Efficacy and Safety of the Glucagon Receptor Antagonist RVT-1502 in Type 2 Diabetes Uncontrolled on Metformin Monotherapy: A 12-Week Dose-Ranging Study
Pettus, Jeremy H, D'Alessio, David, Frias, Juan P, Vajda, Eric G, Pipkin, James D, Rosenstock, Julio, Williamson, Gretchen, Zangmeister, Miriam A, Zhi, Lin, Marschke, Keith B
Published in Diabetes care (01.01.2020)
Published in Diabetes care (01.01.2020)
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Pharmacokinetics and pharmacodynamics of single and multiple doses of the glucagon receptor antagonist LGD‐6972 in healthy subjects and subjects with type 2 diabetes mellitus
Vajda, Eric G., Logan, Douglas, Lasseter, Kenneth, Armas, Danielle, Plotkin, Diane J., Pipkin, JD, Li, Yong-Xi, Zhou, Rong, Klein, David, Wei, Xiaoxiong, Dilzer, Stacy, Zhi, Lin, Marschke, Keith B.
Published in Diabetes, obesity & metabolism (01.01.2017)
Published in Diabetes, obesity & metabolism (01.01.2017)
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An Orally Active Selective Androgen Receptor Modulator Is Efficacious on Bone, Muscle, and Sex Function with Reduced Impact on Prostate
Miner, Jeffrey N, Chang, William, Chapman, Mark S, Finn, Patricia D, Hong, Mei Hua, López, Francisco J, Marschke, Keith B, Rosen, Jon, Schrader, William, Turner, Russell, van Oeveren, Arjan, Viveros, Humberto, Zhi, Lin, Negro-Vilar, Andres
Published in Endocrinology (Philadelphia) (01.01.2007)
Published in Endocrinology (Philadelphia) (01.01.2007)
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Discovery of 6-N,N-Bis(2,2,2-trifluoroethyl)amino- 4-trifluoromethylquinolin-2(1H)-one as a Novel Selective Androgen Receptor Modulator
van Oeveren, Arjan, Motamedi, Mehrnouch, Mani, Neelakandha S, Marschke, Keith B, López, Francisco J, Schrader, William T, Negro-Vilar, Andrés, Zhi, Lin
Published in Journal of medicinal chemistry (19.10.2006)
Published in Journal of medicinal chemistry (19.10.2006)
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Antiinflammatory glucocorticoid receptor ligand with reduced side effects exhibits an altered protein-protein interaction profile
Miner, Jeffrey N, Ardecky, Bob, Benbatoul, Khalid, Griffiths, Kimberly, Larson, Christopher J, Mais, Dale E, Marschke, Keith, Rosen, Jon, Vajda, Eric, Zhi, Lin, Negro-Vilar, Andres
Published in Proceedings of the National Academy of Sciences - PNAS (04.12.2007)
Published in Proceedings of the National Academy of Sciences - PNAS (04.12.2007)
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Biological Characterization of a Heterodimer-Selective Retinoid X Receptor Modulator: Potential Benefits for the Treatment of Type 2 Diabetes
Leibowitz, Mark D, Ardecky, Robert J, Boehm, Marcus F, Broderick, Carol L, Carfagna, Mark A, Crombie, Diane L, D’Arrigo, Jennifer, Etgen, Garrett J, Faul, Margaret M, Grese, Timothy A, Havel, Henry, Hein, Nancy I, Heyman, Richard A, Jolley, Diane, Klausing, Kay, Liu, Sha, Mais, Dale E, Mapes, Christopher M, Marschke, Keith B, Michellys, Pierre-Yves, Montrose-Rafizadeh, Chahrzad, Ogilvie, Kathleen M, Pascual, Bernadette, Rungta, Deepa, Tyhonas, John S, Urcan, Mary S, Wardlow, Marilyn, Yumibe, Nathan, Reifel-Miller, Anne
Published in Endocrinology (Philadelphia) (01.02.2006)
Published in Endocrinology (Philadelphia) (01.02.2006)
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Discovery of nonsteroidal glucocorticoid receptor ligands based on 6-indole-1,2,3,4-tetrahydroquinolines
Roach, Steven L., Higuchi, Robert I., Adams, Mark E., Liu, Yan, Karanewsky, Donald S., Marschke, Keith B., Mais, Dale E., Miner, Jeffrey N., Zhi, Lin
Published in Bioorganic & medicinal chemistry (15.06.2008)
Published in Bioorganic & medicinal chemistry (15.06.2008)
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6-Aryl-1,4-dihydro-benzo[d][1,3]oxazin- 2-ones: A Novel Class of Potent, Selective, and Orally Active Nonsteroidal Progesterone Receptor Antagonists
Zhang, Puwen, Terefenko, Eugene A, Fensome, Andrew, Wrobel, Jay, Winneker, Richard, Lundeen, Scott, Marschke, Keith B, Zhang, Zhiming
Published in Journal of medicinal chemistry (26.09.2002)
Published in Journal of medicinal chemistry (26.09.2002)
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Substituted 6-(1-Pyrrolidine)quinolin-2(1H)-ones as Novel Selective Androgen Receptor Modulators
Martinborough, Esther, Shen, Yixing, van Oeveren, Arjan, Long, Yun Oliver, Lau, Thomas L. S, Marschke, Keith B, Chang, William Y, López, Francisco J, Vajda, Eric G, Rix, Peter J, Viveros, O. Humberto, Negro-Vilar, Andrés, Zhi, Lin
Published in Journal of medicinal chemistry (18.10.2007)
Published in Journal of medicinal chemistry (18.10.2007)
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Synthesis and Characterization of Nonsteroidal Glucocorticoid Receptor Modulators for Multiple Myeloma
