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Published in Clinical cancer research (01.03.2019)
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Transcriptional downregulation of MHC class I and melanoma de- differentiation in resistance to PD-1 inhibition
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Published in Nature communications (20.04.2020)
Published in Nature communications (20.04.2020)
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BRAF Inhibitor Resistance Mechanisms in Metastatic Melanoma: Spectrum and Clinical Impact
RIZOS, Helen, MENZIES, Alexander M, HOWIE, Julie, SAW, Robyn, THOMPSON, John F, KEFFORD, Richard F, SCOLYER, Richard A, LONG, Georgina V, PUPO, Gulietta M, CARLINO, Matteo S, FUNG, Carina, HYMAN, Jessica, HAYDU, Lauren E, MIJATOV, Branka, BECKER, Therese M, BOYD, Suzanah C
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Published in Clinical cancer research (01.04.2014)
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Phase II Trial (BREAK-2) of the BRAF Inhibitor Dabrafenib (GSK2118436) in Patients With Metastatic Melanoma
ASCIERTO, Paolo A, MINOR, David, HAMID, Omid, AMARAVADI, Ravi, SIMEONE, Ester, WILHELM, Tabea, KIM, Kevin B, LONG, Georgina V, MARTIN, Anne-Marie, MAZUMDAR, Jolly, GOODMAN, Vicki L, TREFZER, Uwe, RIBAS, Antoni, LEBBE, Celeste, O'HAGAN, Anne, ARYA, Niki, GUCKERT, Mary, SCHADENDORF, Dirk, KEFFORD, Richard F, GROB, Jean-Jacques
Published in Journal of clinical oncology (10.09.2013)
Published in Journal of clinical oncology (10.09.2013)
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Dynamic Changes in PD-L1 Expression and Immune Infiltrates Early During Treatment Predict Response to PD-1 Blockade in Melanoma
Vilain, Ricardo E, Menzies, Alexander M, Wilmott, James S, Kakavand, Hojabr, Madore, Jason, Guminski, Alexander, Liniker, Elizabeth, Kong, Benjamin Y, Cooper, Adam J, Howle, Julie R, Saw, Robyn P M, Jakrot, Valerie, Lo, Serigne, Thompson, John F, Carlino, Matteo S, Kefford, Richard F, Long, Georgina V, Scolyer, Richard A
Published in Clinical cancer research (01.09.2017)
Published in Clinical cancer research (01.09.2017)
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Prognostic and Clinicopathologic Associations of Oncogenic BRAF in Metastatic Melanoma
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Published in Journal of clinical oncology (01.04.2011)
Published in Journal of clinical oncology (01.04.2011)
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Dabrafenib in patients with Val600Glu or Val600Lys BRAF-mutant melanoma metastatic to the brain (BREAK-MB): a multicentre, open-label, phase 2 trial
Long, Georgina V, Dr, Trefzer, Uwe, MD, Davies, Michael A, MD, Kefford, Richard F, Prof, Ascierto, Paolo A, MD, Chapman, Paul B, MD, Puzanov, Igor, MD, Hauschild, Axel, MD, Robert, Caroline, PhD, Algazi, Alain, MD, Mortier, Laurent, Prof, Tawbi, Hussein, PhD, Wilhelm, Tabea, MD, Zimmer, Lisa, MD, Switzky, Julie, MSN, Swann, Suzanne, PhD, Martin, Anne-Marie, PhD, Guckert, Mary, MSN, Goodman, Vicki, MD, Streit, Michael, MD, Kirkwood, John M, Prof, Schadendorf, Dirk, Prof
Published in The lancet oncology (01.11.2012)
Published in The lancet oncology (01.11.2012)
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Increased MAPK reactivation in early resistance to dabrafenib/trametinib combination therapy of BRAF-mutant metastatic melanoma
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Published in Nature communications (02.12.2014)
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PD-L1 expression in melanoma shows marked heterogeneity within and between patients: implications for anti-PD-1/PD-L1 clinical trials
Madore, Jason, Vilain, Ricardo E., Menzies, Alexander M., Kakavand, Hojabr, Wilmott, James S., Hyman, Jessica, Yearley, Jennifer H., Kefford, Richard F., Thompson, John F., Long, Georgina V., Hersey, Peter, Scolyer, Richard A.
