Development of 14-epi-19-Nortachysterol and Its Unprecedented Binding Configuration for the Human Vitamin D Receptor
Sawada, Daisuke, Tsukuda, Yuya, Saito, Hiroshi, Kakuda, Shinji, Takimoto-Kamimura, Midori, Ochiai, Eiji, Takenouchi, Kazuya, Kittaka, Atsushi
Published in Journal of the American Chemical Society (11.05.2011)
Published in Journal of the American Chemical Society (11.05.2011)
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Journal Article
Synthesis and Biological Activities of 1α,4α,25- and 1α,4β,25-Trihydroxyvitamin D3 and Their Metabolism by Human CYP24A1 and UDP-Glucuronosyltransferase
Sawada, Daisuke, Tsukuda, Yuya, Yasuda, Kaori, Sakaki, Toshiyuki, Saito, Hiroshi, Takagi, Ken-ichiro, Takenouchi, Kazuya, Chen, Tai C., Reddy, G. Satyanarayana, Kittaka, Atsushi
Published in Chemical & pharmaceutical bulletin (01.10.2012)
Published in Chemical & pharmaceutical bulletin (01.10.2012)
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Journal Article
Synthesis and Biological Evaluation of 4-Substituted Vitamin D and 14-Epi-Previtamin D Analogs
Sawada, Daisuke, Tsukuda, Yuya, Saito, Hiroshi, Takagi, Ken-ichiro, Horie, Kyouhei, Ochiai, Eiji, Takenouchi, Kazuya, Kittaka, Atsushi
Published in Chemical & Pharmaceutical Bulletin (01.12.2009)
Published in Chemical & Pharmaceutical Bulletin (01.12.2009)
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Journal Article
Structure–activity relationship studies on vitamin D lactam derivatives as vitamin D receptor antagonist
Cho, Kaori, Uneuchi, Fumito, Kato-Nakamura, Yuko, Namekawa, Jun-ichi, Ishizuka, Seiichi, Takenouchi, Kazuya, Nagasawa, Kazuo
Published in Bioorganic & medicinal chemistry (01.08.2008)
Published in Bioorganic & medicinal chemistry (01.08.2008)
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Journal Article
Synthesis and Biological Activities of 14-epi-MART-10 and 14-epi-MART-11: Implications for Cancer and Osteoporosis Treatment
KITTAKA, Atsushi, HARA, Hideki, ISHIZUKA, Seiichi, HAYASHI, Keiko, IKUSHIRO, Shinichi, SAKAKI, Toshiyuki, SUGIURA, Takayuki, CHEN, Tai C, TAKANO, Masashi, SAWADA, Daisuke, ARAI, Midori A, TAKAGI, Kenichiro, CHIDA, Takayuki, HARADA, Yoshifumi, SAITO, Hiroshi, TAKENOUCHI, Kazuya
Published in Anticancer research (01.09.2009)
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Published in Anticancer research (01.09.2009)
Journal Article
Conference Proceeding
Creative synthesis of novel vitamin D analogs for health and disease
Kittaka, Atsushi, Saito, Nozomi, Honzawa, Shinobu, Takenouchi, Kazuya, Ishizuka, Seiichi, Chen, Tai C., Peleg, Sara, Kato, Shigeaki, Arai, Midori A.
