TAS4464, A Highly Potent and Selective Inhibitor of NEDD8-Activating Enzyme, Suppresses Neddylation and Shows Antitumor Activity in Diverse Cancer Models
Yoshimura, Chihoko, Muraoka, Hiromi, Ochiiwa, Hiroaki, Tsuji, Shingo, Hashimoto, Akihiro, Kazuno, Hiromi, Nakagawa, Fumio, Komiya, Yu, Suzuki, Satoshi, Takenaka, Toru, Kumazaki, Masafumi, Fujita, Naoya, Mizutani, Takashi, Ohkubo, Shuichi
Published in Molecular cancer therapeutics (01.07.2019)
Published in Molecular cancer therapeutics (01.07.2019)
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Discovery of Futibatinib: The First Covalent FGFR Kinase Inhibitor in Clinical Use
Ito, Satoru, Otsuki, Sachie, Ohsawa, Hirokazu, Hirano, Atsushi, Kazuno, Hideki, Yamashita, Satoshi, Egami, Kosuke, Shibata, Yoshihiro, Yamamiya, Ikuo, Yamashita, Fumiaki, Kodama, Yasuo, Funabashi, Kaoru, Kazuno, Hiromi, Komori, Toshiharu, Suzuki, Satoshi, Sootome, Hiroshi, Hirai, Hiroshi, Sagara, Takeshi
Published in ACS medicinal chemistry letters (13.04.2023)
Published in ACS medicinal chemistry letters (13.04.2023)
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Possible antitumor activity of 1‐(3‐C‐ethynyl‐β‐d‐ribo‐pentofuranosyl)cytosine (ECyd, TAS‐106) against an established gemcitabine (dFdCyd)‐resistant human pancreatic cancer cell line
Kazuno, Hiromi, Sakamoto, Kazuki, Fujioka, Akio, Fukushima, Masakazu, Matsuda, Akira, Sasaki, Takuma
Published in Cancer science (01.05.2005)
Published in Cancer science (01.05.2005)
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Sensitivity of Human Cancer Cells to the New Anticancer Ribo‐nucleoside TAS–106 Is Correlated with Expression of Uridine‐cytidine Kinase 2
Shimamoto, Yuji, Koizumi, Katsuhisa, Okabe, Hiroyuki, Kazuno, Hiromi, Murakami, Yuko, Nakagawa, Fumio, Matsuda, Akira, Sasaki, Takuma, Fukushima, Masakazu
Published in Cancer science (01.07.2002)
Published in Cancer science (01.07.2002)
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Cellular and Biochemical Mechanisms of the Resistance of Human Cancer Cells to a New Anticancer Ribo‐nucleoside, TAS‐106
Shimamoto, Yuji, Kazuno, Hiromi, Murakami, Yuko, Azuma, Atsushi, Koizumi, Katsuhisa, Matsuda, Akira, Sasaki, Takuma, Fukushima, Masakazu
Published in Cancer science (01.04.2002)
Published in Cancer science (01.04.2002)
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Combination of pimitespib (TAS‐116) with sunitinib is an effective therapy for imatinib‐resistant gastrointestinal stromal tumors
Teranishi, Ryugo, Takahashi, Tsuyoshi, Obata, Yuuki, Nishida, Toshirou, Ohkubo, Shuichi, Kazuno, Hiromi, Saito, Yurina, Serada, Satoshi, Fujimoto, Minoru, Kurokawa, Yukinori, Saito, Takuro, Yamamoto, Kazuyoshi, Yamashita, Kotaro, Tanaka, Koji, Makino, Tomoki, Nakajima, Kiyokazu, Hirota, Seiichi, Naka, Tetsuji, Eguchi, Hidetoshi, Doki, Yuichiro
Published in International journal of cancer (15.06.2023)
Published in International journal of cancer (15.06.2023)
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Repeated oral dosing of TAS-102 confers high trifluridine incorporation into DNA and sustained antitumor activity in mouse models
TANAKA, NOZOMU, SAKAMOTO, KAZUKI, OKABE, HIROYUKI, FUJIOKA, AKIO, YAMAMURA, KEISUKE, NAKAGAWA, FUMIO, NAGASE, HIDEKI, YOKOGAWA, TATSUSHI, OGUCHI, KEI, ISHIDA, KEIJI, OSADA, AKIKO, KAZUNO, HIROMI, YAMADA, YUKARI, MATSUO, KENICHI
Published in Oncology reports (01.12.2014)
Published in Oncology reports (01.12.2014)
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Crucial roles of thymidine kinase 1 and deoxyUTPase in incorporating the antineoplastic nucleosides trifluridine and 2′-deoxy-5-fluorouridine into DNA
SAKAMOTO, KAZUKI, YOKOGAWA, TATSUSHI, UENO, HIROYUKI, OGUCHI, KEI, KAZUNO, HIROMI, ISHIDA, KEIJI, TANAKA, NOZOMU, OSADA, AKIKO, YAMADA, YUKARI, OKABE, HIROYUKI, MATSUO, KENICHI
Published in International journal of oncology (01.06.2015)
Published in International journal of oncology (01.06.2015)
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Abstract C176: TAS4464, a novel, highly potent, and selective inhibitor of NEDD8 activating enzyme demonstrates sustained target inhibition and antitumor activity in a preclinical model
Yoshimura, Chihoko, Muraoka, Hiromi, Ochiiwa, Hiroaki, Tsuji, Shingo, Hashimoto, Akihiro, Takenaka, Toru, Kazuno, Hiromi, Ishida, Keiji, Mizutani, Takashi, Ohkubo, Shuichi, Matsuo, Kenichi, Utsugi, Teruhiro, Iwasawa, Yoshikazu
Published in Molecular cancer therapeutics (01.12.2015)
Published in Molecular cancer therapeutics (01.12.2015)
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1-(3-C-Ethynyl-β-D-ribo-pentofuranosyl)cytosine (ECyd, TAS-106), a novel potent inhibitor of RNA polymerase, potentiates the cytotoxicity of CDDP in human cancer cells both in vitro and in vivo
KAZUNO, Hiromi, FUJIOKA, Akio, FUKUSHIMA, Masakazu, WATAYA, Yusuke, MATSUDA, Akira, SASAKI, Takuma
Published in International journal of oncology (01.05.2009)
Published in International journal of oncology (01.05.2009)
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Journal Article
Mechanism of action of a new antitumor ribonucleoside, 1-(3 -C -ethynyl -β-D -ribo -pentofuranosyl )cytosine (ECyd, TAS-106), differs from that of 5-fluorouracil
KAZUNO, Hiromi, SHIMAMOTO, Yuji, TSUJIMOTO, Hiroaki, FUKUSHIMA, Masakazu, MATSUDA, Akira, SASAKI, Takuma
Published in Oncology reports (01.06.2007)
Published in Oncology reports (01.06.2007)
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Journal Article
Antitumor activity and pharmacokinetics of TAS-106, 1-(3-C-ethynyl-β-D-ribopentofuranosyl)cytosine
SHIMAMOTO, Yuji, FUJIOKA, Akio, KAZUNO, Hiromi, MURAKAMI, Yuko, OHSHIMO, Hideyuki, KATO, Toshiyuki, MATSUDA, Akira, SASAKI, Takuma, FUKUSHIMA, Masakazu
Published in Japanese journal of cancer research (Gann) (01.03.2001)
Published in Japanese journal of cancer research (Gann) (01.03.2001)
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