Genotype and Subtype Profiling of PSI-7977 as a Nucleotide Inhibitor of Hepatitis C Virus
Lam, Angela M, Espiritu, Christine, Bansal, Shalini, Micolochick Steuer, Holly M, Niu, Congrong, Zennou, Veronique, Keilman, Meg, Zhu, Yuao, Lan, Shuiyun, Otto, Michael J, Furman, Phillip A
Published in Antimicrobial Agents and Chemotherapy (01.06.2012)
Published in Antimicrobial Agents and Chemotherapy (01.06.2012)
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PSI-7851, a Pronucleotide of β-d-2′-Deoxy-2′-Fluoro-2′-C-Methyluridine Monophosphate, Is a Potent and Pan-Genotype Inhibitor of Hepatitis C Virus Replication
LAM, Angela M, MURAKAMI, Eisuke, MORREY, John D, SMEE, Donald F, FRICK, David N, HECK, Julie A, PEIYUAN WANG, NAGARATHNAM, Dhanapalan, ROSS, Bruce S, SOFIA, Michael J, OTTO, Michael J, FURMAN, Phillip A, ESPIRITU, Christine, MICOLOCHICK STEUER, Holly M, NIU, Congrong, KEILMAN, Meg, HAIYING BAO, ZENNOU, Veronique, BOURNE, Nigel, JULANDER, Justin G
Published in Antimicrobial Agents and Chemotherapy (01.08.2010)
Published in Antimicrobial Agents and Chemotherapy (01.08.2010)
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Inhibition of Hepatitis C Virus Replicon RNA Synthesis by PSI-352938, a Cyclic Phosphate Prodrug of β-d-2′-Deoxy-2′-α-Fluoro-2′-β-C-Methylguanosine
LAM, Angela M, ESPIRITU, Christine, VESELENAK, Ronald L, GANAPATI REDDY, P, CHANG, Wonsuk, JINFA DU, NAGARATHNAM, Dhanapalan, SOFIA, Michael J, OTTO, Michael J, FURMAN, Phillip A, MURAKAMI, Eisuke, ZENNOU, Veronique, BANSAL, Shalini, MICOLOCHICK STEUER, Holly M, CONGRONG NIU, KEILMAN, Meg, HAIYING BAO, BOURNE, Nigel
Published in Antimicrobial Agents and Chemotherapy (01.06.2011)
Published in Antimicrobial Agents and Chemotherapy (01.06.2011)
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Discovery of PSI-353661, a Novel Purine Nucleotide Prodrug for the Treatment of HCV Infection
Chang, Wonsuk, Bao, Donghui, Chun, Byoung-Kwon, Naduthambi, Devan, Nagarathnam, Dhanapalan, Rachakonda, Suguna, Reddy, P. Ganapati, Ross, Bruce S, Zhang, Hai-Ren, Bansal, Shalini, Espiritu, Christine L, Keilman, Meg, Lam, Angela M, Niu, Congrong, Steuer, Holly Micolochick, Furman, Phillip A, Otto, Michael J, Sofia, Michael J
Published in ACS medicinal chemistry letters (10.02.2011)
Published in ACS medicinal chemistry letters (10.02.2011)
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Phosphoramidate Prodrugs of (−)-β-D-(2R,4R)-dioxolane-thymine (DOT) as Potent Anti-HIV Agents
Wang, Peiyuan, Rachakonda, Suguna, Zennou, Veronique, Keilman, Meg, Niu, Congrong, Bao, Donghui, Ross, Bruce S, Furman, Phillip A, Otto, Michael J, Sofia, Michael J
Published in Antiviral chemistry & chemotherapy (01.04.2012)
Published in Antiviral chemistry & chemotherapy (01.04.2012)
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Discovery of a β-d-2′-Deoxy-2′-α-fluoro-2′-β-C-methyluridine Nucleotide Prodrug (PSI-7977) for the Treatment of Hepatitis C Virus
Sofia, Michael J, Bao, Donghui, Chang, Wonsuk, Du, Jinfa, Nagarathnam, Dhanapalan, Rachakonda, Suguna, Reddy, P. Ganapati, Ross, Bruce S, Wang, Peiyuan, Zhang, Hai-Ren, Bansal, Shalini, Espiritu, Christine, Keilman, Meg, Lam, Angela M, Steuer, Holly M. Micolochick, Niu, Congrong, Otto, Michael J, Furman, Phillip A
Published in Journal of medicinal chemistry (14.10.2010)
Published in Journal of medicinal chemistry (14.10.2010)
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Discovery of a Novel Class of Potent HCV NS4B Inhibitors: SAR Studies on Piperazinone Derivatives
Kakarla, Ramesh, Liu, Jian, Naduthambi, Devan, Chang, Wonsuk, Mosley, Ralph T., Bao, Donghui, Steuer, Holly M. Micolochick, Keilman, Meg, Bansal, Shalini, Lam, Angela M., Seibel, William, Neilson, Sandra, Furman, Phillip A., Sofia, Michael J.