Published in Journal of steroid biochemistry and molecular biology (01.03.2007)
Published in Journal of steroid biochemistry and molecular biology (01.03.2007)
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Journal Article
Conference Proceeding
Synthesis and structure-activity relationships of TEI-9647 derivatives as Vitamin D3 antagonists
TAKENOUCHI, Kazuya, SOGAWA, Ryo, MANABE, Kenji, SAITOH, Hiroshi, QINGZHI GAO, MIURA, Daishiro, ISHIZUKA, Seiichi
Published in Journal of steroid biochemistry and molecular biology (01.05.2004)
Published in Journal of steroid biochemistry and molecular biology (01.05.2004)
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Conference Proceeding
Journal Article
Synthesis and biological activities of vitamin D3 derivatives with cyanoalkyl side chain at C-2 position
Saitoh, Hiroshi, Watanabe, Hidekazu, Kakuda, Shinji, Takimoto-Kamimura, Midori, Takagi, Kenichiro, Takeuchi, Akiko, Takenouchi, Kazuya
Published in The Journal of steroid biochemistry and molecular biology (01.04.2015)
Published in The Journal of steroid biochemistry and molecular biology (01.04.2015)
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Journal Article
Design and synthesis of 2α-(tetrazolylethyl)-1α,25-dihydroxyvitamin D3 as a high affinity ligand for vitamin D receptor
Matsuo, Miki, Hasegawa, Asami, Takano, Masashi, Saito, Hiroshi, Kakuda, Shinji, Takagi, Kenichiro, Ochiai, Eiji, Horie, Kyohei, Takimoto-Kamimura, Midori, Takenouchi, Kazuya, Sawada, Daisuke, Kittaka, Atsushi
Published in The Journal of steroid biochemistry and molecular biology (01.10.2014)
Published in The Journal of steroid biochemistry and molecular biology (01.10.2014)
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Journal Article
Synthesis of 14-epi-2α-hydroxypropoxy-1α,25-dihydroxy-19-nortachysterol and its hVDR binding
Sawada, Daisuke, Tsukuda, Yuya, Saito, Hiroshi, Takagi, Kenichiro, Kakuda, Shinji, Takimoto-Kamimura, Midori, Ochiai, Eiji, Takenouchi, Kazuya, Kittaka, Atsushi
Published in The Journal of steroid biochemistry and molecular biology (01.07.2013)
Published in The Journal of steroid biochemistry and molecular biology (01.07.2013)
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Journal Article
Synthesis of C-2 substituted vitamin D derivatives having ringed side chains and their biological evaluation, especially biological effect on bone by modification at the C-2 position
Saitoh, Hiroshi, Chida, Takayuki, Takagi, Kenichiro, Horie, Kyohei, Sawai, Yoshiyuki, Nakamura, Yuko, Harada, Yoshifumi, Takenouchi, Kazuya, Kittaka, Atsushi
Published in Organic & biomolecular chemistry (21.05.2011)
Published in Organic & biomolecular chemistry (21.05.2011)
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Journal Article
Synthesis of novel C-2 substituted vitamin D derivatives having ringed side chains and their biological evaluation on bone
Saito, Hiroshi, Takagi, Kenichiro, Horie, Kyohei, Kakuda, Shinji, Takimoto-Kamimura, Midori, Ochiai, Eiji, Chida, Takayuki, Harada, Yoshifumi, Takenouchi, Kazuya, Kittaka, Atsushi
Published in The Journal of steroid biochemistry and molecular biology (01.07.2013)
Published in The Journal of steroid biochemistry and molecular biology (01.07.2013)
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Journal Article
Synthesis of 2α-Heteroarylalkyl Active Vitamin D3 with Therapeutic Effect on Enhancing Bone Mineral Density in Vivo
Matsuo, Miki, Hasegawa, Asami, Takano, Masashi, Saito, Hiroshi, Kakuda, Shinji, Chida, Takayuki, Takagi, Ken-ichiro, Ochiai, Eiji, Horie, Kyohei, Harada, Yoshifumi, Takimoto-Kamimura, Midori, Takenouchi, Kazuya, Sawada, Daisuke, Kittaka, Atsushi
