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Published in Nature (London) (30.03.2017)
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Published in Nature (London) (07.07.2016)
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CRISPR Screens Provide a Comprehensive Assessment of Cancer Vulnerabilities but Generate False-Positive Hits for Highly Amplified Genomic Regions
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Published in Proceedings of the National Academy of Sciences - PNAS (25.02.2014)
Published in Proceedings of the National Academy of Sciences - PNAS (25.02.2014)
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Published in Journal of cell science (01.09.2006)
Published in Journal of cell science (01.09.2006)
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Global chromatin profiling reveals NSD2 mutations in pediatric acute lymphoblastic leukemia
Jaffe, Jacob D, Wang, Yan, Chan, Ho Man, Zhang, Jinghui, Huether, Robert, Kryukov, Gregory V, Bhang, Hyo-eun C, Taylor, Jordan E, Hu, Min, Englund, Nathan P, Yan, Feng, Wang, Zhaofu, Robert McDonald, 3rd, E, Wei, Lei, Ma, Jing, Easton, John, Yu, Zhengtian, deBeaumount, Rosalie, Gibaja, Veronica, Venkatesan, Kavitha, Schlegel, Robert, Sellers, William R, Keen, Nicholas, Liu, Jun, Caponigro, Giordano, Barretina, Jordi, Cooke, Vesselina G, Mullighan, Charles, Carr, Steven A, Downing, James R, Garraway, Levi A, Stegmeier, Frank
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Published in Structure (London) (07.09.2011)
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AZD1152, a Selective Inhibitor of Aurora B Kinase, Inhibits Human Tumor Xenograft Growth by Inducing Apoptosis
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Published in Clinical cancer research (15.06.2007)
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Mortlock, Andrew A, Foote, Kevin M, Heron, Nicola M, Jung, Frédéric H, Pasquet, Georges, Lohmann, Jean-Jacques M, Warin, Nicolas, Renaud, Fabrice, De Savi, Chris, Roberts, Nicola J, Johnson, Trevor, Dousson, Cyril B, Hill, George B, Perkins, David, Hatter, Glenn, Wilkinson, Robert W, Wedge, Stephen R, Heaton, Simon P, Odedra, Rajesh, Keen, Nicholas J, Crafter, Claire, Brown, Elaine, Thompson, Katherine, Brightwell, Stephen, Khatri, Liz, Brady, Madeleine C, Kearney, Sarah, McKillop, David, Rhead, Steve, Parry, Tony, Green, Stephen
Published in Journal of medicinal chemistry (03.05.2007)
Published in Journal of medicinal chemistry (03.05.2007)
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Published in ACS chemical biology (18.10.2013)
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Antitumor Properties of RAF709, a Highly Selective and Potent Inhibitor of RAF Kinase Dimers, in Tumors Driven by Mutant RAS or BRAF
Shao, Wenlin, Mishina, Yuji M, Feng, Yun, Caponigro, Giordano, Cooke, Vesselina G, Rivera, Stacy, Wang, Yingyun, Shen, Fang, Korn, Joshua M, Mathews Griner, Lesley A, Nishiguchi, Gisele, Rico, Alice, Tellew, John, Haling, Jacob R, Aversa, Robert, Polyakov, Valery, Zang, Richard, Hekmat-Nejad, Mohammad, Amiri, Payman, Singh, Mallika, Keen, Nicholas, Dillon, Michael P, Lees, Emma, Ramurthy, Savithri, Sellers, William R, Stuart, Darrin D
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BT7480, a novel fully synthetic Bicycle tumor-targeted immune cell agonist™ (Bicycle TICA™) induces tumor localized CD137 agonism
Hurov, Kristen, Lahdenranta, Johanna, Upadhyaya, Punit, Haines, Eric, Cohen, Heather, Repash, Elizabeth, Kanakia, Drasti, Ma, Jun, Kristensson, Julia, You, Fanglei, Campbell, Carly, Witty, David, Kelly, Mike, Blakemore, Stephen, Jeffrey, Phil, McDonnell, Kevin, Brandish, Philip, Keen, Nicholas
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ERG signaling in prostate cancer is driven through PRMT5-dependent methylation of the Androgen Receptor
Mounir, Zineb, Korn, Joshua M, Westerling, Thomas, Lin, Fallon, Kirby, Christina A, Schirle, Markus, McAllister, Gregg, Hoffman, Greg, Ramadan, Nadire, Hartung, Anke, Feng, Yan, Kipp, David Randal, Quinn, Christopher, Fodor, Michelle, Baird, Jason, Schoumacher, Marie, Meyer, Ronald, Deeds, James, Buchwalter, Gilles, Stams, Travis, Keen, Nicholas, Sellers, William R, Brown, Myles, Pagliarini, Raymond A
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Aurora B kinase regulates the postmitotic endoreduplication checkpoint via phosphorylation of the retinoblastoma protein at serine 780
Nair, Jayasree S, Ho, Alan L, Tse, Archie N, Coward, Jesse, Cheema, Haider, Ambrosini, Grazia, Keen, Nicholas, Schwartz, Gary K
Published in Molecular biology of the cell (15.04.2009)
Published in Molecular biology of the cell (15.04.2009)
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Anticancer immunity induced by a synthetic tumor-targeted CD137 agonist
Upadhyaya, Punit, Lahdenranta, Johanna, Hurov, Kristen, Battula, Sailaja, Dods, Rachel, Haines, Eric, Kleyman, Marianna, Kristensson, Julia, Kublin, Jessica, Lani, Rachid, Ma, Jun, Mudd, Gemma, Repash, Elizabeth, Van Rietschoten, Katerine, Stephen, Tom, You, Fanglei, Harrison, Helen, Chen, Liuhong, McDonnell, Kevin, Brandish, Philip, Keen, Nicholas
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888 An integrative approach to optimize a synthetic EphA2/CD137 agonist: balancing potency, physiochemical properties, and pharmacokinetics to achieve robust anti-tumor activity
Upadhyaya, Punit, Mudd, Gemma, Hurov, Kristen, Lahdenranta, Johanna, Repash, Elizabeth, Kristensson, Julia, McDonnell, Kevin, Brandish, Philip, Jeffrey, Phil, Keen, Nicholas
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2 Quantitation of CD137 and Nectin-4 expression across multiple tumor types to support indication selection for BT7480, a Bicycle tumor-targeted immune cell agonist™ (Bicycle TICA™)
Cohen, Heather, Campbell, Carly, Hurov, Kristen, Lahdenranta, Johanna, Gelb, Tara, Galbraith, David, Rozelle, Dan, Nagy, Mate, Au, Qingyan, Parnell, Erinn, Brandish, Phil, Hazard, Sebastien, Smethurst, Dominic, Keen, Nicholas, Blakemore, Stephen
Published in Journal for immunotherapy of cancer (01.11.2021)
Published in Journal for immunotherapy of cancer (01.11.2021)
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