Cancer-Associated SF3B1 Hotspot Mutations Induce Cryptic 3′ Splice Site Selection through Use of a Different Branch Point
Darman, Rachel B., Seiler, Michael, Agrawal, Anant A., Lim, Kian H., Peng, Shouyong, Aird, Daniel, Bailey, Suzanna L., Bhavsar, Erica B., Chan, Betty, Colla, Simona, Corson, Laura, Feala, Jacob, Fekkes, Peter, Ichikawa, Kana, Keaney, Gregg F., Lee, Linda, Kumar, Pavan, Kunii, Kaiko, MacKenzie, Crystal, Matijevic, Mark, Mizui, Yoshiharu, Myint, Khin, Park, Eun Sun, Puyang, Xiaoling, Selvaraj, Anand, Thomas, Michael P., Tsai, Jennifer, Wang, John Y., Warmuth, Markus, Yang, Hui, Zhu, Ping, Garcia-Manero, Guillermo, Furman, Richard R., Yu, Lihua, Smith, Peter G., Buonamici, Silvia
Published in Cell reports (Cambridge) (03.11.2015)
Published in Cell reports (Cambridge) (03.11.2015)
Get full text
Journal Article
Total Synthesis of 6‑Deoxypladienolide D and Assessment of Splicing Inhibitory Activity in a Mutant SF3B1 Cancer Cell Line
Arai, Kenzo, Buonamici, Silvia, Chan, Betty, Corson, Laura, Endo, Atsushi, Gerard, Baudouin, Hao, Ming-Hong, Karr, Craig, Kira, Kazunobu, Lee, Linda, Liu, Xiang, Lowe, Jason T, Luo, Tuoping, Marcaurelle, Lisa A, Mizui, Yoshiharu, Nevalainen, Marta, O’Shea, Morgan Welzel, Park, Eun Sun, Perino, Samantha A, Prajapati, Sudeep, Shan, Mingde, Smith, Peter G, Tivitmahaisoon, Parcharee, Wang, John Yuan, Warmuth, Markus, Wu, Kuo-Ming, Yu, Lihua, Zhang, Huiming, Zheng, Guo-Zhu, Keaney, Gregg F
Published in Organic letters (07.11.2014)
Published in Organic letters (07.11.2014)
Get full text
Journal Article
Total Synthesis of (±)-Kalihinol C
White, Ryan D, Keaney, Gregg F, Slown, Corin D, Wood, John L
Published in Organic letters (01.04.2004)
Published in Organic letters (01.04.2004)
Get full text
Journal Article
헤테로방향족 NMDA 수용체 조절제 및 이의 용도
KEANEY GREGG F, PISER TIMOTHY, VOLKMANN ROBERT A, ANDERSON DAVID R, MALEKIANI SAM, LEISER STEVEN C
Year of Publication 09.04.2021
Get full text
Year of Publication 09.04.2021
Patent
칼륨 채널 조절제
KEANEY GREGG F, JEFSON MARTIN R, LARSEN JANUS SCHREIBER, FOSTER KELLY, JACOBSEN THOMAS AMOS, NIELSEN KARIN SANDAGER, AMRUTKAR DIPAK VASANTRAO
Year of Publication 30.09.2019
Get full text
Year of Publication 30.09.2019
Patent
플라디에놀리드 화합물 및 그의 용도
HAO MING HONG, KANADA SONOBE REGINA MIKIE, LIU XIANG, NEVALAINEN MARTA, ENDO ATSUSHI, WANG JOHN, ARAI KENZO, REYNOLDS DOMINIC, GEARHART NICHOLAS C, ZHENG GUO ZHU, MURAI NORIO, KEANEY GREGG F, COOK ANDREW, LUO TOUPING, TIVITMAHAISOON PARCHAREE, O'SHEA MORGAN WELZEL, LOWE JASON T, ELLERY SHELBY, GERARD BAUDOUIN, KOTAKE YOSHIHIKO, MARCAURELLE LISA A, NAGAO SATOSHI, KIRA KAZUNOBU, MIYANO MASAYUKI, PRAJAPATI SUDEEP, PALACINO JAMES
Year of Publication 19.01.2021
Get full text
Year of Publication 19.01.2021
Patent
플라디에놀리드 피리딘 화합물의 고체 상태 형태 및 사용 방법
LIM KIAN HUAT, KANADA SONABE REGINA MIKIE, LIU XIANG, BUONAMICI SILVIA, ENDO ATSUSHI, WANG JOHN, PAZOLLI ERMIRA, CHANDA ARANI, ARAI KENZO, GEARHART NICHOLAS C, ZHENG GUO ZHU, MURAI NORIO, KEANEY GREGG F, TIVITMAHAISOON PARCHAREE, CHAN BETTY, GERARD BAUDOUIN, KOTAKE YOSHIHIKO, NAGAO SATOSHI, THOMAS MICHAEL P, YU LIHUA, KIRA KAZUNOBU, PARK EUNICE SUN, MIYANO MASAYUKI, SMITH PETER G, PRAJAPATI SUDEEP
Year of Publication 20.07.2018
Get full text
Year of Publication 20.07.2018
Patent
PLADIENOLIDE PYRIDINE COMPOUNDS AND METHODS OF USE
KEANEY GREGG F, TIVITMAHAISOON PARCHAREE, LIU XIANG, WANG JOHN, GERARD BAUDOUIN, KOTAKE YOSHIHIKO, NAGAO SATOSHI, ARAI KENZO, KANADA SONOBE REGINA, KIRA KAZUNOBU, GEARHART NICHOLAS C, ZHENG GUO ZHU, MIYANO MASAYUKI, PRAJAPATI SUDEEP, MURAI NORIO
Year of Publication 28.02.2017
Get full text
Year of Publication 28.02.2017
Patent
PLADIENOLIDE PYRIDINE COMPOUNDS AND METHODS OF USE
