Characterization of the 5-HT2 receptor antagonist MDL 100907 as a putative atypical antipsychotic: behavioral, electrophysiological and neurochemical studies
SORENSEN, S. M, KEHNE, J. H, FADAYEL, G. M, HUMPHREYS, T. M, KETTELER, H. J, SULLIVAN, C. K, TAYLOR, V. L, SCHMIDT, C. J
Published in The Journal of pharmacology and experimental therapeutics (01.08.1993)
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Published in The Journal of pharmacology and experimental therapeutics (01.08.1993)
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Preclinical characterization of the potential of the putative atypical antipsychotic MDL 100,907 as a potent 5-HT2A antagonist with a favorable CNS safety profile
Kehne, J H, Baron, B M, Carr, A A, Chaney, S F, Elands, J, Feldman, D J, Frank, R A, van Giersbergen, P L, McCloskey, T C, Johnson, M P, McCarty, D R, Poirot, M, Senyah, Y, Siegel, B W, Widmaier, C
Published in The Journal of pharmacology and experimental therapeutics (01.05.1996)
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Published in The Journal of pharmacology and experimental therapeutics (01.05.1996)
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NMDA receptor complex antagonists have potential anxiolytic effects as measured with separation-induced ultrasonic vocalizations
Kehne, J H, McCloskey, T C, Baron, B M, Chi, E M, Harrison, B L, Whitten, J P, Palfreyman, M G
Published in European journal of pharmacology (14.02.1991)
Published in European journal of pharmacology (14.02.1991)
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Effects of the serotonin releasers 3,4-methylenedioxymethamphetamine (MDMA), 4-chloroamphetamine (PCA) and fenfluramine on acoustic and tactile startle reflexes in rats
Kehne, J H, McCloskey, T C, Taylor, V L, Black, C K, Fadayel, G M, Schmidt, C J
Published in The Journal of pharmacology and experimental therapeutics (01.01.1992)
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Published in The Journal of pharmacology and experimental therapeutics (01.01.1992)
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3-(2-Carboxyindol-3-yl)propionic acid-based antagonists of the N-methyl-D-aspartic acid receptor associated glycine binding site
SALITURO, F. G, HARRISON, B. L, BARON, B. M, NYCE, P. L, STEWART, K. T, KEHNE, J. H, WHITE, H. S, MCDONALD, I. A
Published in Journal of medicinal chemistry (15.05.1992)
Published in Journal of medicinal chemistry (15.05.1992)
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Contribution of serotonin neurotoxins to understanding psychiatric disorders: the role of 5-HT2 receptors in schizophrenia and antipsychotic activity
Schmidt, C J, Kehne, J H, Carr, A A, Fadayel, G M, Humphreys, T M, Kettler, H J, McCloskey, T C, Padich, R A, Taylor, V L, Sorensen, S M
Published in International clinical psychopharmacology (01.11.1993)
Published in International clinical psychopharmacology (01.11.1993)
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Reversal of amphetamine-induced behaviours by MDL 100,907, a selective 5-HT2A antagonist
MOSER, P. C, MORAN, P. M, FRANK, R. A, KEHNE, J. H
Published in Behavioural brain research (15.12.1995)
Published in Behavioural brain research (15.12.1995)
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Conference Proceeding
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Cyclic Nitrone Free Radical Traps: Isolation, Identification, and Synthesis of 3,3-Dimethyl-3,4-dihydroisoquinolin-4-ol N-Oxide, a Metabolite with Reduced Side Effects
Thomas, Craig E, Bernardelli, Patrick, Bowen, S. Marc, Chaney, Stephen F, Friedrich, Dirk, Janowick, David A, Jones, Bryan K, Keeley, Frederick J, Kehne, John H, Ketteler, Bert, Ohlweiler, David F, Paquette, Leo A, Robke, David J, Fevig, Thomas L
Published in Journal of medicinal chemistry (06.12.1996)
Published in Journal of medicinal chemistry (06.12.1996)
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The role of 5-HT2A receptors in antipsychotic activity
Schmidt, C J, Sorensen, S M, Kehne, J H, Carr, A A, Palfreyman, M G
Published in Life sciences (1973) (12.05.1995)
Published in Life sciences (1973) (12.05.1995)
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The role of spinal cord cyclic AMP in the acoustic startle response in rats
Kehne, JH, Astrachan, DI, Astrachan, E, Tallman, JF, Davis, M
Published in The Journal of neuroscience (01.11.1986)
Published in The Journal of neuroscience (01.11.1986)
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