Published in Journal of medicinal chemistry (13.03.2014)
Published in Journal of medicinal chemistry (13.03.2014)
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Inhibition of hepatitis C virus NS5A by fluoro-olefin based γ-turn mimetics
Chang, Wonsuk, Mosley, Ralph T., Bansal, Shalini, Keilman, Meg, Lam, Angela M., Furman, Phillip A., Otto, Michael J., Sofia, Michael J.
Published in Bioorganic & medicinal chemistry letters (15.04.2012)
Published in Bioorganic & medicinal chemistry letters (15.04.2012)
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2′-Deoxy-2′-α-fluoro-2′-β- C-methyl 3′,5′-cyclic phosphate nucleotide prodrug analogs as inhibitors of HCV NS5B polymerase: Discovery of PSI-352938
Reddy, P. Ganapati, Bao, Donghui, Chang, Wonsuk, Chun, Byoung-Kwon, Du, Jinfa, Nagarathnam, Dhanapalan, Rachakonda, Suguna, Ross, Bruce S., Zhang, Hai-Ren, Bansal, Shalini, Espiritu, Christine L., Keilman, Meg, Lam, Angela M., Niu, Congrong, Steuer, Holly Micolochick, Furman, Phillip A., Otto, Michael J., Sofia, Michael J.
Published in Bioorganic & medicinal chemistry letters (15.12.2010)
Published in Bioorganic & medicinal chemistry letters (15.12.2010)
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Journal Article
Activity and the metabolic activation pathway of the potent and selective hepatitis C virus pronucleotide inhibitor PSI-353661
Furman, Phillip A., Murakami, Eisuke, Niu, Congrong, Lam, Angela M., Espiritu, Christine, Bansal, Shalini, Bao, Haiying, Tolstykh, Tatiana, Micolochick Steuer, Holly, Keilman, Meg, Zennou, Veronique, Bourne, Nigel, Veselenak, Ronald L., Chang, Wonsuk, Ross, Bruce S., Du, Jinfa, Otto, Michael J., Sofia, Michael J.
Published in Antiviral research (01.08.2011)
Published in Antiviral research (01.08.2011)
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Inhibition of hepatitis C virus NS5A by fluoro-olefin based I3-turn mimetics
Chang, Wonsuk, Mosley, Ralph T, Bansal, Shalini, Keilman, Meg, Lam, Angela M, Furman, Phillip A, Otto, Michael J, Sofia, Michael J
Published in Bioorganic & medicinal chemistry letters (15.04.2012)
Published in Bioorganic & medicinal chemistry letters (15.04.2012)
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Journal Article
PSI-7851, a Pronucleotide of ?-D-2'-Deoxy-2'-Fluoro-2'-C-Methyluridine Monophosphate, Is a Potent and Pan-Genotype Inhibitor of Hepatitis C Virus Replication
Lam, Angela M, Murakami, Eisuke, Espiritu, Christine, Micolochick Steuer, Holly M, Niu, Congrong, Keilman, Meg, Bao, Haiying, Zennou, Veronique, Bourne, Nigel, Julander, Justin G
Published in Antimicrobial agents and chemotherapy (01.08.2010)
Published in Antimicrobial agents and chemotherapy (01.08.2010)
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Journal Article
2'-Deoxy-2'-a-fluoro-2'-b-C-methyl 3',5'-cyclic phosphate nucleotide prodrug analogs as inhibitors of HCV NS5B polymerase: Discovery of PSI-352938
Reddy, PGanapati, Bao, Donghui, Chang, Wonsuk, Chun, Byoung-Kwon, Du, Jinfa, Nagarathnam, Dhanapalan, Rachakonda, Suguna, Ross, Bruce S, Zhang, Hai-Ren, Bansal, Shalini, Espiritu, Christine L, Keilman, Meg, Lam, Angela M, Niu, Congrong, Steuer, Holly Micolochick, Furman, Phillip A, Otto, Michael J, Sofia, Michael J
Published in Bioorganic & medicinal chemistry letters (15.12.2010)
Published in Bioorganic & medicinal chemistry letters (15.12.2010)
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Journal Article
Synthesis of Stable Isotope Labeled Analogs of the Anti-Hepatitis C Virus Nucleotide Prodrugs PSI-7977 and PSI-352938
Chun, Byoung-Kwon, Du, Jinfa, Zhang, Hai-Ren, Chang, Wonsuk, Ross, Bruce S., Jiang, Ying, Bao, Donghui, Espiritu, Christine L., Keilman, Meg, Steuer, Holly M. Micolochick, Furman, Phillip A., Sofia, Michael J.
Published in Nucleosides, nucleotides & nucleic acids (01.11.2011)
Published in Nucleosides, nucleotides & nucleic acids (01.11.2011)
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