KEANEY GREGG F, TIVITMAHAISOON PARCHAREE, LIU XIANG, WANG JOHN, GERARD BAUDOUIN, KOTAKE YOSHIHIKO, NAGAO SATOSHI, ARAI KENZO, KANADA SONOBE REGINA, KIRA KAZUNOBU, GEARHART NICHOLAS C, ZHENG GUO ZHU, MIYANO MASAYUKI, PRAJAPATI SUDEEP, MURAI NORIO
Year of Publication 08.07.2016
Get full text
Year of Publication 08.07.2016
Patent
H3B-8800, an Orally Bioavailable Modulator of the SF3b Complex, Shows Efficacy in Spliceosome-Mutant Myeloid Malignancies
Buonamici, Silvia, Yoshimi, Akihide, Thomas, Michael, Seiler, Michael, Chan, Betty, Caleb, Benjamin, Darman, Rachel, Fekkes, Peter, Karr, Craig, Keaney, Gregg F., Klimek, Virginia M., Kunii, Kaiko, Lee, Linda, Lee, Stanley Chun-Wei, Liu, Xiang, Meeske, Carol, Mizui, Yoshiharu, Padron, Eric, Park, Eunice, Pazolli, Ermira, Prajapati, Sudeep, Taylor, Justin, Wang, John, Warmuth, Markus, Yu, Lihua, Zhu, Ping, Abdel-Wahab, Omar, Smith, Peter G
Published in Blood (02.12.2016)
Published in Blood (02.12.2016)
Get full text
Journal Article
Abstract B125: Mutant SF3B1 downregulates proteins involved in differentiation, including ABCB7
Darman, Rachel B., Perino, Samantha A., Seiler, Michael, Peng, Shouyong, Feala, Jacob, Fekkes, Peter, Keaney, Gregg F., Kunii, Kaiko, Lee, Linda, Lim, Kian Huat, Oda, Yoshiya, Myint, Khin, Obeng, Esther A., Pazolli, Ermira, Park, Eun Sun, Wang, John Yuan, Warmuth, Markus, Yu, Lihua, Zhu, Ping, Mizui, Yoshiharu, Ebert, Benjamin L., Smith, Peter G., Buonamici, Silvia
Published in Molecular cancer therapeutics (01.12.2015)
Published in Molecular cancer therapeutics (01.12.2015)
Get full text
Journal Article
Heterozygous Hotspot SF3B1 Mutations Found in Myelodysplastic Syndromes Downregulate Genes Involved in Differentiation of Erythroid Cells
Buonamici, Silvia, Darman, Rachel, Perino, Samantha, Agrawal, Anant, Peng, Shouyong, Seiler, Michael, Lim, Kian Huat, Bhavsar, Erica B., Feala, Jacob, Obeng, Esther A., Bailey, Suzanna, Chan, Betty, Fekkes, Peter, Keaney, Gregg F., Kumar, Pavan, Kunii, Kaiko, Lee, Linda, Mackenzie, Crystal, Matijevic, Mark, Mizui, Yoshiharu, Myint, Khin, Park, Eunice, Pazolli, Ermira, Thomas, Michael, Wang, John, Warmuth, Markus, Yu, Lihua, Zhu, Ping, Furman, Richard R., Ebert, Benjamin L, Smith, Peter G
Published in Blood (03.12.2015)
Published in Blood (03.12.2015)
Get full text
Journal Article
Abstract 5564: Total synthesis of 6-deoxypladienolide D and assessment of splicing inhibitory activity in a mutant SF3B1 cancer cell line
Arai, Kenzo, Buonamici, Silvia, Chan, Betty, Corson, Laura, Endo, Atsushi, Gerard, Baudouin, Hao, Ming-Hong, Karr, Craig, Kira, Kazunobu, Lee, Linda, Liu, Xiang, Lowe, Jason T., Luo, Tuoping, Marcaurelle, Lisa A., Mizui, Yoshiharu, Nevalainen, Marta, Welzel O'Shea, Morgan, Park, Eun Sun, Perino, Samantha A., Prajapati, Sudeep, Shan, Mingde, Smith, Peter G., Tivitmahaisoon, Parcharee, Wang, John Yuan, Warmuth, Markus, Wu, Kuo-Ming, Yu, Lihua, Zhang, Huiming, Zheng, Guo Zhu, Keaney, Gregg F.
Published in Cancer research (Chicago, Ill.) (01.08.2015)
Published in Cancer research (Chicago, Ill.) (01.08.2015)
Get full text
Journal Article
Cancer-Associated Mutations in SF3B1 Exhibit Neomorphic Splicing Activity and Block Erythroid Differentiation
Buonamici, Silvia, Perino, Samantha, Lim, Kian Huat, Feala, Jacob, Obeng, Esther A., Aicher, Michelle, Aird, Daniel, Bailey, Suzanna, Berkenblit, Anna, Chan, Betty, Erik, Corcoran, Corson, Laura, Darman, Rachel, Fekkes, Peter, Furman, Richard R., Keaney, Gregg F, Kumar, Pavan, Kunii, Kaiko, Lee, Linda, Mackenzie, Crystal, Park, Eunice, Puyang, Xiaoling, Selvaraj, Anand, Thomas, Michael, Wang, John, Warmuth, Markus, Yu, Lihua, Zhu, Ping, Mizui, Yoshiharu, Ebert, Benjamin L., Smith, Peter G
Published in Blood (06.12.2014)
Published in Blood (06.12.2014)
Get full text
Journal Article