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Published in Molecular cancer (17.01.2018)
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Acquired resistance and clonal evolution in melanoma during BRAF inhibitor therapy
Shi, Hubing, Hugo, Willy, Kong, Xiangju, Hong, Aayoung, Koya, Richard C, Moriceau, Gatien, Chodon, Thinle, Guo, Rongqing, Johnson, Douglas B, Dahlman, Kimberly B, Kelley, Mark C, Kefford, Richard F, Chmielowski, Bartosz, Glaspy, John A, Sosman, Jeffrey A, van Baren, Nicolas, Long, Georgina V, Ribas, Antoni, Lo, Roger S
Published in Cancer discovery (01.01.2014)
Published in Cancer discovery (01.01.2014)
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Phase I Dose-Escalation and -Expansion Study of the BRAF Inhibitor Encorafenib (LGX818) in Metastatic BRAF -Mutant Melanoma
Delord, Jean-Pierre, Robert, Caroline, Nyakas, Marta, McArthur, Grant A, Kudchakar, Ragini, Mahipal, Amit, Yamada, Yasuhide, Sullivan, Ryan, Arance, Ana, Kefford, Richard F, Carlino, Matteo S, Hidalgo, Manuel, Gomez-Roca, Carlos, Michel, Daniela, Seroutou, Abdelkader, Aslanis, Vassilios, Caponigro, Giordano, Stuart, Darrin D, Moutouh-de Parseval, Laure, Demuth, Tim, Dummer, Reinhard
Published in Clinical cancer research (15.09.2017)
Published in Clinical cancer research (15.09.2017)
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Immunohistochemistry is highly sensitive and specific for the detection of V600E BRAF mutation in melanoma
Long, Georgina V, Wilmott, James S, Capper, David, Preusser, Matthias, Zhang, Yuxiao E, Thompson, John F, Kefford, Richard F, von Deimling, Andreas, Scolyer, Richard A
Published in The American journal of surgical pathology (01.01.2013)
Published in The American journal of surgical pathology (01.01.2013)
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Dabrafenib in patients with melanoma, untreated brain metastases, and other solid tumours: a phase 1 dose-escalation trial
Falchook, Gerald S, Dr, Long, Georgina V, PhD, Kurzrock, Razelle, Prof, Kim, Kevin B, MD, Arkenau, Tobias H, PhD, Brown, Michael P, PhD, Hamid, Omid, MD, Infante, Jeffrey R, MD, Millward, Michael, MD, Pavlick, Anna C, MD, O’Day, Steven J, MD, Blackman, Samuel C, PhD, Curtis, C Martin, BA, Lebowitz, Peter, PhD, Ma, Bo, PhD, Ouellet, Daniele, PhD, Kefford, Richard F, Prof
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Published in The Lancet (British edition) (19.05.2012)
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PD-L1 Expression and Tumor-Infiltrating Lymphocytes Define Different Subsets of MAPK Inhibitor-Treated Melanoma Patients
Kakavand, Hojabr, Wilmott, James S, Menzies, Alexander M, Vilain, Ricardo, Haydu, Lauren E, Yearley, Jennifer H, Thompson, John F, Kefford, Richard F, Hersey, Peter, Long, Georgina V, Scolyer, Richard A
Published in Clinical cancer research (15.07.2015)
Published in Clinical cancer research (15.07.2015)
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Interferon Signaling Is Frequently Downregulated in Melanoma
Alavi, Sara, Stewart, Ashleigh Jacqueline, Kefford, Richard F, Lim, Su Yin, Shklovskaya, Elena, Rizos, Helen
Published in Frontiers in immunology (21.06.2018)
Published in Frontiers in immunology (21.06.2018)
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Differential activity of MEK and ERK inhibitors in BRAF inhibitor resistant melanoma
Carlino, Matteo S., Todd, Jason R., Gowrishankar, Kavitha, Mijatov, Branka, Pupo, Gulietta M., Fung, Carina, Snoyman, Stephanie, Hersey, Peter, Long, Georgina V., Kefford, Richard F., Rizos, Helen
Published in Molecular oncology (01.05.2014)
Published in Molecular oncology (01.05.2014)
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Intrapatient homogeneity of BRAFV600E expression in melanoma
Menzies, Alexander M, Lum, Trina, Wilmott, James S, Hyman, Jessica, Kefford, Richard F, Thompson, John F, O'Toole, Sandra, Long, Georgina V, Scolyer, Richard A
Published in The American journal of surgical pathology (01.03.2014)
Published in The American journal of surgical pathology (01.03.2014)
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Inter- and intra-patient heterogeneity of response and progression to targeted therapy in metastatic melanoma
Menzies, Alexander M, Haydu, Lauren E, Carlino, Matteo S, Azer, Mary W F, Carr, Peter J A, Kefford, Richard F, Long, Georgina V
Published in PloS one (06.01.2014)
Published in PloS one (06.01.2014)
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Dose Selection, Pharmacokinetics, and Pharmacodynamics of BRAF Inhibitor Dabrafenib (GSK2118436)
FALCHOOK, Gerald S, LONG, Georgina V, CHIN, Melvin T, O'DAY, Steven J, BLACKMAN, Samuel C, CURTIS, C. Martin, LEBOWITZ, Peter, BO MA, OUELLET, Daniele, KEFFORD, Richard F, KURZROCK, Razelle, KIM, Kevin B, ARKENAU, H.-Tobias, BROWN, Michael P, HAMID, Omid, INFANTE, Jeffrey R, MILLWARD, Michael, PAVLICK, Anna
Published in Clinical cancer research (01.09.2014)
Published in Clinical cancer research (01.09.2014)
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