Published in ACS medicinal chemistry letters (11.07.2013)
Published in ACS medicinal chemistry letters (11.07.2013)
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Journal Article
Synthesis of 2 alpha-Heteroarylalkyl Active Vitamin D-3 with Therapeutic Effect on Enhancing Bone Mineral Density in Vivo
Matsuo, Mild, Hasegawa, Asami, Takano, Masashi, Saito, Hiroshi, Kakuda, Shinji, Chida, Takayuld, Takagi, Ken-ichiro, Ochiai, Eiji, Horie, Kyohei, Harada, Yoshifumi, Takimoto-Kamimura, Midori, Takenouchi, Kazuya, Sawada, Daisuke, Kittaka, Atsushi
Published in ACS medicinal chemistry letters (11.07.2013)
Published in ACS medicinal chemistry letters (11.07.2013)
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Journal Article
Further synthetic and biological studies on vitamin D hormone antagonists based on C24-alkylation and C2 alpha-functionalization of 25-dehydro-1 alpha-hydroxyvitamin D-3-26,23-lactones
Saito, Nozomi, Matsunaga, Toshihiro, Saito, Hiroshi, Anzai, Miyuki, Takenouchi, Kazuya, Miura, Daishiro, Namekawa, Jun-ichi, Ishizuka, Seiichi, Kittaka, Atsushi
Published in Journal of medicinal chemistry (30.11.2006)
Published in Journal of medicinal chemistry (30.11.2006)
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Journal Article
Synthesis of 2α- and 2β-substituted-14- epi-previtamin D 3 and their genomic activity
Sawada, Daisuke, Katayama, Tomoyuki, Tsukuda, Yuya, Saito, Nozomi, Saito, Hiroshi, Takagi, Ken-ichiro, Ochiai, Eiji, Ishizuka, Seiichi, Takenouchi, Kazuya, Kittaka, Atsushi
Published in Tetrahedron (17.07.2010)
Published in Tetrahedron (17.07.2010)
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Journal Article
New C15-Substituted Active Vitamin D3
Shindo, Kanako, Kumagai, Go, Takano, Masashi, Sawada, Daisuke, Saito, Nozomi, Saito, Hiroshi, Kakuda, Shinji, Takagi, Ken-ichiro, Ochiai, Eiji, Horie, Kyohei, Takimoto-Kamimura, Midori, Ishizuka, Seiichi, Takenouchi, Kazuya, Kittaka, Atsushi
Published in Organic letters (03.06.2011)
Published in Organic letters (03.06.2011)
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Journal Article
New C15-Substituted Active Vitamin D-3
Shindo, Kanako, Kumagai, Go, Takano, Masashi, Sawada, Daisuke, Saito, Nozomi, Saito, Hiroshi, Kakuda, Shinji, Takagi, Ken-ichiro, Ochiai, Eiji, Horie, Kyohei, Takimoto-Kamimura, Midori, Ishizuka, Seiichi, Takenouchi, Kazuya, Kittaka, Atsushi
Published in Organic letters (03.06.2011)
Published in Organic letters (03.06.2011)
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Journal Article
Synthesis and Biological Activities of 1 alpha,4 alpha,25-and 1 alpha,4 beta,25-Trihydroxyvitamin D-3 and Their Metabolism by Human CYP24A1 and UDP-Glucuronosyltransferase
Sawada, Daisuke, Tsukuda, Yuya, Yasuda, Kaori, Sakaki, Toshiyuki, Saito, Hiroshi, Takagi, Ken-ichiro, Takenouchi, Kazuya, Chen, Tai C., Reddy, G. Satyanarayana, Kittaka, Atsushi
Published in Chemical & pharmaceutical bulletin (01.10.2012)
Published in Chemical & pharmaceutical bulletin (01.10.2012)
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Journal Article
Practical Synthesis and Evaluation of the Biological Activities of 1α,25-dihydroxyvitamin D3 Antagonists, 1α,25-dihydroxyvitamin D3-26,23-lactams. Designed on the Basis of the Helix 12-Folding Inhibition Hypothesis
Nakano, Yusuke, Kato, Yuko, Imai, Keisuke, Ochiai, Eiji, Namekawa, Jun-ichi, Ishizuka, Seiichi, Takenouchi, Kazuya, Tanatani, Aya, Hashimoto, Yuichi, Nagasawa, Kazuo
Published in Journal of medicinal chemistry (20.04.2006)
Published in Journal of medicinal chemistry (20.04.2006)
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Journal Article