Hudson, Andrew R, Roach, Steven L, Higuchi, Robert I, Phillips, Dean P, Bissonnette, Reid P, Lamph, William W, Yen, Jean, Li, Yongkai, Adams, Mark E, Valdez, Lino J, Vassar, Angie, Cuervo, Catalina, Kallel, E. Adam, Gharbaoui, Catherine J, Mais, Dale E, Miner, Jeffrey N, Marschke, Keith B, Rungta, Deepa, Negro-Vilar, Andrés, Zhi, Lin
Published in Journal of medicinal chemistry (20.09.2007)
Published in Journal of medicinal chemistry (20.09.2007)
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Tetrahydroquinoline glucocorticoid receptor agonists: Discovery of a 3-hydroxyl for improving receptor selectivity
Roach, Steven L., Higuchi, Robert I., Hudson, Andrew R., Adams, Mark E., Syka, Peter M., Mais, Dale E., Miner, Jeffrey N., Marschke, Keith B., Zhi, Lin
Published in Bioorganic & medicinal chemistry letters (01.01.2011)
Published in Bioorganic & medicinal chemistry letters (01.01.2011)
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Journal Article
Discovery of orally available tetrahydroquinoline-based glucocorticoid receptor agonists
Hudson, Andrew R., Higuchi, Robert I., Roach, Steven L., Adams, Mark E., Vassar, Angela, Syka, Peter M., Mais, Dale E., Miner, Jeffrey N., Marschke, Keith B., Zhi, Lin
Published in Bioorganic & medicinal chemistry letters (15.03.2011)
Published in Bioorganic & medicinal chemistry letters (15.03.2011)
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Discovery of an androgen receptor modulator pharmacophore based on 2-quinolinones
van Oeveren, Arjan, Pio, Barbara A., Tegley, Christopher M., Higuchi, Robert I., Wu, Min, Jones, Todd K., Marschke, Keith B., Negro-Vilar, Andrés, Zhi, Lin
Published in Bioorganic & medicinal chemistry letters (15.03.2007)
Published in Bioorganic & medicinal chemistry letters (15.03.2007)
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A Tissue-Selective Nonsteroidal Progesterone Receptor Modulator: 7,9-Difluoro-5-(3-methylcyclohex-2-enyl)-2,2,4-trimethyl-1,2-dihydrochromeno[3,4-f]quinoline
Pedram, Bijan, Oeveren, Arjan van, Mais, Dale E, Marschke, Keith B, Verbost, Pieter M, Groen, Marinus B, Zhi, Lin
Published in Journal of medicinal chemistry (10.07.2008)
Published in Journal of medicinal chemistry (10.07.2008)
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Novel Series of Potent, Nonsteroidal, Selective Androgen Receptor Modulators Based on 7H-[1,4]Oxazino[3,2-g]quinolin-7-ones
Higuchi, Robert I, Arienti, Kristen L, López, Francisco J, Mani, Neelakhanda S, Mais, Dale E, Caferro, Thomas R, Long, Yun Oliver, Jones, Todd K, Edwards, James P, Zhi, Lin, Schrader, William T, Negro-Vilar, Andrés, Marschke, Keith B
Published in Journal of medicinal chemistry (17.05.2007)
Published in Journal of medicinal chemistry (17.05.2007)
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Nonsteroidal 2,3-dihydroquinoline glucocorticoid receptor agonists with reduced PEPCK activation
Hudson, Andrew R., Higuchi, Robert I., Roach, Steven L., Valdez, Lino J., Adams, Mark E., Vassar, Angie, Rungta, Deepa, Syka, Peter M., Mais, Dale E., Marschke, Keith B., Zhi, Lin
Published in Bioorganic & medicinal chemistry letters (15.03.2011)
Published in Bioorganic & medicinal chemistry letters (15.03.2011)
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Journal Article
Novel selective androgen receptor modulators: SAR studies on 6-bisalkylamino-2-quinolinones
van Oeveren, Arjan, Motamedi, Mehrnoush, Martinborough, Esther, Zhao, Shuo, Shen, Yixing, West, Sarah, Chang, William, Kallel, Adam, Marschke, Keith B., López, Francisco J., Negro-Vilar, Andrés, Zhi, Lin
Published in Bioorganic & medicinal chemistry letters (15.03.2007)
Published in Bioorganic & medicinal chemistry letters (15.03.2007)
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Journal Article
5-Benzylidene-1,2-dihydrochromeno[3,4-f]quinolines as Selective Progesterone Receptor Modulators
Zhi, Lin, Tegley, Christopher M, Pio, Barbara, Edwards, James P, Motamedi, Mehrnouch, Jones, Todd K, Marschke, Keith B, Mais, Dale E, Risek, Boris, Schrader, William T
Published in Journal of medicinal chemistry (11.09.2003)
Published in Journal of medicinal chemistry (11.09.2003)
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Tetrahydroquinolin-3-yl carbamate glucocorticoid receptor agonists with reduced PEPCK activation
Roach, Steven L., Higuchi, Robert I., Hudson, Andrew R., Vassar, Angie, Grant, Virginia H.S., Lamer, Ryan, Hooper, Charlene, Rungta, Deepa, Syka, Peter M., Mais, Dale E., Marschke, Keith B., Zhi, Lin
Published in Bioorganic & medicinal chemistry letters (15.03.2011)
Published in Bioorganic & medicinal chemistry letters (15.03.2011)
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