANTIBODY CONJUGATES

PYRROLOBENZODIAZEPINE ANTIBODY CONJUGATES

by KELLEHER, Eugene W, THOMAS, Joshua D, YURKOVETSKIY, Aleksandr V, JONES, Brian D, YIN, Mao, LOWINGER, Timothy B, YANG, Liping
Year of Publication 29.09.2022

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Patent

PYRROLOBENZODIAZEPINES AND CONJUGATES THEREOF

PYRROLOBENZODIAZEPINES AND CONJUGATES THEREOF

by TANG, Shuyi, CONLON, Patrick R, KELLEHER, Eugene W, THOMAS, Joshua D, YURKOVETSKIY, Aleksandr V, YIN, Mao, DU, Bingfan, LOWINGER, Timothy B
Year of Publication 05.07.2023

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Patent

BIS-[N-((5-CARBAMOYL)-1H-BENZO[D]IMIDAZOL-2-YL)-PYRAZOL-5-CARBOXAMIDE] DERIVATIVES AND RELATED COMPOUNDS AS STING (STIMULATOR OF INTERFERON GENES) AGONISTS FOR THE TREATMENT OF CANCER

BIS-[N-((5-CARBAMOYL)-1H-BENZO[D]IMIDAZOL-2-YL)-PYRAZOL-5-CARBOXAMIDE] DERIVATIVES AND RELATED COMPOUNDS AS STING (STIMULATOR OF INTERFERON GENES) AGONISTS FOR THE TREATMENT OF CANCER

by KELLEHER, Eugene W, RAY, Soumya S, THOMAS, Joshua D, BENTLEY, Keith W, DUVALL, Jeremy R, TOADER, Dorin, JONES, Brian D
Year of Publication 08.06.2022

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Patent

STING AGONIST COMPOUNDS AND METHODS OF USE

STING AGONIST COMPOUNDS AND METHODS OF USE

by KELLEHER, Eugene W, RAY, Soumya S, THOMAS, Joshua D, BENTLEY, Keith W, DUVALL, Jeremy R, TOADER, Dorin, JONES, Brian D
Year of Publication 03.03.2022

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Patent

Bis-[N-((5-carbamoyl)-1H-benzo[d]imidazol-2-yl)-pyrazol-5-carboxamide] derivatives and related compounds as STING (Stimulator of Interferon Genes) agonists for the treatment of cancer

Bis-[N-((5-carbamoyl)-1H-benzo[d]imidazol-2-yl)-pyrazol-5-carboxamide] derivatives and related compounds as STING (Stimulator of Interferon Genes) agonists for the treatment of cancer

by KELLEHER, Eugene W, RAY, Soumya S, THOMAS, Joshua D, BENTLEY, Keith W, DUVALL, Jeremy R, TOADER, Dorin, JONES, Brian D
Year of Publication 24.02.2022

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Patent

ANTIBODY DRUG CONJUGATES COMPRISING STING AGONISTS

ANTIBODY DRUG CONJUGATES COMPRISING STING AGONISTS

by KELLEHER, Eugene W, DAMELIN, Marc I, XU, Ling, THOMAS, Joshua D, BENTLEY, Keith W, DUVALL, Jeremy R, TOADER, Dorin, BUKHALID, Raghida A, CETINBAS, Naniye, LOWINGER, Timothy B, YANG, Liping
Year of Publication 25.10.2023

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Patent

ANTIBODY DRUG CONJUGATES COMPRISING STING AGONISTS

ANTIBODY DRUG CONJUGATES COMPRISING STING AGONISTS

by KELLEHER, Eugene W, DAMELIN, Marc I, XU, Ling, THOMAS, Joshua D, BENTLEY, Keith W, DUVALL, Jeremy R, TOADER, Dorin, BUKHALID, Raghida A, CETINBAS, Naniye, LOWINGER, Timothy B, YANG, Liping
Year of Publication 12.10.2023

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Patent

PYRROLOBENZODIAZEPINES AND CONJUGATES THEREOF

PYRROLOBENZODIAZEPINES AND CONJUGATES THEREOF

by HILMY, Ahmed, TANG, Shuyi, CONLON, Patrick R, KELLEHER, Eugene W, THOMAS, Joshua D, STEVENSON, Cheri A, YIN, Mao, YURKOVETSKIY, Aleksandr, LOWINGER, Timothy B
Year of Publication 02.11.2022

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Patent

Sting agonist compounds and methods of use

Sting agonist compounds and methods of use

by Kelleher, Eugene W, Duvall, Jeremy R, Jones, Brian D, Ray, Soumya S, Thomas, Joshua D, Toader, Dorin, Bentley, Keith W
Year of Publication 26.10.2021

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Patent

ANTIBODY DRUG CONJUGATES COMPRISING STING AGONISTS

ANTIBODY DRUG CONJUGATES COMPRISING STING AGONISTS

by KELLEHER, Eugene W, DAMELIN, Marc I, XU, Ling, THOMAS, Joshua D, BENTLEY, Keith W, DUVALL, Jeremy R, TOADER, Dorin, BUKHALID, Raghida A, CETINBAS, Naniye, LOWINGER, Timothy B, YANG, Liping
Year of Publication 02.08.2023

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Patent

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